LOCUS       NM_016709               1345 bp    mRNA    linear   ROD 12-NOV-2023
DEFINITION  Mus musculus AU RNA binding protein/enoyl-coenzyme A hydratase
            (Auh), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_016709
VERSION     NM_016709.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1345)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   2  (bases 1 to 1345)
  AUTHORS   Brennan LE, Nakagawa J, Egger D, Bienz K and Moroni C.
  TITLE     Characterisation and mitochondrial localisation of AUH, an
            AU-specific RNA-binding enoyl-CoA hydratase
  JOURNAL   Gene 228 (1-2), 85-91 (1999)
   PUBMED   10072761
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY741014.1, BC049597.1 and BB207692.1.
            
            [WARNING] On Dec 5, 2023 this sequence was replaced by NM_016709.3.
            
            On Oct 19, 2006 this sequence version replaced NM_016709.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049597.1, AK003219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BY741014.1         2-17
            17-1331             BC049597.1         1-1315
            1332-1345           BB207692.1         319-332
FEATURES             Location/Qualifiers
     source          1..1345
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 27.68 cM"
     gene            1..1345
                     /gene="Auh"
                     /note="AU RNA binding protein/enoyl-coenzyme A hydratase"
                     /db_xref="GeneID:11992"
                     /db_xref="MGI:MGI:1338011"
     exon            1..223
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..981
                     /gene="Auh"
                     /EC_number="4.2.1.18"
                     /EC_number="4.2.1.56"
                     /note="methylglutaconyl-CoA hydratase, mitochondrial;
                     muAUH; AU-binding enoyl-CoA hydratase; AU-specific
                     RNA-binding enoyl-CoA hydratase; itaconyl-CoA hydratase;
                     3-MG-CoA hydratase"
                     /codon_start=1
                     /product="methylglutaconyl-CoA hydratase, mitochondrial
                     precursor"
                     /protein_id="NP_057918.2"
                     /db_xref="CCDS:CCDS26518.1"
                     /db_xref="GeneID:11992"
                     /db_xref="MGI:MGI:1338011"
                     /translation="MAAAAPGALGALRTVGVRLVAACCARLGPAAWARGTAPRRGYSS
                     EVKTEDELRVRHLEEENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTI
                     IIRSEVPGIFCAGADLKERAKMHSSEVGPFVSKIRSVINDIANLPVPTIAAIDGLALG
                     GGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVL
                     DGQEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDL
                     VTGLAIEEACYAQTISTKDRLEGLLAFKEKRPPRYKGE"
     exon            224..291
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
     exon            292..379
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
     exon            380..466
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
     exon            467..559
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
     exon            560..616
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
     exon            617..804
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
     exon            805..855
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
     exon            856..903
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1345
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcctggcc gcgggcgccc gctgtaaaca tacaacatgg cggcggcggc tccaggcgct
       61 ctgggcgcct tgagaacggt tggcgtccgc ctggtggccg cgtgctgcgc gcggctcggc
      121 cccgcggcct gggctagggg taccgccccg aggaggggct acagctcgga ggtgaagacg
      181 gaggatgagt tgcgcgtgcg gcacctggag gaggagaacc gaggcattgt ggtgctcggg
      241 attaacagag cttatgggaa aaatgcactc agtaaaaatc tcctcaagat gttatcaaaa
      301 gcggtggatg cattaaagtc agataagaaa gttcggacca ttatcatcag aagtgaagtc
      361 cctgggatat tctgtgctgg tgctgacctt aaggaacgag ccaagatgca ttccagtgaa
      421 gttggtccct ttgtctccaa gatccgatcg gtgatcaatg acattgcaaa cctcccggtg
      481 cccaccatcg cagccataga cggccttgcc ctcggagggg gtctggagct ggctctagcg
      541 tgtgacattc gagtagcagc ttcctctgca aaaatgggcc tggttgaaac aaagttggca
      601 attattcctg gcggaggagg gacacagaga ttaccacgtg ccatcgggat gtccctggct
      661 aaggaactca tcttctctgc ccgagttctt gacggtcaag aagccaaagc tgtgggcttg
      721 atcagccatg tgttagaaca gaaccaggaa ggggatgcag cctacaggaa ggcgctggac
      781 ctggcgagag agtttctacc tcaggggcct gttgcaatga gagtggccaa actagcaatt
      841 aaccaaggga tggaggtcga cttagtaaca gggttagcca tagaagaagc ctgctatgct
      901 cagaccatct caacaaagga cagactggaa ggtcttcttg cttttaagga gaaaagacct
      961 cctcgctaca agggagaata ggaggagagc ccgccgcagc ctcccatagt gctggaagtg
     1021 gttcagagcc accccgtgct gccatgggaa attgcagtga ccaaagtgga gagtgggttc
     1081 tcactacacc cggagcaggc ccatctgtac tcaagccact gtgcgccatg tcatatttat
     1141 tcagatttat aaagctagca atgtccgtgg tcaaaacacg taaaaattag gtatatgttt
     1201 ttaatatttc ccgcatatca ggctttgtcg ttaatttttt aatgtgaata atttatattg
     1261 cacactctag gaaataattg attgtatgtc taccatgctg cattaagaaa ataaaactat
     1321 ttctgtatcc caaaaatgtg aagtt
//
