LOCUS       NM_001403855            3924 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus ataxin 7-like 3 (Atxn7l3), transcript variant 8, mRNA.
ACCESSION   NM_001403855 XM_006533046
VERSION     NM_001403855.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3924)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3924)
  AUTHORS   Khang,R., Jo,A., Kang,H., Kim,H., Kwag,E., Lee,J.Y., Koo,O.,
            Park,J., Kim,H.K., Jo,D.G., Hwang,I., Ahn,J.Y., Lee,Y., Choi,J.Y.,
            Lee,Y.S. and Shin,J.H.
  TITLE     Loss of zinc-finger protein 212 leads to Purkinje cell death and
            locomotive abnormalities with phospholipase D3 downregulation
  JOURNAL   Sci Rep 11 (1), 22745 (2021)
   PUBMED   34815492
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3924)
  AUTHORS   Wang,F., El-Saafin,F., Ye,T., Stierle,M., Negroni,L., Durik,M.,
            Fischer,V., Devys,D., Vincent,S.D. and Tora,L.
  TITLE     Histone H2Bub1 deubiquitylation is essential for mouse development,
            but does not regulate global RNA polymerase II transcription
  JOURNAL   Cell Death Differ 28 (8), 2385-2403 (2021)
   PUBMED   33731875
REFERENCE   4  (bases 1 to 3924)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 3924)
  AUTHORS   Bonnet,J., Wang,C.Y., Baptista,T., Vincent,S.D., Hsiao,W.C.,
            Stierle,M., Kao,C.F., Tora,L. and Devys,D.
  TITLE     The SAGA coactivator complex acts on the whole transcribed genome
            and is required for RNA polymerase II transcription
  JOURNAL   Genes Dev 28 (18), 1999-2012 (2014)
   PUBMED   25228644
REFERENCE   6  (bases 1 to 3924)
  AUTHORS   Zhao,Y., Lang,G., Ito,S., Bonnet,J., Metzger,E., Sawatsubashi,S.,
            Suzuki,E., Le Guezennec,X., Stunnenberg,H.G., Krasnov,A.,
            Georgieva,S.G., Schule,R., Takeyama,K., Kato,S., Tora,L. and
            Devys,D.
  TITLE     A TFTC/STAGA module mediates histone H2A and H2B deubiquitination,
            coactivates nuclear receptors, and counteracts heterochromatin
            silencing
  JOURNAL   Mol Cell 29 (1), 92-101 (2008)
   PUBMED   18206972
REFERENCE   7  (bases 1 to 3924)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 3924)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
REFERENCE   9  (bases 1 to 3924)
  AUTHORS   Brand,M., Moggs,J.G., Oulad-Abdelghani,M., Lejeune,F.,
            Dilworth,F.J., Stevenin,J., Almouzni,G. and Tora,L.
  TITLE     UV-damaged DNA-binding protein in the TFTC complex links DNA damage
            recognition to nucleosome acetylation
  JOURNAL   EMBO J 20 (12), 3187-3196 (2001)
   PUBMED   11406595
REFERENCE   10 (bases 1 to 3924)
  AUTHORS   Brand,M., Yamamoto,K., Staub,A. and Tora,L.
  TITLE     Identification of TATA-binding protein-free TAFII-containing
            complex subunits suggests a role in nucleosome acetylation and
            signal transduction
  JOURNAL   J Biol Chem 274 (26), 18285-18289 (1999)
   PUBMED   10373431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954730.15.
            
            On Apr 5, 2022 this sequence version replaced XM_006533046.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.604868.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               AL954730.15        129969-130355       c
            388-498             AL954730.15        128515-128625       c
            499-631             AL954730.15        128076-128208       c
            632-803             AL954730.15        127700-127871       c
            804-901             AL954730.15        127410-127507       c
            902-924             AL954730.15        127212-127234       c
            925-991             AL954730.15        126842-126908       c
            992-1077            AL954730.15        126633-126718       c
            1078-1146           AL954730.15        126271-126339       c
            1147-1190           AL954730.15        126008-126051       c
            1191-1262           AL954730.15        125702-125773       c
            1263-1420           AL954730.15        125464-125621       c
            1421-3924           AL954730.15        122866-125369       c
FEATURES             Location/Qualifiers
     source          1..3924
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.29 cM"
     gene            1..3924
                     /gene="Atxn7l3"
                     /gene_synonym="E030022H21Rik"
                     /note="ataxin 7-like 3"
                     /db_xref="GeneID:217218"
                     /db_xref="MGI:MGI:3036270"
     exon            1..387
                     /gene="Atxn7l3"
                     /gene_synonym="E030022H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            388..498
                     /gene="Atxn7l3"
                     /gene_synonym="E030022H21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             448..1569
                     /gene="Atxn7l3"
                     /gene_synonym="E030022H21Rik"
                     /note="isoform d is encoded by transcript variant 8;
                     SAGA-associated factor 11 homolog; ataxin-7-like protein
                     3"
                     /codon_start=1
                     /product="ataxin-7-like protein 3 isoform d"
                     /protein_id="NP_001390784.1"
                     /db_xref="GeneID:217218"
                     /db_xref="MGI:MGI:3036270"
                     /translation="MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVK
                     CGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHL
                     EKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKL
                     WYLPFQNPNSPRRSKSLKHKNGFSVCTSASNTLPLLFSSSGELSNSDPFKYSNSTGIS
                     YETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPE
                     VESSLDNDGFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKT
                     KKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN"
     exon            499..631
                     /gene="Atxn7l3"
                     /gene_synonym="E030022H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            632..803
                     /gene="Atxn7l3"
                     /gene_synonym="E030022H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            804..901
                     /gene="Atxn7l3"
                     /gene_synonym="E030022H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            902..924
                     /gene="Atxn7l3"
                     /gene_synonym="E030022H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            925..991
                     /gene="Atxn7l3"
                     /gene_synonym="E030022H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1077
                     /gene="Atxn7l3"
                     /gene_synonym="E030022H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1146
                     /gene="Atxn7l3"
                     /gene_synonym="E030022H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1190
                     /gene="Atxn7l3"
                     /gene_synonym="E030022H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1262
                     /gene="Atxn7l3"
                     /gene_synonym="E030022H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1420
                     /gene="Atxn7l3"
                     /gene_synonym="E030022H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..3924
                     /gene="Atxn7l3"
                     /gene_synonym="E030022H21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3901..3906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atxn7l3"
                     /gene_synonym="E030022H21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3924
                     /gene="Atxn7l3"
                     /gene_synonym="E030022H21Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtcctcgctc gctccatcca tccatcctcc ggtcgcggca cgcgcgcgcg ctccgggctc
       61 gcgccgcacc ccccgcccgg gagaggcggg ctggagtggg gggcgggggg aggggcgcgc
      121 ggacggcgcg cggactgcgc gcgggcgggg tgaggtgagg aggaggaggc ggcgacggga
      181 cgagaaggga ggggaagggg ccatggccgc ccggtgaggc ggcgaggcgg gggggcagcc
      241 cgaccccccg gccccgggcc ccgggccccg gggagaggcg aggacggacc gacggacatg
      301 gggctccgga gcagccgccg tcgccgccgc cgccggagga cgcggccctg agaggccgcc
      361 gggccccggc gcggcccccc gggcgggccg tgttgccgcc cgctgtgcta tgagcagtca
      421 gagcgccgtc tccacaagag tttacaaatg aaaatggagg aaatgtcttt gtctggcctg
      481 gataacagca aactagaggc catcgctcag gagatatatg ctgacctggt cgaggattct
      541 tgtttgggat tctgctttga agtacaccgg gctgttaagt gtggctactt cttcctggat
      601 gatacggatc ctgacagcat gaaggatttt gagatcgtgg accagcctgg gttggacatc
      661 tttggacagg ttttcaacca gtggaagagc aaggagtgtg tttgccccaa ttgcagccgc
      721 agtattgctg cttcccgctt tgccccccac ctggagaagt gcctgggaat gggtcgcaac
      781 agcagccgaa tcgccaaccg tcggattgcc aatagcaaca atatgaacaa gtctgagagt
      841 gaccaagaag acaacgatga catcaatgac aatgactggt cctatggctc agagaagaaa
      901 gccaagaaga gaaaatcaga caagctatgg tatctcccat tccagaaccc taattcccct
      961 cgaagatcca agtctctaaa acacaaaaat gggttctctg tctgtacctc tgcatcaaac
     1021 acccttcccc ttcttttttc ttcttcaggg gaacttagca actccgatcc ttttaagtat
     1081 agcaactcaa ctgggatcag ctatgagacc ctgggtccag aggagctgcg gagcctgctc
     1141 accacgcaat gtggagtgat ttctgaacat accaagaaga tgtgcacaag gtcactacgc
     1201 tgcccgcagc acacggatga acagaggcga accgtacgga tttatttcct tgggccctcg
     1261 gccgttcttc cagaggtaga gagctccttg gataacgatg gctttgacat gactgatagc
     1321 caggccctca tcagccggct tcagtgggac ggctcttctg atctctcacc ttctgattca
     1381 ggctcctcca agactagtga aaatcaggga tggggtttag gtaccaacag ctctgaatca
     1441 cggaaaacca agaaaaagaa atcccatctg agcttggtag ggactgcctc tggcctgggc
     1501 tccaacaaga agaaaaagcc aaagccaccg gctcccccaa cgcccagcat ctatgatgac
     1561 atcaactgac ttgggtgcaa gggatagcct ttggctgaga gagccctctc tcccgacccc
     1621 cacccaggca gcatagcctg gcatatggac agctgctggg ggtctgggct tgggaagctt
     1681 ggtgggccag gcaggcagag gatccaatta tgtgcccctg gggggtgtca ggatcctctg
     1741 caacggagca tgacccctcg gcgtgcggga ctcagacctg gacatattat gccttggaca
     1801 taagtttggt ggggagacgg ttttcctatt tattctgtga gttactggat gtccagctag
     1861 gctgggggcc tgacctgggc actgtgccag ggcactgcct gctccccacc ccaggaactg
     1921 gactaagccc tgccgagggg catcgtggct acccaggcgg ctttgggttg gaagctgagc
     1981 ccagaggggg cctcccctgg ctgccctcag caatgtgaaa ggttcggtgc ttggagctga
     2041 ggggcagggc tgctatgtcc tgtttgtgtg cagagtccta tcagatgtcc ccattccccg
     2101 gggtcagcag gcacagtgct gtctgctacg gtgggcatcc agaactgcct cacaggaggc
     2161 agccctttcc cctcagtccc catgggcctc cttggcagca ggagctgtcc ttttgttgtt
     2221 gggtgccggg aaaggacctc cagcctctac agcttcaagg aatgggaagg ggagggtagg
     2281 aagagggagc ctgtatcaga gtggccccct gccctccctg ccccagggct gtgagatggc
     2341 ccaggtgaga gggacggtgc tgctttattt gaaatgtttc ttacctcatt ccctgcccca
     2401 ggaaggggcc cagcctcacc ctcctggggt ggccccgtgt tctccctccc atcctgcccc
     2461 ctgccctgcc ctgctggggc agcctgagct cccagctgct gcttgccccc cacccccttt
     2521 cccttgacca gcttcagttc ctctcagtgc tctcgcctct aaagcctgcc ctctctcccc
     2581 tcccttgccg cttttaagtt atttattctg tacttgtggt ttggggctct gaggaaaaac
     2641 cctaatcttg tgcctctctc cctttgctag gagtaggatg ggatgagaag gtagtctctg
     2701 ccctgggttg tcagtggagt taggaggggt gctcttgccc ctctgtggga ctgtcatgcc
     2761 agagcactca cctacctgac ctgtatccca cctcccagca ggtagcatca caccttggag
     2821 ctggaagatc tggctatggg ctgattgaca gggatggggt tgatcctgag cctagttttc
     2881 tggctcttgc tatacatgtc ccctcttccc aggaggaggc actcccacat tgggtagcta
     2941 gtacccaaga ctggttggac tgatttgggt tagggaccca gcgggctaag ggaacaaccg
     3001 tgctagggct gcagcgccct gtctggaacc cagtctccct ggggtggcgc tcattgtggc
     3061 tgaggcctgc ttacaagttg atttttaacc caagtattgt gattattttt taaaaagtca
     3121 agctaatttt ggcaggagtt agaataaatc cttggagcct gggcccctct gtccttggcc
     3181 ctccatagcc ttctcgctag agggggaaag aaggttctcg ggccggcccc actaccaagc
     3241 atagcttggg aacctgctga aggtcagggg aagccggccc aggttcttat ccctttggag
     3301 tagctgcagc tcaggccaac tcactctgct ctccttccca cctctccctt ttccctctgg
     3361 ttggagggag tagtttggga actggtttgt ccacaaaaac ttccccattg ttccttggct
     3421 caccctcagg gcagaacccc ctgcccaggc tgggtgagag atgggcttgg tccagcaggg
     3481 accctgaggg aacaaacccc ttctttgggg agtatgccct ccctactgtg tagttgaaca
     3541 ggggctagga actccccact ccctccctct aacagcaggc tgtgtgggtt tcaattccca
     3601 tcctccccac cctggctagg tgtcgtccac cctgtatcct atcatgtgtc tgtgtgtggg
     3661 ggggttctgt actaatttcc atggccggtg gcttttcctt ccatgcatca ctcccccccg
     3721 catgcccagg ggccacccgc ctggcattac cgcatgctgg ggtcattggg ggaggggggt
     3781 ggggctcacg ctgtcctgtg gtcttgagat ttttattttt gcatatgtaa tccatcctgt
     3841 acaggtagct aactttgtaa acgctgtgta ttcccctctg ccctcatggc tgctggtgta
     3901 aataaactgc atttcccgtt ggta
//
