LOCUS       NM_172774               2572 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus ATR interacting protein (Atrip), mRNA.
ACCESSION   NM_172774
VERSION     NM_172774.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2572)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2572)
  AUTHORS   Matos-Rodrigues,G.E., Tan,P.B., Rocha-Martins,M., Charlier,C.F.,
            Gomes,A.L., Cabral-Miranda,F., Grigaravicius,P., Hofmann,T.G.,
            Frappart,P.O. and Martins,R.A.P.
  TITLE     Progenitor death drives retinal dysplasia and neuronal degeneration
            in a mouse model of ATRIP-Seckel syndrome
  JOURNAL   Dis Model Mech 13 (10) (2020)
   PUBMED   32994318
  REMARK    GeneRIF: Progenitor death drives retinal dysplasia and neuronal
            degeneration in a mouse model of ATRIP-Seckel syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2572)
  AUTHORS   Matos-Rodrigues,G.E., Grigaravicius,P., Lopez,B.S., Hofmann,T.G.,
            Frappart,P.O. and Martins,R.A.P.
  TITLE     ATRIP protects progenitor cells against DNA damage in vivo
  JOURNAL   Cell Death Dis 11 (10), 923 (2020)
   PUBMED   33110058
  REMARK    Erratum:[Cell Death Dis. 2020 Dec 15;11(12):1074. doi:
            10.1038/s41419-020-03227-w.. PMID: 33323930]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2572)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2572)
  AUTHORS   Feng,W.
  TITLE     Mec1/ATR, the Program Manager of Nucleic Acids Inc
  JOURNAL   Genes (Basel) 8 (1), 10 (2016)
   PUBMED   28036033
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2572)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 2572)
  AUTHORS   Refolio,E., Cavero,S., Marcon,E., Freire,R. and San-Segundo,P.A.
  TITLE     The Ddc2/ATRIP checkpoint protein monitors meiotic recombination
            intermediates
  JOURNAL   J Cell Sci 124 (Pt 14), 2488-2500 (2011)
   PUBMED   21693576
REFERENCE   8  (bases 1 to 2572)
  AUTHORS   Takai,H., Xie,Y., de Lange,T. and Pavletich,N.P.
  TITLE     Tel2 structure and function in the Hsp90-dependent maturation of
            mTOR and ATR complexes
  JOURNAL   Genes Dev 24 (18), 2019-2030 (2010)
   PUBMED   20801936
REFERENCE   9  (bases 1 to 2572)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2572)
  AUTHORS   Cortez,D., Guntuku,S., Qin,J. and Elledge,S.J.
  TITLE     ATR and ATRIP: partners in checkpoint signaling
  JOURNAL   Science 294 (5547), 1713-1716 (2001)
   PUBMED   11721054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB649616.1, AK031257.1 and AC140383.2.
            
            On Jan 7, 2010 this sequence version replaced NM_172774.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031257.1, SRR7345562.1527298.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BB649616.1         2-14
            14-1341             AK031257.1         4-1331
            1342-1506           AC140383.2         64514-64678
            1507-2570           AK031257.1         1497-2560
            2571-2572           AC140383.2         70402-70403
FEATURES             Location/Qualifiers
     source          1..2572
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.63 cM"
     gene            1..2572
                     /gene="Atrip"
                     /gene_synonym="6620401K05Rik"
                     /note="ATR interacting protein"
                     /db_xref="GeneID:235610"
                     /db_xref="MGI:MGI:1925349"
     exon            1..370
                     /gene="Atrip"
                     /gene_synonym="6620401K05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..2478
                     /gene="Atrip"
                     /gene_synonym="6620401K05Rik"
                     /note="ATM and Rad3 related interacting protein"
                     /codon_start=1
                     /product="ATR-interacting protein"
                     /protein_id="NP_766362.2"
                     /db_xref="CCDS:CCDS23545.1"
                     /db_xref="GeneID:235610"
                     /db_xref="MGI:MGI:1925349"
                     /translation="MAGTPAPNSHRKQSGGLEPFPGLSRSIENPPSKRARSFSETTVP
                     DPEDPFGEHAEFTADDLEELDILASQALSQCPVAPRNLSSAHKVRRLDGLPNSPIRKS
                     REDIPVKDNFELEVLQIQYKELKEKLKAMEEEILIKNGEIKILRDSLRQTESVLEEQK
                     RSHFLLEQEKTQALSEKEKEFSRKLQSLQSELQFKDAEMNELRTKSQSNGRTNKPAAP
                     SVSHVSPRKGSSVVLKSEACSPHVGKTTFPTKESFSANTPLFHPCQTEAGHRFLVGQE
                     VSDNKNHSLGGSLMKQDVQQRILADGWMQRKDAQGSILINLLLKQPLVPGSSLGLCHL
                     LSSCPEVPTGTLLQPPGLSTLPGTSGLRTISSSDGPFSPSALREAQNLAFTGLNLVAR
                     TESSHDGDMAGRRVFPLHQLPGAVHLLPLVQFFVGLHCQALQDLAPAKKSGVPGDSAT
                     HTSCMSSGVEASPEDSIHGLESFSVASLSVLQNLVCHSGAVVCLLLSGMGTEAAAREG
                     NLVQTCADTTSASREDAHDQDQHPLLKMLLQLMASSSAASGHFQASVLGLCLKVLVKL
                     AENASSDLLPRFSCVFPVLPQCLGSALPLPCVLLAVELLSVLLDHDSLAWQLCSHPEG
                     CLLLRLYMYITSRPDRTASETQWLQLEQEVVWLLAKLSVQSPAPAGIGSDCHCNVEAV
                     RALTVMLHRQWLTVRRAGGPRTHQQKQTIRCLRDTVLLLHSLSQKDKLFTVHCVEVLH
                     QYDQVMPGVSMLIRALPDVTDCEEAALDDLCAAETDLEDSEMDCN"
     exon            371..501
                     /gene="Atrip"
                     /gene_synonym="6620401K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            502..672
                     /gene="Atrip"
                     /gene_synonym="6620401K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            673..791
                     /gene="Atrip"
                     /gene_synonym="6620401K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            792..949
                     /gene="Atrip"
                     /gene_synonym="6620401K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1051
                     /gene="Atrip"
                     /gene_synonym="6620401K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1178
                     /gene="Atrip"
                     /gene_synonym="6620401K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1850
                     /gene="Atrip"
                     /gene_synonym="6620401K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1987
                     /gene="Atrip"
                     /gene_synonym="6620401K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2079
                     /gene="Atrip"
                     /gene_synonym="6620401K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2160
                     /gene="Atrip"
                     /gene_synonym="6620401K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2410
                     /gene="Atrip"
                     /gene_synonym="6620401K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2572
                     /gene="Atrip"
                     /gene_synonym="6620401K05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2542..2547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atrip"
                     /gene_synonym="6620401K05Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2572
                     /gene="Atrip"
                     /gene_synonym="6620401K05Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggctgggga gacgctggaa ggcgagggga acggcggcgc gcgggcggtt gggccagctc
       61 aggctttctg tggacaaggc tgtgcttggc gtcttcggat gctgcgggtt gaaggtagtc
      121 atggccggga cccccgcacc gaacagccac aggaaacaga gtggcggcct ggagcctttc
      181 cccggtctgt ctcgatccat tgagaaccct ccgagcaagc gggcccggag cttctctgag
      241 accacagtcc cggaccccga agacccattc ggtgagcacg cggaatttac tgcggacgac
      301 ctagaggaac tcgacatcct cgcgtcacag gccctgagcc agtgtcccgt cgcgcctcgg
      361 aacctgtcca gtgctcataa ggtccgccga ttagatgggt taccaaatag tcctataagg
      421 aaaagcagag aagatattcc agttaaagat aattttgaat tagaagtact tcagatacaa
      481 tacaaagaac ttaaagaaaa gctgaaagca atggaagaag aaatcctaat taagaatgga
      541 gaaattaaaa ttttgcgtga ctctctgcgt cagacagaat ccgttctaga agaacagaaa
      601 agatcacatt tccttcttga gcaagaaaag actcaagcac tcagtgaaaa ggaaaaggaa
      661 ttctccagaa agctccaatc actgcagtct gaactgcagt ttaaagacgc agaaatgaat
      721 gagttaagga caaagtctca gagcaacgga cgaacaaata agccagccgc tccctccgtc
      781 tcccacgtca gtcctaggaa aggctcttct gtggttctca agtcagaagc atgttctcca
      841 catgttggaa aaacaacttt ccctacaaaa gaatctttta gtgctaacac gcctctcttc
      901 cacccctgtc agactgaggc aggacacaga tttctggtgg gccaagaggt ttcagataat
      961 aaaaaccaca gtctgggagg tagcctcatg aagcaagatg tgcagcagag aattctggct
     1021 gatggctgga tgcagagaaa agatgctcaa ggttctattt tgataaactt gctcctgaag
     1081 caacctttgg tgccagggtc atctctaggt ctttgtcacc ttctgagcag ttgtcctgag
     1141 gttcctactg gcaccctctt gcagccacca gggctcagta ctttgcctgg gacttcaggc
     1201 ctcaggacca tcagttcttc tgatgggcca ttttccccct ctgccctgag agaagcacag
     1261 aacttggcat tcactggatt aaatctggtt gccaggactg agagctcaca tgatggagac
     1321 atggcaggca gaagagtctt cccgctccac cagcttcctg gagctgtgca tctccttcct
     1381 cttgtgcagt ttttcgtcgg cttacactgc caggctctgc aagatttagc cccagctaag
     1441 aagagtgggg tgcctgggga ctctgcgaca catacctcct gcatgagctc tggggtcgag
     1501 gctagcccag aggactccat tcatggcttg gagagctttt ctgtggcatc actcagcgtc
     1561 cttcagaacc tggtgtgcca cagtggggca gttgtctgcc tgttactgtc aggcatgggg
     1621 acagaagctg ccgccaggga aggaaacttg gtccagactt gtgcagatac aacctcagcc
     1681 tccagggagg atgctcatga ccaagaccag cacccactgc taaagatgct tcttcagctg
     1741 atggcttcct cctctgcagc atcaggtcat tttcaagcca gtgtcctggg cctgtgcctc
     1801 aaagttttgg tgaaattagc agaaaacgct tcctctgatt tgttgcccag gttctcctgt
     1861 gtgttcccgg tgttgccaca gtgcctcggc tcagcgctgc cgctgccctg tgtgctcctg
     1921 gctgttgagc tgctctctgt gctgctggac catgacagcc tagcatggca gctatgctcc
     1981 cacccagaag gctgccttct cctgaggctg tacatgtaca tcacatcaag gcctgacaga
     2041 acggcctcag agacacagtg gcttcagctg gaacaagagg tagtatggct cttggccaag
     2101 ctgagtgtac agagccctgc ccccgctggc attggttctg actgtcactg caatgtagag
     2161 gcagtcagag cgctcactgt gatgttgcac aggcaatggc tgacggtgcg gcgggcagga
     2221 ggtccaagga cccaccagca gaagcagacg atacgctgtc tgcgggacac tgtgctgctg
     2281 ctgcatagcc tatctcagaa ggacaagctc ttcactgtgc actgtgtcga ggtcctgcat
     2341 cagtacgacc aggtgatgcc aggggtcagc atgctgattc gagcccttcc tgatgtgact
     2401 gactgtgaag aggctgccct ggatgacctc tgtgctgcgg agactgattt ggaagactct
     2461 gagatggact gtaactgagg gcctgagcat ccagccacaa ggtggcgcca gctcccaccg
     2521 ccgtctttgc catatccact gattaaaact gcacttcctg ctgagaacac aa
//
