LOCUS       NM_175406               2518 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus ATPase, H+ transporting, lysosomal V0 subunit D2
            (Atp6v0d2), mRNA.
ACCESSION   NM_175406
VERSION     NM_175406.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2518)
  AUTHORS   Boyer,C.K., Blom,S.E., Machado,A.E., Rohli,K.E., Maxson,M.E. and
            Stephens,S.B.
  TITLE     Loss of the Golgi-localized v-ATPase subunit does not alter insulin
            granule formation or pancreatic islet beta-cell function
  JOURNAL   Am J Physiol Endocrinol Metab 326 (3), E245-E257 (2024)
   PUBMED   38265287
  REMARK    GeneRIF: Loss of the Golgi-localized v-ATPase subunit does not
            alter insulin granule formation or pancreatic islet beta-cell
            function.
REFERENCE   2  (bases 1 to 2518)
  AUTHORS   Wang,S., Han,Y., Liu,R., Hou,M., Neumann,D., Zhang,J., Wang,F.,
            Li,Y., Zhao,X., Schianchi,F., Dai,C., Liu,L., Nabben,M.,
            Glatz,J.F.C., Wu,X., Lu,X., Li,X. and Luiken,J.J.F.P.
  TITLE     Glycolysis-Mediated Activation of v-ATPase by Nicotinamide
            Mononucleotide Ameliorates Lipid-Induced Cardiomyopathy by
            Repressing the CD36-TLR4 Axis
  JOURNAL   Circ Res 134 (5), 505-525 (2024)
   PUBMED   38422177
  REMARK    GeneRIF: Glycolysis-Mediated Activation of v-ATPase by Nicotinamide
            Mononucleotide Ameliorates Lipid-Induced Cardiomyopathy by
            Repressing the CD36-TLR4 Axis.
REFERENCE   3  (bases 1 to 2518)
  AUTHORS   Hong,J., Mukherjee,B., Sanjoba,C., Yamagishi,J. and Goto,Y.
  TITLE     Upregulation of ATP6V0D2 benefits intracellular survival of
            Leishmania donovani in erythrocytes-engulfing macrophages
  JOURNAL   Front Cell Infect Microbiol 14, 1332381 (2024)
   PUBMED   38357442
  REMARK    GeneRIF: Upregulation of ATP6V0D2 benefits intracellular survival
            of Leishmania donovani in erythrocytes-engulfing macrophages.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2518)
  AUTHORS   Im,E., Jiang,Y., Stavrides,P.H., Darji,S., Erdjument-Bromage,H.,
            Neubert,T.A., Choi,J.Y., Wegiel,J., Lee,J.H. and Nixon,R.A.
  TITLE     Lysosomal dysfunction in Down syndrome and Alzheimer mouse models
            is caused by v-ATPase inhibition by Tyr682-phosphorylated APP
            betaCTF
  JOURNAL   Sci Adv 9 (30), eadg1925 (2023)
   PUBMED   37494443
  REMARK    GeneRIF: Lysosomal dysfunction in Down syndrome and Alzheimer mouse
            models is caused by v-ATPase inhibition by Tyr[682]-phosphorylated
            APP betaCTF.
REFERENCE   5  (bases 1 to 2518)
  AUTHORS   Shin,Y.K., Jo,Y.R., Lee,S.H., Park,H.T. and Shin,J.E.
  TITLE     Regulation of the V-ATPase subunit ATP6V0D2 and its role in
            demyelination after peripheral nerve injury
  JOURNAL   Biochem Biophys Res Commun 646, 1-7 (2023)
   PUBMED   36689911
REFERENCE   6  (bases 1 to 2518)
  AUTHORS   Nishi,T., Kawasaki-Nishi,S. and Forgac,M.
  TITLE     Expression and function of the mouse V-ATPase d subunit isoforms
  JOURNAL   J Biol Chem 278 (47), 46396-46402 (2003)
   PUBMED   12963731
  REMARK    GeneRIF: d2 is expressed mainly in kidney and at lower levels in
            heart, spleen, skeletal muscle, and testis. The d2 isoform can
            complement the yeast vma6Delta phenotype when cells are grown at
            25, but not 30, degrees C.
REFERENCE   7  (bases 1 to 2518)
  AUTHORS   Ueda,T., Ugawa,S. and Shimada,S.
  TITLE     A novel putative M9.2 isoform of V-ATPase expressed in the nervous
            system
  JOURNAL   Neuroreport 14 (1), 25-30 (2003)
   PUBMED   12544825
REFERENCE   8  (bases 1 to 2518)
  AUTHORS   Sun-Wada,G.H., Yoshimizu,T., Imai-Senga,Y., Wada,Y. and Futai,M.
  TITLE     Diversity of mouse proton-translocating ATPase: presence of
            multiple isoforms of the C, d and G subunits
  JOURNAL   Gene 302 (1-2), 147-153 (2003)
   PUBMED   12527205
REFERENCE   9  (bases 1 to 2518)
  AUTHORS   Oka,T., Murata,Y., Namba,M., Yoshimizu,T., Toyomura,T.,
            Yamamoto,A., Sun-Wada,G.H., Hamasaki,N., Wada,Y. and Futai,M.
  TITLE     a4, a unique kidney-specific isoform of mouse vacuolar H+-ATPase
            subunit a
  JOURNAL   J Biol Chem 276 (43), 40050-40054 (2001)
   PUBMED   11498539
REFERENCE   10 (bases 1 to 2518)
  AUTHORS   Hackam,D.J., Rotstein,O.D., Zhang,W., Gruenheid,S., Gros,P. and
            Grinstein,S.
  TITLE     Host resistance to intracellular infection: mutation of natural
            resistance-associated macrophage protein 1 (Nramp1) impairs
            phagosomal acidification
  JOURNAL   J Exp Med 188 (2), 351-364 (1998)
   PUBMED   9670047
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK075745.1, AY517482.1 and AK137586.1.
            
            On Mar 21, 2009 this sequence version replaced NM_175406.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY145896.1, AK170405.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1424              AK075745.1         41-1464
            1425-1675           AY517482.1         1417-1667
            1676-1679           AK137586.1         1658-1661
            1680-2518           AY517482.1         1668-2506
FEATURES             Location/Qualifiers
     source          1..2518
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 7.67 cM"
     gene            1..2518
                     /gene="Atp6v0d2"
                     /gene_synonym="1620401A02Rik; V-ATPase"
                     /note="ATPase, H+ transporting, lysosomal V0 subunit D2"
                     /db_xref="GeneID:242341"
                     /db_xref="MGI:MGI:1924415"
     exon            1..199
                     /gene="Atp6v0d2"
                     /gene_synonym="1620401A02Rik; V-ATPase"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1122
                     /gene="Atp6v0d2"
                     /gene_synonym="1620401A02Rik; V-ATPase"
                     /EC_number="7.1.2.2"
                     /note="vacuolar proton-translocating ATPase d subunit d2;
                     V-ATPase subunit d 2; vacuolar proton pump subunit d 2;
                     osteoclast-specific vacuolar ATP synthase"
                     /codon_start=1
                     /product="V-type proton ATPase subunit d 2"
                     /protein_id="NP_780615.2"
                     /db_xref="CCDS:CCDS17994.1"
                     /db_xref="GeneID:242341"
                     /db_xref="MGI:MGI:1924415"
                     /translation="MLETAELYFNVDHGYLEGLVRGCKASLLTQQDYVNLVQCETLED
                     LKIHLQTTDYGNFLANETNPLTVSKIDTEMRKKLCREFDYFRNHSLEPLSTFLTYMTC
                     SYMIDNIILLMNGALQKKSVKEVLAKCHPLGRFTEMEAVNIAETPSDLFKAVLVETPL
                     APFFQDCMSENTLDELNIELLRNKLYKSYLEAFYKFCKDHGDVTADVMCPILEFEADR
                     RALIITLNSFGTELSKEDRETLFPTCGRLYPEGLRLLAQAEDFEQMKRVADNYGVYKP
                     LFDAVGGSGGKTLEDVFYEREVQMNVLAFNRQFHYGVFYAYVKLKEQEMRNIVWIAEC
                     ISQRHRTKINSYIPIL"
     exon            200..371
                     /gene="Atp6v0d2"
                     /gene_synonym="1620401A02Rik; V-ATPase"
                     /inference="alignment:Splign:2.1.0"
     exon            372..550
                     /gene="Atp6v0d2"
                     /gene_synonym="1620401A02Rik; V-ATPase"
                     /inference="alignment:Splign:2.1.0"
     exon            551..630
                     /gene="Atp6v0d2"
                     /gene_synonym="1620401A02Rik; V-ATPase"
                     /inference="alignment:Splign:2.1.0"
     exon            631..708
                     /gene="Atp6v0d2"
                     /gene_synonym="1620401A02Rik; V-ATPase"
                     /inference="alignment:Splign:2.1.0"
     exon            709..885
                     /gene="Atp6v0d2"
                     /gene_synonym="1620401A02Rik; V-ATPase"
                     /inference="alignment:Splign:2.1.0"
     exon            886..960
                     /gene="Atp6v0d2"
                     /gene_synonym="1620401A02Rik; V-ATPase"
                     /inference="alignment:Splign:2.1.0"
     exon            961..2503
                     /gene="Atp6v0d2"
                     /gene_synonym="1620401A02Rik; V-ATPase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1256..1261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v0d2"
                     /gene_synonym="1620401A02Rik; V-ATPase"
                     /note="hexamer: AGTAAA"
     polyA_site      1278
                     /gene="Atp6v0d2"
                     /gene_synonym="1620401A02Rik; V-ATPase"
                     /note="major polyA site"
     regulatory      2480..2485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v0d2"
                     /gene_synonym="1620401A02Rik; V-ATPase"
                     /note="hexamer: AATAAA"
     polyA_site      2503
                     /gene="Atp6v0d2"
                     /gene_synonym="1620401A02Rik; V-ATPase"
                     /note="major polyA site"
ORIGIN      
        1 acactttccc ggaccagggc cagtgttcag ttgctatcca ggactcggag ccacttcagc
       61 ctgagcagta tgcttgagac tgcagagctg tacttcaatg tggaccatgg ctacctggag
      121 ggcctggttc gaggatgcaa agccagcctc ctaactcagc aggactatgt caacctagtg
      181 cagtgtgaga ccttggaaga cctgaaaatt catctccaga ccacggacta tggcaacttc
      241 ctggctaatg aaacaaatcc tctcactgtt tccaaaattg acacggagat gaggaagaag
      301 ctctgcagag agtttgacta tttccggaat cattccttgg agcccctgag cacatttctc
      361 acctacatga catgcagcta tatgatagac aatataattc tacttatgaa tggggccttg
      421 caaaagaaat ctgtgaaaga agttctagcc aagtgtcacc cactgggccg tttcacagag
      481 atggaagctg tcaacattgc agagaccccc tcagatctct tcaaggctgt gctggttgaa
      541 acaccattag ctccattctt tcaagattgt atgtctgaaa acactcttga tgaactgaat
      601 attgaattac tgcgcaataa actatacaag tcttaccttg aggcattcta caaattctgc
      661 aaggatcacg gtgatgtcac agcagacgtt atgtgtccca ttcttgagtt tgaggccgac
      721 agacgcgctt taatcatcac tctgaactca tttggcactg aactaagcaa agaagacagg
      781 gagaccctct tccccacctg cggcaggctc tatccagagg ggttgcggtt gttagctcaa
      841 gctgaagact ttgagcagat gaagagagtg gcagataatt atggagttta caagcctttg
      901 tttgacgctg tcggtggcag tggggggaag acactggaag acgttttcta tgagagagag
      961 gtacagatga atgtgctggc attcaacagg caattccatt atggtgtgtt ttatgcgtat
     1021 gtaaagttga aggagcaaga gatgagaaat atcgtgtgga tagcagaatg catctcacag
     1081 aggcatcgaa ctaaaatcaa cagctacatt ccaattttat aagccagtgt acagaagatc
     1141 atacatgttg ccatgaagtt attgaggaaa ggaaggggga ttgtgtcaca ttatctagat
     1201 tatataaaag taagtcatac cacctttcca taaactacat gtccactgga agcccagtaa
     1261 acagaacttg aaacaaaata tgcctttctt gtttccaaca agccccagtc gttttttcac
     1321 atttatgact tcctgctcac tggcctcata cgttcatttt cattgaccct gtggcacttt
     1381 ttgtattctc atttggtcag actaaaatca tacgtaatca ggttcttcac gagttctttt
     1441 ccgttcttct ccccaagctc aaacactgct ttgcctttta cgtgtttggt ccttccatgc
     1501 attcacgaaa atgcaaagct gtgggtagct aacatacacc atgcttggtg aagacacgtt
     1561 cccttccttt cccccaagac ttttgagaaa gatagattcc ccaaatgcaa gcattgttaa
     1621 atttattact aaattagatt atcaacgcac acatagagac agagagagag agagagagac
     1681 agacagacag acagacagaa ggatgaataa cttatatcga tatgtatacc agtggttctg
     1741 tcatacttta ttccagaaaa tccaactaat tgtactttat tccttcagaa gatgtagata
     1801 cagcatggtt gctacataaa gttgaaacaa tgcagaggtt gctcagaaaa agaaaaatag
     1861 caaaatgtgt ctccaatctt ttctttaaat aggaaatttt tcttaaatat agtctatgct
     1921 tgctctgctt cacaaattaa atctgtgcag tcaacatgat gactcagcag gtaagagctt
     1981 gaagtcaact ccatgagttc gattcctgga atctcacata tggaaggagg gaactgcaaa
     2041 actacaagat catctttaat cctttaatct ttacttatgc accccaccac tacacacact
     2101 tacaaaagaa ttttaaagaa gggcacagaa ataatgtgaa ctaattttac tatacactct
     2161 ctatatacac atgctatgta gaatagtatg cataaactaa ggagcacaac atttttatgt
     2221 agaataatca tttataaata taacaaaaat aatgttttgt tgaactaaga agaaagccaa
     2281 gtgcctactc cttgactgca gatgcaattt acccagctgc ctcctgccca gaccaacaca
     2341 ccttctcaac caccttagac tgtcctctca aaccctgacc caaaagaaac ccttcccttt
     2401 ctaaactgtt gtttcaggta ttttgtggca gcaacacaac aaagtaacta atacagaaaa
     2461 ctgatactgc cattgctaca ataaacttga ttttgggatt gccaaaaaaa aaaaaaaa
//
