LOCUS       NM_177195               4474 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus ATPase, class I, type 8B, member 5 (Atp8b5), mRNA.
ACCESSION   NM_177195
VERSION     NM_177195.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4474)
  AUTHORS   Suzuki,A., Yabuta,N., Shimada,K., Mashiko,D., Tokuhiro,K.,
            Oyama,Y., Miyata,H., Garcia,T.X., Matzuk,M.M. and Ikawa,M.
  TITLE     Individual disruption of 12 testis-enriched genes via the
            CRISPR/Cas9 system does not affect the fertility of male mice
  JOURNAL   J Reprod Immunol 163, 104252 (2024)
   PUBMED   38697008
REFERENCE   2  (bases 1 to 4474)
  AUTHORS   Xu,P., Okkeri,J., Hanisch,S., Hu,R.Y., Xu,Q., Pomorski,T.G. and
            Ding,X.Y.
  TITLE     Identification of a novel mouse P4-ATPase family member highly
            expressed during spermatogenesis
  JOURNAL   J Cell Sci 122 (Pt 16), 2866-2876 (2009)
   PUBMED   19657017
  REMARK    GeneRIF: These findings point to an essential role of FetA in Golgi
            morphology and secretory function, suggesting a crucial role for
            this novel murine P4-ATPase in spermatogenesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732504.23.
            
            On Mar 1, 2007 this sequence version replaced NM_177195.2.
            
            CCDS Note: The coding region has been updated to extend the
            C-terminus to one that is more supported by available transcript
            and homology data. The update results in a much more complete MgtA
            cation transport ATPase domain and adds a haloacid
            dehalogenase-like hydrolase region.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF377342.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AL732504.23        71351-71434
            85-128              AL732504.23        75436-75479
            129-203             AL732504.23        95849-95923
            204-259             AL732504.23        106774-106829
            260-373             AL732504.23        108842-108955
            374-472             AL732504.23        109923-110021
            473-534             AL732504.23        112680-112741
            535-607             AL732504.23        115648-115720
            608-678             AL732504.23        116088-116158
            679-761             AL732504.23        124784-124866
            762-920             AL732504.23        126602-126760
            921-1009            AL732504.23        129032-129120
            1010-1206           AL732504.23        138337-138533
            1207-1415           AL732504.23        146629-146837
            1416-1459           AL732504.23        148622-148665
            1460-1622           AL732504.23        157739-157901
            1623-1811           AL732504.23        159736-159924
            1812-1927           AL732504.23        161157-161272
            1928-2092           AL732504.23        165975-166139
            2093-2204           AL732504.23        168301-168412
            2205-2310           AL732504.23        169684-169789
            2311-2458           AL732504.23        170133-170280
            2459-2642           AL732504.23        170788-170971
            2643-2866           AL732504.23        172113-172336
            2867-2950           AL732504.23        173822-173905
            2951-3196           AL732504.23        174768-175013
            3197-3335           AL732504.23        175153-175291
            3336-3466           AL732504.23        176789-176919
            3467-4474           AL732504.23        177016-178023
FEATURES             Location/Qualifiers
     source          1..4474
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.01 cM"
     gene            1..4474
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /note="ATPase, class I, type 8B, member 5"
                     /db_xref="GeneID:320571"
                     /db_xref="MGI:MGI:2444287"
     exon            1..84
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            85..128
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..3652
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /EC_number="7.6.2.1"
                     /note="probable phospholipid-transporting ATPase FetA;
                     testis flippase; ATPase class I type 8B member 2-like
                     protein; flippase expressed in testis A"
                     /codon_start=1
                     /product="phospholipid-transporting ATPase FetA"
                     /protein_id="NP_796169.2"
                     /db_xref="CCDS:CCDS18091.2"
                     /db_xref="GeneID:320571"
                     /db_xref="MGI:MGI:2444287"
                     /translation="MKYVKAFVSEISWDCSWYCSAMQERRNEDRQKEEEERILQANNR
                     RFNSLFEYPDNSIKTSKYGFFNFLPMNLFEQFQRLANAYFLILLFLQLVPQISSLAWY
                     TTVIPLIVVLSITGVKDAIDDVKRHRSDQQINNRSVSILVNGRVEEIKWRNVQVGDII
                     KLENNHPVTADMLLLSSSEPYGLTYIETADLDGETNLKVKQAISVTSAMEDNLELLSS
                     FNGEVRCDPPNNKLDKFSGTLSYLGNTYLLNHERLLLRGCVIRNTDWCYGLVVYTGQD
                     TKLMQNSGRSTFKRTHIDHLMNVLVVWIFMFLGGMCFLLSIGHGIWENSRGYYFQAFL
                     PWKHYITSSATSSALIFWSYFIVLNTMVPISLYVSVEIIRLGNSYYINWDRKMFYAPK
                     NMPAQARTTTLNEELGQVQYVFSDKTGTLTENVMIFNKCSINGKTYGYSYDDNGEYVP
                     KSPKDKVDFSYNHLADPKFSFYDKTLVEAVKSEDPLVYLFFLCLSLCHTVMSEEKVEG
                     ELVYQAQSPDEGALVTATRNFGFVFCSRTPETITVIEMGKIRVYRLLAILDFSNERKR
                     MSVIVRTPEDRVMLFCKGADTIIYELLHPSCASLSEVTMDHLDDFASEGLRTLMVAYR
                     ELDKAYFQTWIKKHGEAWLTLENRERKLALVYEEIERDLMLLGATAIEDKLQRGVPET
                     IVTLSKAKIKIWVLTGDKQETAVNIAYSCRIFKDEMDGVFMVEGTDRETVLEELRTAR
                     KKMKPESLLESDPINMYLARKPKMPFKSLDEVANGNYGLVISGYSLAYALEGSLEFEL
                     LRTACMCKGVVCCRMTPLQKAQVVDLVKRYKKVVTLAIGDGANDISMIKAAHIGVGIS
                     NQEGMQATLSSDFSFCQFHFLQRLLLVHGRLSYNRMCKFLSYFFYKNFAFTLVHFWYA
                     FFNGFSAQTVYDIWFITFYNLIYTSLPVLGLSLFEKDVNETWSLCYPELYEPGQHNLY
                     FNKKEFVKCLLHGIYNSFVLFFVPMGTVFNSERNDGKDISDFQSFSLLVQTTLIGVMT
                     MQIALRTTSWTMINHTFTWGSLGLYFCILILLCSDGLCLRYPSIFNFLGVARNSLSQP
                     QIWLCLILSTILCMIPLIGYNFLRPLLWPINADKVLNRIHFCLKHPIPTQVQTKIKHP
                     SLRRSAYAFSHKQGFGALITSGKTLKSSALAKSKRFL"
     exon            129..203
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            204..259
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            260..373
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            374..472
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            473..534
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            535..607
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            608..678
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            679..761
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            762..920
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1009
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1206
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1415
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1459
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1622
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1811
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1927
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2092
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2204
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2310
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2458
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2642
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2866
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..2950
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3196
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3335
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..3466
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..4474
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4457..4462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp8b5"
                     /gene_synonym="4930417M19Rik; Feta"
ORIGIN      
        1 gggcggaagc tgtggttctg tggcacaagc gcagaaaggt gcgttaagat ggaggttgct
       61 ggagtaggag gctgtgaggc gacggtggtg tttctctgag atgaaatacg taaaagcttt
      121 tgtttcagag atttcatggg attgtagctg gtactgctct gcaatgcaag agaggaggaa
      181 tgaagacaga cagaaggaag aagaggaaag gattttgcag gccaacaata gaaggttcaa
      241 ctctcttttt gagtatccgg acaattccat caagacatca aagtatggtt tctttaactt
      301 cctgcccatg aacctgtttg aacagttcca gagacttgca aatgcctatt tcctcatttt
      361 gctcttccta cagttggtcc cgcagatctc ctccctggcc tggtacacga ccgtgatacc
      421 cctgattgtg gtgctatcca taactggagt gaaagacgcc atcgatgacg tgaaaagaca
      481 ccgaagtgac cagcagatca acaaccgctc tgtttcaatc ctggtgaacg gcagggttga
      541 ggagatcaag tggaggaatg tccaagtggg ggacataatt aagctggaga ataaccatcc
      601 tgttaccgca gacatgctgt tgctctctag cagtgagccg tacggcctga catacattga
      661 aacagcagac ctggacggtg aaaccaacct gaaagtgaag caagccatct ccgtcaccag
      721 tgccatggag gacaacctgg agctgctgtc ctcctttaat ggagaagtta ggtgtgatcc
      781 tcctaataac aagctggaca agttttctgg aaccctgagc tacctgggga acacctactt
      841 actgaaccat gaaaggctac tgctccgagg ctgcgtcatc cggaacacag actggtgcta
      901 cggtttggtc gtttacactg ggcaagacac caaattaatg cagaacagtg gacggtccac
      961 cttcaaacga acacatatag atcatctcat gaatgtcctt gtggtctgga ttttcatgtt
     1021 tttaggtgga atgtgttttc tgctgtcgat tggacatggc atctgggaga acagcagagg
     1081 ctactatttc caggcctttc tcccatggaa acattatatt acctcatcgg ctacgagttc
     1141 tgccctcatt ttctggtcct acttcatagt gctcaacacc atggtaccca tttccctcta
     1201 tgtcagtgtg gaaataataa gactgggcaa cagttactac atcaactggg atcgaaagat
     1261 gttttacgcc ccaaagaaca tgccagcgca ggctcgcacc accactctta atgaggagct
     1321 gggccaagtc caatacgtgt tctctgacaa aacaggaacc ctgactgaga atgtgatgat
     1381 tttcaacaaa tgttctatca acgggaagac ctatggttat tcctacgacg acaatggaga
     1441 gtatgtgcca aaatctccaa aagacaaggt ggacttctct tacaaccacc tggctgaccc
     1501 taagttttcc ttctatgaca agaccttggt ggaagcggtg aagagtgaag acccgctggt
     1561 ctacctgttc ttcctctgtc tctcgctgtg ccacacggtg atgtcagagg agaaggtgga
     1621 aggtgagctg gtgtaccagg ctcagtcacc agatgaaggt gccctggtta cggctactag
     1681 gaactttggc tttgtgttct gctcccgcac acctgagact atcacagtga tcgaaatggg
     1741 gaaaatccga gtttaccgcc tactggctat cttggacttc agcaatgagc gcaagaggat
     1801 gtctgtcatt gttcggacac ctgaagatcg agtcatgttg ttctgcaagg gagcagacac
     1861 catcatctat gagctgctgc atccatcttg tgcatccctt agtgaagtga ccatggacca
     1921 cttagatgat tttgccagcg aaggccttcg caccctcatg gtagcttacc gagagctgga
     1981 taaggcatat ttccagacat ggattaaaaa gcatggtgaa gcctggctga ctttagagaa
     2041 tcgagaaagg aaactagctc tggtctatga agaaatcgaa agagacttga tgttactagg
     2101 ggccacagcc atagaagaca agcttcagag aggagtacct gagaccattg tcaccctgag
     2161 caaagccaaa attaaaatat gggttctgac tggcgataag caagagactg ctgtgaacat
     2221 cgcctactcc tgtaggatat tcaaggatga aatggatggg gtgttcatgg tggaaggcac
     2281 agatagggaa actgttctgg aagaactcag aacagctagg aagaagatga aacccgagtc
     2341 tctgctggaa tcagatccca taaacatgta cctcgccagg aagcccaaaa tgcctttcaa
     2401 atcacttgac gaggtggcca acggcaacta tggcttggtc atcagtggct acagtctggc
     2461 ctatgctcta gaagggagcc tggagttcga gctgctgcgg accgcatgca tgtgcaaggg
     2521 cgtggtctgc tgccggatga cacccctcca gaaggcccaa gtggtagacc tggtgaagag
     2581 gtacaagaag gtggtgacac tggccatcgg ggatggggcc aatgacatca gcatgatcaa
     2641 agctgcccat atcggggttg gcatcagcaa ccaggaaggg atgcaggcca cgctcagcag
     2701 tgacttctcc ttctgccagt tccactttct tcagcgcctg ctcttggtgc acggccgctt
     2761 gtcttacaat cgcatgtgca agtttctcag ctacttcttt tacaaaaact ttgcctttac
     2821 cttggtgcac ttctggtatg ccttcttcaa cggcttctct gcgcagacag tttacgacat
     2881 ctggttcatc accttctaca atctcatcta cacttccctc ccggtcctgg gcttgagtct
     2941 gtttgaaaag gatgtgaatg aaacttggag tctgtgttat ccagagctgt atgaaccagg
     3001 acagcacaac ctgtacttca acaagaaaga atttgtgaag tgcttactgc atggcatcta
     3061 caattccttc gtgctgttct ttgtccccat ggggaccgtc ttcaactcag agcgcaatga
     3121 tgggaaggac atctccgact tccagtcctt ctccctgcta gtgcagacga ctctgattgg
     3181 cgtcatgaca atgcagattg ccctgaggac aacctcctgg acgatgataa accacacctt
     3241 cacgtggggc agcctggggc tctacttctg catcctaatc ttactgtgta gtgatggcct
     3301 gtgtctcagg taccccagca tcttcaattt cctaggtgtg gccaggaaca gccttagcca
     3361 gccacagatc tggctgtgtc tcatcctcag caccatcctc tgcatgattc ctctgattgg
     3421 atacaacttt ctcagaccac tcctctggcc catcaacgct gacaaggttc tgaacaggat
     3481 ccatttttgc ttgaaacatc caataccaac ccaagtccag accaaaataa aacacccaag
     3541 ccttcgacgt tctgcctacg cgttctccca caaacagggc tttggggccc tcatcacgtc
     3601 tggcaagacg ctgaaatcca gtgccttggc aaaaagcaag aggttcttgt aaaacataga
     3661 tgcccttaag gaaaccttca cccagtcaac tgttgctcta catccctttt atttatgcaa
     3721 cttagtaaaa gagggatcag ggtgcttcag aaaccagggt ttcaacttct ccactcccca
     3781 gaaagctgta cccaggaaag gtaagggaag aggctgcagc atttccagaa gaggcgagtc
     3841 taagcctccc ggcattccct cagttcttaa cccagacaag cacatgcaga agccatgaaa
     3901 ggggaaagga ggaggaagat ggggcctgaa cgtcttagtc tggcccctga ctctgccaca
     3961 cacagagcaa ctgtaaccct tcccagaccc caggtgacag tgttcccacc cagacactat
     4021 tctcagactt atctgaaaga ttcagggggc cggggtgagt attttgttgg ccctgagtag
     4081 cgaagatggg ggtggtagct atgaagagtt ggtcttaaga agctgaatga gtttctggat
     4141 caagtaggaa aaagaaaaga agaagaagaa aaggaagaaa ggaaagaaaa ggaaggcagt
     4201 cctgcctgga taggacagct cagagttttg ccttcttgcc ctctgacccc ttagatctaa
     4261 gaactgatgc ttatgcaggc attagaagca agaggggaac agatgcaggg gattaaaaca
     4321 ataacttctc aaggggatgt aagccattac tggtgagcat ttgtcttcta taaaattatt
     4381 ttgagaagta attatatgta ctttgtatgt acttgcgcaa ctgtttctaa gacatttgtg
     4441 gagaaataaa cgaagaaata aattgcttat tttg
//
