LOCUS       NM_133699               1567 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ATPase, H+ transporting, lysosomal V1 subunit C2
            (Atp6v1c2), transcript variant 2, mRNA.
ACCESSION   NM_133699
VERSION     NM_133699.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1567)
  AUTHORS   Jones,M.R., Lingampally,A., Ahmadvand,N., Chong,L., Wu,J.,
            Wilhem,J., Vazquez-Armendariz,A.I., Ansari,M., Herold,S.,
            Ornitz,D.M., Schiller,H.B., Chao,C.M., Zhang,J.S., Carraro,G. and
            Bellusci,S.
  TITLE     FGFR2b signalling restricts lineage-flexible alveolar progenitors
            during mouse lung development and converges in mature alveolar type
            2 cells
  JOURNAL   Cell Mol Life Sci 79 (12), 609 (2022)
   PUBMED   36445537
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1567)
  AUTHORS   Honda,K., Kim,S.H., Kelly,M.C., Burns,J.C., Constance,L., Li,X.,
            Zhou,F., Hoa,M., Kelley,M.W., Wangemann,P., Morell,R.J. and
            Griffith,A.J.
  TITLE     Molecular architecture underlying fluid absorption by the
            developing inner ear
  JOURNAL   Elife 6, e26851 (2017)
   PUBMED   28994389
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1567)
  AUTHORS   Golder,Z.J. and Karet Frankl,F.E.
  TITLE     Extra-renal locations of the a4 subunit of H(+)ATPase
  JOURNAL   BMC Cell Biol 17 (1), 27 (2016)
   PUBMED   27368196
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1567)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1567)
  AUTHORS   Ghazalpour,A., Doss,S., Zhang,B., Wang,S., Plaisier,C.,
            Castellanos,R., Brozell,A., Schadt,E.E., Drake,T.A., Lusis,A.J. and
            Horvath,S.
  TITLE     Integrating genetic and network analysis to characterize genes
            related to mouse weight
  JOURNAL   PLoS Genet 2 (8), e130 (2006)
   PUBMED   16934000
REFERENCE   6  (bases 1 to 1567)
  AUTHORS   Jouret,F., Auzanneau,C., Debaix,H., Wada,G.H., Pretto,C.,
            Marbaix,E., Karet,F.E., Courtoy,P.J. and Devuyst,O.
  TITLE     Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are
            differentially expressed during nephrogenesis
  JOURNAL   J Am Soc Nephrol 16 (11), 3235-3246 (2005)
   PUBMED   16177003
REFERENCE   7  (bases 1 to 1567)
  AUTHORS   Sun-Wada,G.H., Murata,Y., Namba,M., Yamamoto,A., Wada,Y. and
            Futai,M.
  TITLE     Mouse proton pump ATPase C subunit isoforms (C2-a and C2-b)
            specifically expressed in kidney and lung
  JOURNAL   J Biol Chem 278 (45), 44843-44851 (2003)
   PUBMED   12947086
  REMARK    GeneRIF: results suggest that V-ATPases with the C2-a and C2-b
            isoform are involved in luminal acidification of lamellar bodies
            and regulation of the renal acid-base balance, respectively
REFERENCE   8  (bases 1 to 1567)
  AUTHORS   Sun-Wada,G.H., Yoshimizu,T., Imai-Senga,Y., Wada,Y. and Futai,M.
  TITLE     Diversity of mouse proton-translocating ATPase: presence of
            multiple isoforms of the C, d and G subunits
  JOURNAL   Gene 302 (1-2), 147-153 (2003)
   PUBMED   12527205
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159815.3.
            
            On Apr 25, 2009 this sequence version replaced NM_133699.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the central coding region, compared to variant 1. The
            resulting isoform (2) lacks an internal segment, compared to
            isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB088357.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC159815.3         152745-152845       c
            102-274             AC159815.3         151453-151625       c
            275-342             AC159815.3         149713-149780       c
            343-428             AC159815.3         136387-136472       c
            429-523             AC159815.3         129236-129330       c
            524-615             AC159815.3         125844-125935       c
            616-714             AC159815.3         122791-122889       c
            715-783             AC159815.3         122260-122328       c
            784-876             AC159815.3         119743-119835       c
            877-970             AC159815.3         119544-119637       c
            971-1108            AC159815.3         117111-117248       c
            1109-1206           AC159815.3         116198-116295       c
            1207-1339           AC159815.3         113228-113360       c
            1340-1567           AC159815.3         112836-113063       c
FEATURES             Location/Qualifiers
     source          1..1567
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.06 cM"
     gene            1..1567
                     /gene="Atp6v1c2"
                     /gene_synonym="1110038G14Rik"
                     /note="ATPase, H+ transporting, lysosomal V1 subunit C2"
                     /db_xref="GeneID:68775"
                     /db_xref="MGI:MGI:1916025"
     exon            1..101
                     /gene="Atp6v1c2"
                     /gene_synonym="1110038G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            102..274
                     /gene="Atp6v1c2"
                     /gene_synonym="1110038G14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1429
                     /gene="Atp6v1c2"
                     /gene_synonym="1110038G14Rik"
                     /EC_number="7.1.2.2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ATPase, H+ transporting, V1 subunit C; V-type proton
                     ATPase subunit C 2; V-ATPase subunit C 2; vacuolar proton
                     pump subunit C 2"
                     /codon_start=1
                     /product="V-type proton ATPase subunit C 2 isoform 2"
                     /protein_id="NP_598460.1"
                     /db_xref="CCDS:CCDS25827.1"
                     /db_xref="GeneID:68775"
                     /db_xref="MGI:MGI:1916025"
                     /translation="MSEFWLISAPGDKENLQALERMNNVTSKSNLSHNTKFAIPDFKV
                     GTLDSLVGLSDELGKLDTFAESLIKRMAQSVVEVMEDSKGKAHETLLANGVDLTSFVT
                     HFEWDMAKYPAKQPLVSVVDTLAKQLAQIETDLKSRTAAYSVLKANLENLEKRSTGNL
                     FTRTLSDIVSKEDFVLDSEYLITLLVIVPKSSFAQWQKTYESLSDMVVPRSTKLIAED
                     NEGGLFTVTLFRKVIEDFKVKAKENKFIVREFYYDEKEIKREREEMTRLLSDKKQQYP
                     TSCVALKKGSATYRDHKVKVAPLGNPARPAAGQTDRDRESEGEGEGPLLRWLKVNFSE
                     AFIAWIHIKALRVFVESVLRYGLPVNFQAVLLQPHKKSATKRLREVLNSVFRHLDEVA
                     AASILDASVEIPGLQLSNQDYFPYVYFHIDLSLLD"
     exon            275..342
                     /gene="Atp6v1c2"
                     /gene_synonym="1110038G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            343..428
                     /gene="Atp6v1c2"
                     /gene_synonym="1110038G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            429..523
                     /gene="Atp6v1c2"
                     /gene_synonym="1110038G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            524..615
                     /gene="Atp6v1c2"
                     /gene_synonym="1110038G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            616..714
                     /gene="Atp6v1c2"
                     /gene_synonym="1110038G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            715..783
                     /gene="Atp6v1c2"
                     /gene_synonym="1110038G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            784..876
                     /gene="Atp6v1c2"
                     /gene_synonym="1110038G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            877..970
                     /gene="Atp6v1c2"
                     /gene_synonym="1110038G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1108
                     /gene="Atp6v1c2"
                     /gene_synonym="1110038G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1206
                     /gene="Atp6v1c2"
                     /gene_synonym="1110038G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1339
                     /gene="Atp6v1c2"
                     /gene_synonym="1110038G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1567
                     /gene="Atp6v1c2"
                     /gene_synonym="1110038G14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1547..1552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v1c2"
                     /gene_synonym="1110038G14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1566
                     /gene="Atp6v1c2"
                     /gene_synonym="1110038G14Rik"
                     /note="major polyA site"
ORIGIN      
        1 atagaagccg ctgcctcccg ggagccggcc gtgcgctccc gcggagcctc ccgcacggtg
       61 tccccgcgtg tcttctacag ctcagtcttc cgtcgctcct gtcttggtgc ctgtcggtaa
      121 ctagataacc ggaagacttg caaacatgtc tgagttttgg cttatttcgg cccctggcga
      181 taaggaaaat ttacaggctc tggaaaggat gaacaatgta acttcaaagt ctaacctgtc
      241 ccacaacacc aagtttgcca tcccagactt caaggtgggg actttggatt cccttgttgg
      301 cctctctgat gagctgggga aactcgatac ctttgctgaa agcctcataa agagaatggc
      361 acagagtgtg gtggaggtca tggaagattc caaggggaaa gcacacgaga ccctcctggc
      421 taacggagtt gacctgacat ccttcgtgac gcacttcgag tgggacatgg ccaaatatcc
      481 cgccaagcag ccactggtga gcgtggtgga cacactggcc aagcaactgg cacaaatcga
      541 gacagacctg aagtcccgga cagccgccta cagcgttctg aaggccaacc tggagaactt
      601 ggagaagaga tccacgggga acctcttcac tcggacactg agcgatattg tcagcaagga
      661 agacttcgta cttgattctg aatatctcat aaccctcctg gtcatcgtcc ccaagtcaag
      721 ctttgcacag tggcagaaga catatgagtc cctatcggac atggtggtcc ctcggtcaac
      781 caaattgatc gccgaggaca acgaaggtgg cctcttcacg gtgactctct tccgaaaagt
      841 gatcgaagat ttcaaagtca aagccaaaga aaacaagttc attgtccggg aattttacta
      901 tgatgaaaaa gaaattaaac gagaaaggga ggagatgacc aggttgctgt ctgataagaa
      961 acaacagtat ccaacttcct gtgttgctct aaaaaaggga tcagccacct accgtgacca
     1021 caaggttaag gtagccccgc taggtaaccc tgctaggcct gctgcggggc agaccgacag
     1081 agacagagag agtgagggcg agggtgaggg acctctgctg cgctggctca aggtgaactt
     1141 cagcgaggcc tttattgcct ggatccacat taaggccctg agagtgtttg tggagtctgt
     1201 gctcaggtat ggacttccag tgaacttcca ggctgtgctc ctacagcccc ataaaaagtc
     1261 agccaccaaa cgcctgagag aggtgctcaa ctctgtcttc cggcacctgg atgaagttgc
     1321 tgcagcaagc atactggatg catccgtgga gattcctgga ctgcagctca gcaaccagga
     1381 ctatttcccc tatgtgtact tccatatcga cctcagcctt cttgactagg tggccagcct
     1441 gtttcactgc agcctcagac cttgccagac aaccgagtcc tgcaggattc tgactcagaa
     1501 gataatcaca gacgttagtt agagtgtatt tattttttta agttacaata aagtgctcag
     1561 tcctgag
//
