LOCUS       NM_007509               2742 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus ATPase, H+ transporting, lysosomal V1 subunit B2
            (Atp6v1b2), mRNA.
ACCESSION   NM_007509
VERSION     NM_007509.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2742)
  AUTHORS   Pepe,S., Aprile,D., Castroflorio,E., Marte,A., Giubbolini,S.,
            Hopestone,S., Parsons,A., Soares,T., Benfenati,F., Oliver,P.L. and
            Fassio,A.
  TITLE     TBC1D24 interacts with the v-ATPase and regulates intraorganellar
            pH in neurons
  JOURNAL   iScience 28 (1), 111515 (2024)
   PUBMED   39758816
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2742)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2742)
  AUTHORS   Rousseau,J., Tene Tadoum,S.B., Lavertu Jolin,M., Nguyen,T.T.M.,
            Ajeawung,N.F., Flenniken,A.M., Nutter,L.M.J., Vukobradovic,I.,
            Rossignol,E. and Campeau,P.M.
  TITLE     The ATP6V1B2 DDOD/DOORS-Associated p.Arg506* Variant Causes
            Hyperactivity and Seizures in Mice
  JOURNAL   Genes (Basel) 14 (8), 1538 (2023)
   PUBMED   37628590
  REMARK    GeneRIF: The ATP6V1B2 DDOD/DOORS-Associated p.Arg506* Variant
            Causes Hyperactivity and Seizures in Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2742)
  AUTHORS   Kurtzeborn,K., Kwon,H.N., Iaroshenko,V., Faisal,I., Ambroz,M.,
            Jin,X., Qureshi,T., Kupari,J., Ihermann-Hella,A., Vaananen,J.,
            Tyynismaa,H., Bousova,I., Park,S. and Kuure,S.
  TITLE     Comparative whole-genome transcriptome analysis in renal cell
            populations reveals high tissue specificity of MAPK/ERK targets in
            embryonic kidney
  JOURNAL   BMC Biol 20 (1), 112 (2022)
   PUBMED   35550069
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2742)
  AUTHORS   Lee,J.U., Hong,J., Shin,H., Ryu,C.B., Park,S.W. and Jeong,S.H.
  TITLE     Overexpression of V-ATPase B2 attenuates lung injury/fibrosis by
            stabilizing lysosomal membrane permeabilization and increasing
            collagen degradation
  JOURNAL   Exp Mol Med 54 (5), 662-672 (2022)
   PUBMED   35624153
  REMARK    GeneRIF: Overexpression of V-ATPase B2 attenuates lung
            injury/fibrosis by stabilizing lysosomal membrane permeabilization
            and increasing collagen degradation.
REFERENCE   6  (bases 1 to 2742)
  AUTHORS   Paunescu,T.G., Da Silva,N., Marshansky,V., McKee,M., Breton,S. and
            Brown,D.
  TITLE     Expression of the 56-kDa B2 subunit isoform of the vacuolar
            H(+)-ATPase in proton-secreting cells of the kidney and epididymis
  JOURNAL   Am J Physiol Cell Physiol 287 (1), C149-C162 (2004)
   PUBMED   15013950
  REMARK    GeneRIF: expressed in most, if not all, proton-secreting cells in
            the epithelium lining the nephron and the collecting ducts, and it
            is also present in proton-secreting clear cells of the epididymis
REFERENCE   7  (bases 1 to 2742)
  AUTHORS   Tateossian,H., Powles,N., Dickinson,R., Ficker,M. and Maconochie,M.
  TITLE     Determination of downstream targets of FGF signalling using gene
            trap and cDNA subtractive approaches
  JOURNAL   Exp Cell Res 292 (1), 101-114 (2004)
   PUBMED   14720510
REFERENCE   8  (bases 1 to 2742)
  AUTHORS   Lee,B.S., Holliday,L.S., Ojikutu,B., Krits,I. and Gluck,S.L.
  TITLE     Osteoclasts express the B2 isoform of vacuolar H(+)-ATPase
            intracellularly and on their plasma membranes
  JOURNAL   Am J Physiol 270 (1 Pt 1), C382-C388 (1996)
   PUBMED   8772466
REFERENCE   9  (bases 1 to 2742)
  AUTHORS   Laitala-Leinonen,T., Howell,M.L., Dean,G.E. and Vaananen,H.K.
  TITLE     Resorption-cycle-dependent polarization of mRNAs for different
            subunits of V-ATPase in bone-resorbing osteoclasts
  JOURNAL   Mol Biol Cell 7 (1), 129-142 (1996)
   PUBMED   8741845
REFERENCE   10 (bases 1 to 2742)
  AUTHORS   van Hille,B., Richener,H., Schmid,P., Puettner,I., Green,J.R. and
            Bilbe,G.
  TITLE     Heterogeneity of vacuolar H(+)-ATPase: differential expression of
            two human subunit B isoforms
  JOURNAL   Biochem J 303 (Pt 1) (Pt 1), 191-198 (1994)
   PUBMED   7945239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151200.1, BC046302.1 and AK197153.1.
            
            On Apr 25, 2009 this sequence version replaced NM_007509.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151200.1, AK170110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AK151200.1         2-46
            46-2735             BC046302.1         1-2690
            2736-2742           AK197153.1         293-299
FEATURES             Location/Qualifiers
     source          1..2742
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 33.88 cM"
     gene            1..2742
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /note="ATPase, H+ transporting, lysosomal V1 subunit B2"
                     /db_xref="GeneID:11966"
                     /db_xref="MGI:MGI:109618"
     exon            1..193
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1593
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /EC_number="7.1.2.2"
                     /note="ATPase, H+ transporting, lysosomal 56/58kD, V1
                     subunit B; ATPase, H+ transporting, V1 subunit B; V-ATPase
                     subunit B 2; vacuolar proton pump subunit B 2;
                     endomembrane proton pump 58 kDa subunit; lysosomal
                     56/58kDa; ATPase, H+ transporting, lysosomal (vacuolar
                     proton pump), beta 56/58 kDa"
                     /codon_start=1
                     /product="V-type proton ATPase subunit B, brain isoform"
                     /protein_id="NP_031535.2"
                     /db_xref="CCDS:CCDS40358.1"
                     /db_xref="GeneID:11966"
                     /db_xref="MGI:MGI:109618"
                     /translation="MALRAMRGIVNGAAPELPVPTGGPMAGAREQALAVSRNYLSQPR
                     LTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGT
                     SGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPVVLAEDFLDIMGQPINP
                     QCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKD
                     VVDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPR
                     LALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATI
                     YERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPI
                     NVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLL
                     YLEFLQKFEKNFITQGPYENRTVYETLDIGWQLLRIFPKEMLKRIPQSTLSEFYPRDS
                     AKH"
     exon            194..249
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /inference="alignment:Splign:2.1.0"
     exon            250..348
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /inference="alignment:Splign:2.1.0"
     exon            349..442
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /inference="alignment:Splign:2.1.0"
     exon            443..520
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /inference="alignment:Splign:2.1.0"
     exon            521..660
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /inference="alignment:Splign:2.1.0"
     exon            661..762
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /inference="alignment:Splign:2.1.0"
     exon            763..860
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /inference="alignment:Splign:2.1.0"
     exon            861..984
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1135
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1218
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1323
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1453
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..2742
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2709..2714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /note="hexamer: AATAAA"
     regulatory      2721..2726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /note="hexamer: ATTAAA"
     polyA_site      2731
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
                     /note="major polyA site"
     polyA_site      2742
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b2; HO57"
ORIGIN      
        1 gctatatgtg cgcctgcgcc gcgctgctgc ggggccagtc gggacggagg agacaagatg
       61 gcgttgcgag cgatgcgggg aatcgtgaac ggggccgcac ccgaactgcc cgtgcccacc
      121 ggtgggccga tggccggagc tcgggagcag gcgctggcgg tgagccggaa ctacctatcc
      181 cagcctcgtc tcacctacaa gactgtctct ggggtgaatg gtccactagt gatcctagat
      241 catgtgaagt ttcccagata cgctgagatt gtccacttga cattaccaga tggcacaaag
      301 agaagtgggc aagtcctaga agttagtggc tccaaagcag tggttcaggt atttgaaggg
      361 acatctggta tagacgccaa gaaaacatcc tgtgagttta ctggagatat tctccgaaca
      421 ccagtgtctg aggatatgct tggtcgagta ttcaacggat caggaaaacc cattgaccga
      481 ggccctgtgg tgctggctga agacttcctt gacatcatgg gtcagccaat caaccctcag
      541 tgtcggatct atccagaaga gatgattcag acgggcattt ccgccatcga tggcatgaac
      601 agtattgcta ggggacagaa aatccccatc ttttctgctg ctggattacc acacaacgag
      661 attgcagctc agatctgtcg ccaggctggt ttggtaaaga aatccaaaga tgtagtggac
      721 tatagtgaag aaaattttgc cattgtgttt gctgctatgg gagtaaacat ggaaacagcc
      781 cggttcttta aatctgactt tgaagaaaat ggctcaatgg acaatgtctg cctttttttg
      841 aatctggcta atgacccaac cattgagcgg atcatcactc ctcgcctggc tctgaccacg
      901 gccgagtttc tggcatatca gtgtgagaag cacgtgctgg tgatcctgac ggacatgagc
      961 tcctacgctg aagcgctgcg agaggtttca gctgccaggg aagaggtccc tggtcggcga
     1021 ggcttcccag gctacatgta taccgactta gccacaatct atgaacgtgc cggtcgagtg
     1081 gaaggtagaa acggctctat tacccaaatc cctattctca ccatgcccaa tgacgatatc
     1141 actcatccca tccctgactt gactgggtac attactgagg gccagatcta tgtggacaga
     1201 cagctgcaca acagacagat ttaccctcct attaatgtgc tgccctcact ctctcggtta
     1261 atgaagtcag ctatcggaga aggaatgacc agaaaggatc acgctgatgt gtctaaccag
     1321 ttgtatgcgt gctatgccat cggtaaggac gtgcaagcca tgaaagccgt ggtgggagag
     1381 gaagccctga cctcagatga tctcctttac ctggaatttc tgcagaagtt tgagaagaac
     1441 ttcattactc agggtcccta tgaaaaccga actgtttatg agactttgga cattggctgg
     1501 cagttgcttc gaatcttccc caaagaaatg ctgaagagaa tccctcagag caccctgagc
     1561 gaattttacc ctcgagactc tgcaaaacac tagtagctgc tgctgcttgt gtggcgtgac
     1621 cctcttgtga agtactggtt ctgtttcctg attccttttg cactcctcca tcccacctgt
     1681 gagtgggagt ttacctgtta ccctgtaatt aaaaacaaag gctaggtaac tattgtgcca
     1741 gtgttgacag tttaaactgc taacagattg agagatccct gctcagaaac ctcaccttta
     1801 gtgctttctt taaagaagct gaggggtgaa gtttgcttac tgatgtatct atttgtacag
     1861 atagtggaga gctagttgct aataatgtct tgtttgggtc tcccaaaccc tacctctcaa
     1921 ctcccttaag agtatcactg ttctgaagct aaaatgcttc agtctcaaat ttaggggcaa
     1981 agtggagact ggaagaattc tcctttcaga agaaccacga ggctctggct gagcctccct
     2041 ctggagtgct agtgtacctg tgggtctgtc ctctgctctg tgcagatggg ttttactgtc
     2101 tgctgtgttt tcttacgaaa agagtttcgt tctgccagtg ctgtgagttg ggaattcctg
     2161 cgtggcgact ttctctgagg cccacagaga atcaggtaac attgcacagc ctgcgttctc
     2221 ctgcagtggt ggcacgcctt gtgctgacga cccccactgg gctacagtca caggagaatt
     2281 gagacttgga aaaggcttgg gtacaattaa gaaaaaccct acatcccacc ctcctcttga
     2341 cgcgtttctg gtggtttcgg tttctgcgtt gccctccaga tcctgaggtg ggccgtgaga
     2401 cgacttgctt taaactctgt tcaatcccca ggctttctga gtccgctcta ccttttctgg
     2461 gtgatcttgt ggcacatgta gcaatgtttc tttcattcct gtcccttcct ggcttgagct
     2521 cttggctgta ttctgtgtgc ctctaccatg tctgctgttt gggtctctgc gctgtgtgtt
     2581 ctcaggtgca gccatgactc cccactctgt gcattccacc ttccagttgt ttttctctga
     2641 gggggtagtg ggggggtcag catgattata ttttaatgta gaaaatgtga catctcgtta
     2701 taaatgaaaa taaatgttaa attaaatgga agttacctga aa
//
