LOCUS       NM_019864               8074 bp    mRNA    linear   ROD 15-OCT-2023
DEFINITION  Mus musculus ataxia telangiectasia and Rad3 related (Atr), mRNA.
ACCESSION   NM_019864
VERSION     NM_019864.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8074)
  AUTHORS   Zhao R, Cai K, Yang JJ, Zhou Q, Cao W, Xiang J, Shen YH, Cheng LL,
            Zang WD, Lin Y, Yuan YY, Xu W, Tao H, Zhao SM and Zhao JY.
  TITLE     Nuclear ATR lysine-tyrosylation protects against heart failure by
            activating DNA damage response
  JOURNAL   Cell Rep 42 (4), 112400 (2023)
   PUBMED   37071536
  REMARK    GeneRIF: Nuclear ATR lysine-tyrosylation protects against heart
            failure by activating DNA damage response.
REFERENCE   2  (bases 1 to 8074)
  AUTHORS   Kuzelova A, Dupacova N, Antosova B, Sunny SS, Kozmik Z Jr, Paces J,
            Skoultchi AI, Stopka T and Kozmik Z.
  TITLE     Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell
            Proliferation and Photoreceptor Maintenance
  JOURNAL   Cells 12 (7), 1035 (2023)
   PUBMED   37048108
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8074)
  AUTHORS   Kalogeropoulou A, Mougkogianni M, Iliadou M, Nikolopoulou E,
            Flordelis S, Kanellou A, Arbi M, Nikou S, Nieminuszczy J,
            Niedzwiedz W, Kardamakis D, Bravou V, Lygerou Z and Taraviras S.
  TITLE     Intrinsic neural stem cell properties define brain hypersensitivity
            to genotoxic stress
  JOURNAL   Stem Cell Reports 17 (6), 1395-1410 (2022)
   PUBMED   35623353
REFERENCE   4  (bases 1 to 8074)
  AUTHORS   Qiu M, Tu L, Zhao M, Yang M, Qi J, Xie Y and Gu J.
  TITLE     Ataxia-televangelist mutated (ATM)/ ATR serine/threonine kinase
            (ATR)-mediated RAD51 recombinase (RAD51) promotes osteogenic
            differentiation and inhibits osteoclastogenesis in osteoporosis
  JOURNAL   Bioengineered 13 (2), 4201-4211 (2022)
   PUBMED   35176943
  REMARK    GeneRIF: Ataxia-televangelist mutated (ATM)/ ATR serine/threonine
            kinase (ATR)-mediated RAD51 recombinase (RAD51) promotes osteogenic
            differentiation and inhibits osteoclastogenesis in osteoporosis.
REFERENCE   5  (bases 1 to 8074)
  AUTHORS   Abt ER, Le TM, Dann AM, Capri JR, Poddar S, Lok V, Li L, Liang K,
            Creech AL, Rashid K, Kim W, Wu N, Cui J, Cho A, Lee HR, Rosser EW,
            Link JM, Czernin J, Wu TT, Damoiseaux R, Dawson DW, Donahue TR and
            Radu CG.
  TITLE     Reprogramming of nucleotide metabolism by interferon confers
            dependence on the replication stress response pathway in pancreatic
            cancer cells
  JOURNAL   Cell Rep 38 (2), 110236 (2022)
   PUBMED   35021095
  REMARK    GeneRIF: Reprogramming of nucleotide metabolism by interferon
            confers dependence on the replication stress response pathway in
            pancreatic cancer cells.
REFERENCE   6  (bases 1 to 8074)
  AUTHORS   Cortez D, Guntuku S, Qin J and Elledge SJ.
  TITLE     ATR and ATRIP: partners in checkpoint signaling
  JOURNAL   Science 294 (5547), 1713-1716 (2001)
   PUBMED   11721054
REFERENCE   7  (bases 1 to 8074)
  AUTHORS   de Klein A, Muijtjens M, van Os R, Verhoeven Y, Smit B, Carr AM,
            Lehmann AR and Hoeijmakers JH.
  TITLE     Targeted disruption of the cell-cycle checkpoint gene ATR leads to
            early embryonic lethality in mice
  JOURNAL   Curr Biol 10 (8), 479-482 (2000)
   PUBMED   10801416
REFERENCE   8  (bases 1 to 8074)
  AUTHORS   Brown EJ and Baltimore D.
  TITLE     ATR disruption leads to chromosomal fragmentation and early
            embryonic lethality
  JOURNAL   Genes Dev 14 (4), 397-402 (2000)
   PUBMED   10691732
REFERENCE   9  (bases 1 to 8074)
  AUTHORS   Moens PB, Tarsounas M, Morita T, Habu T, Rottinghaus ST, Freire R,
            Jackson SP, Barlow C and Wynshaw-Boris A.
  TITLE     The association of ATR protein with mouse meiotic chromosome cores
  JOURNAL   Chromosoma 108 (2), 95-102 (1999)
   PUBMED   10382071
REFERENCE   10 (bases 1 to 8074)
  AUTHORS   Keegan KS, Holtzman DA, Plug AW, Christenson ER, Brainerd EE,
            Flaggs G, Bentley NJ, Taylor EM, Meyn MS, Moss SB, Carr AM, Ashley
            T and Hoekstra MF.
  TITLE     The Atr and Atm protein kinases associate with different sites
            along meiotically pairing chromosomes
  JOURNAL   Genes Dev 10 (19), 2423-2437 (1996)
   PUBMED   8843195
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091531.9 and AC121499.9.
            
            [WARNING] On Jan 10, 2024 this sequence was replaced by
            NM_019864.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN00849384, SAMN00849385
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               AC091531.9         7194-7380           c
            188-279             AC091531.9         3517-3608           c
            280-429             AC091531.9         2045-2194           c
            430-434             AC091531.9         5-9                 c
            435-1307            AC121499.9         204855-205727       c
            1308-1486           AC121499.9         203939-204117       c
            1487-1678           AC121499.9         203015-203206       c
            1679-1869           AC121499.9         200628-200818       c
            1870-2022           AC121499.9         199928-200080       c
            2023-2215           AC121499.9         199504-199696       c
            2216-2469           AC121499.9         199013-199266       c
            2470-2660           AC121499.9         196432-196622       c
            2661-2761           AC121499.9         196249-196349       c
            2762-2933           AC121499.9         195826-195997       c
            2934-3104           AC121499.9         194936-195106       c
            3105-3299           AC121499.9         192051-192245       c
            3300-3485           AC121499.9         189289-189474       c
            3486-3578           AC121499.9         187492-187584       c
            3579-3709           AC121499.9         185228-185358       c
            3710-3853           AC121499.9         182457-182600       c
            3854-3947           AC121499.9         179844-179937       c
            3948-4073           AC121499.9         177160-177285       c
            4074-4280           AC121499.9         172958-173164       c
            4281-4394           AC121499.9         171550-171663       c
            4395-4510           AC121499.9         166922-167037       c
            4511-4631           AC121499.9         164842-164962       c
            4632-4769           AC121499.9         163267-163404       c
            4770-4980           AC121499.9         162240-162450       c
            4981-5159           AC121499.9         160043-160221       c
            5160-5324           AC121499.9         155599-155763       c
            5325-5416           AC121499.9         154179-154270       c
            5417-5508           AC121499.9         150264-150355       c
            5509-5686           AC121499.9         149856-150033       c
            5687-5866           AC121499.9         148868-149047       c
            5867-6026           AC121499.9         147793-147952       c
            6027-6206           AC121499.9         143352-143531       c
            6207-6349           AC121499.9         138228-138370       c
            6350-6447           AC121499.9         135124-135221       c
            6448-6680           AC121499.9         134173-134405       c
            6681-6815           AC121499.9         133052-133186       c
            6816-7016           AC121499.9         131350-131550       c
            7017-7160           AC121499.9         129687-129830       c
            7161-7311           AC121499.9         127964-128114       c
            7312-7468           AC121499.9         125456-125612       c
            7469-7622           AC121499.9         125203-125356       c
            7623-7774           AC121499.9         123459-123610       c
            7775-7880           AC121499.9         120050-120155       c
            7881-8074           AC121499.9         119056-119249       c
FEATURES             Location/Qualifiers
     source          1..8074
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 50.27 cM"
     gene            1..8074
                     /gene="Atr"
                     /note="ataxia telangiectasia and Rad3 related"
                     /db_xref="GeneID:245000"
                     /db_xref="MGI:MGI:108028"
     exon            1..187
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..8054
                     /gene="Atr"
                     /EC_number="2.7.11.1"
                     /note="ataxia telangiectasia and Rad3-related protein"
                     /codon_start=1
                     /product="serine/threonine-protein kinase ATR"
                     /protein_id="NP_063917.1"
                     /db_xref="CCDS:CCDS52890.1"
                     /db_xref="GeneID:245000"
                     /db_xref="MGI:MGI:108028"
                     /translation="MGDHGLELASMIPALRELASATPEEYNTVVQKPRQILCQFIDRI
                     LTDVNVVALELVKKTDAQPTSVMLLDFIQHIMKSSPLMFVNVNGSQGQNEAKDSCIEF
                     SHWIITRLLRIAATPSCHMLHKKICEVICSLLFLFKSKNPAIFGVLTRELLYLFEDLI
                     YLHKRNAVGEVMEWPVVVSRFLSRLDEHMGCLQPAPLQFMNVQNVEFIEVTLLMVLIH
                     IVPTVFFRRQELLLWQIGCALLEHGSPKIRSLAISLLTELFELGGLPAQPASTFFSLF
                     LELLQHLVGMDADQLKLYEEPLSKLLKTLFPFEAEAYRNIEPVYLNVLLEKLSVMFED
                     RVLMRLKSDLLKAALCHLLQYFLTFVPAGYESALQVRKVYVTNICRALVDALGVQKHV
                     GYLLGPFYAALKMESKEIIERIQCQAQQENLSGNNDEVSPKRRKLSSSLSSYKKPSRQ
                     PEEIIHVDMDKKSILWNVLKQKAESLQISLECGTLKNSVAEALEGITVVLQLTALCTV
                     HCSHQDMDGHNVKDHQHKYKKKPPVVVTWMSLDFYTKVLKSCRSLLESVQKLELELVI
                     DSMVRICDALMYMQVKSSFKDHVLEELCGMLSLPWIYSYSDDNSLKMTTFATNLLPLS
                     QRVWDSYSPQAQSKCVFLLTLFPRRIFLEWRTAVYNWALKSSHEVIRASCVKGFFILL
                     HQQNSCNQIPKMLVDRVKDDSDMVKKEFASVLGQLVCTLHGMFYLSSSVEPCFEHMDL
                     FSKNLKATSQHECSSSQVKASTCKPFLFLLTKNTPSPVKLAFIDNLHHLCKHLDFQED
                     EREVKAVLGTLLNLMEDPDKDVRIAFSGNIKYILESLNSEDGFVKELFVLRMKEAYTH
                     AQIARNNELKDTLILTTGDIGRAAKGDLIPFALLHLLHCLLSKSASVSGAAYTEIRAL
                     VAAKSVKLQNFFSQYKKPICQFLVESLHSSQMTALPSAPCQSSEIRKQDVAHHREMAL
                     NTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQLNVSRREILI
                     NNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELLLRIGEHYQ
                     QVFNGLSILASFASSDDPYQGPRDITSPELMADYLQPKLLGILAFFNMQLLSSSVGIE
                     DKKMALTSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLD
                     HAYLGPLLSHVIVALLPLIHMQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPELE
                     KIKAVLQEYRKETSETTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIK
                     YATDSETVEPVISQLVTVILKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQG
                     KDFTFVTGVEDLSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMQSN
                     GPGYQLWKRFPEHVREILEPHLNTRYKSSQKSTDWSGVTKPIYLSKLGNNFAEWSSSW
                     AGYLITKVRDNLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEI
                     MAVLKHDEQHAISTQDSASDLCQLSTQTVFSVLDHLTQWARHKFQALNAEKLAQNKPK
                     GGKVNKILSNVNFEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQN
                     IQKHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESIGLLRDATACYDRAI
                     QLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQW
                     DLVENYLAADGKSTTWSVRLGQLLLSAKKRDTTTFYDTLKLVRAEQIVPLSAASFERG
                     SYQRGYEFIVRLHMLCELEHSLKPLFRKSPGDSCNEDSLNWGARLEMTQNSYRAKEPI
                     LALRRALLSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVE
                     RAKWLWSKGDVHQALIVLQKGVELCFPENKSPSESKHMLIHGRATLLVGRFMEETANF
                     ESNAVMKKYKDVTLFLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGR
                     SLQYGNQFIYQSMPRMLSLWLDFGAKAYEWEKGGRSDRLQMRNDLAKINSVLTEHTNR
                     LAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMR
                     VNRCKEILTKAIHMKKSLEKFVGDATRLTDKLLELCNKSVDGSNSTLSMSTHFKMLKR
                     LVEDPTFSEILIPLQSVMIPTLPSVLGAHANHDPFPGHWAYLAGFDDVVEILSSLQKP
                     KKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKSLRKDAESRRRELHIRTYAV
                     IPLNDECGIIEWVNNTAGLRPILTKIYKEKGVYMTGKELRQCMLPKSAALSEKLKVFQ
                     ELLLPRHPPVFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILF
                     DSFTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTLR
                     LMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRL
                     QGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM"
     exon            188..279
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            280..429
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            430..1307
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1486
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1678
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1869
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2022
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2215
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2469
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2660
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2761
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2933
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3104
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3299
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3485
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..3578
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            3579..3709
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..3853
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            3854..3947
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..4073
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            4074..4280
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            4281..4394
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            4395..4510
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            4511..4631
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            4632..4769
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            4770..4980
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            4981..5159
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            5160..5324
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            5325..5416
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            5417..5508
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            5509..5686
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            5687..5866
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            5867..6026
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            6027..6206
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            6207..6349
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            6350..6447
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            6448..6680
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            6681..6815
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            6816..7016
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            7017..7160
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            7161..7311
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            7312..7468
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            7469..7622
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            7623..7774
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            7775..7880
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
     exon            7881..8074
                     /gene="Atr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcggcttc cgggaggaga attttggacc tcgcggggct ccgtcgacgc tccgccctct
       61 ccaccggagg cggctgtgga gaagcccggc gccggcggcg gctgttttga gagccgctcg
      121 gtgtcaccat gggcgaccac gggctggagc tggcgtccat gatccccgcc ctgcgggagt
      181 tggccagtgc tactccagaa gaatataaca ctgttgtaca gaaaccaaga cagattctct
      241 gccagttcat tgacagaata cttacagatg taaatgttgt tgctctagaa cttgtaaaga
      301 aaactgacgc tcagccgacc tctgtgatgt tacttgattt tatccagcac atcatgaagt
      361 cttctccgct tatgtttgta aatgtgaatg gaagccaggg ccaaaatgag gccaaagaca
      421 gttgtattga attcagtcat tggatcatta caagactttt acggattgca gcaactccat
      481 cctgccacat gctacacaag aaaatatgtg aagttatctg ctcgttatta tttcttttta
      541 aaagcaagaa tcctgctatt tttggggtac tcacaagaga attactttat ctttttgaag
      601 acttaattta cctccacaaa agaaatgcag tgggtgaggt tatggaatgg ccagtggttg
      661 ttagtcggtt tttaagccga ttggatgaac atatgggatg tttacagcca gctcctttgc
      721 agttcatgaa cgtgcaaaat gtagaattta ttgaagtcac tctattaatg gttcttattc
      781 atattgttcc aaccgtgttt tttagacgac aagaattgtt actgtggcaa atcggctgcg
      841 ctctgctaga gcacggtagt cccaaaatca ggtctttagc aattagcctt ctaactgagc
      901 tctttgagct tggagggtta ccagcacagc cagccagcac ttttttcagc ttatttttgg
      961 agttgctaca acaccttgtt ggaatggatg ctgaccaatt gaaattgtat gaagagccat
     1021 tgtcaaagct gctaaaaacg ctctttccct ttgaagcaga ggcttataga aatattgaac
     1081 ctgtctactt aaatgtgcta ctggaaaaac tcagtgtcat gtttgaagat cgcgtgctta
     1141 tgcggctcaa gtctgatttg ctgaaggctg ctttgtgtca tttactgcag tatttcctta
     1201 catttgtgcc agctgggtat gaatcggctt tacaggtcag gaaggtttat gtgacaaata
     1261 tttgtagagc tcttgtagac gctcttggag ttcagaaaca tgttgggtat ttgttgggac
     1321 cattttatgc agccttgaaa atggaaagta aggaaattat tgaaagaatt caatgccaag
     1381 ctcaacagga gaatctcagt ggtaataatg atgaggtgtc accaaagagg cgtaaactca
     1441 gctcctctct cagctcttac aaaaagccat ccagacagcc tgaagaaatt attcatgtgg
     1501 atatggacaa aaagagcata ttatggaatg ttctgaaaca gaaagccgaa tcccttcaga
     1561 tctctctcga atgtggtact ctcaagaatt ctgttgctga ggcattagaa ggaatcactg
     1621 ttgtattaca gctgactgct ctctgcactg ttcactgttc tcatcaagac atggatggcc
     1681 ataatgtcaa ggatcatcaa cacaaatata agaagaaacc tccagtagta gtaacttgga
     1741 tgtctttgga tttttataca aaagtgctta aaagctgtag gagtttgtta gaatctgttc
     1801 agaaacttga actggaatta gtcattgata gcatggtgag aatttgtgat gctctgatgt
     1861 atatgcaagt aaaaagttca ttcaaggatc atgttctgga agagttatgt ggaatgctct
     1921 cacttccatg gatttattcc tattctgatg ataactcttt aaagatgacc acatttgcta
     1981 ctaaccttct gccattaagc cagagggttt gggatagtta ctctccacag gcacagtcaa
     2041 aatgtgtgtt tcttctgaca ctgtttccaa gaagaatatt ccttgaatgg agaacagcag
     2101 tttataattg ggccctaaag agctcccatg aagtaatccg ggctagttgt gttaaaggat
     2161 tttttatctt attgcatcag cagaattctt gtaaccaaat tcccaagatg cttgtagata
     2221 gagtcaaaga tgattctgac atggtcaaga aagaatttgc ttctgtcctt ggtcaacttg
     2281 tctgtactct tcacggcatg ttttatttga gttcctcagt agagccttgc tttgaacata
     2341 tggacttgtt cagtaagaac ctgaaagcca cttctcagca tgaatgttca tcttctcaag
     2401 taaaagcttc cacttgcaag ccattccttt tcctgctgac caaaaataca cctagtccag
     2461 taaaacttgc tttcatagac aatctacatc atctttgtaa gcatcttgat tttcaagaag
     2521 atgaaagaga ggtaaaagca gttcttggga ctttattaaa tttgatggaa gatccagaca
     2581 aggatgttag aattgctttt agtggaaata tcaagtatat attggaatcc ttgaactctg
     2641 aagatggatt cgtaaaagag ctttttgtct taagaatgaa ggaagcatat actcatgccc
     2701 aaatagcaag gaataatgag ctaaaggata ctttgattct tacaacaggg gatattggaa
     2761 gggcagcaaa aggagatttg atacctttcg cactcttgca tttactgcat tgcttgctgt
     2821 ctaagtctgc atccgtctct ggagcggcat acacagagat tcgagcacta gttgcagcta
     2881 aaagtgttaa actgcagaat tttttcagtc aatataagaa accgatctgt cagtttttgg
     2941 tagaatctct ccactccagt cagatgacag cactcccaag tgctccttgc cagtcttctg
     3001 agattcgaaa acaagatgtt gctcatcaca gagagatggc tttaaatacc ttatcagaaa
     3061 ttgccaatgt ttttgacttt cctgatctta atcgtttcct gacaaggaca ttacaagttc
     3121 tgcttcctga tcttgctgcc aaagcaagtc ctgcagcatc ggctctcatt cgaactttag
     3181 ggaaacaatt aaatgtcagt cgtcgagaga ttttaataaa taacttcaaa tacatctttt
     3241 cccatttggt ttgttcttgt tccaaagatg aattagaacg tgctcttcat tatctgaaga
     3301 atgaaacaga aattgagttg gggagcctgt taagacagga ttttcaagga ttgcataacg
     3361 aattattgct gcgtattgga gaacattatc aacaagtttt caatggtttg tcaatacttg
     3421 cctcatttgc atctagtgat gatccatatc agggaccacg agatattaca tcacctgaac
     3481 tgatggctga ttatttgcaa ccaaaattgt tgggcattct ggcctttttt aatatgcagt
     3541 tgctgagctc cagtgttggc attgaagata agaaaatggc cttgactagt ttgatgtctt
     3601 tgatgaagtt gatgggacct aaacatgtca gttctgtgag agtaaaaatg atgaccacac
     3661 tgagaactgg tcttagattc aaggatgatt ttcctgagtt atgctgcaga gcatgggact
     3721 gctttgttcg ctgtctggat cacgcttacc tgggacccct gctcagtcat gtcatagtgg
     3781 ctttgttacc tctcatacac atgcagccta aagaaactgc tgctatcttt cactacctca
     3841 tcattgaaaa cagggatgct gtgcaagatt ttcttcatga aatatatttt ttgcctgatc
     3901 atccagaatt agaaaagata aaagcagttc tccaggaata tagaaaggaa acctctgaga
     3961 ctactgatct tcaaaccact ctccagctat ctatgaaagc aattcaacac gaaaatgtag
     4021 atgttcgaat tcatgctctt acaagcttga aggaaacctt gtacaaaaat caggaaaaac
     4081 tgataaaata tgcaactgat agtgagacag tggagcccgt tatctcccag cttgtgacgg
     4141 taattctgaa aggctgccaa gatgcaaact ctcaagctcg cttactctgt ggggaatgtt
     4201 taggagaact gggggcaata gacccagggc gattggattt ctcaacaaca gaaactcaag
     4261 gaaaagattt tacatttgtg actggagtag aagatttaag ctttgcctat ggattgctaa
     4321 tggagctaac aagagcttac cttgcatatg ctgataacag ccgagcacaa gattcagctg
     4381 cttatgctat tcaggagttg ctttctattt atgactgtag agagatgcag agcaatggcc
     4441 caggttacca gttgtggaaa agattccctg agcatgtccg ggaaatatta gagcctcatc
     4501 tcaatactag atataagagt tcccagaaat caacagattg gtctggagta acgaagccaa
     4561 tttacttaag taaactaggt aataactttg cagaatggtc atcatcttgg gcaggttatc
     4621 ttataacaaa ggttcgggat aatcttgcca gtaagatctt cacatgctgt agcataatga
     4681 tgaagcatga ttttaaagtc accatctatc ttcttccaca tatcctagta tatgtcttgt
     4741 tgggttgtaa tcaagaagat cagcaagagg tttatgcaga aattatggca gtacttaagc
     4801 atgatgagca gcatgccatc agtacccaag acagtgcatc tgatctgtgc cagctgagta
     4861 cacagactgt gttctctgtg cttgaccatc tcacccaatg ggcaaggcac aaatttcagg
     4921 cattgaatgc tgagaaactt gcacaaaaca aaccaaaagg aggtaaggtc aacaaaatat
     4981 tatcaaatgt gaattttgaa gactatcaga gtgtaactcg ttttctagac ctcatacctc
     5041 aggatactct ggctgtagcg tcctttcgtt ccaaagcata cacacgagcc gtaatgcact
     5101 ttgagtcatt tattacagaa aagaagcaaa atattcaaaa gcatcttgga tttctacaga
     5161 aattgtatgc tgctatgcat gagccagatg gagtggctgg agtaagtgca attcggaaag
     5221 ccgagccatc cctgaaggaa cagattcttg aacatgaaag tattggcttg ctgagggatg
     5281 ccactgcctg ttatgacagg gctattcagc tagaaccaga ccagatcatt cattatcatg
     5341 gtgttgtgaa gtccatgtta ggtcttggtc agctgtctac tgttatcacc caggtcaatg
     5401 gagtacatgc taataggtct gaatggacag atgaattaaa cacatacaga gttgaagcag
     5461 cttggaaact gtcacagtgg gatttggtgg aaaactattt agcagcagac gggaaatcca
     5521 caacatggag tgtcagacta ggacagctac tgttatcagc taaaaagaga gacaccacaa
     5581 ctttttatga cacactgaag ctagtgagag cagaacaaat cgtacctctc tcagctgcca
     5641 gctttgaaag aggctcctac caacgaggct atgagtttat tgtcagatta cacatgttgt
     5701 gtgagttgga gcacagcctc aaaccgcttt ttcgcaagtc tccaggtgac agttgtaatg
     5761 aagactctct gaactgggga gctcgacttg aaatgaccca gaattcctat agagccaagg
     5821 agcctatcct ggccctccgg agggctttat taagtctcaa caaaaggccg gattacaatg
     5881 aaatggttgg agaatgctgg ctacagagtg ccagggtagc tagaaaggct ggccaccatc
     5941 agacagccta caatgctctc cttaatgctg gagagtcacg acttgctgaa ctgtatgtgg
     6001 agagggcaaa gtggctgtgg tccaagggtg acgttcacca ggcgcttatt gttcttcaaa
     6061 agggcgtgga attatgtttt cctgaaaata agtccccatc tgagagtaag cacatgctaa
     6121 tccatggccg ggccacactg ctagttggcc gctttatgga agaaacggct aactttgaaa
     6181 gcaacgcagt aatgaagaaa tacaaggatg tgaccttgtt tctgccagag tgggaagatg
     6241 gacatttcta ccttgccaag tactatgaca aattgatgcc gatggtaaca gataacaaaa
     6301 tggaaaagca aggtgatctc atccgatata tagttttaca ttttggaaga tctcttcagt
     6361 atggaaatca gttcatatat cagtcaatgc cacgaatgtt atcgctatgg cttgattttg
     6421 gtgctaaggc atacgaatgg gaaaaaggtg gtcgttctga tcgtctgcaa atgagaaatg
     6481 atttggctaa aataaatagt gtactcacag agcacacaaa tcggttagca ccatatcagt
     6541 ttttgactgc tttttcgcag ttgatctctc gaatatgtca ttctcatgat gaagtttttg
     6601 ttgtcttgat ggaaataata gccaaggtat ttctggccta tcctcagcaa gcaatgtgga
     6661 tgatgactgc tgtgtcaaag tcttcttatc ccatgcgtgt gaacagatgc aaggaaattc
     6721 ttaccaaagc catccatatg aaaaagtctt tagaaaagtt tgttggagat gcaactcgtt
     6781 taacagacaa gctactagaa ttatgcaaca aatcggtcga tggaagcaat tccacattaa
     6841 gcatgagcac tcactttaaa atgcttaaaa ggcttgtaga agacccgacc ttcagtgaga
     6901 tcctcattcc cctgcagtca gtcatgatcc ctactcttcc gtcagttctg ggtgcccatg
     6961 cgaatcatga cccctttcct gggcactggg cctatcttgc aggcttcgat gatgtggtag
     7021 aaattctttc ttctcttcag aaaccaaaga aaatctcttt aaagggctca gatggaaagt
     7081 tctacatcat gatgtgtaaa ccaaaagatg acttgagaaa agactgtaga ctaatggaat
     7141 tcaactcttt gattaacaag agcttaagaa aagatgcaga atcacgtcga agagaacttc
     7201 atatccgaac atatgcagtt attccactga atgatgaatg tgggattatt gaatgggtga
     7261 acaatactgc tggcttgaga cctattctga ccaaaatata taaagaaaag ggagtgtata
     7321 tgacaggaaa ggagcttcgc cagtgtatgc taccaaagtc agcagcttta tctgaaaaac
     7381 tcaaagtatt ccaagaatta ctcctgccca ggcatcctcc tgtttttcat gagtggtttc
     7441 tgagaacatt ccctgatcct acatcatggt acagtagcag atctgcatat tgccgctcta
     7501 ctgcagtcat gtcaatggtt ggctacatcc tggggcttgg agaccgtcat ggtgaaaaca
     7561 ttctttttga ctctttcact ggtgaatgtg tacatgtaga tttcaactgt ctttttaata
     7621 agggagaaac gtttgaagtt ccggaaattg taccatttcg actgactcat aatatggtta
     7681 atggaatggg tcctatggga acagagggtc tatttcgaag agcatgtgaa gttacactga
     7741 gactgatgag ggatcagaga gaacctttaa tgagtgtctt aaagactttt ctacacgatc
     7801 ctctagtgga gtggagtaaa ccagtgaaag gacactccaa agcaccactg aatgaaaccg
     7861 gggaagttgt caatgagaag gccaagaccc atgttcttga cattgaacaa cgactacaag
     7921 gtgtgatcaa aacccgaaat agagtaacag ggctgccatt atctattgaa ggacatgtgc
     7981 attacctcat acaagaagct actgatgaaa acttactctg tcagatgtac cttggttgga
     8041 ccccatatat gtaaaataaa attatttcaa agaa
//
