LOCUS       NP_035627                417 aa            linear   ROD 08-AUG-2024
DEFINITION  aurora kinase A isoform a [Mus musculus].
ACCESSION   NP_035627 XP_130737
VERSION     NP_035627.1
DBSOURCE    REFSEQ: accession NM_011497.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 417)
  AUTHORS   Gomaa,A., Maacha,S., Peng,D., Soutto,M., Genoula,M., Bhat,N.,
            Cao,L., Zhu,S., Castells,A., Chen,Z., Zaika,A., McDonald,O.G. and
            El-Rifai,W.
  TITLE     SOX9 is regulated by AURKA in response to Helicobacter pylori
            infection via EIF4E-mediated cap-dependent translation
  JOURNAL   Cancer Lett 593, 216939 (2024)
   PUBMED   38729556
  REMARK    GeneRIF: SOX9 is regulated by AURKA in response to Helicobacter
            pylori infection via EIF4E-mediated cap-dependent translation.
REFERENCE   2  (residues 1 to 417)
  AUTHORS   Yang,Y., Wang,J., Wan,J., Cheng,Q., Cheng,Z., Zhou,X., Wang,O.,
            Shi,K., Wang,L., Wang,B., Zhu,X., Chen,J., Feng,D., Liu,Y.,
            Jahan-Mihan,Y., Haddock,A.N., Edenfield,B.H., Peng,G.,
            Hohenstein,J.D., McCabe,C.E., O'Brien,D.R., Wang,C., Ilyas,S.I.,
            Jiang,L., Torbenson,M.S., Wang,H., Nakhleh,R.E., Shi,X., Wang,Y.,
            Bi,Y., Gores,G.J., Patel,T. and Ji,B.
  TITLE     PTEN deficiency induces an extrahepatic
            cholangitis-cholangiocarcinoma continuum via aurora kinase A in
            mice
  JOURNAL   J Hepatol 81 (1), 120-134 (2024)
   PUBMED   38428643
  REMARK    GeneRIF: PTEN deficiency induces an extrahepatic
            cholangitis-cholangiocarcinoma continuum via aurora kinase A in
            mice.
REFERENCE   3  (residues 1 to 417)
  AUTHORS   Treekitkarnmongkol,W., Solis,L.M., Sankaran,D., Gagea,M.,
            Singh,P.K., Mistry,R., Nguyen,T., Kai,K., Liu,J., Sasai,K.,
            Jitsumori,Y., Liu,J., Nagao,N., Stossi,F., Mancini,M.A.,
            Wistuba,I.I., Thompson,A.M., Lee,J.M., Cadinanos,J., Wong,K.K.,
            Abbott,C.M., Sahin,A.A., Liu,S., Katayama,H. and Sen,S.
  TITLE     eEF1A2 promotes PTEN-GSK3beta-SCF complex-dependent degradation of
            Aurora kinase A and is inactivated in breast cancer
  JOURNAL   Sci Signal 17 (826), eadh4475 (2024)
   PUBMED   38442201
  REMARK    GeneRIF: eEF1A2 promotes PTEN-GSK3beta-SCF complex-dependent
            degradation of Aurora kinase A and is inactivated in breast cancer.
REFERENCE   4  (residues 1 to 417)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 417)
  AUTHORS   Sun,Y., Zhang,S., Zhang,X., Li,G., Sun,F., Wang,M., Ren,C.,
            Jiang,A. and Yang,T.
  TITLE     AURKA Enhances the Glycolysis and Development of Ovarian
            Endometriosis Through ERbeta
  JOURNAL   Endocrinology 165 (4) (2024)
   PUBMED   38340326
  REMARK    GeneRIF: AURKA Enhances the Glycolysis and Development of Ovarian
            Endometriosis Through ERbeta.
REFERENCE   6  (residues 1 to 417)
  AUTHORS   Shindo,M., Nakano,H., Kuroyanagi,H., Shirasawa,T., Mihara,M.,
            Gilbert,D.J., Jenkins,N.A., Copeland,N.G., Yagita,H. and Okumura,K.
  TITLE     cDNA cloning, expression, subcellular localization, and chromosomal
            assignment of mammalian aurora homologues, aurora-related kinase
            (ARK) 1 and 2
  JOURNAL   Biochem Biophys Res Commun 244 (1), 285-292 (1998)
   PUBMED   9514916
REFERENCE   7  (residues 1 to 417)
  AUTHORS   Gopalan,G., Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and
            Donovan,P.J.
  TITLE     Chromosome localization of two new mammalian kinases related to
            yeast and fly chromosome segregation-regulators
  JOURNAL   Mamm Genome 9 (1), 86-87 (1998)
   PUBMED   9434955
REFERENCE   8  (residues 1 to 417)
  AUTHORS   Gopalan,G., Chan,C.S. and Donovan,P.J.
  TITLE     A novel mammalian, mitotic spindle-associated kinase is related to
            yeast and fly chromosome segregation regulators
  JOURNAL   J Cell Biol 138 (3), 643-656 (1997)
   PUBMED   9245792
REFERENCE   9  (residues 1 to 417)
  AUTHORS   Yanai,A., Arama,E., Kilfin,G. and Motro,B.
  TITLE     ayk1, a novel mammalian gene related to Drosophila aurora
            centrosome separation kinase, is specifically expressed during
            meiosis
  JOURNAL   Oncogene 14 (24), 2943-2950 (1997)
   PUBMED   9205101
REFERENCE   10 (residues 1 to 417)
  AUTHORS   Ferguson,J.M., Wallace,M.E. and Johnson,D.R.
  TITLE     A new type of chondrodystrophic mutant in the mouse
  JOURNAL   J Med Genet 15 (2), 128-131 (1978)
   PUBMED   641946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833787.8 and AL844162.9.
            
            On Apr 11, 2004 this sequence version replaced XP_130737.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014711.1, SRR17253011.6950852.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 94.84 cM"
     Protein         1..417
                     /product="aurora kinase A isoform a"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine kinase 6; serine/threonine-protein
                     kinase 6; aurora family kinase 1; aurora-related kinase 1;
                     aurora/IPL1-related kinase 1; ipl1- and aurora-related
                     kinase 1; serine/threonine-protein kinase Ayk1;
                     serine/threonine-protein kinase aurora-A; aurora A; aurora
                     2; serine/threonine-protein kinase 15"
                     /calculated_mol_wt=47042
     Region          140..396
                     /region_name="STKc_Aurora-A"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Aurora-A kinase; cd14116"
                     /db_xref="CDD:271018"
     Site            order(140..141,145,165,167..168,170,172,179,183,188,
                     191..192,195..197,199..202,210..212,214,219,259,263,265,
                     293,295)
                     /site_type="other"
                     /note="TPX2 binding site [polypeptide binding]"
                     /db_xref="CDD:271018"
     Site            order(152..156,160,173,175,207,223..226,230,232,269,271,
                     273..274,276,287,290,304..307)
                     /site_type="active"
                     /db_xref="CDD:271018"
     Site            order(152..156,160,173,175,207,224,226,230,273..274,276,
                     287)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271018"
     Site            order(156,230,232,269,271,273,290,304..307)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271018"
     Site            286..307
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271018"
     CDS             1..417
                     /gene="Aurka"
                     /gene_synonym="AIRK1; ARK-1; Ark1; Aurora-A; Ayk1; IAK;
                     IAK1; Stk6"
                     /coded_by="NM_011497.5:67..1320"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS17129.1"
                     /db_xref="GeneID:20878"
                     /db_xref="MGI:MGI:894678"
ORIGIN      
        1 mavegepgcc krigkavwrr gdmdrckenc vsrpvkttvp fgpkrvlvte qipsqnlgsa
       61 ssgqaqrvlc psnsqrvpsq aqklgagqkp apkqlpaasv prpvsrlnnp qkneqpaasg
      121 ndsekeqasl qktedtkkrq wtledfdigr plgkgkfgnv ylarerqskf ilalkvlfkt
      181 qlekanvehq lrreveiqsh lrhpnilrly gyfhdatrvy lileyaplgt vyrelqklsk
      241 fdeqrtatyi telanalsyc hskrvihrdi kpenlllgsn gelkiadfgw svhapssrrt
      301 tmcgtldylp pemiegrmhd ekvdlwslgv lcyeflvgmp pfeahtyqet yrrisrveft
      361 fpdfvtegar dlisrllkhn asqrltlaev lehpwikans skpptghtsk eptskss
//
