LOCUS       NM_013477               1668 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ATPase, H+ transporting, lysosomal V0 subunit D1
            (Atp6v0d1), mRNA.
ACCESSION   NM_013477
VERSION     NM_013477.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1668)
  AUTHORS   Yuan,W., Lin,H., Sun,Y., Liu,L., Yan,M., Song,Y., Zhang,X., Lu,X.,
            Xu,Y., He,Q., Ouyang,K., Zhang,C., Pan,Y., Huang,Y., Li,Y., Lu,X.
            and Liu,J.
  TITLE     Myocardin reverses insulin resistance and ameliorates
            cardiomyopathy by increasing IRS-1 expression in a murine model of
            lipodystrophy caused by adipose deficiency of vacuolar H+-ATPase
            V0d1 subunit
  JOURNAL   Theranostics 14 (5), 2246-2264 (2024)
   PUBMED   38505620
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1668)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1668)
  AUTHORS   Chen,F., Zhu,S., Kang,R., Tang,D. and Liu,J.
  TITLE     ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal
            pH homeostasis
  JOURNAL   Cell Rep 42 (1), 111911 (2023)
   PUBMED   36640329
  REMARK    GeneRIF: ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated
            lysosomal pH homeostasis.
REFERENCE   4  (bases 1 to 1668)
  AUTHORS   Mohammed,Y., Michaud,S.A., Petrosova,H., Yang,J., Ganguly,M.,
            Schibli,D., Flenniken,A.M., Nutter,L.M.J., Adissu,H.A.,
            Lloyd,K.C.K., McKerlie,C. and Borchers,C.H.
  TITLE     Proteotyping of knockout mouse strains reveals sex- and
            strain-specific signatures in blood plasma
  JOURNAL   NPJ Syst Biol Appl 7 (1), 25 (2021)
   PUBMED   34050187
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1668)
  AUTHORS   Hashimoto,Y., Shirane,M. and Nakayama,K.I.
  TITLE     TMEM55B contributes to lysosomal homeostasis and amino acid-induced
            mTORC1 activation
  JOURNAL   Genes Cells 23 (6), 418-434 (2018)
   PUBMED   29644770
REFERENCE   6  (bases 1 to 1668)
  AUTHORS   Nishi,T., Kawasaki-Nishi,S. and Forgac,M.
  TITLE     Expression and function of the mouse V-ATPase d subunit isoforms
  JOURNAL   J Biol Chem 278 (47), 46396-46402 (2003)
   PUBMED   12963731
  REMARK    GeneRIF: Comparison of the kinetics of V-ATPase complexes
            containing Vma6p and d1 demonstrate that although the Km for ATP
            hydrolysis is similar, the coupling ratio is approximately 3-6-fold
            higher for d1-containing complexes than for Vma6p-containing
            complexes.
REFERENCE   7  (bases 1 to 1668)
  AUTHORS   Miura,G.I., Froelick,G.J., Marsh,D.J., Stark,K.L. and Palmiter,R.D.
  TITLE     The d subunit of the vacuolar ATPase (Atp6d) is essential for
            embryonic development
  JOURNAL   Transgenic Res 12 (1), 131-133 (2003)
   PUBMED   12650533
REFERENCE   8  (bases 1 to 1668)
  AUTHORS   Sun-Wada,G.H., Yoshimizu,T., Imai-Senga,Y., Wada,Y. and Futai,M.
  TITLE     Diversity of mouse proton-translocating ATPase: presence of
            multiple isoforms of the C, d and G subunits
  JOURNAL   Gene 302 (1-2), 147-153 (2003)
   PUBMED   12527205
REFERENCE   9  (bases 1 to 1668)
  AUTHORS   Hackam,D.J., Rotstein,O.D., Zhang,W., Gruenheid,S., Gros,P. and
            Grinstein,S.
  TITLE     Host resistance to intracellular infection: mutation of natural
            resistance-associated macrophage protein 1 (Nramp1) impairs
            phagosomal acidification
  JOURNAL   J Exp Med 188 (2), 351-364 (1998)
   PUBMED   9670047
REFERENCE   10 (bases 1 to 1668)
  AUTHORS   Carrion-Vazquez,M., Fernandez,A.M., Chowen,J. and Nieto-Sampedro,M.
  TITLE     Brain Ac39/physophilin: cloning, coexpression and colocalization
            with synaptophysin
  JOURNAL   Eur J Neurosci 10 (3), 1153-1166 (1998)
   PUBMED   9753184
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151573.2, AK083372.1 and CD776853.1.
            
            On Mar 28, 2018 this sequence version replaced NM_013477.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083372.1, AK171515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC151573.2         183373-183396       c
            25-1641             AK083372.1         2-1618
            1642-1668           CD776853.1         1-27                c
FEATURES             Location/Qualifiers
     source          1..1668
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..1668
                     /gene="Atp6v0d1"
                     /gene_synonym="Ac39; Atp6d; P39; VATX; Vma6"
                     /note="ATPase, H+ transporting, lysosomal V0 subunit D1"
                     /db_xref="GeneID:11972"
                     /db_xref="MGI:MGI:1201778"
     exon            1..282
                     /gene="Atp6v0d1"
                     /gene_synonym="Ac39; Atp6d; P39; VATX; Vma6"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1208
                     /gene="Atp6v0d1"
                     /gene_synonym="Ac39; Atp6d; P39; VATX; Vma6"
                     /EC_number="7.1.2.2"
                     /note="ATPase, H+ transporting, lysosomal 38kDa, V0
                     subunit D; ATPase, H+ transporting, V0 subunit D;
                     physophilin; V-ATPase subunit d 1; V-ATPase AC39 subunit;
                     vacuolar proton pump subunit d 1; V-ATPase 40 kDa
                     accessory protein; ATPase, H+ transporting, lysosomal
                     (vacuolar proton pump), 42 kDa"
                     /codon_start=1
                     /product="V-type proton ATPase subunit d 1"
                     /protein_id="NP_038505.2"
                     /db_xref="CCDS:CCDS22604.1"
                     /db_xref="GeneID:11972"
                     /db_xref="MGI:MGI:1201778"
                     /translation="MSFFPELYFNVDNGYLEGLVRGLKAGVLSQADYLNLVQCETLED
                     LKLHLQSTDYGNFLANEASPLTVSVIDDKLKEKMVVEFRHMRNHAYEPLASFLDFITY
                     SYMIDNVILLITGTLHQRSIAELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPL
                     AAFFQDCISEQDLDEMNIEIIRNTLYKAYLESFYKFCTLLGGTTADAMCPILEFEADR
                     RAFIITINSFGTELSKEDRAKLFPHCGRLYPEGLAQLARADDYEQVKNVADYYPEYKL
                     LFEGAGSNPGDKTLEDRFFEHEVKLNKLAFLNQFHFGVFYAFVKLKEQECRNIVWIAE
                     CIAQRHRAKIDNYIPIF"
     exon            283..454
                     /gene="Atp6v0d1"
                     /gene_synonym="Ac39; Atp6d; P39; VATX; Vma6"
                     /inference="alignment:Splign:2.1.0"
     exon            455..633
                     /gene="Atp6v0d1"
                     /gene_synonym="Ac39; Atp6d; P39; VATX; Vma6"
                     /inference="alignment:Splign:2.1.0"
     exon            634..713
                     /gene="Atp6v0d1"
                     /gene_synonym="Ac39; Atp6d; P39; VATX; Vma6"
                     /inference="alignment:Splign:2.1.0"
     exon            714..791
                     /gene="Atp6v0d1"
                     /gene_synonym="Ac39; Atp6d; P39; VATX; Vma6"
                     /inference="alignment:Splign:2.1.0"
     exon            792..968
                     /gene="Atp6v0d1"
                     /gene_synonym="Ac39; Atp6d; P39; VATX; Vma6"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1046
                     /gene="Atp6v0d1"
                     /gene_synonym="Ac39; Atp6d; P39; VATX; Vma6"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1650
                     /gene="Atp6v0d1"
                     /gene_synonym="Ac39; Atp6d; P39; VATX; Vma6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1624..1629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v0d1"
                     /gene_synonym="Ac39; Atp6d; P39; VATX; Vma6"
                     /note="hexamer: AATAAA"
     polyA_site      1649
                     /gene="Atp6v0d1"
                     /gene_synonym="Ac39; Atp6d; P39; VATX; Vma6"
                     /note="major polyA site"
ORIGIN      
        1 gtgagacgcg gtgcgtcacc tgacgcactt gacagcccgc tgcggccgcc gcgtcagctg
       61 atccggggag tctagttgcg tgcgggcaga tcggggctct ctggtcccgc cgccccccgc
      121 ctcccctgcc gcctcccacc cccgccgcag ccatgtcgtt cttcccggag ctctatttca
      181 acgtggacaa tggctacttg gagggattag tgcgcggcct gaaggccggg gtgctcagcc
      241 aggcggacta cctcaacctg gtgcagtgcg agacgctcga ggacttgaag ctgcacctac
      301 agagtacaga ttatggcaac ttcctggcca atgaagcgtc acctctgacg gtgtcagtca
      361 tcgatgacaa gctcaaggag aagatggtag tagagttccg ccacatgaga aaccatgctt
      421 atgagccgct cgccagcttc ctggacttca taacttatag ctacatgatt gacaacgtga
      481 tcctgctaat cacaggcaca ctgcaccagc gttcaatagc tgaacttgtg cccaagtgcc
      541 atccgctagg cagctttgag cagatggagg ctgtgaacat cgcacagaca cctgcagagc
      601 tctacaatgc cattctggtg gacacacccc tggcggcttt tttccaggac tgcatctcag
      661 agcaggacct tgatgagatg aacatcgaga taatccgaaa tacgctttac aaggcctact
      721 tggagtcctt ctacaagttc tgtactctgt tgggtgggac cacagctgat gccatgtgtc
      781 ctatcctaga gtttgaagca gaccgccgcg ctttcatcat caccatcaac tctttcggca
      841 cagagctgtc caaggaggac cgtgccaagc tcttcccgca ctgtggccgg ctctaccctg
      901 agggcttggc tcagctggcg cgggctgatg actatgaaca ggtcaagaat gtagctgatt
      961 actacccgga atacaaactg ctttttgagg gtgcaggtag caatcctgga gacaagaccc
     1021 tggaggaccg gttttttgaa catgaggtga agctaaacaa gctggccttc ctgaaccagt
     1081 tccattttgg tgtcttttat gcctttgtga agcttaagga acaggaatgt cgcaacatcg
     1141 tatggattgc tgagtgcatt gcccagcgcc atcgcgccaa gatcgacaac tacatcccca
     1201 tcttttagca ttctaactta aggttcccaa gtgcactgtg tgtgtgtctg tgtgctgtgg
     1261 tgaagcccag ggctcacttg tctgacctgg tgaggtgtag cattgtcctg ggattgtttg
     1321 cccagcttcc atgacccctt ctgggactac tcttaggcct aaaaaggggt taggcacctc
     1381 tcccctgatc aagaatggac caagattccc tccagagcag agaggccccc agccctatgt
     1441 ttacagccac tgacatgtct aagaaacttg tatgactttc atgtccctcc ttagcctaag
     1501 gacccctggg acagtgtcca taggtcatcc ccagaacctg tgggaagagt agagaatatg
     1561 tattcttggg gtattgggaa agcagctttg tagccttctc cctccgctct gcccctctga
     1621 gacaataaaa ttgccctctt taaaaaccct aaaaaaaaaa aaaaaaaa
//
