LOCUS       NM_001080944            5529 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ATPase, class I, type 8B, member 4 (Atp8b4),
            transcript variant 2, mRNA.
ACCESSION   NM_001080944 XM_001004089 XM_001005370 XM_619811 XM_894365
            XM_901491 XM_901499 XM_925437 XM_925438 XM_925440 XM_985405
VERSION     NM_001080944.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5529)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5529)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK173307.1, BC130260.1 and AL929245.13.
            
            On Sep 26, 2007 this sequence version replaced NM_001080944.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169967.1, SRR13422597.1420623.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2254              AK173307.1         1-2254
            2255-3757           BC130260.1         229-1731
            3758-5529           AL929245.13        69072-70843         c
FEATURES             Location/Qualifiers
     source          1..5529
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.76 cM"
     gene            1..5529
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /note="ATPase, class I, type 8B, member 4"
                     /db_xref="GeneID:241633"
                     /db_xref="MGI:MGI:1859664"
     exon            1..73
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            74..138
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..3692
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /EC_number="7.6.2.1"
                     /note="ATPase 8B4, p type; ATPase B4, class I"
                     /codon_start=1
                     /product="probable phospholipid-transporting ATPase IM"
                     /protein_id="NP_001074413.2"
                     /db_xref="CCDS:CCDS50698.1"
                     /db_xref="GeneID:241633"
                     /db_xref="MGI:MGI:1859664"
                     /translation="MMFCNKKKLLEVERVVKANDRDYNEKFQYADNRIHTSKYNVLTF
                     LPINLFEQLQRVANAYFLFLLILQLIPEISSLTWFTTIVPLVLVISMTAVKDATDDYF
                     RHKSDNQVNNRQSKVLINSKLQNEKWMNVKVGDIIKLENNQFVAADLLLLSSSEPHGL
                     CYVETAELDGETNLKVRQALPVTSELGADISSLAEFDGIVRCEAPNNKLDRFSGVLSW
                     KDSKHALSNQKIILRGCVLRNTSWCFGMVLFAGPDTKLMQNSGKTKFKRTSIDRLMNT
                     LVLWIFGFLVCLGIILAVGSSILESEVGDQFRTPPFWREGEKSFLFSGFLTFWSYVII
                     LNTLVPISLYVSVEVIRLGHSYFINWDRKMYYASKAMPAEARTTTLNEELGQIEYIFS
                     DKTGTLTQNIMTFKKCSINGRVYAGEVLDDPIQKKEITKEKEATDFSSKSKSEKTLHF
                     FDQSLMESIELGDPKVHEFLRLLALCHTVMSEENSAGQLVYQVQSPDEGALVTAARNF
                     GFIFKSRTPETITIEELGTPVTYQLLAFLDFNNIRKRMSVIVRNPEGRIKLYSKGADT
                     ILFEKLHPSNEDLQSLTSDHLSEFAGEGLRTLAIAYRELDDKYFKMWQKMLEDANSAT
                     LERDERISGLYEEIERDLMLLGATAVEDKLQEGVIETITSLSLANIKIWILTGDKQET
                     AINIGYACNVLTDAMDALFVITGNTAGEVREELRKAKENLLGQSTSFSNGHAVYDNKQ
                     RLGLDAGAGEAVTGEYALVINGHSLAHALESDVENDLLELACVCKTVVCCRVTPLQKA
                     QVVELVKKHRNAVTLAIGDGANDVSMIKSAHIGIGISGQEGLQAVLASDYALAQFRYL
                     QRLLLVHGRWSYYRMCKFLCYFFYKNFAFTLVHFWFAFFCGFSAQTVYDQWFITLFNI
                     VYTSLPVLAMGMFDQDINEQNSMDYPQLYEPGQLNLLFNKRRFFICVAHGIYTSLALF
                     FIPYGAFYNVAAEDGQHIADLQSFAVTVATSLVIVVSIQIALDTSYWTVVNHVFIWGS
                     VATYFSILLAMHSDGVFGIFPRHFPFVGNARHSLSQKFVWLVVLLTAVTSVMPVVVVR
                     FLKMYLYPSLSDQIRRWQKAQRKKRPLRSRRPQTRRSSSRRSGYAFAHQEGYGELITS
                     GKNMRAKSPAPASGLEKKLYNNTSWIENLCKKTTDAVSGFSHDKTVKL"
     exon            139..197
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            198..311
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            312..410
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            411..472
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            473..545
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            546..616
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            617..699
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            700..858
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            859..947
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1144
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1353
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1400
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1566
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1755
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1871
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2036
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2148
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2254
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2402
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2586
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2810
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2894
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3140
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3279
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3410
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     exon            3411..5529
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5509..5514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /note="hexamer: AGTAAA"
     polyA_site      5529
                     /gene="Atp8b4"
                     /gene_synonym="Im"
                     /note="major polyA site"
ORIGIN      
        1 gagcatttct gaagtgcaga cacgaggagt gaacagagga ttgtggaaag tgagggaagg
       61 agggagaaac caggctgaca cccatgacgt ggtgaaaact cagggtgatg atgttctgca
      121 ataagaagaa gctacttgaa gtggagcggg tggtgaaagc caatgaccgt gactacaatg
      181 agaagttcca gtatgcggac aatcgtatcc atacgtccaa gtacaacgtt ctcacatttt
      241 tgccaattaa tttatttgag cagttacaaa gagtggcaaa tgcctacttt cttttccttc
      301 tgatactaca gctcattcca gaaatctctt ccctgacatg gttcaccacc attgtgccac
      361 tggtcctggt gatctcgatg acggctgtca aggatgccac cgacgactat ttccgtcaca
      421 agagtgataa tcaagtgaat aaccggcagt ctaaggtgct catcaatagc aaactgcaga
      481 atgaaaaatg gatgaatgtt aaagttggag acatcattaa attagaaaac aaccaatttg
      541 tcgctgctga cctgctgctc ctgtcgagca gtgagccaca cggtctctgt tatgttgaaa
      601 cagctgagct tgacggggaa acaaacctga aggttcgtca ggcactacct gtcacctcag
      661 aacttggagc agacattagc agtcttgcag agtttgatgg gatcgtcagg tgtgaggcgc
      721 ctaacaacaa gttagacaga ttctcggggg tcctctcttg gaaggacagc aagcatgccc
      781 tcagcaacca gaagataatc ctgagaggct gcgtcctgag gaacaccagc tggtgctttg
      841 gaatggttct ttttgcaggt ccagacacta aactaatgca gaacagtggt aagacaaagt
      901 ttaaaaggac aagcattgac agactgatga ataccctagt cctctggatt tttgggtttc
      961 tggtatgctt gggaattatt cttgcagtag gaagttcaat cttggagagt gaagttgggg
     1021 accagttcag aactcccccc ttctggagag aaggcgagaa gagcttcttg ttctctggat
     1081 tcttaacatt ctggtcatat gtcatcattc tcaacacgct tgtgcccatt tcattatatg
     1141 tgagtgtgga agtaatccgt ctgggacaca gttattttat aaactgggac cggaagatgt
     1201 attatgcttc gaaagcaatg cctgctgaag cccggacgac cactctaaat gaggaactgg
     1261 gccagatcga atatatcttc tctgacaaaa caggaactct cacccaaaac atcatgactt
     1321 ttaaaaaatg ttccattaat ggaagagtct acgcaggtga agtgctagat gacccaatcc
     1381 agaagaaaga aataactaag gaaaaggagg ctacggactt ctcaagcaag tcgaaatcag
     1441 aaaaaacact gcatttcttt gaccagagtc taatggaatc cattgagctg ggggacccca
     1501 aagtccatga attccttcgc ttactcgcac tctgccatac tgtaatgtca gaagagaaca
     1561 gtgcaggaca actggtttac caagttcaat cgcctgatga aggagctcta gttactgctg
     1621 ctagaaattt tgggttcatt tttaagtctc gaactccaga gacaattaca atagaagaat
     1681 tgggaacacc ggtgacttat cagttacttg cctttttgga tttcaacaac atccggaaaa
     1741 ggatgtctgt catagttcga aacccagaag gacgtataaa actttattcc aaaggggcag
     1801 atactatttt gtttgaaaag ctccatcctt ccaatgaaga cctgcagtcc ttaacatcag
     1861 accatctcag cgaatttgca ggggaaggcc tccgaacctt ggcaattgct tatcgagagc
     1921 ttgatgacaa gtactttaaa atgtggcaga agatgcttga agatgcaaat tctgccacct
     1981 tggaaaggga tgaacggata tctgggctgt atgaagaaat cgagagggat ttgatgctat
     2041 taggtgccac cgctgtcgaa gataaattac aagaaggtgt tattgaaaca attacaagtc
     2101 tctcactagc caatattaag atctggattc taacaggaga caaacaagaa actgccatca
     2161 atatcggtta tgcctgcaat gtgctgacag acgccatgga tgctctattt gtgataacgg
     2221 ggaacacggc tggggaagtg cgagaagaac tcaggaaagc aaaggaaaat ttgcttggac
     2281 aaagcacgag tttttccaat ggacatgcag tttatgacaa caagcagcgg ttggggttgg
     2341 acgcgggtgc aggagaggct gtgacaggag aatatgcctt agtcataaat ggccacagtt
     2401 tggcccatgc ccttgaaagt gatgtcgaga acgatctttt ggagctcgcc tgtgtgtgta
     2461 agactgtggt ttgctgcaga gtcaccccac tccagaaagc ccaagtagta gagttggtaa
     2521 aaaagcacag aaatgctgtg actttggcca ttggtgatgg ggccaacgat gtcagcatga
     2581 ttaaaagtgc ccacattggc attggcatca gtggtcagga aggactgcaa gcagtcttag
     2641 ccagtgacta tgcattggct cagtttagat atctccaacg actgcttctt gttcatggaa
     2701 ggtggtccta ctacaggatg tgcaagttct tatgctattt cttctacaag aactttgcgt
     2761 tcacccttgt gcacttctgg tttgccttct tctgtggctt ctcggcacag actgtctacg
     2821 accagtggtt catcactctt tttaacattg tttacacctc actacccgtt ttagccatgg
     2881 gaatgtttga ccaggacata aatgaacaga acagcatgga ctatcctcag ctctacgaac
     2941 ctggacaact gaatctcctt tttaacaagc gcagattttt catctgtgtg gcacatggaa
     3001 tctacacctc attagccctt ttcttcattc cctacggggc cttttacaat gtggctgcag
     3061 aggacgggca acacattgct gacctccagt cctttgcagt taccgtggcc acatcattgg
     3121 tcattgtggt cagcatacag atagccttgg acacgagtta ctggactgtg gttaatcacg
     3181 tcttcatctg gggcagtgtt gccacctatt tctccatttt actggccatg cacagtgatg
     3241 gtgtctttgg aatcttccca cgccatttcc cctttgttgg aaatgcacgg cactccctga
     3301 gccagaagtt tgtctggctt gtggttctct tgacagcagt gacgtcagtc atgccagtgg
     3361 tggtggtcag atttctgaag atgtatttat acccaagcct gagtgatcag atccgccggt
     3421 ggcagaaagc tcagcgaaag aaaagacccc tgcgaagcag aaggcctcag acccgcaggt
     3481 cgagctctag aagatctgga tacgcgtttg ctcaccagga gggctacgga gagctcatca
     3541 catctggaaa aaatatgcga gcgaaaagtc cagccccagc atcggggctg gaaaagaagc
     3601 tttataataa cacgagctgg attgaaaatt tatgtaagaa aaccacagac gcggtgagcg
     3661 gctttagtca tgataagaca gtgaaattgt gagtcaagat agacttgacc acaaagccgt
     3721 cttttcacct catctggggc tgagcttagg cagctcaggg gccaggagca gggcagatca
     3781 cattgcttaa cttaaatcca tggcctccag ctgccaacgc ctgtcagata gcgatgtttt
     3841 ctgcaggatt ccaggccaga tgggcactgt ccaatctgtg attctgtaga ccaaggcctc
     3901 atgggacaag tacagatttt attaacttaa acaccaatcc atccgaattt tgaatcttat
     3961 ttatggaaaa aaaaaaaagg ccgtaaatta gcatctatgt tggatgggtc ttaggtatgt
     4021 aaaaggtatg ttccaatgat gtgtttcaac caaaaacgca tgtcaacaga tacaccacgt
     4081 acgtgaagag tgcctttccc agatgcaatt gcagaattta aagtatgtgg tgtggtgctc
     4141 tcagatcgag agtgagtctt tctctagact tgagctcccc ttgccaggat aacaaagcct
     4201 tacatgctca gagaatgcat taaaaagtcc gtggggttat ctgtttacaa acagggacaa
     4261 aagcaactga atgtttctgc cgagggggct gctaacatgg ttaggtttat agagagagtg
     4321 ttcagactgt tccatgtggg gacaaaatac agtggctcct ctaatgtccc taatgtgtca
     4381 aggacttgtg tgacaatgtc agtagtaatc cgttgcatgt tacatggatg cagacagaac
     4441 catcagcgtg gtagaacact gccctttatt gacagtgttc catgcaggcc atgggcaaat
     4501 gctgctgaca gatcccattt aaaaacttga aacttgaaag tctctacagg cagtctctac
     4561 tgttaccatt cactcaggct taggccattg agactcagtt ccttttagtg tctagctgtc
     4621 ctgtttatgg ctcaaacatc taaatgtata gatatataga tgaagctgat ttttaaaata
     4681 gacattgcag cccaatttgg ggatctgtag acaactcact aggttctgta ttcaaattgc
     4741 tgctgacacc cacttacctc cgtgatgggg aggtaaggtg cctttcctga gactcctcta
     4801 caaagtcagg acgcactacc tacctcccgt ggttgatgac tatcaagcac acattctcaa
     4861 accatcagaa acacaactca catacgaatg tactcatcag gctttagcta actcatcatc
     4921 agagaagcag aggggagaga cttcaggacc tgggatgcca gtcgccagtg ggactgtcaa
     4981 agaaatgagg ttgctaagta tgatagaaag caaataaaac tgtagactgg ggaatagatt
     5041 tatctacaag gaaataaaca aaaccaaaca aaaccaacca accaaccaac caaccaacca
     5101 aacaaacaaa caaaaagtca tgttttccaa aaatcagcaa ttagctctct agccttcctt
     5161 ctctgggttc ccaggcaatt gctgatcaac caaaactact ttgcacaaag agcttgttaa
     5221 tcttatgtgg tcttgatgga tgatgggctg ggatggtgtt aataggtcag tgtcccctgc
     5281 ccaatgggtc ttgatttcta agcctaatgt tttctaaatg atactcagtg agataatcgg
     5341 tatgcagtag cctactacct agagccttta cccatagcaa atgcttgtca tgattccttt
     5401 ctctatacat atctacctag aaaaaaaggt aagattttca tgtctaatga tcagctaaag
     5461 tgtgcttgtt tatgttttat aacaattttg aagactttgg atatttccag taaatgtttt
     5521 accatcgtt
//
