LOCUS       NM_009124              10599 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus ataxin 1 (Atxn1), transcript variant 2, mRNA.
ACCESSION   NM_009124 XM_003084921 XM_003085862
VERSION     NM_009124.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10599)
  AUTHORS   Morrison,L.M., Huang,H., Handler,H.P., Fu,M., Jones,D.M.,
            Bushart,D.D., Pappas,S.S., Orr,H.T. and Shakkottai,V.G.
  TITLE     Increased intrinsic membrane excitability is associated with
            olivary hypertrophy in spinocerebellar ataxia type 1
  JOURNAL   Hum Mol Genet 33 (24), 2159-2176 (2024)
   PUBMED   39475127
REFERENCE   2  (bases 1 to 10599)
  AUTHORS   Hamel,K., Moncada,E.L., Sheeler,C., Rosa,J.G., Gilliat,S., Zhang,Y.
            and Cvetanovic,M.
  TITLE     Cerebellar Heterogeneity and Selective vulnerability in
            Spinocerebellar Ataxia Type 1 (SCA1)
  JOURNAL   Neurobiol Dis 197, 106530 (2024)
   PUBMED   38750673
REFERENCE   3  (bases 1 to 10599)
  AUTHORS   Homma,H., Yoshioka,Y., Fujita,K., Shirai,S., Hama,Y., Komano,H.,
            Saito,Y., Yabe,I., Okano,H., Sasaki,H., Tanaka,H. and Okazawa,H.
  TITLE     Dynamic molecular network analysis of iPSC-Purkinje cells
            differentiation delineates roles of ISG15 in SCA1 at the earliest
            stage
  JOURNAL   Commun Biol 7 (1), 413 (2024)
   PUBMED   38594382
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10599)
  AUTHORS   Tejwani,L., Ravindra,N.G., Lee,C., Cheng,Y., Nguyen,B., Luttik,K.,
            Ni,L., Zhang,S., Morrison,L.M., Gionco,J., Xiang,Y., Yoon,J.,
            Ro,H., Haidery,F., Grijalva,R.M., Bae,E., Kim,K., Martuscello,R.T.,
            Orr,H.T., Zoghbi,H.Y., McLoughlin,H.S., Ranum,L.P.W.,
            Shakkottai,V.G., Faust,P.L., Wang,S., van Dijk,D. and Lim,J.
  TITLE     Longitudinal single-cell transcriptional dynamics throughout
            neurodegeneration in SCA1
  JOURNAL   Neuron 112 (3), 362-383 (2024)
   PUBMED   38016472
REFERENCE   5  (bases 1 to 10599)
  AUTHORS   Gall-Duncan,T., Luo,J., Jurkovic,C.M., Fischer,L.A., Fujita,K.,
            Deshmukh,A.L., Harding,R.J., Tran,S., Mehkary,M., Li,V., Leib,D.E.,
            Chen,R., Tanaka,H., Mason,A.G., Levesque,D., Khan,M., Razzaghi,M.,
            Prasolava,T., Lanni,S., Sato,N., Caron,M.C., Panigrahi,G.B.,
            Wang,P., Lau,R., Castel,A.L., Masson,J.Y., Tippett,L., Turner,C.,
            Spies,M., La Spada,A.R., Campos,E.I., Curtis,M.A., Boisvert,F.M.,
            Faull,R.L.M., Davidson,B.L., Nakamori,M., Okazawa,H., Wold,M.S. and
            Pearson,C.E.
  TITLE     Antagonistic roles of canonical and Alternative-RPA in
            disease-associated tandem CAG repeat instability
  JOURNAL   Cell 186 (22), 4898-4919 (2023)
   PUBMED   37827155
REFERENCE   6  (bases 1 to 10599)
  AUTHORS   Takeuchi,T.
  TITLE     jumonji gene maps to mouse chromosome 13
  JOURNAL   Genomics 45 (1), 240-242 (1997)
   PUBMED   9339385
REFERENCE   7  (bases 1 to 10599)
  AUTHORS   Clark,H.B., Burright,E.N., Yunis,W.S., Larson,S., Wilcox,C.,
            Hartman,B., Matilla,A., Zoghbi,H.Y. and Orr,H.T.
  TITLE     Purkinje cell expression of a mutant allele of SCA1 in transgenic
            mice leads to disparate effects on motor behaviors, followed by a
            progressive cerebellar dysfunction and histological alterations
  JOURNAL   J Neurosci 17 (19), 7385-7395 (1997)
   PUBMED   9295384
REFERENCE   8  (bases 1 to 10599)
  AUTHORS   Banfi,S., Servadio,A., Chung,M., Capozzoli,F., Duvick,L.A.,
            Elde,R., Zoghbi,H.Y. and Orr,H.T.
  TITLE     Cloning and developmental expression analysis of the murine homolog
            of the spinocerebellar ataxia type 1 gene (Sca1)
  JOURNAL   Hum Mol Genet 5 (1), 33-40 (1996)
   PUBMED   8789437
REFERENCE   9  (bases 1 to 10599)
  AUTHORS   Servadio,A., McCall,A., Zoghbi,H. and Eicher,E.M.
  TITLE     Mapping of the Sca1 and pcd genes on mouse chromosome 13 provides
            evidence that they are different genes
  JOURNAL   Genomics 29 (3), 812-813 (1995)
   PUBMED   8575786
REFERENCE   10 (bases 1 to 10599)
  AUTHORS   Burright,E.N., Clark,H.B., Servadio,A., Matilla,T., Feddersen,R.M.,
            Yunis,W.S., Duvick,L.A., Zoghbi,H.Y. and Orr,H.T.
  TITLE     SCA1 transgenic mice: a model for neurodegeneration caused by an
            expanded CAG trinucleotide repeat
  JOURNAL   Cell 82 (6), 937-948 (1995)
   PUBMED   7553854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK165114.1, AK048268.1, AC154817.2 and BE993799.1.
            
            On or before Jun 2, 2011 this sequence version replaced
            XM_003084921.1, XM_003085862.1, NM_009124.5.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction at the 3' end of an exon compared to variant 1. The
            resulting isoform (b) has the same N- and C-termini but is shorter
            compared to isoform a. Variants 2 and 3 both encode the same
            isoform (b).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048268.1, SRR13422598.720267.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AK165114.1         2-16
            16-4012             AK048268.1         3-3999
            4013-10574          AC154817.2         72395-78956
            10575-10599         BE993799.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..10599
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 21.98 cM"
     gene            1..10599
                     /gene="Atxn1"
                     /gene_synonym="2900016G23Rik; Atx1; Gm10786; Sca1"
                     /note="ataxin 1"
                     /db_xref="GeneID:20238"
                     /db_xref="MGI:MGI:104783"
     exon            1..177
                     /gene="Atxn1"
                     /gene_synonym="2900016G23Rik; Atx1; Gm10786; Sca1"
                     /inference="alignment:Splign:2.1.0"
     exon            178..298
                     /gene="Atxn1"
                     /gene_synonym="2900016G23Rik; Atx1; Gm10786; Sca1"
                     /inference="alignment:Splign:2.1.0"
     exon            299..427
                     /gene="Atxn1"
                     /gene_synonym="2900016G23Rik; Atx1; Gm10786; Sca1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..556
                     /gene="Atxn1"
                     /gene_synonym="2900016G23Rik; Atx1; Gm10786; Sca1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..620
                     /gene="Atxn1"
                     /gene_synonym="2900016G23Rik; Atx1; Gm10786; Sca1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..745
                     /gene="Atxn1"
                     /gene_synonym="2900016G23Rik; Atx1; Gm10786; Sca1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..2753
                     /gene="Atxn1"
                     /gene_synonym="2900016G23Rik; Atx1; Gm10786; Sca1"
                     /inference="alignment:Splign:2.1.0"
     CDS             909..3284
                     /gene="Atxn1"
                     /gene_synonym="2900016G23Rik; Atx1; Gm10786; Sca1"
                     /note="isoform b is encoded by transcript variant 2;
                     spinocerebellar ataxia 1 homolog"
                     /codon_start=1
                     /product="ataxin-1 isoform b"
                     /protein_id="NP_033150.2"
                     /db_xref="CCDS:CCDS26483.1"
                     /db_xref="GeneID:20238"
                     /db_xref="MGI:MGI:104783"
                     /translation="MKSNQERSNECLPPKKREIPATSRPSEEKATALPSDNHCVEGVA
                     WLPSTPGIRGHGGGRHGSAGTSGEHGLQGMGLHKALSAGLDYSPPSAPRSVPTANTLP
                     TVYPPPQSGTPVSPVQYAHLSHTFQFIGSSQYSGPYAGFIPSQLISPSGNPVTSAVAS
                     AAGATTPSQRSQLEAYSTLLANMGSLSQAPGHKVEPPPQQHLSRAAGLVNPGSPPPPT
                     QQNQYIHISSSPQSSGRATSPPPIPVHLHPHQTMIPHTLTLGPSSQVVVQYSDAGGHF
                     VPRESTKKAESSRLQQAMQAKEVLNGEMEKSRRYGASSSVELSLGKASSKSVPHPYES
                     RHVVVHPSPADYSSRDTSGVRGSVMVLPNSSTPSADLEAQQTTHREASPSTLNDKSGL
                     HLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITY
                     AGGLPQHLVIPGNQPLLIPVGSPDMDTPGAASAIVTSSPQFAAVPHTFVTTALPKSEN
                     FNPEALVTQAAYPAMVQAQIHLPVVQSVASPTTASPTLPPYFMKGSIIQLANGELKKV
                     EDLKTEDFIQSAEISNDLKIDSSTVERIEESHSPGVAVIQFAVGEHRAQVSVEVLVEY
                     PFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASV
                     LLKQAKTDSLAGSRHRYAEQENGINQGSAQVLSENGELKFPEKIGLPAAPFLSKIEPS
                     KPTATRKRRWSAPETRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK"
     exon            2754..10584
                     /gene="Atxn1"
                     /gene_synonym="2900016G23Rik; Atx1; Gm10786; Sca1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10559..10564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atxn1"
                     /gene_synonym="2900016G23Rik; Atx1; Gm10786; Sca1"
                     /note="hexamer: AATAAA"
     polyA_site      10584
                     /gene="Atxn1"
                     /gene_synonym="2900016G23Rik; Atx1; Gm10786; Sca1"
                     /note="major polyA site"
ORIGIN      
        1 ataccgcaga catcatttct actacagtgg aggagccgta caggacctgt ttcactgcag
       61 ggggatccaa aacaagccct gtggagccgc agctagagct acagcagccg caggacactg
      121 tgtctctccc tctgttaccc cttccccacg caaccccaga tccatttaca ctttacaaag
      181 tatcctgcac cgtgcaacaa gtacgagggc ggtcgcttca agctgcagat ctgtctgtca
      241 tccttatcca acagtctctt cctccactcc ctccacaggg aagggcgtca cctgtcagat
      301 tgcagcatcc tggaacagaa tgaaaggatc tgtgttgaaa cagctacagt agggttacag
      361 tagaccctga gaaaaacaga gtggacttca gcctgcacgg atgagcttga agcaggaatg
      421 gtttggggtt caggcctctt acactgaatt tctctactgc caccctttct actcaagcaa
      481 catcttcagg aaaagatctc ccgggaagga agtggctgct tgtggctttg cactgtgatg
      541 aaggcaaatg gtacagtttt ccaaagaaaa tagaccaaaa ctttcttctt gagaagaaac
      601 aaacctgctg ttggcagagg gtatttctaa cctctctgcg aaagaaagaa agacaccacc
      661 agaacctggg catcccagct gctgagggaa gtttccatgg tgaagtctca gggaggcttc
      721 ctgggagcag agcatagtga atgctaatcc ggagctgcca ctgccagcct aaagaaccca
      781 cggggagatg attccccatg aagggcctgg atcccctaca gaaatccaat gtgactctct
      841 gtttatcaga ctaaaaccag agccggccag ccagtgaaac agccaccgtg gaggggggac
      901 ggcgaaaaat gaaatccaac caagagcgga gcaacgaatg cctgcctccc aagaaacgtg
      961 agatccccgc caccagccgg ccctcggagg agaaggccac tgctctgccc agcgacaacc
     1021 actgcgtgga gggtgtggcc tggctcccca gcacccctgg catccgcggc catgggggtg
     1081 ggcggcacgg gtcagcaggg acttccgggg agcatggttt acaaggaatg ggtttacata
     1141 aagcactgtc cgcagggctg gattactccc cacccagtgc ccccaggtca gtccccacag
     1201 ccaacacgct gcccaccgtg taccctcctc ctcagtcagg gaccccggtg tctcctgtgc
     1261 agtacgccca cctttcgcat accttccagt tcattgggtc ctcccaatac agtgggcctt
     1321 acgcgggctt tatcccttcc cagctgatct ccccatcagg caacccggtc accagtgcag
     1381 tagcctcagc tgcaggggcc accactccat cacagcgctc ccagctggag gcttattcca
     1441 ccctgctggc caacatgggc agtctgagcc aggcaccagg acataaggtt gagccccctc
     1501 cgcagcagca cctcagcagg gctgcaggat tagtcaaccc ggggtcccct cctccaccca
     1561 cccagcagaa ccagtacatc catatttcca gctctccaca gagctccggg cgggcgacat
     1621 ctcccccacc catcccggtc cacctccatc cccatcagac gatgatcccg cacacactca
     1681 ccctggggcc ttcatcccag gtggttgtgc aatatagtga tgccggaggc cactttgttc
     1741 ctcgagagtc caccaaaaaa gccgagagca gcaggttgca gcaggctatg caagccaagg
     1801 aagtcctgaa tggggagatg gagaaaagcc ggaggtatgg ggcatcatct tctgtggagc
     1861 tgagcctagg caaggcaagc agtaagtcag tgcctcatcc ctatgagtcc aggcatgtgg
     1921 tggtccaccc aagcccagca gactacagca gtcgtgatac ctccggggtc cgtggatctg
     1981 tgatggttct gcctaatagc agcacaccct cagccgacct ggaggcccag cagaccacgc
     2041 atcgagaggc ctccccatcc accctcaatg acaagagcgg cctgcaccta gggaagccgg
     2101 gccacaggtc ttatgcgctg tccccccaca cggtcattca gaccacacac agtgcatcag
     2161 agcctctccc ggtgggccta ccagccacgg ccttctacgc tggcactcaa cctcctgtca
     2221 tcggctacct gagcggccag cagcaagcaa tcacctatgc tggtggtctg ccgcagcacc
     2281 tggtgatccc aggtaaccag cccctgctca tcccggtggg cagccctgac atggacacgc
     2341 ctggggcagc ctcggccatc gtgacgtcat caccccagtt tgctgcagta cctcacacgt
     2401 ttgtcaccac cgccctgccc aagagcgaga acttcaaccc agaggctctg gtcacccagg
     2461 ctgcctaccc agccatggtg caggcccaga tccacctgcc ggtggtgcag tccgtggcgt
     2521 cccccaccac ggcgtctccc acgctgccgc catatttcat gaaaggctcc atcatccagc
     2581 tggccaacgg ggagctgaag aaggtggagg acctgaagac ggaggatttc atccagagtg
     2641 cagagattag caatgacctc aagatcgact ccagtactgt ggagagaatc gaggagagcc
     2701 acagccccgg ggtggccgtg atacagtttg ctgttggtga acaccgagcc caggtcagtg
     2761 tcgaagtctt ggtagagtat cctttttttg tatttggaca gggctggtca tcctgctgtc
     2821 ctgagcggac cagccagctc tttgatctgc cgtgttccaa actctctgtt ggggacgtct
     2881 gcatctcgct caccctcaag aacctgaaga atggctctgt taaaaagggc cagcctgtgg
     2941 accctgccag cgtcctgctg aagcaggcaa agaccgacag cctggctggc agcagacaca
     3001 gatacgcgga gcaggaaaac ggaatcaacc agggaagcgc ccaggtgctc tctgagaatg
     3061 gcgaactgaa gtttccagaa aaaataggat tgcctgcagc acccttcctc agcaaaatag
     3121 aaccgagcaa acccacagcc acgaggaaga ggaggtggtc ggcgccggag acccgtaaac
     3181 tggagaagtc ggaggacgag ccacctttga ctcttcccaa gccttcgctc attcctcagg
     3241 aggttaagat ctgcatcgaa ggccgatcta acgtgggcaa gtagagacct tgcgggcagc
     3301 ggaggcccgg ggcctccttt tactgtctgt atccagatta ctgtactgta ggctaagtaa
     3361 cacagtattt acatgttaca tcctctttag gtttgtattc taaccttgtc attagagtca
     3421 aacaggtgtg tcgcaggaga ctggtgcgtt tgcattgtct gcaagggtct gttgaggagc
     3481 tggtgggtgg aggatggtca gaaccatgtc catggagctc ccgggcatcc ttagtggccc
     3541 tgaatgtggc ttcatcagcc cctgccttct ccggcagtgt gcagagtcga ggggcatcag
     3601 ttcccactgg tttcaagaac aaacacagtg ggaagtatcc tgcaagggag tgtctgggtg
     3661 cgtgtccctt gtgaaggagt gcgagtgagg gtgtctcttt ctctgcctct gtctccctca
     3721 cttgctccct ctcagtgtgg ggttggggga cctgggtttc ccacctgcaa agtcatcagg
     3781 gaacccagct tccaggcatt gtagggagac atcagacagg cagatgggaa actagtttca
     3841 aagaacgtgg ttctctccaa catattttac aataaaaagc aacttttaat catagatata
     3901 tagatatata tatatatttc cccccatggg gcctgactgc actgaggttt ttttgtttta
     3961 ttttgttttg ttgggttttt gtttttgttc tttttttttt tttttttttt ttttttttta
     4021 agagcagctg ccacttgcag gatttcattt ctgctttacc cggtccagtc cagtgacatc
     4081 atcagtcgtc atggtgggca gggaaagtcc ttgctcaggt cactcctggt caggcaggta
     4141 gcagtggggc gggagggacg gagggagcac ccacactggt ttctgtgcag tgttaggaaa
     4201 agcaatcagg ttacttgcgt tggcttccaa gaaggaaaat gcaagccccg cttcccgcga
     4261 gagccagctt ctcccagctg tgccggcagc atcttttctg tattttaggt ctagtactgt
     4321 tcatgactat ggacaactcg ggtgccgctt tttttttttc tttctttctt ttttcctcaa
     4381 tcccagtgtg acatgaggag ttagatctgg aagatgctcc tctgttactt tatctcgcaa
     4441 acagctaaaa atgctgtgca ggcttcttaa ccaagcatct tggtctgtca ttcaacaagt
     4501 actgtatctc actttcgact ctttttggga aaagaaaagg aaaaaaaaaa tgacaaacct
     4561 aagttgcttt tgtttttgtt tttgtttttt cttctcaaca ctgtaactac acttcagctc
     4621 tgctcacaag ccagcaatcg aaaactccaa tctggtttaa aaggatgaat gtgaagtacg
     4681 aactagcccg tgacaatata tgactaccga gtactacctg acggcaggca cttgtcactt
     4741 tgatgttgga gaaagagtta aaggcatatg cagagttggc agagaaaccg agacaagaca
     4801 cagaggaaaa gacactcggt tgtgtccagt gtttttagga cgaacttcta aagaactttg
     4861 cgatttgcac atcttgagtt tataatttgt gtgatattcc tgcagttttt atctaataac
     4921 attgtgggaa aggtttggga gggttacaag agcataaata aatgtagcaa aattactttc
     4981 taacctgcct agaccctagg cccttcttag aaggttctgt cccctttgag acttcatttt
     5041 gtcatctacc acatctgtca ccagaagcca ggtctgaggg tcttcttcag cgccattgag
     5101 agtttcccat atagacattt tatatatgtg agcaagtatt ttcatttctg gaaaaaaaag
     5161 tgttaaattt ttttttaaaa gaaacttatg tttctatttg aaatccaact aggatctaat
     5221 gtttggtaca aaactccaga aatggtattt tcataaagtc acaagttttc attcccagag
     5281 gtcaaaatat catttgtggg ttctgagtgg gtcttaaagt actttaaccc tagttttata
     5341 aatggggaga agtttttaaa cattctttct tggctacaac ctaagtaagt acttatttga
     5401 cgtttctttt tagcaattta aaaagaaaag atttcttcca tttctcaaaa tagaaaaaaa
     5461 aaaaaaccaa aaagaccctc ccctggcaac ccacatacat gttggctatc cagtctccat
     5521 tcacagtggc ttttgttggg actaatgatc tttttccaga ccattttctg ggatgtacca
     5581 aacacctttg agtaggtccg gaatagctgg cctctcccta aacttcatcg ccctctccgc
     5641 ccgctggcag agctgggtga gcccgttctt gcaatcagac gcttatttag tgctgtgatc
     5701 cttttgtttt attttatttt ttttaatctt tctgttcaga gaccttgctt gatcttccct
     5761 atatctgctc agggcactgg cacttactag gttttcggtt ttgttttgtt ttgttttgtt
     5821 ttaacctcca atggtgagag gactaggagg ttgccacgga ggcgctgtgt gccagttatc
     5881 tacaacagcc cctgtgagct cagaaaacac acacacacac acacacacac acacacaaac
     5941 acacactctg ctctctggct aactccgagg agtgaactga ctgcatccac taagctgaca
     6001 ctaaaacagg taaaaacaca catggctcag agcaatagga atatcataac ttgtggttct
     6061 atttcaggta taggaattat acaaatcatt gattcttccg aagcatccgt cccatctcat
     6121 tctctggctc ccttagcatg tgcaatactt tgtgtgccaa tagtgtgcta tctagttaaa
     6181 gttcattccc ttttggcctt ttccttgttc ggtgggctga cctttcttcc cctcgctggc
     6241 cagagaaagg ctggaggagt gagccaggag aggcgagccc cttccatttc tccttaacac
     6301 cgatggatgc agagtgctag ggtaggcagc ctatgggagc ctgtgtgtgt ctgtcaccag
     6361 gacacagtga gagccagcca aggagacctg agggaagcac tttgaaggtc cgtcaccaca
     6421 ctctgcaaag gcccctcgct ctgtagtgaa gctggaatgg agccaggagg cggagtggct
     6481 cctaggacga actctggagc ggaatggtct tcagtcaact cattttcagt ctcttctgtg
     6541 tccttgagac tttgatccct gcctttgaca caagcaactt attgcatatg tgtgtgttct
     6601 gagcatgccc accagtggct ttggagggca acctggcaac cacagtcacc attcccttgg
     6661 gacagctttc tcttcaaaca ggaagaacac acagaggcag gagccacctc ttatttgcag
     6721 acattggtgg ggtcctccag gctcccggag cacctttggt caactgtgta gggagcacgg
     6781 taatagcagt gccctcatcg gacaaggatc agccacgcgc ctctgtacct gtcctctttg
     6841 caatatttac caacagccga cttttccttc ttctctttcc tgctttccat tttaaaacaa
     6901 agtaacagca ggcctttttt gtgtttacaa cggaacacaa tcaccaagaa attagtcagg
     6961 gcaaaaagaa aacatagtaa tattactcat aagaaatcag caaacaagaa cctctttcta
     7021 gggatttcta aatacacaac aacgtgactg ttccttagac tgtttaactt tagaattatt
     7081 tcagtttgtc tgggccacct tgggggtcag tgggatgggg tagggactgg ggtgggggaa
     7141 ggccagggat accacttacc tcaaatcttt ttaaaagtgg aaatccaaat tgcatttggg
     7201 ggagggtggg gaggggggac ttgcaggata atcgtctatg ttggtcacat tttgcttttc
     7261 tcgattcatc caactcagtt tgggatggcc tgatgtttgt ggtggtggca acagaacgtc
     7321 cttaactctg aaccccaacc ttgtatgttt tctgttaggt gagcttgttg ggttcctccc
     7381 caccccctta ccccataagg aagtggcagc gtcctttctc ccttgcaagg aaccctgcag
     7441 aaccttccac acctcttact cagggatggg gctggtgtgt gtgtgtggaa cacagatgtg
     7501 ttcagcaaca gcactttgga ctgctctgga gtagggttgt acaatttcaa ggaatgtttg
     7561 gatctccccg cacagtgtgg attgctcctt agctactgca cagattgcaa tataatgctg
     7621 cacgttcaag acgagcagta gctcctcata atcagaagaa aaaaaatata tccactcttt
     7681 gcacatagtt tgatctttac tgaaatatgt tgccaaaatc tgtttttgtt ctagctttgt
     7741 atcttttcat ttctttcttt ctctctctct ctcttttttc ttttaaggaa acaattgata
     7801 ataccttgta acatctgtga ctactaagga aacctatttt gtagatgctt ttgaagacac
     7861 taacacctat ttcagacacg ggtgaggagg cagagctctt gggatagaaa gccagacttt
     7921 gtaagttgag ttggcatggc aactgtttcc tgagccacaa gaccctcaac caactggtct
     7981 gctctctctc tcgagagccc ttcgctcctc atttcccagt cacccccttt gactccaggg
     8041 gaatacaggg cctccagtct ccgggtccta tccagtttct ttagtggttg agatgaacgg
     8101 caagagaatc atattttgtt gttttaaaag tggagcaaag gcctttgcat ccacagttgt
     8161 gttttgatgc caggatttcc gaaatagaaa atttaaggaa aaatcgagta ataactatag
     8221 agaatttact tttcttttaa taaagcacat gcgtatgacc tgttgagttg ggttggtttt
     8281 ctccctgtcc atgaacagtg ttgtatttct gttcctaagg caactcgaaa cagtttgcac
     8341 acctctactc tggagctggg atttctttca tagatgacct cgcttcaaat gttaccttac
     8401 tgataggctt tttcttgtag cgctatacct tgtgggaagt ttttttgttt tgttttgttt
     8461 ttttctttaa agtacaccca atttgagcag ctggggggtg ggggagggag ggttgagaca
     8521 ctcactttgg gggtgggtgg gttacagata attttttttt aaaaaaattg cacaaaagaa
     8581 aaatgaatgt tgaaatgatt cattcagtgt ttgaaagaga cagatctgtt gaaactatga
     8641 gtttcatatt ttgtgtgtaa aaaaaacaaa aaaacaaaac aaaaaaaaca aaacagagga
     8701 ggggtttgaa agttacatgt ttgggggttt atttttcctg tatatagcaa tttgttgtct
     8761 tgatcatcaa atttgtatgg ttatggcctg gaagaattat gatgtcagag gctcttcaac
     8821 tataccgtac ctatgcttac tgttctgttt ttgttacaca cggctcttgt gtgaaggatg
     8881 ggggaactct gtattccgct atttgaggat actgtccatt cctaggccga aagtacttcc
     8941 ctaagttccc ttcttaagcc attgcaactt tactttggat gatgtctgac attttcagca
     9001 cttcctgttc ctatcaaccc aaagaatata atcctgaaca tgaagtgttt ctaaaaggga
     9061 tcctccttcc cagtagacag aaaaaagtcg agcctttctt ctgcctccca ccccagacct
     9121 cattcctaca ggggtagaac acccattttg gcttgaatgc ctggcttttg ttttgatgtt
     9181 tctcaagtag aggccagacg aaatgcagaa cggtttctca gagttatatt ccagctcagc
     9241 agttgcgctg ggtggtgcaa accagacagc gtgggggcag taaacagacc ctacctttaa
     9301 ttcttcaatt tgggttcatg tcccctccct taaggcgcaa gttcttattg cttagattga
     9361 ccttgacaaa ggcagaagcg agacatcggg tcagcttttc acatcctgac acgtgcatac
     9421 aggaacttca cctgtattca gatgaagtgt gtttggccaa tagataccgt ctacatgata
     9481 ccagtctcta agaacttccc taacactttt taactgaaag gagttaagtc ttccactaca
     9541 gatcacttgg agactccatc cacgcatgtc ctcttgtccc tttgcttgcc tggatggctc
     9601 atgtgaaggc ctgtgtggga agcactgttt acagtaaccc ttaccaagat aatatactgt
     9661 cccctagact accgagctga ggtgacactg gcttagaact gttggagtga aagatcagtt
     9721 actaagaagg ttggtgcaca ggttttctcc agttcttaca ggagcccctt gctcggaagt
     9781 tattctccag tccaagggtg ggatgcactg ttgagtccat gatgaggcgt aaccatggca
     9841 acccaccaca gtcccattct gtgactactg ccccctcccc aacccacact gctcaagtgt
     9901 gacccaggta gtgtcagcag aaagggggtt gcggtggagt cctgtcagta tttatggtgg
     9961 cctttcggta agacagtcta catctctaac cagtggagtc ttggccctcc ggaacctgag
    10021 atctgcacca gttgaagggt tttaacatca ggttcccaga ccctccaatt tccattcatt
    10081 gcctccccac aggccaagcg gaaacagaca ccaaaacttg ggctaagggt actaccatgt
    10141 ggagaactag ggaaaacaaa atggtttttt tttttgcacc ttattgaaaa gaaactttta
    10201 agtgcataca tagttaagag cttttatcgt gacaggagaa cgtttccata tgcgtgcata
    10261 ctctctgtaa ttccagtgta aaatgttgta tttgcactag cttttttaaa acaaatatta
    10321 aaaaaatgga agaattcata ttctattttc taatcgtggt gtgtctattt gtaggataca
    10381 ctcgagtctg tttattgaat tttatggtcc ctttctttga tggtgcttgc aggttttcta
    10441 ggtagaaatt atttcattat tataataaaa caatgtttga ttcaaaattt gaacaaaatt
    10501 gttttaaata aattgtctgt ataccagtac aagtttattg tataatactc gtactactaa
    10561 taaaataaca gtgccaattg caaaaaaaaa aaaaaaaaa
//
