LOCUS       NM_023721               1410 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ATPase, H+ transporting, lysosomal V1 subunit D
            (Atp6v1d), mRNA.
ACCESSION   NM_023721
VERSION     NM_023721.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1410)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1410)
  AUTHORS   Yoo,D., Park,J., Lee,C., Song,I., Lee,Y.H., Yun,T., Lee,H.,
            Heguy,A., Han,J.Y., Dasen,J.S., Kim,H. and Baek,M.
  TITLE     Little skate genome provides insights into genetic programs
            essential for limb-based locomotion
  JOURNAL   Elife 11, e78345 (2022)
   PUBMED   36288084
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1410)
  AUTHORS   Castroflorio,E., den Hoed,J., Svistunova,D., Finelli,M.J.,
            Cebrian-Serrano,A., Corrochano,S., Bassett,A.R., Davies,B. and
            Oliver,P.L.
  TITLE     The Ncoa7 locus regulates V-ATPase formation and function,
            neurodevelopment and behaviour
  JOURNAL   Cell Mol Life Sci 78 (7), 3503-3524 (2021)
   PUBMED   33340069
REFERENCE   4  (bases 1 to 1410)
  AUTHORS   Bodzeta,A., Kahms,M. and Klingauf,J.
  TITLE     The Presynaptic v-ATPase Reversibly Disassembles and Thereby
            Modulates Exocytosis but Is Not Part of the Fusion Machinery
  JOURNAL   Cell Rep 20 (6), 1348-1359 (2017)
   PUBMED   28793259
REFERENCE   5  (bases 1 to 1410)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 1410)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1410)
  AUTHORS   Golder,Z.J. and Karet Frankl,F.E.
  TITLE     Extra-renal locations of the a4 subunit of H(+)ATPase
  JOURNAL   BMC Cell Biol 17 (1), 27 (2016)
   PUBMED   27368196
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1410)
  AUTHORS   Smith,A.N., Francis,R.W., Sorrell,S.L. and Karet,F.E.
  TITLE     The d subunit plays a central role in human vacuolar H(+)-ATPases
  JOURNAL   J Bioenerg Biomembr 40 (4), 371-380 (2008)
   PUBMED   18752060
REFERENCE   9  (bases 1 to 1410)
  AUTHORS   Sun-Wada,G.H., Yoshimizu,T., Imai-Senga,Y., Wada,Y. and Futai,M.
  TITLE     Diversity of mouse proton-translocating ATPase: presence of
            multiple isoforms of the C, d and G subunits
  JOURNAL   Gene 302 (1-2), 147-153 (2003)
   PUBMED   12527205
REFERENCE   10 (bases 1 to 1410)
  AUTHORS   Kennell,J.A., Richards,N.W., Schaner,P.E. and Gumucio,D.L.
  TITLE     cDNA cloning, chromosomal localization and evolutionary analysis of
            mouse vacuolar ATPase subunit D, Atp6m
  JOURNAL   Cytogenet Cell Genet 92 (3-4), 337-341 (2001)
   PUBMED   11435709
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY096594.1 and AK147910.1.
            
            On Nov 6, 2005 this sequence version replaced NM_023721.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033457.1, AK147910.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                BY096594.1         2-85
            85-1410             AK147910.1         2-1327
FEATURES             Location/Qualifiers
     source          1..1410
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 35.51 cM"
     gene            1..1410
                     /gene="Atp6v1d"
                     /gene_synonym="1110004P10Rik; Atp6m; VATD; Vma8"
                     /note="ATPase, H+ transporting, lysosomal V1 subunit D"
                     /db_xref="GeneID:73834"
                     /db_xref="MGI:MGI:1921084"
     exon            1..220
                     /gene="Atp6v1d"
                     /gene_synonym="1110004P10Rik; Atp6m; VATD; Vma8"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..923
                     /gene="Atp6v1d"
                     /gene_synonym="1110004P10Rik; Atp6m; VATD; Vma8"
                     /EC_number="7.1.2.2"
                     /note="ATPase, H+ transporting, lysosomal 34kD, V1 subunit
                     D; ATPase, H+ transporting, V1 subunit D; vacuolar proton
                     pump subunit D; V-ATPase 28 kDa accessory protein;
                     lysosomal 34kDa; ATPase, H+ transporting lysosomal
                     (vacuolar proton pump); V-ATPase subunit D"
                     /codon_start=1
                     /product="V-type proton ATPase subunit D"
                     /protein_id="NP_076210.1"
                     /db_xref="CCDS:CCDS26002.1"
                     /db_xref="GeneID:73834"
                     /db_xref="MGI:MGI:1921084"
                     /translation="MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRF
                     RQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVA
                     GVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDE
                     AIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKIIKEKFEK
                     DLERRRAAGEVMEPANLLAEEKDEDLLFE"
     exon            221..338
                     /gene="Atp6v1d"
                     /gene_synonym="1110004P10Rik; Atp6m; VATD; Vma8"
                     /inference="alignment:Splign:2.1.0"
     exon            339..418
                     /gene="Atp6v1d"
                     /gene_synonym="1110004P10Rik; Atp6m; VATD; Vma8"
                     /inference="alignment:Splign:2.1.0"
     exon            419..486
                     /gene="Atp6v1d"
                     /gene_synonym="1110004P10Rik; Atp6m; VATD; Vma8"
                     /inference="alignment:Splign:2.1.0"
     exon            487..531
                     /gene="Atp6v1d"
                     /gene_synonym="1110004P10Rik; Atp6m; VATD; Vma8"
                     /inference="alignment:Splign:2.1.0"
     exon            532..635
                     /gene="Atp6v1d"
                     /gene_synonym="1110004P10Rik; Atp6m; VATD; Vma8"
                     /inference="alignment:Splign:2.1.0"
     exon            636..702
                     /gene="Atp6v1d"
                     /gene_synonym="1110004P10Rik; Atp6m; VATD; Vma8"
                     /inference="alignment:Splign:2.1.0"
     exon            703..781
                     /gene="Atp6v1d"
                     /gene_synonym="1110004P10Rik; Atp6m; VATD; Vma8"
                     /inference="alignment:Splign:2.1.0"
     exon            782..1410
                     /gene="Atp6v1d"
                     /gene_synonym="1110004P10Rik; Atp6m; VATD; Vma8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1390..1395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v1d"
                     /gene_synonym="1110004P10Rik; Atp6m; VATD; Vma8"
                     /note="hexamer: AGTAAA"
     polyA_site      1410
                     /gene="Atp6v1d"
                     /gene_synonym="1110004P10Rik; Atp6m; VATD; Vma8"
                     /note="major polyA site"
ORIGIN      
        1 agtcctcgcc caacaggaac cggaagtggg aaccggtttc ctggttgcct cttagcaacg
       61 cagttgtcaa gtgacccggt cagctgactc ccgtggaggc gggcactggg gtaaccggtt
      121 ctggaggtgt tgcggtcccg attgtctcgc cggggggccc gagccgagtc accgtcagga
      181 tgtcgggcaa agaccggatt gaaatcttcc cttcgcgaat ggcacagacc atcatgaagg
      241 ctcgattaaa aggagcacag actggtcgaa accttctgaa gaaaaagtct gatgccttaa
      301 ctcttcgatt tcgacagatc ctgaagaaga taatagagac taaaatgctg atgggtgaag
      361 tgatgagaga agctgccttc tcattggctg aggccaaatt cacagcaggg gacttcagca
      421 ccacagttat ccaaaatgta aataaagccc aagtgaagat cagagcaaag aaagacaatg
      481 tagcaggtgt taccttgcca gtgtttgaac attaccacga aggaactgac agctatgaac
      541 tgaccggttt agccagaggt ggggagcagc tggctaaact aaagcggaat tatgccaaag
      601 cagtggaact actggtggaa ctggcttccc tgcagacttc ctttgttacc ctggatgaag
      661 ccattaaaat caccaacagg cgtgttaatg ccattgagca tgtcattatt ccccggattg
      721 aacgcaccct tgcctatatc atcacagaac tggatgagag agagcgagaa gaattctata
      781 ggttaaagaa aatacaggag aagaaaaaga ttatcaagga aaaatttgag aaggacttgg
      841 agcggcggag agcagctgga gaggtgatgg agcctgccaa cctgctggct gaagagaagg
      901 atgaagacct gctgttcgaa tagctgccct cgtctgctcc cttcagactg agcatcagct
      961 ccatgttaac tcagtgtgta ggttcggtat gtgtggatat ttattttggc atatgaattt
     1021 ctctggctgt aagatttatc agaatgcctt gtaagacttt ttcctgcatc ataattcagc
     1081 aacccgagat ttgcaaaacc tgcccagcaa cctacagaat ttcctctgtg aaaagtgtca
     1141 tattattcta tttacaattg tttgaccgat ctgtttaaaa ctttaggaaa tatgtactat
     1201 aaacattcat ggtcgcaggc aaaggctgtg agcaaccttc cttcctaccc acttggaaac
     1261 cttgccgctg ttgtccgagg ctgtacagcc attgtgttcc tatggctcaa ttcttcacct
     1321 atttttcttt gcacgatatg tgtttgtaat ggaagcagtt ctgcccattt aaatgtgacc
     1381 tatgaacaga gtaaaatgat tttaaaaaca
//
