LOCUS       NP_001188498            1146 aa            linear   ROD 28-APR-2025
DEFINITION  probable phospholipid-transporting ATPase IIB isoform 1 [Mus
            musculus].
ACCESSION   NP_001188498
VERSION     NP_001188498.1
DBSOURCE    REFSEQ: accession NM_001201569.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1146)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1146)
  AUTHORS   Tosti,E., Almeida,A.S., Tran,T.T.T., Barbachan E Silva,M.,
            Broin,P.O., Dubin,R., Chen,K., Beck,A.P., Mclellan,A.S., Vilar,E.,
            Golden,A., O'Toole,P.W. and Edelmann,W.
  TITLE     Loss of MMR and TGFBR2 Increases the Susceptibility to
            Microbiota-Dependent Inflammation-Associated Colon Cancer
  JOURNAL   Cell Mol Gastroenterol Hepatol 14 (3), 693-717 (2022)
   PUBMED   35688320
  REMARK    GeneRIF: Loss of MMR and TGFBR2 Increases the Susceptibility to
            Microbiota-Dependent Inflammation-Associated Colon Cancer.
REFERENCE   3  (residues 1 to 1146)
  AUTHORS   Rizzolio,F., Bione,S., Sala,C., Tribioli,C., Ciccone,R.,
            Zuffardi,O., di Iorgi,N., Maghnie,M. and Toniolo,D.
  TITLE     Highly conserved non-coding sequences and the 18q critical region
            for short stature: a common mechanism of disease?
  JOURNAL   PLoS One 3 (1), e1460 (2008)
   PUBMED   18213369
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1146)
  AUTHORS   Tashiro-Yamaji,J., Einaga-Naito,K., Kubota,T. and Yoshida,R.
  TITLE     A novel receptor on allograft (H-2d)-induced macrophage (H-2b)
            toward an allogeneic major histocompatibility complex class I
            molecule, H-2Dd, in mice
  JOURNAL   Microbiol Immunol 50 (2), 105-116 (2006)
   PUBMED   16490928
REFERENCE   5  (residues 1 to 1146)
  AUTHORS   Paulusma,C.C. and Oude Elferink,R.P.
  TITLE     The type 4 subfamily of P-type ATPases, putative aminophospholipid
            translocases with a role in human disease
  JOURNAL   Biochim Biophys Acta 1741 (1-2), 11-24 (2005)
   PUBMED   15919184
  REMARK    Review article
REFERENCE   6  (residues 1 to 1146)
  AUTHORS   Schauwecker,P.E., Williams,R.W. and Santos,J.B.
  TITLE     Genetic control of sensitivity to hippocampal cell death induced by
            kainic acid: a quantitative trait loci analysis
  JOURNAL   J Comp Neurol 477 (1), 96-107 (2004)
   PUBMED   15281082
REFERENCE   7  (residues 1 to 1146)
  AUTHORS   Halleck,M.S., Lawler,J.F. Jr., Blackshaw,S., Gao,L., Nagarajan,P.,
            Hacker,C., Pyle,S., Newman,J.T., Nakanishi,Y., Ando,H.,
            Weinstock,D., Williamson,P. and Schlegel,R.A.
  TITLE     Differential expression of putative transbilayer amphipath
            transporters
  JOURNAL   Physiol Genomics 1 (3), 139-150 (1999)
   PUBMED   11015572
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK166562.1 and BC079626.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079626.1, SRR1660815.167996.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1146
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 53.9 cM"
     Protein         1..1146
                     /product="probable phospholipid-transporting ATPase IIB
                     isoform 1"
                     /EC_number="7.6.2.1"
                     /note="probable phospholipid-transporting ATPase IIB;
                     macrophage MHC receptor; ATPase, class 2, member b; ATPase
                     9B, p type; ATPase 9B, class II"
                     /calculated_mol_wt=128915
     Region          131..1055
                     /region_name="P-type_ATPase_APLT_Neo1-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Neo1p and human putative APLT,
                     ATP9B; cd07541"
                     /db_xref="CDD:319841"
     Site            144..164
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98195.4)"
     Site            173..193
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98195.4)"
     Site            382..402
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98195.4)"
     Site            408..427
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98195.4)"
     Site            order(467..469,632,656..658,718,765..767,847,850,853,873,
                     876)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319841"
     Region          508..535
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P98195.4)"
     Region          548..659
                     /region_name="Cation_ATPase"
                     /note="Cation transport ATPase (P-type); pfam13246"
                     /db_xref="CDD:463817"
     Site            939..959
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98195.4)"
     Site            962..982
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98195.4)"
     Site            1012..1032
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98195.4)"
     Site            1041..1061
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98195.4)"
     Site            1066..1086
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98195.4)"
     Site            1106..1128
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P98195.4)"
     CDS             1..1146
                     /gene="Atp9b"
                     /gene_synonym="Atpc2b; IIb; MMR"
                     /coded_by="NM_001201569.1:120..3560"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS89288.1"
                     /db_xref="GeneID:50771"
                     /db_xref="MGI:MGI:1354757"
ORIGIN      
        1 madqiplypv rsagaaashr raayyssagp gpgadrrgry qledesahld emplmmseeg
       61 fendesdyht lpraritrrk rglewfvcgg wkflctsccd wlinvcqrkk elkartvwlg
      121 cpekceekhp rnsiknqkyn vftfipgvly eqfkfflnly flvvscsqfv palkigylyt
      181 ywaplgfvla vtiareaide frrfqrdkem nsqlyskltv rgkvqvkssd iqvgdliive
      241 knqripsdmv flrtsekags cfirtdqldg etdwklkvav sctqrlpalg dlfsisayvy
      301 aqkpqldihs fegtftreds dppiheslsi entlwastiv asgtvigvvi ytgketrsvm
      361 ntsnpknkvg lldlelnqlt kalflalvvl svvmvtlqgf agpwyrnlfr flllfsyiip
      421 islrvnldmg kaaygwmimk denipgtvvr tstipeelgr lvylltdktg tltqnemvfk
      481 rlhlgtvsyg tdtmdeiqsh vlnsylqvhs qpsghnpssa plrrsqsstp kvkksvssri
      541 heavkaialc hnvtpvyear agitgetefa eadqdfsden rtyqasspde valvrwtesv
      601 gltlisrdla smqlktpsgq vltycilqmf pftseskrmg iivrdestae itfymkgadv
      661 amstivqynd wleeecgnma reglrtlvva krtlteeqyq dfesrysqak lsihdralkv
      721 aavveslere mellcltgve dqlqadvrpt lemlrnagik iwmltgdkle tatciakssh
      781 lvsrtqdihv frpvtsrgea hlelnafrrk hdcalvisgd slevclryye helvelacqc
      841 pavvccrcsp tqkahivtll rqhtrkrtca igdggndvsm iqaadcgigi egkegkqasl
      901 aadfsitqfr higrllmvhg rnsykrsaal gqfvmhrgli istmqavfss vfyfasvply
      961 qgflmvgyat iytmfpvfsl vldqdvkpem ailypelykd ltkgrslsfk tfliwvlisi
     1021 yqggilmyga lllfedefvh vvaisftali ltellmvalt irtwhwlmvv aeflslgcyv
     1081 aslaflneyf gigrvsfgaf ldvafittvt flwkvsaitv vsclplyvlk ylkrklspps
     1141 ysklss
//
