LOCUS       NM_007510               1233 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ATPase, H+ transporting, lysosomal V1 subunit E1
            (Atp6v1e1), mRNA.
ACCESSION   NM_007510 XM_359325
VERSION     NM_007510.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1233)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1233)
  AUTHORS   Hai,Q., Ritchey,B., Robinet,P., Alzayed,A.M., Brubaker,G., Zhang,J.
            and Smith,J.D.
  TITLE     Quantitative Trait Locus Mapping of Macrophage Cholesterol
            Metabolism and CRISPR/Cas9 Editing Implicate an ACAT1 Truncation as
            a Causal Modifier Variant
  JOURNAL   Arterioscler Thromb Vasc Biol 38 (1), 83-91 (2018)
   PUBMED   29097366
REFERENCE   3  (bases 1 to 1233)
  AUTHORS   Desgrange,A., Heliot,C., Skovorodkin,I., Akram,S.U., Heikkila,J.,
            Ronkainen,V.P., Miinalainen,I., Vainio,S.J. and Cereghini,S.
  TITLE     HNF1B controls epithelial organization and cell polarity during
            ureteric bud branching and collecting duct morphogenesis
  JOURNAL   Development 144 (24), 4704-4719 (2017)
   PUBMED   29158444
REFERENCE   4  (bases 1 to 1233)
  AUTHORS   Bodzeta,A., Kahms,M. and Klingauf,J.
  TITLE     The Presynaptic v-ATPase Reversibly Disassembles and Thereby
            Modulates Exocytosis but Is Not Part of the Fusion Machinery
  JOURNAL   Cell Rep 20 (6), 1348-1359 (2017)
   PUBMED   28793259
REFERENCE   5  (bases 1 to 1233)
  AUTHORS   Golder,Z.J. and Karet Frankl,F.E.
  TITLE     Extra-renal locations of the a4 subunit of H(+)ATPase
  JOURNAL   BMC Cell Biol 17 (1), 27 (2016)
   PUBMED   27368196
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1233)
  AUTHORS   Matsumoto,M., Tanaka,T., Kaisho,T., Sanjo,H., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A. and Akira,S.
  TITLE     A novel LPS-inducible C-type lectin is a transcriptional target of
            NF-IL6 in macrophages
  JOURNAL   J Immunol 163 (9), 5039-5048 (1999)
   PUBMED   10528209
REFERENCE   7  (bases 1 to 1233)
  AUTHORS   Wang,K., Yin,X.M., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Keck,C.L., Zimonjic,D.B., Popescu,N.C. and Korsmeyer,S.J.
  TITLE     BID, a proapoptotic BCL-2 family member, is localized to mouse
            chromosome 6 and human chromosome 22q11
  JOURNAL   Genomics 53 (2), 235-238 (1998)
   PUBMED   9790773
REFERENCE   8  (bases 1 to 1233)
  AUTHORS   Footz,T.K., Birren,B., Minoshima,S., Asakawa,S., Shimizu,N.,
            Riazi,M.A. and McDermid,H.E.
  TITLE     The gene for death agonist BID maps to the region of human 22q11.2
            duplicated in cat eye syndrome chromosomes and to mouse chromosome
            6
  JOURNAL   Genomics 51 (3), 472-475 (1998)
   PUBMED   9721221
REFERENCE   9  (bases 1 to 1233)
  AUTHORS   Puech,A., Saint-Jore,B., Funke,B., Gilbert,D.J., Sirotkin,H.,
            Copeland,N.G., Jenkins,N.A., Kucherlapati,R., Morrow,B. and
            Skoultchi,A.I.
  TITLE     Comparative mapping of the human 22q11 chromosomal region and the
            orthologous region in mice reveals complex changes in gene
            organization
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14608-14613 (1997)
   PUBMED   9405660
REFERENCE   10 (bases 1 to 1233)
  AUTHORS   Laitala-Leinonen,T., Howell,M.L., Dean,G.E. and Vaananen,H.K.
  TITLE     Resorption-cycle-dependent polarization of mRNAs for different
            subunits of V-ATPase in bone-resorbing osteoclasts
  JOURNAL   Mol Biol Cell 7 (1), 129-142 (1996)
   PUBMED   8741845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139791.1 and AI844873.1.
            
            On Feb 14, 2018 this sequence version replaced NM_007510.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003421.1, AB074758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1216              AK139791.1         5-1220
            1217-1233           AI844873.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1233
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.01 cM"
     gene            1..1233
                     /gene="Atp6v1e1"
                     /gene_synonym="2410029D23Rik; Atp6e; Atp6e2; Atp6v1e;
                     D6Ertd385e; p31; Vma4"
                     /note="ATPase, H+ transporting, lysosomal V1 subunit E1"
                     /db_xref="GeneID:11973"
                     /db_xref="MGI:MGI:894326"
     exon            1..111
                     /gene="Atp6v1e1"
                     /gene_synonym="2410029D23Rik; Atp6e; Atp6e2; Atp6v1e;
                     D6Ertd385e; p31; Vma4"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..759
                     /gene="Atp6v1e1"
                     /gene_synonym="2410029D23Rik; Atp6e; Atp6e2; Atp6v1e;
                     D6Ertd385e; p31; Vma4"
                     /EC_number="7.1.2.2"
                     /note="ATPase, H+ transporting, lysosomal 31kDa, V1
                     subunit E; V-ATPase subunit E 1; V-ATPase 31 kDa subunit;
                     vacuolar proton pump subunit E 1; VATPase, H+
                     transporting, lysosomal V1 subunit E1; H(+)-ATPase E-like
                     protein"
                     /codon_start=1
                     /product="V-type proton ATPase subunit E 1"
                     /protein_id="NP_031536.2"
                     /db_xref="CCDS:CCDS20484.1"
                     /db_xref="GeneID:11973"
                     /db_xref="MGI:MGI:894326"
                     /translation="MALSDADVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGR
                     LVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITDLLNEAKQRL
                     SKVVKDTTRYQVLLDGLVLQGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATK
                     KDVDVQIDQEAYLPEEIAGGVEIYNGDRKIKVSNTLESRLDLIAQQMMPEVRGALFGA
                     NANRKFLD"
     exon            112..177
                     /gene="Atp6v1e1"
                     /gene_synonym="2410029D23Rik; Atp6e; Atp6e2; Atp6v1e;
                     D6Ertd385e; p31; Vma4"
                     /inference="alignment:Splign:2.1.0"
     exon            178..287
                     /gene="Atp6v1e1"
                     /gene_synonym="2410029D23Rik; Atp6e; Atp6e2; Atp6v1e;
                     D6Ertd385e; p31; Vma4"
                     /inference="alignment:Splign:2.1.0"
     exon            288..354
                     /gene="Atp6v1e1"
                     /gene_synonym="2410029D23Rik; Atp6e; Atp6e2; Atp6v1e;
                     D6Ertd385e; p31; Vma4"
                     /inference="alignment:Splign:2.1.0"
     exon            355..444
                     /gene="Atp6v1e1"
                     /gene_synonym="2410029D23Rik; Atp6e; Atp6e2; Atp6v1e;
                     D6Ertd385e; p31; Vma4"
                     /inference="alignment:Splign:2.1.0"
     exon            445..513
                     /gene="Atp6v1e1"
                     /gene_synonym="2410029D23Rik; Atp6e; Atp6e2; Atp6v1e;
                     D6Ertd385e; p31; Vma4"
                     /inference="alignment:Splign:2.1.0"
     exon            514..608
                     /gene="Atp6v1e1"
                     /gene_synonym="2410029D23Rik; Atp6e; Atp6e2; Atp6v1e;
                     D6Ertd385e; p31; Vma4"
                     /inference="alignment:Splign:2.1.0"
     exon            609..696
                     /gene="Atp6v1e1"
                     /gene_synonym="2410029D23Rik; Atp6e; Atp6e2; Atp6v1e;
                     D6Ertd385e; p31; Vma4"
                     /inference="alignment:Splign:2.1.0"
     exon            697..1217
                     /gene="Atp6v1e1"
                     /gene_synonym="2410029D23Rik; Atp6e; Atp6e2; Atp6v1e;
                     D6Ertd385e; p31; Vma4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1194..1199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v1e1"
                     /gene_synonym="2410029D23Rik; Atp6e; Atp6e2; Atp6v1e;
                     D6Ertd385e; p31; Vma4"
                     /note="hexamer: ATTAAA"
     polyA_site      1217
                     /gene="Atp6v1e1"
                     /gene_synonym="2410029D23Rik; Atp6e; Atp6e2; Atp6v1e;
                     D6Ertd385e; p31; Vma4"
                     /note="major polyA site"
ORIGIN      
        1 gttttcgtct caggtttgct ccgccgccac tttgaaccca gattcgaagc tgtcccctgg
       61 ccggactttg ccttcgccat ggcgctcagc gatgcagatg tacagaagca gattaagcac
      121 atgatggctt tcattgaaca agaagccaat gagaaagcag aagaaataga tgcaaaggca
      181 gaagaagagt tcaacattga gaaaggtcgc cttgtgcaaa cgcaaagact gaagattatg
      241 gaatactacg agaagaaaga aaagcagatt gagcagcaga agaaaattca gatgtccaac
      301 ttgatgaatc aagcaaggct caaagtcctc agagcaaggg atgacctcat cactgatctg
      361 ctaaatgagg caaagcagag actcagtaag gtggtaaaag atacgacccg ttaccaagtg
      421 ctgctggatg ggctggtcct tcagggcttg taccagctgc tggagcctcg aatgatcgtg
      481 cgttgcagaa aacaagattt ccctttggtg aaggccgcag tacaaaaagc aatccctatg
      541 tataaaattg ctaccaaaaa ggatgttgat gtccagattg accaggaggc ctacctgcct
      601 gaggaaatag ctggtggcgt tgagatctat aatggggatc gcaagataaa ggtttccaac
      661 accctggaaa gccggctgga cctgatagcc cagcagatga tgccagaagt ccgtggagcc
      721 ttgtttggtg caaatgccaa taggaagttt ctggactgag cttcaggagg agcagttccc
      781 ccacggctgt tctcctggag aagcagatta tctgtgtggc ttcctctttc tgttctaata
      841 ctggtaatca gtggacaccc tctacagcta atgccctcgg ctcagtgtca acagcagggc
      901 cacttggtgt gggcaagaac ccagccccag ctcatctgag gccacagctg ttcactgggt
      961 ttgcagcagg acgggagggt cagatgtgct gcacggcctc acccaggacc cattctttcc
     1021 ctgtcctgct ctagtctaga gtgagttgtg catgctgtcc ctgctctttg ggcataaagt
     1081 gcatgtggga ctcacattcc tccaggaaca ctaccttcgc tgttactgtt taggtctagt
     1141 cttccttctc tgtaaatgtg atttaaaatc taagccacaa atattcttta tttattaaaa
     1201 cagagggctt atgtggaaaa aaaaaaaaaa aaa
//
