LOCUS       NM_025494               2117 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ATPase, H+ transporting, lysosomal V1 subunit C1
            (Atp6v1c1), mRNA.
ACCESSION   NM_025494
VERSION     NM_025494.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2117)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2117)
  AUTHORS   Castroflorio,E., den Hoed,J., Svistunova,D., Finelli,M.J.,
            Cebrian-Serrano,A., Corrochano,S., Bassett,A.R., Davies,B. and
            Oliver,P.L.
  TITLE     The Ncoa7 locus regulates V-ATPase formation and function,
            neurodevelopment and behaviour
  JOURNAL   Cell Mol Life Sci 78 (7), 3503-3524 (2021)
   PUBMED   33340069
REFERENCE   3  (bases 1 to 2117)
  AUTHORS   Wang,Y., Chen,W., Hao,L., McVicar,A., Wu,J., Gao,N., Liu,Y. and
            Li,Y.P.
  TITLE     C1 Silencing Attenuates Inflammation and Alveolar Bone Resorption
            in Endodontic Disease
  JOURNAL   J Endod 45 (7), 898-906 (2019)
   PUBMED   31104818
  REMARK    GeneRIF: results showed that adneno-associated virus-mediated
            Atp6v1c1 knockdown in periapical tissues slowed endodontic disease
            progression, prevented bone erosion, and alleviated inflammation in
            the periapical tissues and periodontal ligament potentially through
            regulation of toll-like receptor signaling
REFERENCE   4  (bases 1 to 2117)
  AUTHORS   Jing,F., Geng,Y., Xu,X.Y., Xu,H.Y., Shi,J.S. and Xu,Z.H.
  TITLE     MicroRNA29a Reverts the Activated Hepatic Stellate Cells in the
            Regression of Hepatic Fibrosis through Regulation of ATPase H
            Transporting V1 Subunit C1
  JOURNAL   Int J Mol Sci 20 (4), 796 (2019)
   PUBMED   30781750
  REMARK    GeneRIF: MIR29a plays an important role during the
            trans-differentiation of Activated hepatic stellate cells in the
            resolution of liver fibrosis, in part, through regulation of
            ATP6V1C1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2117)
  AUTHORS   Bodzeta,A., Kahms,M. and Klingauf,J.
  TITLE     The Presynaptic v-ATPase Reversibly Disassembles and Thereby
            Modulates Exocytosis but Is Not Part of the Fusion Machinery
  JOURNAL   Cell Rep 20 (6), 1348-1359 (2017)
   PUBMED   28793259
REFERENCE   6  (bases 1 to 2117)
  AUTHORS   Feng,S., Zhu,G., McConnell,M., Deng,L., Zhao,Q., Wu,M., Zhou,Q.,
            Wang,J., Qi,J., Li,Y.P. and Chen,W.
  TITLE     Silencing of atp6v1c1 prevents breast cancer growth and bone
            metastasis
  JOURNAL   Int J Biol Sci 9 (8), 853-862 (2013)
   PUBMED   24155661
  REMARK    GeneRIF: Silencing of atp6v1c1 prevents breast cancer growth and
            bone metastasis.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2117)
  AUTHORS   Feng,S., Deng,L., Chen,W., Shao,J., Xu,G. and Li,Y.P.
  TITLE     Atp6v1c1 is an essential component of the osteoclast proton pump
            and in F-actin ring formation in osteoclasts
  JOURNAL   Biochem J 417 (1), 195-203 (2009)
   PUBMED   18657050
  REMARK    GeneRIF: Study demonstrates that Atp6v1c1 is an essential component
            of the osteoclast proton pump at the osteoclast ruffled border and
            that it may regulate F-actin ring formation in osteoclast
            activation.
REFERENCE   8  (bases 1 to 2117)
  AUTHORS   Hurtado-Lorenzo,A., Skinner,M., El Annan,J., Futai,M.,
            Sun-Wada,G.H., Bourgoin,S., Casanova,J., Wildeman,A., Bechoua,S.,
            Ausiello,D.A., Brown,D. and Marshansky,V.
  TITLE     V-ATPase interacts with ARNO and Arf6 in early endosomes and
            regulates the protein degradative pathway
  JOURNAL   Nat Cell Biol 8 (2), 124-136 (2006)
   PUBMED   16415858
REFERENCE   9  (bases 1 to 2117)
  AUTHORS   Jouret,F., Auzanneau,C., Debaix,H., Wada,G.H., Pretto,C.,
            Marbaix,E., Karet,F.E., Courtoy,P.J. and Devuyst,O.
  TITLE     Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are
            differentially expressed during nephrogenesis
  JOURNAL   J Am Soc Nephrol 16 (11), 3235-3246 (2005)
   PUBMED   16177003
REFERENCE   10 (bases 1 to 2117)
  AUTHORS   Sun-Wada,G.H., Yoshimizu,T., Imai-Senga,Y., Wada,Y. and Futai,M.
  TITLE     Diversity of mouse proton-translocating ATPase: presence of
            multiple isoforms of the C, d and G subunits
  JOURNAL   Gene 302 (1-2), 147-153 (2003)
   PUBMED   12527205
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB869068.1, AK151237.1 and BQ746792.1.
            
            On Jun 4, 2008 this sequence version replaced NM_025494.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.133200.1, AK151237.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BB869068.1         2-41
            41-2090             AK151237.1         2-2051
            2091-2117           BQ746792.1         533-559
FEATURES             Location/Qualifiers
     source          1..2117
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 15.18 cM"
     gene            1..2117
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
                     /note="ATPase, H+ transporting, lysosomal V1 subunit C1"
                     /db_xref="GeneID:66335"
                     /db_xref="MGI:MGI:1913585"
     exon            1..180
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            181..344
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1361
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
                     /EC_number="7.1.2.2"
                     /note="ATPase, H+ transporting, V1 subunit C; V-ATPase
                     subunit C 1; vacuolar proton pump subunit C 1"
                     /codon_start=1
                     /product="V-type proton ATPase subunit C 1"
                     /protein_id="NP_079770.2"
                     /db_xref="CCDS:CCDS27439.1"
                     /db_xref="GeneID:66335"
                     /db_xref="MGI:MGI:1913585"
                     /translation="MTEFWLISAPGEKTCQQTWEKLHAATTKNNNLAVSSKFNIPDLK
                     VGTLDVLVGLSDELAKLDAFVEGVVKKVAQYMADVLEDSKDKVQENLLASGVDLVTYI
                     TRFQWDMAKYPIKQSLKNISEIIAKGVTQIDNDLKSRASAYNNLKGNLQNLERKNAGS
                     LLTRSLAEIVKKDDFVLDSEYLVTLLVVVPKLNHNDWIKQYETLAEMVVPRSSNVLSE
                     DQDSYLCNVTLFRKAVDDFRHKARENKFIVRDFQYNEEEMKADKEEMTRLSTDKKKQF
                     GPLVRWLKVNFSEAFIAWIHIKALRVFVESVLRYGLPVNFQAMLLQPNKKSVKKLREV
                     LHELYKHLDSSAAAIIDAPMDIPGLNLSQQEYYPYVYYKIDCNLLEFK"
     exon            345..412
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            413..498
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            499..593
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            594..685
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            686..784
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            785..853
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            854..946
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1040
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1138
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1265
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..2098
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1832..1837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1852
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
     regulatory      2079..2084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2098
                     /gene="Atp6v1c1"
                     /gene_synonym="1700025B18Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggcgtgcgcc gcggtcagct gactgctccg gctggcacgt gacttgctct gggcgcaggg
       61 gtcgaggaag ccgaaaggcc ggagcttagg tccgggaggg atggagcgct gagcggttaa
      121 cgtctaccag gcttcctgcc tccgcacctg tcgccgccgc cgcctcctga gacacctcgg
      181 cttctccctt gcttgccaaa gaggtaacaa acatgactga gttctggctc atatctgctc
      241 ctggggagaa aacctgtcag caaacatggg agaaactaca tgcagcgacc accaagaaca
      301 ataatcttgc cgtctcttcc aagttcaaca ttcctgacct aaaggttggc acgttggatg
      361 tcttggttgg cttgtcggat gaactggcta aactggatgc atttgtagaa ggtgtggtca
      421 agaaagtggc tcagtacatg gctgatgtgc tggaggacag caaagataaa gttcaggaga
      481 acttgctggc cagcggagtt gacttggtta cttacataac aaggttccag tgggatatgg
      541 ctaaatatcc aatcaagcag tctctgaaaa atatttctga aataattgcc aagggagtga
      601 ctcagatcga taatgaccta aagtctcggg cgtctgcata caataacctg aaagggaatc
      661 ttcagaattt agagcgaaag aacgcgggaa gtttgctaac gcgaagcctg gcggaaatcg
      721 tgaagaaaga tgactttgtt cttgattcgg agtatcttgt cacattgctg gtggtagttc
      781 ccaagctgaa ccacaatgac tggattaagc agtatgaaac gctcgcagaa atggtagtac
      841 caaggtcaag caatgttctt tcagaggacc aagacagtta tctttgtaac gtcaccttgt
      901 ttagaaaagc agttgatgat ttcagacaca aagccagaga aaacaagttc atagttcgtg
      961 acttccagta taacgaggag gagatgaaag cagataaaga agaaatgacc aggctgtcta
     1021 ctgacaagaa gaagcagttt ggaccacttg tgcggtggct taaagtgaat ttcagtgagg
     1081 cgtttattgc gtggattcat ataaaagcat tacgggtttt tgtggagtct gttttaaggt
     1141 atggcttgcc ggtgaacttc caagcaatgc tccttcagcc gaataagaag tcagtgaaga
     1201 agctaagaga agtgctgcac gagttgtaca agcatctgga cagcagtgcg gctgccatca
     1261 ttgacgctcc catggatatc cctggcctaa acctgagtca gcaggaatac tacccctatg
     1321 tgtattacaa gattgattgc aacttgctgg aattcaagta aactgagctc ctcccagtca
     1381 atcctggcct tgtgttggtg ttgctcacac aagtaactct cataactctc acgccctctg
     1441 cttgctcctt ccccttcccc tagatgaatt tctcatgtgg tccatatctc aacatttgct
     1501 ttttaaagaa aaatatatat attgtttctt tttattgatc aggtctgtaa atgtgtactg
     1561 aaaaaaatca gagtttattt ataaatagaa tagtttattt aaagaggtat tttcctcctt
     1621 gatatcatgg tatgcataat tctgtgtgtt actgttgtgc acagccttgt ttacagggaa
     1681 tggtctaagc ataccatttc attcactgta ttagtagaca taactgttga gtagttacta
     1741 agttgtgatg tagtgctatg tgacaacgtt caggtgtgtg cttttggaat gctctgacta
     1801 tcttgtcagc actgttgacc ccacaggaca gaataaaaga acctgtgccc actgtgctgt
     1861 gtgtgacttg agaggctcca ggggccgccg cctcctgggc tgcttcaggg gctgctgctg
     1921 ccgagctctg agcactcctg tctgactcgc ataggattta gttgtgccaa atttgggtca
     1981 gagcgcaaat cagaaggtta tttttccaac acatggtgat atttatattt ggacactggg
     2041 cgtttagctc tcttaaataa gaagtgggac cagttttgaa taaagtgtag caaaactaaa
     2101 aaaaaaaaaa aaaaaaa
//
