LOCUS       NM_001403709            6591 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus ATPase, copper transporting, beta polypeptide (Atp7b),
            transcript variant 1, mRNA.
ACCESSION   NM_001403709 XM_006509007
VERSION     NM_001403709.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6591)
  AUTHORS   Mazi,T.A., Shibata,N.M., Sarode,G.V. and Medici,V.
  TITLE     Hepatic oxylipin profiles in mouse models of Wilson disease: New
            insights into early hepatic manifestations
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1869 (2), 159446 (2024)
   PUBMED   38072238
REFERENCE   2  (bases 1 to 6591)
  AUTHORS   Hao,W., Yang,W., Yang,Y., Cheng,T., Wei,T., Tang,L., Qian,N.,
            Yang,Y., Li,X., Jiang,H. and Wang,M.
  TITLE     Identification of lncRNA-miRNA-mRNA Networks in the Lenticular
            Nucleus Region of the Brain Contributes to Hepatolenticular
            Degeneration Pathogenesis and Therapy
  JOURNAL   Mol Neurobiol 61 (3), 1673-1686 (2024)
   PUBMED   37759104
REFERENCE   3  (bases 1 to 6591)
  AUTHORS   Padula,A., Spinelli,M., Nusco,E., Bujanda Cundin,X., Capolongo,F.,
            Campione,S., Perna,C., Bastille,A., Ericson,M., Wang,C.C.,
            Zhang,S., Amoresano,A., Nacht,M. and Piccolo,P.
  TITLE     Genome editing without nucleases confers proliferative advantage to
            edited hepatocytes and corrects Wilson disease
  JOURNAL   JCI Insight 8 (21), e171281 (2023)
   PUBMED   37707949
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6591)
  AUTHORS   Sarode,G.V., Mazi,T.A., Neier,K., Shibata,N.M., Jospin,G.,
            Harder,N.H.O., Caceres,A., Heffern,M.C., Sharma,A.K., More,S.K.,
            Dave,M., Schroeder,S.M., Wang,L., LaSalle,J.M., Lutsenko,S. and
            Medici,V.
  TITLE     The role of intestine in metabolic dysregulation in murine Wilson
            disease
  JOURNAL   Hepatol Commun 7 (10), e0247 (2023)
   PUBMED   37695076
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6591)
  AUTHORS   Washington-Hughes,C.L., Roy,S., Seneviratne,H.K.,
            Karuppagounder,S.S., Morel,Y., Jones,J.W., Zak,A., Xiao,T.,
            Boronina,T.N., Cole,R.N., Bumpus,N.N., Chang,C.J., Dawson,T.M. and
            Lutsenko,S.
  TITLE     Atp7b-dependent choroid plexus dysfunction causes transient copper
            deficit and metabolic changes in the developing mouse brain
  JOURNAL   PLoS Genet 19 (1), e1010558 (2023)
   PUBMED   36626371
  REMARK    GeneRIF: Atp7b-dependent choroid plexus dysfunction causes
            transient copper deficit and metabolic changes in the developing
            mouse brain.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6591)
  AUTHORS   Reed,V., Williamson,P., Bull,P.C., Cox,D.W. and Boyd,Y.
  TITLE     Mapping of the mouse homologue of the Wilson disease gene to mouse
            chromosome 8
  JOURNAL   Genomics 28 (3), 573-575 (1995)
   PUBMED   7490097
REFERENCE   7  (bases 1 to 6591)
  AUTHORS   Strader,C.D., Fong,T.M., Tota,M.R., Underwood,D. and Dixon,R.A.
  TITLE     Structure and function of G protein-coupled receptors
  JOURNAL   Annu Rev Biochem 63, 101-132 (1994)
   PUBMED   7979235
  REMARK    Review article
REFERENCE   8  (bases 1 to 6591)
  AUTHORS   Mercer,J.F., Grimes,A. and Rauch,H.
  TITLE     Hepatic metallothionein gene expression in toxic milk mice
  JOURNAL   J Nutr 122 (6), 1254-1259 (1992)
   PUBMED   1588441
REFERENCE   9  (bases 1 to 6591)
  AUTHORS   Biempica,L., Rauch,H., Quintana,N. and Sternlieb,I.
  TITLE     Morphologic and chemical studies on a murine mutation (toxic milk
            mice) resulting in hepatic copper toxicosis
  JOURNAL   Lab Invest 59 (4), 500-508 (1988)
   PUBMED   2845190
REFERENCE   10 (bases 1 to 6591)
  AUTHORS   Rauch,H.
  TITLE     Toxic milk, a new mutation affecting cooper metabolism in the mouse
  JOURNAL   J Hered 74 (3), 141-144 (1983)
   PUBMED   6863890
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163439.3 and AL590619.9.
            
            On Apr 4, 2022 this sequence version replaced XM_006509007.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.56791.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-420               AC163439.3         58560-58979
            421-1627            AL590619.9         3906-5112
            1628-1885           AL590619.9         10088-10345
            1886-2049           AL590619.9         11718-11881
            2050-2211           AL590619.9         14432-14593
            2212-2288           AL590619.9         16688-16764
            2289-2463           AL590619.9         17955-18129
            2464-2697           AL590619.9         19033-19266
            2698-2789           AL590619.9         19840-19931
            2790-2917           AL590619.9         20750-20877
            2918-3072           AL590619.9         20983-21137
            3073-3207           AL590619.9         21493-21627
            3208-3402           AL590619.9         26188-26382
            3403-3585           AL590619.9         28267-28449
            3586-3739           AL590619.9         29781-29934
            3740-3883           AL590619.9         32450-32593
            3884-4026           AL590619.9         34275-34417
            4027-4230           AL590619.9         34956-35159
            4231-4348           AL590619.9         35239-35356
            4349-4451           AL590619.9         36986-37088
            4452-6591           AL590619.9         37718-39857
FEATURES             Location/Qualifiers
     source          1..6591
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.78 cM"
     gene            1..6591
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /note="ATPase, copper transporting, beta polypeptide"
                     /db_xref="GeneID:11979"
                     /db_xref="MGI:MGI:103297"
     exon            1..420
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..4725
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /EC_number="7.2.2.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     copper-transporting ATPase 2; copper pump 2; wilson
                     disease-associated protein homolog; toxic milk; Wilson
                     protein; ATPase, Cu++ transporting, beta polypeptide"
                     /codon_start=1
                     /product="copper-transporting ATPase 2 isoform 1"
                     /protein_id="NP_001390638.1"
                     /db_xref="GeneID:11979"
                     /db_xref="MGI:MGI:103297"
                     /translation="MEKAQGKMHQNLEHSFLASLSSPQVTLLSVQKRCTFRRSSGLGS
                     WARSASSEEKGPPQPEEELSPGVLARTLERRSQILSKLALPGRPWEQSMKQSFAFDNV
                     GYEGGLDSTSSSPAATDVVNILGMTCHSCVKSIEDRISSLKGIVNIKVSLEQGSATVR
                     YVPSVMNLQQICLQIEDMGFEASAAEGKAASWPSRSSPAQEAVVKLRVEGMTCQSCVS
                     SIEGKIRKLQGVVRIKVSLSNQEAVITYQPYLIQPEDLRDHICDMGFEAAIKNRTAPL
                     RLGPIDVNKLESTNLKKETVSPVQISNHFETLGHQGSYLATLPLRIDGMHCKSCVLNI
                     EGNIGQLPGVQNIHVSLENKTAQIQYDPSCVTPMFLQTAIEALPPGHFKVSLPDGVEE
                     NEPQSGSSQRHQEQGPGRTAVLTISGITCASSVQPIEDMLSQRKGVQQTSISLAEGTG
                     AVLYDPSIVSLDELRTAVEDMGFEVSVNSETFTINPVRNFKSGNSVPQTMGDIAGSVQ
                     KMAPDTRGLPTHQGPGHSSETPSSPGATASQKCFVQIKGMTCASCVSNIERSLQRHAG
                     ILSVLVALMSGKAEVKYDPEIIQSPRIAQLIQDLGFEASVMEDNTVSEGDIELIITGM
                     TCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIVGPRDIIKIIEEIGFHASL
                     AQRNPNAHHLDHKTEIKQWKKSFLCSLVFGIPVMGLMVYMLIPSSTPQETMVLDHNII
                     PGLSVLNLIFFILCTFVQFLGGWYFYVQAYKSLRHRSANMDVLIVLATTIAYAYSLVI
                     LVVAVAEKAEKSPVTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLMSLQATEATV
                     VTLGEDNLILREEQVPMELVQRGDVIKVVPGGKFPVDGKVLEGNTMADESLITGEAMP
                     VTKKPGSIVIAGSINAHGSVLLKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFS
                     GYFVPFIIIISTLTLVVWIVIGFVDFGVVQKYFPSPSKHISQTEVIIRFAFQTSITVL
                     CIACPCSLGLATPTAVMVGTGVAAQNGVLIKGGKPLEMAHKIKTVMFDKTGTITHGVP
                     RVMRFLLLADVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYSTDFQ
                     AVPGCGISCKVSNVEGILARSDLTAHPVGVGNPPTGEGAGPQTFSVLIGNREWMRRNG
                     LTISSDISDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKPEAALAIYTLKSMGVDV
                     ALITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNEGKKVAMVGDGVNDSPA
                     LAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRVNLVLALIYN
                     MVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYRKPDLERYEAQAHG
                     RMKPLSASQVSVHIGMDDRRRDSPRATAWDQVSYVSQVSLSSLTSDRLSRHGGAAEDG
                     GDKWSLLLSDRDEEQCI"
     exon            421..1627
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1885
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2049
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2211
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2288
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2463
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2697
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2789
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2917
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3072
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3207
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3402
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3585
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..3739
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..3883
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            3884..4026
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            4027..4230
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            4231..4348
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            4349..4451
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     exon            4452..6591
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6566..6571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /note="hexamer: AATAAA"
     polyA_site      6591
                     /gene="Atp7b"
                     /gene_synonym="Atp7a; tx; WND"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgtgca agttcctgag ctggccgcag actgaagact gccgctccct gcctgcagtt
       61 tcccccctct ggctgggaag ggtgcctgtc cctgctaatg agcaagacct tttgaaagca
      121 tttccctccg taccagaagt gtggtgaagc tggactgtgg gaagggaagg agtgacggtg
      181 gacccgacta tggagaaagc tcagggcaag atgcaccaga acctggaaca ctctttcctg
      241 gccagtctga gtagccccca ggtgacgctg ctgtctgtgc agaagaggtg caccttcagg
      301 aggagctcgg ggcttgggag ctgggcccga tcggcgtctt cggaggagaa aggtcctccc
      361 cagccagagg aagaattgtc accgggagtt ttagctagaa ccctggaaag gaggtcccag
      421 atcttatcta aacttgcttt gcccggccgg ccctgggagc aatcaatgaa gcagagcttc
      481 gccttcgaca atgttggcta cgaagggggt ctggacagca ccagctcgtc cccagcagcc
      541 actgatgtgg ttaacatcct gggcatgact tgtcattctt gcgtcaagtc cattgaggac
      601 aggatctcca gtctgaaagg cattgtgaac atcaaggtgt ccctggaaca aggcagcgcc
      661 actgtcagat atgtgccgtc tgtcatgaac ctgcagcaga tttgccttca gattgaggat
      721 atgggctttg aggccagcgc tgcagaggga aaggccgcct cctggccttc caggtcctcc
      781 ccagcccagg aggcggtggt caagctccgg gtagagggca tgacctgtca gtcctgtgtc
      841 agctctatcg agggcaagat ccggaaactg caaggggttg tgagaatcaa agtctcccta
      901 agcaaccaag aggcagtcat tacctatcag ccttacctca ttcaacccga agacctcagg
      961 gaccacatct gtgacatggg atttgaagct gccatcaaga acagaacagc tcccttaagg
     1021 ctgggaccaa ttgatgtcaa caagttagaa agcactaacc taaagaaaga gacggtctct
     1081 cctgtccaga tttccaatca ttttgagacc ctggggcacc aggggagcta cctggccacc
     1141 ctcccactaa gaatagacgg catgcactgt aaatcatgtg ttttgaatat tgaaggaaat
     1201 ataggccaac tcccgggggt tcaaaatatt cacgtgtcct tggagaacaa aaccgcccaa
     1261 atacagtatg acccttcttg tgtcaccccc atgttcctgc agacagccat cgaggcacta
     1321 ccacctgggc actttaaagt gtctcttccc gatggagtag aggagaatga gccccaaagt
     1381 ggctcctccc agagacacca ggagcagggc ccgggcagga ctgcggtgct caccatcagc
     1441 ggcattacct gtgcctcatc tgttcagcct atcgaagaca tgctgtccca gaggaaaggt
     1501 gtgcagcaaa catccatctc tttggcagaa gggactggag cagttcttta cgacccctcc
     1561 atagtcagct tggacgaact ccgaacggct gtagaagaca tgggatttga ggtgtctgtg
     1621 aattctgaaa ccttcactat taaccctgtc agaaacttca aatctgggaa ttctgtgcca
     1681 caaaccatgg gtgatatagc agggtctgtg caaaaaatgg ctcccgacac tagagggctc
     1741 cccacacacc aaggtcctgg ccactcttca gagaccccat catccccggg agcaacagca
     1801 tcacagaagt gcttcgtaca gatcaaaggc atgacctgtg cgtcctgtgt gtctaacata
     1861 gaaaggagtc tccagagaca tgctggtatt ctctcagtgt tggtcgcctt gatgtcggga
     1921 aaggcagagg tcaagtatga tccggagatc atccagtcgc ccaggatagc tcagctcatc
     1981 caggacctgg gcttcgaagc gtcagtcatg gaggacaaca cagtctctga aggtgacatc
     2041 gaactgatta tcacagggat gacctgtgct tcctgtgtcc acaacataga gtccaagctc
     2101 acaaggacaa atggcatcac ttacgcctct gtggcccttg ccaccagcaa agcccatgtg
     2161 aagttcgatc ctgaaattgt tggtccccgt gacatcatca agatcattga ggaaattggc
     2221 tttcatgctt ccctggccca gagaaacccc aacgcccatc acttggacca caagacggaa
     2281 ataaaacagt ggaagaagtc tttcctgtgc agcctggtgt tcggcatccc cgtcatggga
     2341 ttgatggtct acatgttaat ccccagcagt acgcctcagg agacgatggt cctggaccac
     2401 aacatcatcc caggactgtc cgttctcaat ctcatcttct tcatcttgtg tacctttgtc
     2461 caatttctgg gtgggtggta cttctacgta caagcctaca aatcgctgag acacaggtcc
     2521 gccaacatgg acgtactcat cgtgctcgcc acaaccattg cctatgccta ctccctggtc
     2581 atcctggtgg tcgccgtagc cgagaaggca gagaagagcc ccgtgacctt ctttgacacg
     2641 ccccccatgc tctttgtgtt catcgccctg ggacggtggc tggaacacgt ggccaagagc
     2701 aaaacttcag aagcccttgc aaaactcatg tcactccaag ccacagaagc cacagtcgtg
     2761 accctgggtg aggacaactt aatcctcaga gaggagcagg tgcccatgga gctggtgcag
     2821 cgaggcgacg tcatcaaggt tgtccctggg ggcaagttcc cagtggatgg gaaagtcctc
     2881 gaaggcaata ccatggctga tgagtccctc atcacaggag aggccatgcc tgtcactaag
     2941 aaacctggga gcatagtgat tgctggctct attaatgctc atggctctgt gctccttaaa
     3001 gctacccatg tgggtaatga cacaactttg gctcagattg taaagttggt ggaagaggcc
     3061 cagatgtcaa aggctcccat tcagcagctg gctgaccggt tcagtggata ttttgtccca
     3121 ttcatcatca tcatttcaac cttgaccctg gtggtgtgga tcgtcattgg ctttgtcgat
     3181 ttcggtgtgg ttcagaagta ctttcctagc cctagcaagc acatctcgca gacagaggtg
     3241 atcatccgct ttgccttcca gacgtccatc actgtgctgt gcatcgcctg cccctgctcc
     3301 ctggggctgg ccacacccac agcagtcatg gtgggcactg gggtggctgc ccagaacggt
     3361 gtcctaatca aaggagggaa gcctctggag atggcacaca agataaagac cgttatgttt
     3421 gacaaaacgg gcaccatcac ccacggggtc cccagagtca tgcggttcct gctgctcgca
     3481 gacgtggcca cactccccct caggaaggtt ctggccgtgg tgggcaccgc ggaggccagc
     3541 agcgagcacc ccttaggcgt ggccgtcact aaatactgca aagaggaact tgggacggag
     3601 accctgggat acagcacaga cttccaggca gtgcccggct gtggaattag ctgcaaagtt
     3661 agcaacgtgg agggcatcct ggctcgcagt gatctgactg ctcaccctgt tggagttggc
     3721 aaccctccca caggggaagg tgcaggtccc cagaccttct ccgtgctgat tggaaaccgg
     3781 gaatggatgc ggcgaaacgg tttaaccatc tccagtgaca tcagtgacgc catgacagat
     3841 cacgagatga aaggacagac ggccatcctg gtggccattg atggtgtgct ctgcgggatg
     3901 atcgccatcg cagatgctgt caaaccagag gctgccctgg ctatctacac cctgaaaagc
     3961 atgggtgtgg atgtggctct gatcacaggg gacaaccgga agacagccag agccattgct
     4021 actcaggttg gcatcaacaa agtctttgcg gaggtactgc cttctcacaa ggtggccaag
     4081 gtccaggagc ttcagaatga agggaagaaa gtcgccatgg tgggagatgg ggtgaatgac
     4141 tccccagccc tggcccaggc tgacgtgggc atcgccatcg ggactggcac agatgttgcc
     4201 atcgaagcag cagacgtggt cctgatcaga aatgacttat tggacgtcgt ggccagcatt
     4261 catctctcca agaggaccgt ccggaggatc cgggtcaatc tggtgctggc attgatttat
     4321 aacatggttg ggatacctat tgctgcaggt gtcttcatgc ccattggcat cgtgctgcag
     4381 ccgtggatgg gctcagcagc catggctgcg tcctctgtct ctgtggtgct ctcgtctctt
     4441 cagctcaagt gctatagaaa gcccgaccta gagagatatg aggcccaggc ccacggccgc
     4501 atgaagcccc tgagtgcctc ccaagtcagc gtgcacattg gcatggatga ccggcgtcgg
     4561 gattctccca gggccaccgc gtgggaccag gtcagctacg tgagccaagt gtctctgtcc
     4621 tccctgacgt cagacagatt gtctcggcat ggcggggcag cagaggacgg tggcgacaaa
     4681 tggtccctgc tcctgagtga cagggatgaa gagcagtgca tctgagtgtt ctcctgggca
     4741 ggccatggcg ctccttctgg gtgagcctgc tcctgctcat ggtggtggag ccaggaggtg
     4801 cagccttaac aagccactgt gggatggacg aagctcatgg tgagacctga gcatcctgct
     4861 agccttgcct tacagtgtgt ggtgtatctg cagaggctgg gcaggattgc tcttccagaa
     4921 gccactaggt tggggaaagt ataccattcc tgcttttcat gagggcgaga tcacaccctg
     4981 cttgggagga aaccatcact cttcactgaa ccctgccaac tatatttgta tatactatct
     5041 aggcagtgag gaccaggctc atcaggacca caagcctagc tcagcccccc tggagagctc
     5101 caaccagatc tctcctatac taagagctcc cataacacct ggagttaggc agcacacatg
     5161 ggccgtgtaa gcctaaggct ccttcagacg agtctgttct ctgcctggtg tagctggcat
     5221 ccttggtact ggaactgcct gccctctatc ttctgagggt agaattagtg ccttgggtct
     5281 gatgctctgg ctcctgcata tctgcccgcc taaaggtggc gccctggttt gcagcccaat
     5341 gcaagagcta cccagcatcc ctatttactc tgaaaagaat gccatcctgc ttagagccac
     5401 acctacagac tcacatgtgc cgctctcaac cagctggaga gatacctcag agcctgacca
     5461 tagttcattt tcctatgggg tccaggtcct tgcctctcag ggcaccctat acagccatgc
     5521 cataacctgt agtgtataaa gcactgttcc ctgggaggtg tatgcataag ggcacacccc
     5581 tgtcactcag tggggtccag tgaagtttgt cacaaatgct tagtgtgtgt gcctgggggg
     5641 agttttccca ccagaagaga gtgaagttct caatagagag ctgtctgctg ctgaggagac
     5701 atctaaagga gggacaccca cagcgccctc ccccctcccc agtgaaaatg ttcctgttgt
     5761 cagctatgac tatgtgattg gagtggcttc agagggcagg gatggggcca gcttaactga
     5821 gcgagtggct gagccacccg gaacagacta gcagaaatgg gttactctca tttgtgacat
     5881 taaaagaaaa aaagccacaa aactccttta taggatgtca cttattggcc atggcagtgt
     5941 tagtcttttt tttttttttt ttttttgtag gtttctcacc tcttttcccc acaaaaatag
     6001 caccgtaact acctaccgtc tacgactgaa aacaagaaaa cagggtccga gggcctcggt
     6061 gtcttcccag gaactcacag ccaatgtgcc gttcagaggg ttccgaaggc ctttctgtaa
     6121 ttccgctgct gccttacagt atcagtttgc tcggtgagag taaactggac gagggtcctt
     6181 ttgttgctgc acgagcaaac gcgacaggag ctggatgagt tgcatcaggt taggatgcag
     6241 tggtcacgag gttactaccc atcacttggg atggctgctt tgggttttgc accttagcgg
     6301 tgcttgctga gctttatctt ctaaaacccg ggagtatagg gatctattgc gctcttggta
     6361 tccgcaaccc ttccactccc tctccagcga cctcctccca ctgacgtcat ctactcggtc
     6421 tatagttctg ttcttacaga ataagtcttg ttttggaata aggtaatcat tttctaaaga
     6481 atctaattgt attgattttt aaaccttctg agaatgtaag catcatgttc acatgtagac
     6541 atgaaaatat ttatataatt gtacaaataa ataacttttt agatgttcaa a
//
