LOCUS       NM_134157               1986 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus ATPase, H+ transporting, lysosomal V1 subunit B1
            (Atp6v1b1), mRNA.
ACCESSION   NM_134157 NM_201234
VERSION     NM_134157.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1986)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1986)
  AUTHORS   Al-Shebel,A., Michel,G., Breiderhoff,T. and Muller,D.
  TITLE     Urinary Acidification Does Not Explain the Absence of
            Nephrocalcinosis in a Mouse Model of Familial Hypomagnesaemia with
            Hypercalciuria and Nephrocalcinosis (FHHNC)
  JOURNAL   Int J Mol Sci 25 (3), 1779 (2024)
   PUBMED   38339056
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1986)
  AUTHORS   Bourgeois,S., Kovacikova,J., Bugarski,M., Bettoni,C., Gehring,N.,
            Hall,A. and Wagner,C.A.
  TITLE     The B1 H + -ATPase (Atp6v1b1) Subunit in Non-Type A Intercalated
            Cells is Required for Driving Pendrin Activity and the Renal
            Defense Against Alkalosis
  JOURNAL   J Am Soc Nephrol 35 (1), 7-21 (2024)
   PUBMED   37990364
  REMARK    GeneRIF: The B1 H + -ATPase (Atp6v1b1) Subunit in Non-Type A
            Intercalated Cells is Required for Driving Pendrin Activity and the
            Renal Defense Against Alkalosis.
REFERENCE   4  (bases 1 to 1986)
  AUTHORS   Guan,N., Kobayashi,H., Ishii,K., Davidoff,O., Sha,F., Ikizler,T.A.,
            Hao,C.M., Chandel,N.S. and Haase,V.H.
  TITLE     Disruption of mitochondrial complex III in cap mesenchyme but not
            in ureteric progenitors results in defective nephrogenesis
            associated with amino acid deficiency
  JOURNAL   Kidney Int 102 (1), 108-120 (2022)
   PUBMED   35341793
REFERENCE   5  (bases 1 to 1986)
  AUTHORS   Kurtzeborn,K., Kwon,H.N., Iaroshenko,V., Faisal,I., Ambroz,M.,
            Jin,X., Qureshi,T., Kupari,J., Ihermann-Hella,A., Vaananen,J.,
            Tyynismaa,H., Bousova,I., Park,S. and Kuure,S.
  TITLE     Comparative whole-genome transcriptome analysis in renal cell
            populations reveals high tissue specificity of MAPK/ERK targets in
            embryonic kidney
  JOURNAL   BMC Biol 20 (1), 112 (2022)
   PUBMED   35550069
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1986)
  AUTHORS   Finberg,K.E., Wagner,C.A., Stehberger,P.A., Geibel,J.P. and
            Lifton,R.P.
  TITLE     Molecular cloning and characterization of Atp6v1b1, the murine
            vacuolar H+ -ATPase B1-subunit
  JOURNAL   Gene 318, 25-34 (2003)
   PUBMED   14585495
REFERENCE   7  (bases 1 to 1986)
  AUTHORS   Dou,H., Finberg,K., Cardell,E.L., Lifton,R. and Choo,D.
  TITLE     Mice lacking the B1 subunit of H+ -ATPase have normal hearing
  JOURNAL   Hear Res 180 (1-2), 76-84 (2003)
   PUBMED   12782355
REFERENCE   8  (bases 1 to 1986)
  AUTHORS   Grewal,P.K., Bolland,D.J., Todd,L.C. and Hewitt,J.E.
  TITLE     High-resolution mapping of mouse chromosome 8 identifies an
            evolutionary chromosomal breakpoint
  JOURNAL   Mamm Genome 9 (8), 603-607 (1998)
   PUBMED   9680377
REFERENCE   9  (bases 1 to 1986)
  AUTHORS   Naggert,J.K., Fricker,L.D., Varlamov,O., Nishina,P.M., Rouille,Y.,
            Steiner,D.F., Carroll,R.J., Paigen,B.J. and Leiter,E.H.
  TITLE     Hyperproinsulinaemia in obese fat/fat mice associated with a
            carboxypeptidase E mutation which reduces enzyme activity
  JOURNAL   Nat Genet 10 (2), 135-142 (1995)
   PUBMED   7663508
REFERENCE   10 (bases 1 to 1986)
  AUTHORS   van Hille,B., Richener,H., Schmid,P., Puettner,I., Green,J.R. and
            Bilbe,G.
  TITLE     Heterogeneity of vacuolar H(+)-ATPase: differential expression of
            two human subunit B isoforms
  JOURNAL   Biochem J 303 (Pt 1) (Pt 1), 191-198 (1994)
   PUBMED   7945239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK078810.1 and CB173989.1.
            
            On May 29, 2018 this sequence version replaced NM_134157.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF435091.1, AK085549.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1876              AK078810.1         29-1904
            1877-1986           CB173989.1         118-227
FEATURES             Location/Qualifiers
     source          1..1986
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..1986
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /note="ATPase, H+ transporting, lysosomal V1 subunit B1"
                     /db_xref="GeneID:110935"
                     /db_xref="MGI:MGI:103285"
     exon            1..186
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1610
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /EC_number="7.1.2.2"
                     /note="ATPase, H+ transporting, lysosomal 56/58kDa, V1
                     subunit B; ATPase, H+ transporting, V1 subunit B; ATPase,
                     H+ transporting, lysosomal (vacuolar proton pump), beta
                     56/58 kDa; V-ATPase subunit B 1; vacuolar proton pump
                     subunit B 1; endomembrane proton pump 58 kDa subunit"
                     /codon_start=1
                     /product="V-type proton ATPase subunit B, kidney isoform"
                     /protein_id="NP_598918.1"
                     /db_xref="CCDS:CCDS20283.1"
                     /db_xref="GeneID:110935"
                     /db_xref="MGI:MGI:103285"
                     /translation="MATTVDSRSSGFTGNSCDPGTAQEHVQAVTRNYITHPRVTYRTV
                     CSVNGPLVVLDQVKFAQYAEIVNFTLPDGTQRSGQVLEVAGTKAIVQVFEGTSGIDSQ
                     KTTCEFTGDILRTPVSEDMLGRIFNGSGKPIDKGPAVMAEEFLDINGQPINPHDRIYP
                     EEMIQTGISPIDVMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKAVLDYHE
                     DNFAIVFAAMGVNMETARFFKSDFEQNGTMGNVCLFLNLANDPTIERIITPRLALTTA
                     EFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGR
                     VEGRGGSITQIPILTMPNDDITHPIPDLTGFITEGQIYVDRQLHNRQVYPPINVLPSL
                     SRLMKSAIGEGMTRKDHGDVSNQLYACYAIGKDVQAMKAVVGEEALTSEDLLYLEFLQ
                     KFEKNFITQGPYENRTVFESLDLGWKLLRIFPKEMLKRIPQSMTDEFYSRQGAQQDPA
                     SDTAL"
     exon            187..242
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            243..341
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            342..435
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            436..513
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            514..653
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            654..755
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            756..853
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            854..977
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1128
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1211
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1316
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1446
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1972
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1841..1846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /note="hexamer: AACAAA"
     regulatory      1879..1884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /note="hexamer: AACAAG"
     polyA_site      1883
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /note="major polyA site"
     polyA_site      1908
                     /gene="Atp6v1b1"
                     /gene_synonym="Atp6b1; D630003L15; D630030L16Rik;
                     D630039P21Rik; Vpp-3; Vpp3"
                     /note="major polyA site"
ORIGIN      
        1 agataaaact gaagtcttag agctaccacc aggcttctca ggcactagct cccagctctc
       61 cacacgccat ggccacaaca gtagacagca ggtcctcggg attcactggc aatagctgtg
      121 acccaggcac agcccaagag catgtgcagg ctgtgacccg aaactacatc acccaccccc
      181 gagtcaccta taggacagtg tgcagcgtca atgggcctct ggtggtgctg gaccaggtca
      241 agtttgccca gtatgctgag attgtcaact ttaccctccc tgatggtact cagaggagtg
      301 gccaggtgct tgaagtggct gggaccaagg ccattgttca ggtgtttgaa gggacttcag
      361 ggattgattc ccagaagacc acatgtgaat tcacagggga catcctgcgg actcctgtgt
      421 cagaagacat gctgggtcgg attttcaatg gctctggcaa acccattgac aaaggacctg
      481 ctgtcatggc agaggagttt ctggacatca atggccagcc aatcaatccc catgaccgaa
      541 tctaccccga ggagatgatc cagacgggaa tctcccccat tgatgtcatg aacagcatcg
      601 ctcgtggcca gaagatcccc atcttctctg cggctgggct cccccacaat gagattgcag
      661 cccagatctg ccgccaagcc gggctggtga agaaatccaa ggctgtgctg gattatcatg
      721 aagacaactt cgccattgtc tttgcagcca tgggggtgaa catggagaca gccaggttct
      781 tcaagtcaga tttcgagcag aatggaacca tgggaaatgt ctgtctcttc ctgaatttgg
      841 ccaatgaccc tacgattgag cggatcatca cgccacgtct ggcactgacc acggctgagt
      901 tccttgccta ccagtgtgag aagcacgtgc tggtgatact gactgacatg agctcctatg
      961 cggaggcctt gcgggaggtc tcagctgccc gggaggaagt gccaggacgc cgtggctttc
     1021 ctggatatat gtacacagac ttggccacca tctatgagcg agctggccgt gtggagggcc
     1081 ggggtggttc catcacccag atccccattc tcaccatgcc taatgatgat atcacccatc
     1141 ccatcccaga cttgactggc ttcatcacag aggggcagat ttatgtggac cgacagctac
     1201 ataaccggca ggtctaccca cccatcaatg tgctcccatc cctctcgcga ctgatgaagt
     1261 cggccatagg cgagggcatg accagaaagg accacggaga tgtctccaac cagctgtacg
     1321 cctgctacgc catcgggaag gacgtgcagg ccatgaaagc ggtggtgggg gaggaggcgc
     1381 tcacctccga ggacctgctc tacctggagt tcctgcagaa gtttgagaag aatttcatca
     1441 cccaaggtcc ttacgagaac cgcacggtgt tcgagtcgct ggacctgggc tggaaactgc
     1501 tgcgcatctt tccgaaagag atgctgaagc gcattccgca gagcatgacg gacgagttct
     1561 actctcgcca gggggcgcag caggaccccg catccgacac ggcgctctaa atcagtcccc
     1621 agctgcagcc ttctccttta tggcttgaac ccatgtttta tgccctacat tgacaggagt
     1681 gtcttttggt gtaggtgggt gggtgggctt tttttcttta ggggcttttg gagaatggaa
     1741 gcggcgaggg ggagggatat taagcaggca ctcttactcc acctcagtcc tatatattta
     1801 ttatagaagc cccgcctcca aagatgtaac tgaaatggaa aacaaaatag taactgagat
     1861 gaatttgtct ctagtgaaaa caagattggg aataatttgt taactgttga aggtgcagat
     1921 tatatcatgt ggtttgtaaa agtatttttt aaaaaaatct agttggggac aaaaaaaaaa
     1981 aaaaaa
//
