LOCUS       NM_023179               1514 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ATPase, H+ transporting, lysosomal V1 subunit G2
            (Atp6v1g2), transcript variant 1, mRNA.
ACCESSION   NM_023179 XM_356938 XM_359372
VERSION     NM_023179.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1514)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1514)
  AUTHORS   Bodzeta,A., Kahms,M. and Klingauf,J.
  TITLE     The Presynaptic v-ATPase Reversibly Disassembles and Thereby
            Modulates Exocytosis but Is Not Part of the Fusion Machinery
  JOURNAL   Cell Rep 20 (6), 1348-1359 (2017)
   PUBMED   28793259
REFERENCE   3  (bases 1 to 1514)
  AUTHORS   Kawamura,N., Sun-Wada,G.H. and Wada,Y.
  TITLE     Loss of G2 subunit of vacuolar-type proton transporting ATPase
            leads to G1 subunit upregulation in the brain
  JOURNAL   Sci Rep 5, 14027 (2015)
   PUBMED   26353914
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1514)
  AUTHORS   Xie,T., Rowen,L., Aguado,B., Ahearn,M.E., Madan,A., Qin,S.,
            Campbell,R.D. and Hood,L.
  TITLE     Analysis of the gene-dense major histocompatibility complex class
            III region and its comparison to mouse
  JOURNAL   Genome Res 13 (12), 2621-2636 (2003)
   PUBMED   14656967
REFERENCE   5  (bases 1 to 1514)
  AUTHORS   Sun-Wada,G.H., Yoshimizu,T., Imai-Senga,Y., Wada,Y. and Futai,M.
  TITLE     Diversity of mouse proton-translocating ATPase: presence of
            multiple isoforms of the C, d and G subunits
  JOURNAL   Gene 302 (1-2), 147-153 (2003)
   PUBMED   12527205
REFERENCE   6  (bases 1 to 1514)
  AUTHORS   Murata,Y., Sun-Wada,G.H., Yoshimizu,T., Yamamoto,A., Wada,Y. and
            Futai,M.
  TITLE     Differential localization of the vacuolar H+ pump with G subunit
            isoforms (G1 and G2) in mouse neurons
  JOURNAL   J Biol Chem 277 (39), 36296-36303 (2002)
   PUBMED   12133826
  REMARK    GeneRIF: V-ATPase G1 and G2 isoforms are expressed in mouse embryo
            neurons and are involved in synaptic vesicle acidification
REFERENCE   7  (bases 1 to 1514)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU558667.1 and BC020190.1.
            
            On Sep 22, 2006 this sequence version replaced NM_023179.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020190.1, SRR1660821.149720.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-599               BU558667.1         4-602
            600-1514            BC020190.1         596-1510
FEATURES             Location/Qualifiers
     source          1..1514
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.6 cM"
     gene            1..1514
                     /gene="Atp6v1g2"
                     /gene_synonym="1500002D01Rik; Atp6g2; NG38; VAG2"
                     /note="ATPase, H+ transporting, lysosomal V1 subunit G2"
                     /db_xref="GeneID:66237"
                     /db_xref="MGI:MGI:1913487"
     exon            1..250
                     /gene="Atp6v1g2"
                     /gene_synonym="1500002D01Rik; Atp6g2; NG38; VAG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..525
                     /gene="Atp6v1g2"
                     /gene_synonym="1500002D01Rik; Atp6g2; NG38; VAG2"
                     /EC_number="7.1.2.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATPase, H+ transporting, lysosomal 13kD, V1 subunit G;
                     ATPase, H+ transporting, lysosomal (vacuolar proton pump);
                     ATPase, H+ transporting, V1 subunit G; V-type proton
                     ATPase subunit G 2; V-ATPase subunit G 2; V-ATPase 13 kDa
                     subunit 2; vacuolar proton pump subunit G 2; lysosomal
                     13kDa"
                     /codon_start=1
                     /product="V-type proton ATPase subunit G 2 isoform 1"
                     /protein_id="NP_075668.1"
                     /db_xref="CCDS:CCDS37597.1"
                     /db_xref="GeneID:66237"
                     /db_xref="MGI:MGI:1913487"
                     /translation="MASQTQGIQQLLQAEKRAAEKVADARKRKARRLKQAKEEAQMEV
                     EQYRREREQEFQSKQQAAMGSQGNLSAEVEQATRRQVQGMQSSQQRNRERVLAQLLGM
                     VCEVRPQVHPNYRVTV"
     exon            251..351
                     /gene="Atp6v1g2"
                     /gene_synonym="1500002D01Rik; Atp6g2; NG38; VAG2"
                     /inference="alignment:Splign:2.1.0"
     exon            352..1494
                     /gene="Atp6v1g2"
                     /gene_synonym="1500002D01Rik; Atp6g2; NG38; VAG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1470..1475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v1g2"
                     /gene_synonym="1500002D01Rik; Atp6g2; NG38; VAG2"
                     /note="hexamer: AATAAA"
     polyA_site      1494
                     /gene="Atp6v1g2"
                     /gene_synonym="1500002D01Rik; Atp6g2; NG38; VAG2"
                     /note="major polyA site"
ORIGIN      
        1 gaggatgaca gacacccacc cggtgcagga gactgagtga aaacgggagc gctaagaccc
       61 agtgggagtg gaggaccgca tcaagggccc ggaggagtag gcgctggagg gtgggagccg
      121 tctggtacct cggtcgcctt cggaacagca tcctctctag tgataaaaat ggccagtcag
      181 acccagggta tccagcagct cctccaggct gagaagcggg cagcggagaa ggtggccgat
      241 gccaggaaga ggaaggcccg gcgactgaag caggcgaagg aggaggctca aatggaggtg
      301 gagcaatacc gcagggagcg ggaacaggag tttcagagca agcagcaggc ggccatgggc
      361 tctcagggga acctgtctgc tgaagtggag caggccacaa gacggcaggt tcagggcatg
      421 cagagttccc agcagaggaa tcgggagcgc gtcctggctc agcttctcgg catggtctgt
      481 gaagtcaggc cccaggtcca ccccaactat cgggttactg tctagaacca tcgctcaggg
      541 acacatccct agagtgactc cttctgtcag ctccgtccac agagaaatat cccaactcaa
      601 aaccacttgt gtcgcatgcg cagagccttg ggttcaatcc ataatatcat cccccccacc
      661 caccaaatcg cttcacataa taacctgttg ctggagggga ggcttctatg tgacaggatc
      721 caatattccc ccctgagact tacaagtagc ctgttcaaac ccgacaaacc cgaatctctc
      781 tgttccatga cacccactgg aagtttacta atgaatgccc acgtcatccc caccggaccc
      841 ctctgtgaaa tatatgtcct ggtgacagtt atgaaagcac cctgacttca gagcagggga
      901 acctctgttc ctctcccacc cctggtcctt gctggttaca caactgggac aactatttaa
      961 cctggaagcc tcagtgtcct catctttgtg actggaatga cagcaacaac gctcactttg
     1021 taaggtggct gctgtgaatt atctgtgaga attcagcata gttccagatg acggagtgcc
     1081 tgtatcatga ccgcactctg cgtgcctgcc agaattctaa ccccctctcc tgactttttt
     1141 attccttgtg ttccagcttt gttcagccac tgtgacacta gtaaccctct aaagaatttg
     1201 tttctctggc tctcccttgg cacatcatgc ccccgaacag ttaaatgata atgttattta
     1261 gcccctctgt ccgagtccca aatatatatc aaatctctta gcacctctct gtttctcctg
     1321 agctggtctt tctcatggtt ggcccccctc tttctctgtt ttcccaaatc ttgctgcttc
     1381 cgggagctga agatatctat gacattcaca tgcatgcatt cctttgtgtg ccctcagcac
     1441 cttgcctcct tgtgtaacag cggagtgtca ataaaatact ggtggatgag tcaaaaaaaa
     1501 aaaaaaaaaa aaaa
//
