LOCUS       NM_024173               1109 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus ATPase, H+ transporting, lysosomal V1 subunit G1
            (Atp6v1g1), mRNA.
ACCESSION   NM_024173
VERSION     NM_024173.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1109)
  AUTHORS   Li,Y., Wang,Y., Kou,L., Yin,S., Chi,X., Sun,Y., Wu,J., Jin,Z.,
            Zhou,Q., Zou,W., Wang,T. and Xia,Y.
  TITLE     Plasma exosomes impair microglial degradation of alpha-synuclein
            through V-ATPase subunit V1G1
  JOURNAL   CNS Neurosci Ther 30 (5), e14738 (2024)
   PUBMED   38702933
  REMARK    GeneRIF: Plasma exosomes impair microglial degradation of
            alpha-synuclein through V-ATPase subunit V1G1.
REFERENCE   2  (bases 1 to 1109)
  AUTHORS   Wu,J.J., Cai,A., Greenslade,J.E., Higgins,N.R., Fan,C., Le,N.T.T.,
            Tatman,M., Whiteley,A.M., Prado,M.A., Dieriks,B.V., Curtis,M.A.,
            Shaw,C.E., Siddique,T., Faull,R.L.M., Scotter,E.L., Finley,D. and
            Monteiro,M.J.
  TITLE     ALS/FTD mutations in UBQLN2 impede autophagy by reducing
            autophagosome acidification through loss of function
  JOURNAL   Proc Natl Acad Sci U S A 117 (26), 15230-15241 (2020)
   PUBMED   32513711
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2114051118.
            doi: 10.1073/pnas.2114051118. PMID: 34462365]
REFERENCE   3  (bases 1 to 1109)
  AUTHORS   Bodzeta,A., Kahms,M. and Klingauf,J.
  TITLE     The Presynaptic v-ATPase Reversibly Disassembles and Thereby
            Modulates Exocytosis but Is Not Part of the Fusion Machinery
  JOURNAL   Cell Rep 20 (6), 1348-1359 (2017)
   PUBMED   28793259
REFERENCE   4  (bases 1 to 1109)
  AUTHORS   Jauregui,E.J., Akil,O., Acevedo,C., Hall-Glenn,F., Tsai,B.S.,
            Bale,H.A., Liebenberg,E., Humphrey,M.B., Ritchie,R.O., Lustig,L.R.
            and Alliston,T.
  TITLE     Parallel mechanisms suppress cochlear bone remodeling to protect
            hearing
  JOURNAL   Bone 89, 7-15 (2016)
   PUBMED   27085457
REFERENCE   5  (bases 1 to 1109)
  AUTHORS   Jouret,F., Auzanneau,C., Debaix,H., Wada,G.H., Pretto,C.,
            Marbaix,E., Karet,F.E., Courtoy,P.J. and Devuyst,O.
  TITLE     Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are
            differentially expressed during nephrogenesis
  JOURNAL   J Am Soc Nephrol 16 (11), 3235-3246 (2005)
   PUBMED   16177003
REFERENCE   6  (bases 1 to 1109)
  AUTHORS   Sun-Wada,G.H., Yoshimizu,T., Imai-Senga,Y., Wada,Y. and Futai,M.
  TITLE     Diversity of mouse proton-translocating ATPase: presence of
            multiple isoforms of the C, d and G subunits
  JOURNAL   Gene 302 (1-2), 147-153 (2003)
   PUBMED   12527205
REFERENCE   7  (bases 1 to 1109)
  AUTHORS   Murata,Y., Sun-Wada,G.H., Yoshimizu,T., Yamamoto,A., Wada,Y. and
            Futai,M.
  TITLE     Differential localization of the vacuolar H+ pump with G subunit
            isoforms (G1 and G2) in mouse neurons
  JOURNAL   J Biol Chem 277 (39), 36296-36303 (2002)
   PUBMED   12133826
  REMARK    GeneRIF: V-ATPase G1 and G2 isoforms are expressed in mouse embryo
            neurons and are involved in synaptic vesicle acidification
REFERENCE   8  (bases 1 to 1109)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN838691.1, AK007596.1 and AI836426.1.
            
            On Aug 15, 2009 this sequence version replaced NM_024173.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003429.1, AK081611.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                CN838691.1         4-61
            59-1024             AK007596.1         2-967
            1025-1109           AI836426.1         1-85                c
FEATURES             Location/Qualifiers
     source          1..1109
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 34.01 cM"
     gene            1..1109
                     /gene="Atp6v1g1"
                     /gene_synonym="1810024D14Rik; Atp6g1; ATP6J; VAG1; Vma10"
                     /note="ATPase, H+ transporting, lysosomal V1 subunit G1"
                     /db_xref="GeneID:66290"
                     /db_xref="MGI:MGI:1913540"
     exon            1..235
                     /gene="Atp6v1g1"
                     /gene_synonym="1810024D14Rik; Atp6g1; ATP6J; VAG1; Vma10"
                     /inference="alignment:Splign:2.1.0"
     exon            236..336
                     /gene="Atp6v1g1"
                     /gene_synonym="1810024D14Rik; Atp6g1; ATP6J; VAG1; Vma10"
                     /inference="alignment:Splign:2.1.0"
     exon            337..1093
                     /gene="Atp6v1g1"
                     /gene_synonym="1810024D14Rik; Atp6g1; ATP6J; VAG1; Vma10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      603..608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v1g1"
                     /gene_synonym="1810024D14Rik; Atp6g1; ATP6J; VAG1; Vma10"
                     /note="hexamer: ATTAAA"
     polyA_site      619
                     /gene="Atp6v1g1"
                     /gene_synonym="1810024D14Rik; Atp6g1; ATP6J; VAG1; Vma10"
                     /note="major polyA site"
ORIGIN      
        1 gagacaccgg gcggttcttt tgacggtggg gcggggctcc tgcgcgctgc gcaggcgcag
       61 agtctgggtg gtggatcagg tgatccgagg ggcttcggag ggtgtttgag cagttgactt
      121 aggccgttct ctcagcccaa agtcccctca gcaatggcga gtcagtcgca gggcatccag
      181 cagctactgc aggccgagaa gcgggccgcc gagaaggtgt ccgaggcccg caagcgaaag
      241 aaccggaggc tgaagcaggc caaagaagaa gcccaggctg aaattgaaca gtaccgcctg
      301 cagagggaga aggagttcaa ggccaaggaa gctgcggcat tgggctccca tggcagctgc
      361 agcagtgagg tggaaaagga gacccgggag aagatgaccg tcctccagaa ctacttcgag
      421 cagaacaggg atgaagtcct ggataacctc ttggcctttg tgtgtgacat ccggccggaa
      481 atccatgaaa actaccgcat aaacggatag gaggtggaag cgcctgctct gtgggttggc
      541 atgagatctg cccccataga ataggaaaac ctccacagag ctggagttct gttctggaag
      601 gcattaaatt atttctctat gctgttgtag gacccttcac tttttgagag tatcaaatct
      661 agctttttgt acagacttct tatgtacctg aagtttcatc ttcttatctt gtgtgtcttt
      721 aaggagtgta tgtcgcctgt tttcctgtgt cttcatgcaa gtaatcgata tcaatgttga
      781 cttttttttt taattagtct agtaggaaaa attctttgaa ggaagaaggg gagtaaactg
      841 ttcccttctc ctttcttaca ggtcaggggc gttatctatg aaaaagtaga agtagctatt
      901 agtaactcct atgaagaagc agccagcctt agagtactct agcctggata atttaggaca
      961 gtcaatacga tatgcttgtt ccggctgctg ttagtgtaac ctaacccaaa tcactagatg
     1021 ctaggactta acttgttaca tgtttttggt gtgcttataa tcatttaaaa gtaaaaattt
     1081 gtcttgctct tcaaaaaaaa aaaaaaaaa
//
