LOCUS       NM_011497               1975 bp    mRNA    linear   ROD 03-MAY-2023
DEFINITION  Mus musculus aurora kinase A (Aurka), transcript variant 1, mRNA.
ACCESSION   NM_011497 XM_130737
VERSION     NM_011497.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1975)
  AUTHORS   Bharti V, Watkins R, Kumar A, Shattuck-Brandt RL, Mossing A, Mittra
            A, Shen C, Tsung A, Davies AE, Hanel W, Reneau JC, Chung C,
            Sizemore GM, Richmond A, Weiss VL and Vilgelm AE.
  TITLE     BCL-xL inhibition potentiates cancer therapies by redirecting the
            outcome of p53 activation from senescence to apoptosis
  JOURNAL   Cell Rep 41 (12), 111826 (2022)
   PUBMED   36543138
  REMARK    GeneRIF: BCL-xL inhibition potentiates cancer therapies by
            redirecting the outcome of p53 activation from senescence to
            apoptosis.
REFERENCE   2  (bases 1 to 1975)
  AUTHORS   Wildung M, Herr C, Riedel D, Wiedwald C, Moiseenko A, Ramirez F,
            Tasena H, Heimerl M, Alevra M, Movsisyan N, Schuldt M,
            Volceanov-Hahn L, Provoost S, Nothe-Menchen T, Urrego D, Freytag B,
            Wallmeier J, Beisswenger C, Bals R, van den Berge M, Timens W,
            Hiemstra PS, Brandsma CA, Maes T, Andreas S, Heijink IH, Pardo LA
            and Lize M.
  TITLE     miR449 Protects Airway Regeneration by Controlling
            AURKA/HDAC6-Mediated Ciliary Disassembly
  JOURNAL   Int J Mol Sci 23 (14), 7749 (2022)
   PUBMED   35887096
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1975)
  AUTHORS   Kratka C, Drutovic D, Blengini CS and Schindler K.
  TITLE     Using ZINC08918027 inhibitor to determine Aurora kinase-chromosomal
            passenger complex isoforms in mouse oocytes
  JOURNAL   BMC Res Notes 15 (1), 96 (2022)
   PUBMED   35255953
  REMARK    GeneRIF: Using ZINC08918027 inhibitor to determine Aurora
            kinase-chromosomal passenger complex isoforms in mouse oocytes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1975)
  AUTHORS   Tampakakis E, Gangrade H, Glavaris S, Htet M, Murphy S, Lin BL, Liu
            T, Saberi A, Miyamoto M, Kowalski W, Mukouyama YS, Lee G,
            Minichiello L and Kwon C.
  TITLE     Heart neurons use clock genes to control myocyte proliferation
  JOURNAL   Sci Adv 7 (49), eabh4181 (2021)
   PUBMED   34851661
REFERENCE   5  (bases 1 to 1975)
  AUTHORS   Akagawa R, Nabeshima YI and Kawauchi T.
  TITLE     Alternative Functions of Cell Cycle-Related and DNA Repair Proteins
            in Post-mitotic Neurons
  JOURNAL   Front Cell Dev Biol 9, 753175 (2021)
   PUBMED   34746147
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1975)
  AUTHORS   Shindo M, Nakano H, Kuroyanagi H, Shirasawa T, Mihara M, Gilbert
            DJ, Jenkins NA, Copeland NG, Yagita H and Okumura K.
  TITLE     cDNA cloning, expression, subcellular localization, and chromosomal
            assignment of mammalian aurora homologues, aurora-related kinase
            (ARK) 1 and 2
  JOURNAL   Biochem Biophys Res Commun 244 (1), 285-292 (1998)
   PUBMED   9514916
REFERENCE   7  (bases 1 to 1975)
  AUTHORS   Gopalan G, Gilbert DJ, Copeland NG, Jenkins NA and Donovan PJ.
  TITLE     Chromosome localization of two new mammalian kinases related to
            yeast and fly chromosome segregation-regulators
  JOURNAL   Mamm Genome 9 (1), 86-87 (1998)
   PUBMED   9434955
REFERENCE   8  (bases 1 to 1975)
  AUTHORS   Gopalan G, Chan CS and Donovan PJ.
  TITLE     A novel mammalian, mitotic spindle-associated kinase is related to
            yeast and fly chromosome segregation regulators
  JOURNAL   J Cell Biol 138 (3), 643-656 (1997)
   PUBMED   9245792
REFERENCE   9  (bases 1 to 1975)
  AUTHORS   Yanai A, Arama E, Kilfin G and Motro B.
  TITLE     ayk1, a novel mammalian gene related to Drosophila aurora
            centrosome separation kinase, is specifically expressed during
            meiosis
  JOURNAL   Oncogene 14 (24), 2943-2950 (1997)
   PUBMED   9205101
REFERENCE   10 (bases 1 to 1975)
  AUTHORS   Ferguson,J.M., Wallace,M.E. and Johnson,D.R.
  TITLE     A new type of chondrodystrophic mutant in the mouse
  JOURNAL   J Med Genet 15 (2), 128-131 (1978)
   PUBMED   641946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833787.8, CD560646.1, AK145968.1 and AL844162.9.
            
            [WARNING] On May 10, 2023 this sequence was replaced by
            NM_011497.5.
            
            On Mar 28, 2014 this sequence version replaced NM_011497.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014711.1, AF007817.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AL833787.8         13507-13598         c
            93-610              CD560646.1         16-533
            611-1973            AK145968.1         499-1861
            1974-1975           AL844162.9         77408-77409         c
FEATURES             Location/Qualifiers
     source          1..1975
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 94.84 cM"
     gene            1..1975
                     /gene="Aurka"
                     /gene_synonym="AIRK1; ARK-1; Ark1; Aurora-A; Ayk1; IAK;
                     IAK1; Stk6"
                     /note="aurora kinase A"
                     /db_xref="GeneID:20878"
                     /db_xref="MGI:MGI:894678"
     exon            1..176
                     /gene="Aurka"
                     /gene_synonym="AIRK1; ARK-1; Ark1; Aurora-A; Ayk1; IAK;
                     IAK1; Stk6"
                     /inference="alignment:Splign:2.1.0"
     exon            177..223
                     /gene="Aurka"
                     /gene_synonym="AIRK1; ARK-1; Ark1; Aurora-A; Ayk1; IAK;
                     IAK1; Stk6"
                     /inference="alignment:Splign:2.1.0"
     exon            224..473
                     /gene="Aurka"
                     /gene_synonym="AIRK1; ARK-1; Ark1; Aurora-A; Ayk1; IAK;
                     IAK1; Stk6"
                     /inference="alignment:Splign:2.1.0"
     exon            474..528
                     /gene="Aurka"
                     /gene_synonym="AIRK1; ARK-1; Ark1; Aurora-A; Ayk1; IAK;
                     IAK1; Stk6"
                     /inference="alignment:Splign:2.1.0"
     exon            529..720
                     /gene="Aurka"
                     /gene_synonym="AIRK1; ARK-1; Ark1; Aurora-A; Ayk1; IAK;
                     IAK1; Stk6"
                     /inference="alignment:Splign:2.1.0"
     exon            721..859
                     /gene="Aurka"
                     /gene_synonym="AIRK1; ARK-1; Ark1; Aurora-A; Ayk1; IAK;
                     IAK1; Stk6"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1008
                     /gene="Aurka"
                     /gene_synonym="AIRK1; ARK-1; Ark1; Aurora-A; Ayk1; IAK;
                     IAK1; Stk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1183
                     /gene="Aurka"
                     /gene_synonym="AIRK1; ARK-1; Ark1; Aurora-A; Ayk1; IAK;
                     IAK1; Stk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1975
                     /gene="Aurka"
                     /gene_synonym="AIRK1; ARK-1; Ark1; Aurora-A; Ayk1; IAK;
                     IAK1; Stk6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagggtttga ctcctatttt aaaaggagaa cctttgaatt gtaacggctg agctaccggg
       61 atcgcttgga ggcttcggtc gggagcaggt tcctgcctgt gagttggaaa gggacatggc
      121 tgttgagggc gagcctggat gctgcaaacg gatagggaag gctgtgtggc gtcggggtga
      181 catggacaga tgtaaagaaa actgtgtctc caggcctgtt aagaccactg ttcccttcgg
      241 tccgaaacgc gtcttggtga ctgagcagat tccgtctcag aacctaggat ctgctagcag
      301 tggccaggcc cagcgggtcc tgtgtccttc taactcccag cgtgtccctt cacaagccca
      361 gaaacttgga gcaggtcaga agccggcacc aaagcagttg ccagctgcca gtgttcctag
      421 gcctgtgtcc cggctcaata acccccagaa gaatgagcag cctgcagcct ccggaaatga
      481 ttctgaaaag gagcaggcat ccttgcagaa gaccgaagac acaaaaaaaa ggcagtggac
      541 tttggaagat tttgacattg gccgcccact aggaaaaggg aagtttggaa atgtctactt
      601 ggcgcgggag agacaaagca agttcatcct ggctctgaag gtgctgttta aaacacagct
      661 ggagaaggcg aacgtggagc accagcttcg gagagaggtg gagatccagt cgcacctgcg
      721 gcaccccaac atcctcaggc tgtatggcta tttccatgac gccacccgag tttatctgat
      781 tctagaatat gcgccccttg gaacagtcta tagagagctc caaaaactct ccaagtttga
      841 cgagcagaga acagctactt acatcactga gttggcaaac gctctgtctt actgtcattc
      901 aaagagagtg atccacagag acattaagcc agagaactta ctgcttggct caaacggaga
      961 gttgaagatt gcagacttcg ggtggtcggt gcatgctcca tcttccagga gaaccacaat
     1021 gtgtggcacc ctggactacc tgcccccaga gatgattgaa ggccggatgc atgacgagaa
     1081 ggtggacctc tggagcctcg gcgttctctg ctatgagttc ctagtgggga tgcctccttt
     1141 cgaggcacac acgtaccagg agacttacag aaggatatct cgggttgaat tcactttccc
     1201 tgactttgtg acagagggag ccagggacct catttcaaga ctgttaaaac acaacgcaag
     1261 ccaaaggcta acactagcgg aagtccttga gcacccttgg atcaaagcta attcttccaa
     1321 acctccaact ggccacacta gcaaagagcc aaccagcaaa tcatcttagg gaatcctgaa
     1381 ccacggccac cgtgcaactg tgagaaacac cctattgaag ccaccctcct ggaccctcat
     1441 ggctgccctc agggtgcctt gctgagcaac tagtccttgg ccatgcatcc aggaaacccc
     1501 aagaaccatg ctgcttttcc tgatttagta atctggaggg aaggttccac tgcagctgtc
     1561 ccctaccctc accctgggcc tgtgccccaa ggtgtccttg tggggggggg ggtctcactg
     1621 tgggaaactt accagagatc acctgtgtcg tagccttcaa gtgccagagt gtgtgtataa
     1681 cttattgggt caccaggcct agggaaactg ttggaatggg tatgtaatct tttaaatgtc
     1741 aaaataaaga tttgcataga ctttgacttt taagtgacac ccattcaggg tcttgtttcc
     1801 agtcgtctga agcccgtgcg ggatttggat cctcagccac tgctacggag cctgtgcctt
     1861 gtcttgagac ctgactcggg ggtttctttt tctgcatgtt aaaggctatt ttttatgttg
     1921 gagttctgtc atgtatgcaa acttgttaaa tatatatgta taccatctac ctgga
//
