LOCUS       NM_026546               1166 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ATP synthase C subunit lysine N-methyltransferase
            (Atpsckmt), transcript variant 1, mRNA.
ACCESSION   NM_026546
VERSION     NM_026546.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1166)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1166)
  AUTHORS   Willemen,H.L.D.M., Santos Ribeiro,P.S., Broeks,M., Meijer,N.,
            Versteeg,S., Tiggeler,A., de Boer,T.P., Malecki,J.M., Falnes,P.O.,
            Jans,J. and Eijkelkamp,N.
  TITLE     Inflammation-induced mitochondrial and metabolic disturbances in
            sensory neurons control the switch from acute to chronic pain
  JOURNAL   Cell Rep Med 4 (11), 101265 (2023)
   PUBMED   37944527
REFERENCE   3  (bases 1 to 1166)
  AUTHORS   Malecki,J.M., Willemen,H.L.D.M., Pinto,R., Ho,A.Y.Y., Moen,A.,
            Kjonstad,I.F., Burgering,B.M.T., Zwartkruis,F., Eijkelkamp,N. and
            Falnes,P.O.
  TITLE     Lysine methylation by the mitochondrial methyltransferase FAM173B
            optimizes the function of mitochondrial ATP synthase
  JOURNAL   J Biol Chem 294 (4), 1128-1141 (2019)
   PUBMED   30530489
REFERENCE   4  (bases 1 to 1166)
  AUTHORS   Willemen,H.L.D.M., Kavelaars,A., Prado,J., Maas,M., Versteeg,S.,
            Nellissen,L.J.J., Tromp,J., Gonzalez Cano,R., Zhou,W.,
            Jakobsson,M.E., Malecki,J., Posthuma,G., Habib,A.M., Heijnen,C.J.,
            Falnes,P.O. and Eijkelkamp,N.
  TITLE     Identification of FAM173B as a protein methyltransferase promoting
            chronic pain
  JOURNAL   PLoS Biol 16 (2), e2003452 (2018)
   PUBMED   29444090
  REMARK    GeneRIF: we uncover a role for methyltransferase activity of
            FAM173B in the neurobiology of pain. These results also highlight
            FAM173B methyltransferase activity as a potential therapeutic
            target to treat debilitating chronic pain conditions
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1166)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137842.8.
            
            On Apr 29, 2007 this sequence version replaced NM_026546.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK020868.1, SRR5189685.35316.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC137842.8         130528-130561       c
            35-312              AC137842.8         126489-126766       c
            313-450             AC137842.8         124444-124581       c
            451-501             AC137842.8         123061-123111       c
            502-1166            AC137842.8         115142-115806       c
FEATURES             Location/Qualifiers
     source          1..1166
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 13.02 cM"
     gene            1..1166
                     /gene="Atpsckmt"
                     /gene_synonym="A930016P21Rik; Fam173b; mFam173b"
                     /note="ATP synthase C subunit lysine N-methyltransferase"
                     /db_xref="GeneID:68073"
                     /db_xref="MGI:MGI:1915323"
     exon            1..34
                     /gene="Atpsckmt"
                     /gene_synonym="A930016P21Rik; Fam173b; mFam173b"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..765
                     /gene="Atpsckmt"
                     /gene_synonym="A930016P21Rik; Fam173b; mFam173b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM173B; protein N-lysine methyltransferase
                     FAM173B; family with sequence similarity 173, member B;
                     ATP synthase subunit C lysine N-methyltransferase"
                     /codon_start=1
                     /product="ATP synthase subunit C lysine
                     N-methyltransferase isoform 1"
                     /protein_id="NP_080822.1"
                     /db_xref="CCDS:CCDS27412.1"
                     /db_xref="GeneID:68073"
                     /db_xref="MGI:MGI:1915323"
                     /translation="MERVGTPEEERQAGPVLPTSLESDSSKRTSWGFLITGVVGGALL
                     TVYAVATPFITPALRKVCLPFVPATSKQVENVVRMLRHRRGPLVDIGSGDGRIVIAAA
                     KEGFPAVGYELNPWLVWYSRYRAWRAGVHGSAKFYISDLWKVTFAQYSNVVIFGVPQM
                     MPQLEKKLELELEDGARVIACRFPFPRWTPDHTTGEGIDTVWAYDMSAQRGRGGRPNQ
                     EWVGQKNLSETAGLQASSSETRSKLLDVE"
     exon            35..312
                     /gene="Atpsckmt"
                     /gene_synonym="A930016P21Rik; Fam173b; mFam173b"
                     /inference="alignment:Splign:2.1.0"
     exon            313..450
                     /gene="Atpsckmt"
                     /gene_synonym="A930016P21Rik; Fam173b; mFam173b"
                     /inference="alignment:Splign:2.1.0"
     exon            451..501
                     /gene="Atpsckmt"
                     /gene_synonym="A930016P21Rik; Fam173b; mFam173b"
                     /inference="alignment:Splign:2.1.0"
     exon            502..1166
                     /gene="Atpsckmt"
                     /gene_synonym="A930016P21Rik; Fam173b; mFam173b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggtctccc cggaacgcgc gatggagcga gtaggaacgc ctgaggaaga aagacaggcg
       61 ggccctgttc ttcctacgag tctggaatcc gacagttcaa agaggaccag ttggggattc
      121 ttgattactg gggtcgttgg tggtgcactg ctgacagtgt atgctgtggc cacaccattc
      181 atcaccccgg ccctccggaa agtttgtttg ccattcgtgc ctgcaacttc gaagcaggtt
      241 gaaaatgttg tcaggatgct gcgacacaga agaggacccc tggtggacat cggcagtggc
      301 gatgggcgga ttgtgattgc agctgcaaag gaaggcttcc cagcggtggg gtatgaattg
      361 aatccatggc tggtttggta ctccagatat cgtgcctgga gggcaggcgt gcatggctct
      421 gccaagtttt atatttcaga tctctggaag gtcacctttg cacagtactc caatgttgtc
      481 atttttggtg tgccccagat gatgccacag ctggagaaga agcttgagct ggagctggag
      541 gacggagctc gagtcattgc ctgtcggttc ccgttcccac gctggactcc agaccacacc
      601 actggagagg gcatcgacac cgtgtgggcc tatgacatga gtgctcagag aggacgggga
      661 ggacggccga atcaggagtg ggtcggccag aagaacctct cggagacagc aggcctgcag
      721 gcctcctcat ctgagacacg gagcaagctc cttgacgttg agtgacaagt caccgctgct
      781 aatcttccgt tcttgagaaa atgaacagaa ctcagagaag catttaagtt taagctctgc
      841 tgctttttga agggcagttt cacacggcct ggggtggcct tgcacttact gagcacgatg
      901 acccggaact tctgatcctt ccacttctac ctgcccagta aaaggtgctc ctagtgggac
      961 atcctggata gggtgcatga agatataagt aagggaccgt ctgtctgtgg gtcagaaggt
     1021 atcatctcag cagcatggtt taatggctcg ggtgaagagg gcagggcact taggcaaaca
     1081 cctgcagttt cctgtggttt tgtccatgac tgaatttctg tagtgtgtag ctaaattaaa
     1141 tttctaaaga gagtgccatt tagctt
//
