LOCUS       NM_007508               4186 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus ATPase, H+ transporting, lysosomal V1 subunit A
            (Atp6v1a), transcript variant 3, mRNA.
ACCESSION   NM_007508
VERSION     NM_007508.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4186)
  AUTHORS   Pepe,S., Aprile,D., Castroflorio,E., Marte,A., Giubbolini,S.,
            Hopestone,S., Parsons,A., Soares,T., Benfenati,F., Oliver,P.L. and
            Fassio,A.
  TITLE     TBC1D24 interacts with the v-ATPase and regulates intraorganellar
            pH in neurons
  JOURNAL   iScience 28 (1), 111515 (2024)
   PUBMED   39758816
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4186)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4186)
  AUTHORS   Castroflorio,E., den Hoed,J., Svistunova,D., Finelli,M.J.,
            Cebrian-Serrano,A., Corrochano,S., Bassett,A.R., Davies,B. and
            Oliver,P.L.
  TITLE     The Ncoa7 locus regulates V-ATPase formation and function,
            neurodevelopment and behaviour
  JOURNAL   Cell Mol Life Sci 78 (7), 3503-3524 (2021)
   PUBMED   33340069
REFERENCE   4  (bases 1 to 4186)
  AUTHORS   Bodzeta,A., Kahms,M. and Klingauf,J.
  TITLE     The Presynaptic v-ATPase Reversibly Disassembles and Thereby
            Modulates Exocytosis but Is Not Part of the Fusion Machinery
  JOURNAL   Cell Rep 20 (6), 1348-1359 (2017)
   PUBMED   28793259
REFERENCE   5  (bases 1 to 4186)
  AUTHORS   Alzamora,R., Al-Bataineh,M.M., Liu,W., Gong,F., Li,H., Thali,R.F.,
            Joho-Auchli,Y., Brunisholz,R.A., Satlin,L.M., Neumann,D.,
            Hallows,K.R. and Pastor-Soler,N.M.
  TITLE     AMP-activated protein kinase regulates the vacuolar H+-ATPase via
            direct phosphorylation of the A subunit (ATP6V1A) in the kidney
  JOURNAL   Am J Physiol Renal Physiol 305 (7), F943-F956 (2013)
   PUBMED   23863464
REFERENCE   6  (bases 1 to 4186)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 4186)
  AUTHORS   Sun-Wada,G.H., Yoshimizu,T., Imai-Senga,Y., Wada,Y. and Futai,M.
  TITLE     Diversity of mouse proton-translocating ATPase: presence of
            multiple isoforms of the C, d and G subunits
  JOURNAL   Gene 302 (1-2), 147-153 (2003)
   PUBMED   12527205
REFERENCE   8  (bases 1 to 4186)
  AUTHORS   Murata,Y., Sun-Wada,G.H., Yoshimizu,T., Yamamoto,A., Wada,Y. and
            Futai,M.
  TITLE     Differential localization of the vacuolar H+ pump with G subunit
            isoforms (G1 and G2) in mouse neurons
  JOURNAL   J Biol Chem 277 (39), 36296-36303 (2002)
   PUBMED   12133826
REFERENCE   9  (bases 1 to 4186)
  AUTHORS   Oka,T., Murata,Y., Namba,M., Yoshimizu,T., Toyomura,T.,
            Yamamoto,A., Sun-Wada,G.H., Hamasaki,N., Wada,Y. and Futai,M.
  TITLE     a4, a unique kidney-specific isoform of mouse vacuolar H+-ATPase
            subunit a
  JOURNAL   J Biol Chem 276 (43), 40050-40054 (2001)
   PUBMED   11498539
REFERENCE   10 (bases 1 to 4186)
  AUTHORS   Laitala-Leinonen,T., Howell,M.L., Dean,G.E. and Vaananen,H.K.
  TITLE     Resorption-cycle-dependent polarization of mRNAs for different
            subunits of V-ATPase in bone-resorbing osteoclasts
  JOURNAL   Mol Biol Cell 7 (1), 129-142 (1996)
   PUBMED   8741845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125098.4.
            
            On Nov 22, 2017 this sequence version replaced NM_007508.5.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154869.1, AK150742.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               AC125098.4         73033-73330
            299-394             AC125098.4         95410-95505
            395-523             AC125098.4         97550-97678
            524-738             AC125098.4         100580-100794
            739-876             AC125098.4         101060-101197
            877-1028            AC125098.4         102646-102797
            1029-1191           AC125098.4         104405-104567
            1192-1300           AC125098.4         105249-105357
            1301-1423           AC125098.4         110407-110529
            1424-1538           AC125098.4         110613-110727
            1539-1602           AC125098.4         112287-112350
            1603-1806           AC125098.4         113362-113565
            1807-1901           AC125098.4         121027-121121
            1902-2073           AC125098.4         123215-123386
            2074-4186           AC125098.4         124776-126888
FEATURES             Location/Qualifiers
     source          1..4186
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 28.44 cM"
     gene            1..4186
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2"
                     /note="ATPase, H+ transporting, lysosomal V1 subunit A"
                     /db_xref="GeneID:11964"
                     /db_xref="MGI:MGI:1201780"
     exon            1..298
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            299..394
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..2166
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2"
                     /EC_number="7.1.2.2"
                     /note="isoform 1 is encoded by transcript variant 3;
                     ATPase, H+ transporting, lysosomal 70kD, V1 subunit A;
                     ATPase, H+ transporting, V1 subunit A; ATPase, H+
                     transporting, lysosomal (vacuolar proton pump), alpha 70
                     kDa; V-type proton ATPase catalytic subunit A; V-ATPase
                     subunit A; V-ATPase 69 kDa subunit; vacuolar proton pump
                     subunit alpha; lysosomal 70kDa; 70-kDa subunit; ATPase, H+
                     transporting, V1 subunit A1"
                     /codon_start=1
                     /product="V-type proton ATPase catalytic subunit A isoform
                     1"
                     /protein_id="NP_031534.2"
                     /db_xref="CCDS:CCDS28182.1"
                     /db_xref="GeneID:11964"
                     /db_xref="MGI:MGI:1201780"
                     /translation="MDFSKLPKIRDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVR
                     VGHSELVGEIIRLEGDMATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGI
                     QRPLSDISSQTQSIYIPRGVNVSALSRDIKWEFIPSKNLRVGSHITGGDIYGIVNENS
                     LIKHKIMLPPRNRGSVTYIAPPGNYDASDVVLELEFEGVKEKFSMVQVWPVRQVRPVT
                     EKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVG
                     CGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIYTGITLS
                     EYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRV
                     KCLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNW
                     LISYSKYMRALDEYYDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKIT
                     LEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGMLSNMISFYDMARRAVETTAQSDNKIT
                     WSIIREHMGEILYKLSSMKFKDPVKDGEAKIKADYAQLLEDMQNAFRSLED"
     exon            395..523
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            524..738
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            739..876
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1028
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1191
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1300
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1423
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1538
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1602
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1806
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1901
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2073
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..4186
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6a1; Atp6a2; Atp6v1a1; VA68; VPP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcgtcttc tgtactgtag tttctgtaac ccccgtcatt gtaaaaaaaa aaagaaaaag
       61 aaaagaaaaa gaaactaacg cttttctgaa gtcgcggaac cattcacatc caaggcggtc
      121 cgcaaagatt taagcctgcg agacgcggcg tgacgggcga ggggaagcgg ggtggggctt
      181 gaggacacat gactagctag gactggcccg cctcctgcag ctgaagactt cccctctctc
      241 agtgacagag cctctgggtc ccgtctaggt acactttctg catttcgagc ccgggcaggt
      301 aaatttaaca caatggattt ctccaagcta cccaaaatcc gagatgagga taaagaaagt
      361 acatttggtt atgtgcatgg agtctcaggg cctgtggtta cagcctgtga catggcgggc
      421 gctgccatgt acgagctggt gagagtgggg cacagcgagc tggttggaga aattattcga
      481 ttggaaggtg acatggccac cattcaggtg tatgaagaaa cttctggtgt ctctgttgga
      541 gaccccgtac tccgcactgg taaacctctc tcggtcgagc tgggtcccgg gattatggga
      601 gccatttttg atggtataca gagacctctg tcggatatca gcagtcagac ccaaagtatc
      661 tacatcccca gaggagtcaa tgtgtctgct ctcagcagag atatcaaatg ggagtttata
      721 cccagcaaaa acctacgggt tggtagtcat atcactggtg gagacattta tgggattgtc
      781 aatgagaact ccctcatcaa acacaaaatc atgttgcccc cacgtaacag aggaagcgtg
      841 acttacatcg cgccgcctgg gaattatgat gcatccgatg tcgtcctgga gcttgagttt
      901 gaaggtgtga aggagaagtt cagcatggtc caagtgtggc ctgtgcggca ggtgcggcct
      961 gtcactgaga agctgcccgc caatcacccc ttgcttactg gccagagagt cctcgatgcc
     1021 cttttcccgt gtgttcaggg aggaactact gctatcccag gcgcctttgg ctgtggaaag
     1081 actgtgattt cccagtctct atccaagtac tccaacagtg acgtcatcat ctatgtcggc
     1141 tgcggtgaga gaggcaacga gatgtcagaa gttctccgcg acttccctga gctcaccatg
     1201 gaggttgatg ggaaagtaga gtccatcatg aagaggacag cgctggtagc caacacctcc
     1261 aacatgcctg tggctgcgag agaggcctcc atctacactg gaattacact atcagaatat
     1321 ttccgtgaca tgggctacca cgtcagtatg atggccgact ctacctctag atgggctgag
     1381 gccctcagag aaatctctgg tcgcttagct gagatgcctg cagatagtgg ataccctgca
     1441 taccttggtg cccggctggc ttctttctat gagcgagcag gcagagtgaa atgtctcgga
     1501 aaccctgaga gagaagggag tgtcagcatt gtaggagcag tttctccacc tggtggtgat
     1561 ttttctgatc cagtcacttc tgcaacgctg ggtattgttc aggtgttctg gggcttggat
     1621 aagaagttag ctcagcgcaa gcacttcccc tctgtcaact ggctcatcag ctacagcaag
     1681 tacatgcgtg ccctggacga gtactatgac aagcacttca cggagtttgt tcctctgagg
     1741 accaaagcta aggagatcct gcaggaagaa gaggatctgg cagaaatcgt gcagctcgtg
     1801 ggaaaggcct ctttagcaga gacggataaa atcactctgg aggtagcaaa acttattaaa
     1861 gatgacttcc tacagcaaaa tgggtacact ccttatgaca ggttctgtcc attctacaag
     1921 acagtgggga tgctgtccaa catgatttca ttctatgaca tggcccgccg agctgtggag
     1981 accactgccc agagtgacaa taagatcaca tggtccatta tccgggagca catgggggag
     2041 attctctata aactctcctc catgaaattc aaggatccag tgaaagatgg cgaggcaaag
     2101 atcaaggccg actatgcaca gcttcttgaa gatatgcaga atgcattccg tagccttgaa
     2161 gactagaact gtgatttctt ccctcttcca cggcaagctc atacgtgtat attttcctga
     2221 atttctcatc tccaaccctt agcttccata ttgtgcagct ttgagactag tgcctatgtg
     2281 tgttcttgtt cattttgctg tttctttggt aggtcttata aaacaaacat tcctttgttc
     2341 cagtgtttga aggagctagc tcccttacct ttatctgaag tggtgaatgt agtgcatatg
     2401 atatacattg taagatacac attgtaacat gatccatact gtaaacttgt atgtaaggtg
     2461 actacccctt ccctcatctc cagtaaactg taaacaggac tactgcatgt actctgttgg
     2521 gaatggaagg ccagaactcc ataccgtgga tggatgggta cttaggaaac aactcagcat
     2581 ttgtagtcag accacttgta acttagtggt ttgttgagta accattttgc aggaaatact
     2641 tccatttaaa aacataaaag attaatgttc caattatttg tatcaatcag gaccattttt
     2701 gtggggcact tgggaactat ttgtttttca aacagacatt tgcaagactg aacataatag
     2761 ataaatcagt tacctctgaa aatgtgaaag aaaggaaaaa aaaaagaacc aggtggtcaa
     2821 acttaaattg acatcatctt gttaaagcat attttatttc actaagagaa atttaatatc
     2881 agagactttt atatactcaa ttactagaaa accttttttt taagtacaat ttaaaaatca
     2941 ttgaaaatgt gatccacatc atagccattc ttttcctcag acttagtcag acaagcttct
     3001 cagagtggtg ggatggggat tagaatacca cagacactct gcagtgcctg caggcagtcg
     3061 gccccaggac aaccactgct gtaggagttt ggggccaggg tggcatggtt ttcacaaggt
     3121 acacgtgtca cgtgtttgtt tgcctgttga cattctgaaa acagcaagtt taccaattgc
     3181 agaaaatact ttctgttttc tctttcacat gctcagaaag cttctcaaag gtatctggtc
     3241 acagcagctt ccttcctgtt atagaggtaa aaggtgttct tatatttaac tggtaacaaa
     3301 agaaaaaaga aaaaagaaaa gatcaatttt tgtcttgatg tttcagtgtg tttaaataat
     3361 aattcccata cttgcttaat aaggctcgct tcagagagct tggcgagcga gctccctgtt
     3421 cactctctcc agctgatagt gctgtcagta tacacttcag atgtaatgtg taaatccttg
     3481 ctggtgcatg tctacacagt ggactgctgc tgaagaagga tattcttcca attattgaac
     3541 actgttgaca gatatggatt atgcaatggc ttgttgggag gtggattagt ggtgctgctt
     3601 aatcggtttg cttccaatgt ggcttcgtat ccaggagccc tgactagcgg agatgagaaa
     3661 gatttcaaaa cctgtctgct tatacctacc agcaacctag gcttgtgatc agaatgaatg
     3721 atcccaagaa actacttgac caagtttgtt tttgttgtcc tggattcgag atgtgttttc
     3781 ttccttgctc taagactgtt gatgtatgag tgtgaagagg ctacagaaac aatgcccaga
     3841 ttttcactgt aactttccct ttgcccacac tgtagaactt gagattgttc actgatagtg
     3901 cgtctttagt aaggatgtgt taaaatatag cagtcttttt aaaagattat gcagttctct
     3961 atttattgtg ctgtgcctgg tcctaagtgc agccggttaa acaagtttca tatgtatttt
     4021 tccagtgtta aatctcatac ctattccctt tggaaacttc catcctgaac aatgaataga
     4081 agaggctata taaattgcct ccttatcctt aagatttcac tatctttatg ttaagagtaa
     4141 tgtataatta ttaaaatcta tgaaaaataa aaagtggatt taaatt
//
