LOCUS       NM_133826               2063 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ATPase, H+ transporting, lysosomal V1 subunit H
            (Atp6v1h), transcript variant 1, mRNA.
ACCESSION   NM_133826
VERSION     NM_133826.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2063)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2063)
  AUTHORS   Zhao,Z., Wang,X., Ma,Y. and Duan,X.
  TITLE     Atp6v1h Deficiency Blocks Bone Loss in Simulated Microgravity Mice
            through the Fos-Jun-Src-Integrin Pathway
  JOURNAL   Int J Mol Sci 25 (1), 637 (2024)
   PUBMED   38203808
  REMARK    GeneRIF: Atp6v1h Deficiency Blocks Bone Loss in Simulated
            Microgravity Mice through the Fos-Jun-Src-Integrin Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2063)
  AUTHORS   Hou,Y., Yang,S., Zhao,Z., Huang,Y., Zhang,Y., Ruan,W. and Duan,X.
  TITLE     Long Noncoding RNA lnc-TCEA1-3 Affects Osteoclastic Function by
            Regulating ATP6V1H
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (1), 15-26 (2024)
   PUBMED   37824389
  REMARK    GeneRIF: Long Noncoding RNA lnc-TCEA1-3 Affects Osteoclastic
            Function by Regulating ATP6V1H.
REFERENCE   4  (bases 1 to 2063)
  AUTHORS   Liu,J., Qi,Y., Chao,J., Sathuvalli,P., Y Lee,L. and Li,S.
  TITLE     CREG1 promotes lysosomal biogenesis and function
  JOURNAL   Autophagy 17 (12), 4249-4265 (2021)
   PUBMED   33966596
REFERENCE   5  (bases 1 to 2063)
  AUTHORS   Jiang,F., Shan,H., Pan,C., Zhou,Z., Cui,K., Chen,Y., Zhong,H.,
            Lin,Z., Wang,N., Yan,L. and Yu,X.
  TITLE     ATP6V1H facilitates osteogenic differentiation in MC3T3-E1 cells
            via Akt/GSK3beta signaling pathway
  JOURNAL   Organogenesis 15 (2), 43-54 (2019)
   PUBMED   31272281
  REMARK    GeneRIF: ATP6V1H facilitates osteogenic differentiation in MC3T3-E1
            cells via Akt/GSK3beta signaling pathway
REFERENCE   6  (bases 1 to 2063)
  AUTHORS   Bodzeta,A., Kahms,M. and Klingauf,J.
  TITLE     The Presynaptic v-ATPase Reversibly Disassembles and Thereby
            Modulates Exocytosis but Is Not Part of the Fusion Machinery
  JOURNAL   Cell Rep 20 (6), 1348-1359 (2017)
   PUBMED   28793259
REFERENCE   7  (bases 1 to 2063)
  AUTHORS   Duan,X., Liu,J., Zheng,X., Wang,Z., Zhang,Y., Hao,Y., Yang,T. and
            Deng,H.
  TITLE     Deficiency of ATP6V1H Causes Bone Loss by Inhibiting Bone
            Resorption and Bone Formation through the TGF-beta1 Pathway
  JOURNAL   Theranostics 6 (12), 2183-2195 (2016)
   PUBMED   27924156
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2063)
  AUTHORS   Sun-Wada,G.H., Yoshimizu,T., Imai-Senga,Y., Wada,Y. and Futai,M.
  TITLE     Diversity of mouse proton-translocating ATPase: presence of
            multiple isoforms of the C, d and G subunits
  JOURNAL   Gene 302 (1-2), 147-153 (2003)
   PUBMED   12527205
REFERENCE   9  (bases 1 to 2063)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2063)
  AUTHORS   Lu,M., Vergara,S., Zhang,L., Holliday,L.S., Aris,J. and Gluck,S.L.
  TITLE     The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase
            (V-ATPase) interacts with the H subunit and is required for
            V-ATPase function
  JOURNAL   J Biol Chem 277 (41), 38409-38415 (2002)
   PUBMED   12163484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY267800.1, AK078767.1 and AC131067.16.
            
            On Jul 14, 2015 this sequence version replaced NM_133826.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078767.1, BC009154.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                BY267800.1         1-87
            88-1698             AK078767.1         2-1612
            1699-1699           AC131067.16        90855-90855
            1700-2063           AK078767.1         1614-1977
FEATURES             Location/Qualifiers
     source          1..2063
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 1.85 cM"
     gene            1..2063
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /note="ATPase, H+ transporting, lysosomal V1 subunit H"
                     /db_xref="GeneID:108664"
                     /db_xref="MGI:MGI:1914864"
     exon            1..193
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /inference="alignment:Splign:2.1.0"
     exon            194..340
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1679
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /EC_number="7.1.2.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H;
                     vacuolar ATP synthase subunit H; vacuolar proton pump H
                     subunit; V-ATPase H subunit; V-type proton ATPase subunit
                     H; vacuolar ATPase subunit H; V-ATPase subunit H; vacuolar
                     proton pump subunit H; H+ transporting ATPase lysosomal V1
                     subunit H"
                     /codon_start=1
                     /product="V-type proton ATPase subunit H isoform 1"
                     /protein_id="NP_598587.2"
                     /db_xref="CCDS:CCDS14808.1"
                     /db_xref="GeneID:108664"
                     /db_xref="MGI:MGI:1914864"
                     /translation="MTKMDIRGAVDAAVPTNIIAAKAAEVRANKVNWQSYLQGQMISA
                     EDCEFIQRFEMKRSSEDKQEMLQTEGSQCAKTFINLMTHISKEQTVQYILTMVDDMLQ
                     ENHQRVSIFFDYAKRSKSTAWPYFLPMLNRQDPFTVHMAARIIAKLAAWGKELMEGSD
                     LNYYFNWIKTQLSSQKLRGSGVAVETGTISSSDSSQYVQCVAGCLQLMLRVNEYRFAW
                     VEADGVNCIMGVLSNKCGFQLQYQMIFSIWLLAFSPQMCEHLRRYNIIPVLSDILQES
                     VKEKVTRIILAAFRNFLEKSTERETRQEYALAMIQCKVLKQLENLEQQKYDDEDISED
                     IKFLLEKLGESVQDLSSFDEYSSELKSGRLEWSPVHKSEKFWRENAVRLNEKNYELLK
                     ILTKLLEVSDDPQVLAVAAHDVGEYVRHYPRGKRVIEQLGGKQLVMNHMHHEDQQVRY
                     NALLAVQKLMVHNWEYLGKQLQSEQPQTAAARS"
     exon            341..443
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /inference="alignment:Splign:2.1.0"
     exon            444..533
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /inference="alignment:Splign:2.1.0"
     exon            534..647
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /inference="alignment:Splign:2.1.0"
     exon            648..752
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /inference="alignment:Splign:2.1.0"
     exon            753..806
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /inference="alignment:Splign:2.1.0"
     exon            807..904
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1097
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1276
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1402
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1504
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1618
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..2063
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1941..1946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /note="hexamer: ATTAAA"
     polyA_site      1962
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /note="major polyA site"
     regulatory      2002..2007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /note="hexamer: AATAAA"
     regulatory      2022..2027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
                     /note="hexamer: AATAAA"
     polyA_site      2029
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
     polyA_site      2061
                     /gene="Atp6v1h"
                     /gene_synonym="0710001F19Rik; CGI-11; SFD; SFDalpha;
                     SFDbeta; VMA13"
ORIGIN      
        1 ggtcacgtgc ggctgctcac gtgccagacg ctgctgtcac ttcgtagctg ttccggcttc
       61 ctctgagtga ggctcgcaac gtctcccacg gagtcgcctt cgttctgctc tgggtctccc
      121 gtggccactg agacctcgga gctcgaccgg cgcctgcccg cccgtgcggc cctcactccc
      181 cgaggctatc caggtctgtg ggaaacattc aaagtcataa agtttagatg accaagatgg
      241 acattcgagg tgctgtggat gctgctgtcc caactaacat cattgcggcc aaggctgctg
      301 aagttcgtgc caacaaagtg aactggcagt cttatcttca ggggcagatg atttctgctg
      361 aagattgtga atttattcaa aggtttgaaa tgaaaagaag ttccgaggac aagcaagaga
      421 tgcttcaaac tgaaggcagc cagtgtgcta aaacatttat aaatctgatg acgcacatct
      481 ccaaagaaca gacagtgcag tacatactaa ccatggttga cgatatgctg caggaaaatc
      541 accagcgtgt cagcattttc tttgactatg cgaaacgaag caagagcact gcctggccat
      601 acttcctgcc aatgttgaat cgccaggatc cctttactgt tcatatggca gcaagaatta
      661 tcgccaagtt agctgcttgg gggaaagaac tgatggaagg cagtgactta aattactatt
      721 tcaattggat aaaaactcag ctgagttcac agaaacttcg tggcagcggt gttgctgttg
      781 aaacaggaac aatctcttca agtgatagtt ctcagtatgt gcagtgtgtt gctggctgtc
      841 tgcagctgat gctccgggtc aatgagtacc ggtttgcctg ggtagaagca gatggagtga
      901 actgtataat gggcgttttg agtaacaagt gtggttttca acttcaatac caaatgattt
      961 tttcaatatg gctcctggca ttcagtcctc aaatgtgtga gcaccttcgt cgctataata
     1021 tcattcctgt tctatcagac atccttcaag aatctgtcaa agagaaagta acaagaatca
     1081 ttcttgcagc attccggaat ttcttagaaa aatcaacgga aagagaaact cgccaagagt
     1141 atgctctggc tatgattcaa tgcaaagtac tgaaacagtt ggagaatttg gagcagcaga
     1201 agtatgatga tgaagatatc agtgaagaca tcaaatttct tttggaaaaa cttggtgaga
     1261 gtgtccagga ccttagctca tttgatgaat acagttcaga acttaaatct ggaagattgg
     1321 aatggagccc tgtacacaag tctgagaaat tttggagaga aaatgccgtg aggttgaatg
     1381 agaagaacta tgaactcttg aaaatcttga caaaacttct ggaggtatca gatgatccac
     1441 aagtcttagc tgttgctgct cacgatgttg gagaatatgt ccggcattat ccccggggaa
     1501 aacgggttat tgagcagctt ggtggaaagc agttggtgat gaaccacatg caccatgaag
     1561 accagcaggt tcgctacaat gctcttctgg ccgtgcagaa gctcatggtg cacaactggg
     1621 aatatcttgg taaacaacta cagtcagagc agcctcagac tgctgctgct cggagctgag
     1681 ctgacctgtt cagcctttct gcacttccca tggaccagtg gagtgagaac ctcagtcttt
     1741 agggttaaaa gcaaatagtt tttaatttaa tgattacttc ttttctgttg tatagctttt
     1801 ccctatggta attcctggga gaataaaagt gtttgcttgt taaattgtat aaaattagat
     1861 actgcctgta ttagagaaat attactgtta cttatattct ttatgatttt tgtatttatt
     1921 gtcctctgaa aatgaatata attaaaggat tctcactcca aacatgttct taaattttgc
     1981 ttattcctat tgtggacttt gaataaacat catttatttc aaataaaaat tgggagaagt
     2041 gttcccaggt gatgatgaga agt
//
