LOCUS       NM_016843               2569 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus ataxin 10 (Atxn10), mRNA.
ACCESSION   NM_016843
VERSION     NM_016843.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2569)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2569)
  AUTHORS   Bentley-Ford,M.R., Andersen,R.S., Croyle,M.J., Haycraft,C.J.,
            Clearman,K.R., Foote,J.B., Reiter,J.F. and Yoder,B.K.
  TITLE     ATXN10 Is Required for Embryonic Heart Development and Maintenance
            of Epithelial Cell Phenotypes in the Adult Kidney and Pancreas
  JOURNAL   Front Cell Dev Biol 9, 705182 (2021)
   PUBMED   34970537
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2569)
  AUTHORS   Khang,R., Jo,A., Kang,H., Kim,H., Kwag,E., Lee,J.Y., Koo,O.,
            Park,J., Kim,H.K., Jo,D.G., Hwang,I., Ahn,J.Y., Lee,Y., Choi,J.Y.,
            Lee,Y.S. and Shin,J.H.
  TITLE     Loss of zinc-finger protein 212 leads to Purkinje cell death and
            locomotive abnormalities with phospholipase D3 downregulation
  JOURNAL   Sci Rep 11 (1), 22745 (2021)
   PUBMED   34815492
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2569)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2569)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2569)
  AUTHORS   Andrali,S.S., Marz,P. and Ozcan,S.
  TITLE     Ataxin-10 interacts with O-GlcNAc transferase OGT in pancreatic
            beta cells
  JOURNAL   Biochem Biophys Res Commun 337 (1), 149-153 (2005)
   PUBMED   16182253
  REMARK    GeneRIF: Ataxin-10, encoded by the SCA10 gene, interacts with
            O-linked N-acetylglucosamine in vivo and is modified by O-linked
            glycosylation in the insulinoma MIN6 cell line.
REFERENCE   7  (bases 1 to 2569)
  AUTHORS   Lopez-Fernandez,L.A., Parraga,M. and del Mazo,J.
  TITLE     Tex261, a novel gene presumably related but distinct from
            steroidogenic acute regulatory (StAR) gene, is regulated during the
            development of germ cells
  JOURNAL   Biochem Biophys Res Commun 242 (3), 565-569 (1998)
   PUBMED   9464256
REFERENCE   8  (bases 1 to 2569)
  AUTHORS   Lopez-Fernandez,L.A. and del Mazo,J.
  TITLE     Characterization of genes expressed early in mouse spermatogenesis,
            isolated from a subtractive cDNA library
  JOURNAL   Mamm Genome 7 (9), 698-700 (1996)
   PUBMED   8703127
REFERENCE   9  (bases 1 to 2569)
  AUTHORS   Zoppe,M., Frattini,A., Faranda,S. and Vezzoni,P.
  TITLE     The complete sequence of the host cell factor 1 (HCFC1) gene and
            its promoter: a role for YY1 transcription factor in the regulation
            of its expression
  JOURNAL   Genomics 34 (1), 85-91 (1996)
   PUBMED   8661027
REFERENCE   10 (bases 1 to 2569)
  AUTHORS   Kato,K.
  TITLE     A Collection of cDNA Clones with Specific Expression Patterns in
            Mouse Brain
  JOURNAL   Eur J Neurosci 2 (8), 704-711 (1990)
   PUBMED   12106288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC046802.1, AK153271.1 and BQ176715.1.
            
            On Jul 12, 2018 this sequence version replaced NM_016843.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161950.1, AK153271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               BC046802.1         11-136
            127-2551            AK153271.1         3-2427
            2552-2569           BQ176715.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2569
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 40.32 cM"
     gene            1..2569
                     /gene="Atxn10"
                     /gene_synonym="E46; Sca10; TEG-169; Tex169"
                     /note="ataxin 10"
                     /db_xref="GeneID:54138"
                     /db_xref="MGI:MGI:1859293"
     exon            1..326
                     /gene="Atxn10"
                     /gene_synonym="E46; Sca10; TEG-169; Tex169"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1638
                     /gene="Atxn10"
                     /gene_synonym="E46; Sca10; TEG-169; Tex169"
                     /note="brain protein E46; spinocerebellar ataxia type 10
                     protein homolog; testis expressed gene 169"
                     /codon_start=1
                     /product="ataxin-10"
                     /protein_id="NP_058539.2"
                     /db_xref="CCDS:CCDS37170.1"
                     /db_xref="GeneID:54138"
                     /db_xref="MGI:MGI:1859293"
                     /translation="MAAPRMPPSRLSGIMVPAPIQDLEALRALTALFKEQRNRETAPR
                     TIFQRVLDILKKSTHAVELACRDPSQVEHLASSLQLITECFRCLRNACIECSVNQNSI
                     RNLDTIGVAVDLVLLFRELRVEQDSLLTAFRCGLQFLGNVASRNEESQSIVWVHAFPE
                     LFMSCLNHPDKKIVAYCSMILFTSLNAERMKDLEENLNIAINVIEAHQKHPASEWPFL
                     IISDHFLKSPELVEAMYGKLSNQERITLLDIVIAKLVGEEQLTKDDISIFVRHAELIA
                     NSFMDQCRNVLKLTSEPHTEDKEALVTIRLLDVLCEMTSNTELLGYLQVFPGLMERVI
                     DVLRVIHEVGKESTNIFSPSDSLKAEGDIEHMTEGFKSHLIRLIGNLCYKNKENQDKV
                     NELDGIPLILDSSNIDDNNPFMMQWVVYAVRNLTEDNSQNQDVIAKMEEQGLADASLL
                     KKMGFEIEKSGDKLILKSNNDIPPP"
     exon            327..518
                     /gene="Atxn10"
                     /gene_synonym="E46; Sca10; TEG-169; Tex169"
                     /inference="alignment:Splign:2.1.0"
     exon            519..601
                     /gene="Atxn10"
                     /gene_synonym="E46; Sca10; TEG-169; Tex169"
                     /inference="alignment:Splign:2.1.0"
     exon            602..698
                     /gene="Atxn10"
                     /gene_synonym="E46; Sca10; TEG-169; Tex169"
                     /inference="alignment:Splign:2.1.0"
     exon            699..857
                     /gene="Atxn10"
                     /gene_synonym="E46; Sca10; TEG-169; Tex169"
                     /inference="alignment:Splign:2.1.0"
     exon            858..938
                     /gene="Atxn10"
                     /gene_synonym="E46; Sca10; TEG-169; Tex169"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1104
                     /gene="Atxn10"
                     /gene_synonym="E46; Sca10; TEG-169; Tex169"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1213
                     /gene="Atxn10"
                     /gene_synonym="E46; Sca10; TEG-169; Tex169"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1383
                     /gene="Atxn10"
                     /gene_synonym="E46; Sca10; TEG-169; Tex169"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1447
                     /gene="Atxn10"
                     /gene_synonym="E46; Sca10; TEG-169; Tex169"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1635
                     /gene="Atxn10"
                     /gene_synonym="E46; Sca10; TEG-169; Tex169"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..2552
                     /gene="Atxn10"
                     /gene_synonym="E46; Sca10; TEG-169; Tex169"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1890..1895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atxn10"
                     /gene_synonym="E46; Sca10; TEG-169; Tex169"
                     /note="hexamer: AATAAA"
     polyA_site      1927
                     /gene="Atxn10"
                     /gene_synonym="E46; Sca10; TEG-169; Tex169"
                     /note="major polyA site"
     regulatory      2532..2537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atxn10"
                     /gene_synonym="E46; Sca10; TEG-169; Tex169"
                     /note="hexamer: AATAAA"
     polyA_site      2552
                     /gene="Atxn10"
                     /gene_synonym="E46; Sca10; TEG-169; Tex169"
ORIGIN      
        1 ctgccgcgtc gccttgtcct cttcgcctga ggcaagccag ctagtctcgc gctctctgcc
       61 ttgcagcacc acgggatctg ggtgacgcgg gctgcggaag ccagagccgt gcagaccgcg
      121 tctccatctc ctcgcctgtc gtctgtctcc cccacttctc ttcgctctgc tctccgcctg
      181 gtcaggctcg gccccagagc gagtggcaag atggcggcgc ccaggatgcc accctcccgg
      241 ctgtcgggca tcatggtgcc cgcacccatc caggacctgg aggccttgcg cgcgctcacg
      301 gcgctcttca aggagcagcg taaccgggaa acagcaccca gaacgatctt ccagagagtc
      361 ctggatatct taaagaagtc tactcatgct gttgagctgg cctgcaggga tccctcccaa
      421 gtggaacatc tggcttccag tctgcagcta atcactgaat gcttcagatg tcttcggaat
      481 gcttgtatag agtgttctgt gaatcagaat tccatcagga acctggatac gatcggagtt
      541 gctgttgatt tggttcttct ctttcgtgaa cttcgggtgg aacaagactc cttgttgaca
      601 gcttttcgat gtggcctgca gtttttaggc aacgttgcct cacgaaatga agaatcccag
      661 tccattgttt gggtccacgc cttcccagaa ctcttcatgt cttgcttgaa ccatccagac
      721 aaaaagattg ttgcctactg ttccatgatt ctgttcacat ctcttaatgc tgaaaggatg
      781 aaagacctgg aagagaacct caatattgca attaacgtca tagaagctca ccaaaagcac
      841 ccggcgtcag agtggccgtt cttgattatt tcagaccact ttctgaaaag cccggaactg
      901 gtggaagcta tgtatggcaa actcagcaac caggaaagga tcacactgtt agacatagtg
      961 atagccaagc tagtgggtga ggagcagctg acaaaggatg acatctctat ctttgtgcgc
     1021 catgccgagt tgattgcaaa ctcatttatg gatcagtgca ggaacgtgct gaagttgacc
     1081 tcagagcctc acaccgagga taaggaagcc ctggttacga ttcggctcct ggatgtcttg
     1141 tgtgaaatga cgtccaacac tgagcttctc ggctacctgc aggttttccc tggcctgatg
     1201 gaacgcgtga ttgatgtttt acgagtgatt catgaagttg gaaaagaaag cacgaacatc
     1261 ttcagtccct cagactctct aaaagcagag ggtgacatcg aacacatgac tgaaggcttt
     1321 aagtctcatc tcatccgtct gattggaaat ctgtgctaca agaataaaga aaaccaagac
     1381 aaagtgaatg agctggatgg cattcctctg atcctggaca gcagcaacat cgatgacaac
     1441 aaccccttta tgatgcagtg ggtggtgtat gctgtgcgaa atctcactga agacaacagc
     1501 caaaaccaag atgtcattgc caagatggag gagcagggct tggcagacgc atccctactg
     1561 aagaaaatgg gctttgaaat tgaaaagagt ggggataaac tgattctgaa gtctaataat
     1621 gacatccccc cgccttgaat gccatcttca tatgaacaca ttcagattcc atctcacgga
     1681 cctctcatct ctgcagtgta tgaaatcaca agtattggac atgtagggta cagatgaggg
     1741 agcctcctaa tcctttagag taaatgagtg taagctacaa gtggacgttt tctttatttc
     1801 tttgcagtaa gtgttactgt ctgcctcacc tttgtccctc tgggtagaac tcgctttccc
     1861 gtcatataca ttgtgcttac tgttgtagta ataaacgtct ctgtgggcac agccctcact
     1921 cggcaaagac tgggaccctt gattggattc tgcacgccct ttcagatggc aagtgtgctt
     1981 catccctttg attctctgct tctcattgga tttctgaact ctggcgggca cttgaagtaa
     2041 gtttctcact gtgattaatt ctaccaatct cttttctccc cttctgcctt tccaaaacat
     2101 tgacatgact catttccagt taattaattt gagaacccac cctcttcatt ccatgcactg
     2161 cgttgtcaca gagccctgtc ttagaaaggc cgtgagaatg ggtgagagac catgtggcca
     2221 cttaactgtt tgcatcccag gtggacttag agttaagaat tccttaaaag tgatgctgac
     2281 atcttgccca tatccatgct gcctgacaca gaaaggaata ttgtactttt tttgatgtgc
     2341 agtgcctcta gtgtgctgtg cctcatgtga acggggcgtc catagcctct tctgcttaaa
     2401 agtgtggctg tcacagagac aagctaatct ggaggagcga ggatatattg gtatcgagct
     2461 ttagttctat ttttgtagca ggtaaaactg gattatagaa ggcactggac tctgtagcta
     2521 cctgaatcac taataaaatc accttgatct gaaaaaaaaa aaaaaaaaa
//
