LOCUS       NM_009729               1197 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Mus musculus ATPase, H+ transporting, lysosomal V0 subunit C
            (Atp6v0c), transcript variant 3, mRNA.
ACCESSION   NM_009729
VERSION     NM_009729.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1197)
  AUTHORS   Ren,X., Wang,J., Wei,H., Li,X., Tian,Y., Wang,Z., Yin,Y., Guo,Z.,
            Qin,Z., Wu,M. and Zeng,X.
  TITLE     Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular
            cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C
            expression and interacting with SNAREs
  JOURNAL   Int J Biol Sci 20 (5), 1905-1926 (2024)
   PUBMED   38481802
  REMARK    GeneRIF: Impaired TFEB-mediated autophagy-lysosome fusion promotes
            tubular cell cycle G2/M arrest and renal fibrosis by suppressing
            ATP6V0C expression and interacting with SNAREs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1197)
  AUTHORS   Salamon,I., Park,Y., Miskic,T., Kopic,J., Matteson,P., Page,N.F.,
            Roque,A., McAuliffe,G.W., Favate,J., Garcia-Forn,M., Shah,P.,
            Judas,M., Millonig,J.H., Kostovic,I., De Rubeis,S., Hart,R.P.,
            Krsnik,Z. and Rasin,M.R.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1197)
  AUTHORS   Sun-Wada,G.H., Tabata,H. and Wada,Y.
  TITLE     Vacuolar-type proton ATPase is required for maintenance of
            apicobasal polarity of embryonic visceral endoderm
  JOURNAL   Sci Rep 11 (1), 19355 (2021)
   PUBMED   34588579
  REMARK    GeneRIF: Vacuolar-type proton ATPase is required for maintenance of
            apicobasal polarity of embryonic visceral endoderm.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1197)
  AUTHORS   Li,J., Sun,L., Peng,X.L., Yu,X.M., Qi,S.J., Lu,Z.J., Han,J.J. and
            Shen,Q.
  TITLE     Integrative genomic analysis of early neurogenesis reveals a
            temporal genetic program for differentiation and specification of
            preplate and Cajal-Retzius neurons
  JOURNAL   PLoS Genet 17 (3), e1009355 (2021)
   PUBMED   33760820
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1197)
  AUTHORS   Huang,X., Kuang,S., Shen,Z., Liang,M. and Lin,Z.
  TITLE     High glucose disrupts autophagy lysosomal pathway in gingival
            epithelial cells via ATP6V0C
  JOURNAL   J Periodontol 91 (5), 705-714 (2020)
   PUBMED   31471894
  REMARK    GeneRIF: High glucose disrupts autophagy lysosomal pathway in
            gingival epithelial cells via ATP6V0C.
REFERENCE   6  (bases 1 to 1197)
  AUTHORS   Inoue,H., Noumi,T., Nagata,M., Murakami,H. and Kanazawa,H.
  TITLE     Targeted disruption of the gene encoding the proteolipid subunit of
            mouse vacuolar H(+)-ATPase leads to early embryonic lethality
  JOURNAL   Biochim Biophys Acta 1413 (3), 130-138 (1999)
   PUBMED   10556625
REFERENCE   7  (bases 1 to 1197)
  AUTHORS   Bronson,R.T., Donahue,L.R., Johnson,K.R., Tanner,A., Lane,P.W. and
            Faust,J.R.
  TITLE     Neuronal ceroid lipofuscinosis (nclf), a new disorder of the mouse
            linked to chromosome 9
  JOURNAL   Am J Med Genet 77 (4), 289-297 (1998)
   PUBMED   9600738
REFERENCE   8  (bases 1 to 1197)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (bases 1 to 1197)
  AUTHORS   Laitala-Leinonen,T., Howell,M.L., Dean,G.E. and Vaananen,H.K.
  TITLE     Resorption-cycle-dependent polarization of mRNAs for different
            subunits of V-ATPase in bone-resorbing osteoclasts
  JOURNAL   Mol Biol Cell 7 (1), 129-142 (1996)
   PUBMED   8741845
REFERENCE   10 (bases 1 to 1197)
  AUTHORS   Hanada,H., Hasebe,M., Moriyama,Y., Maeda,M. and Futai,M.
  TITLE     Molecular cloning of cDNA encoding the 16 KDa subunit of vacuolar
            H(+)-ATPase from mouse cerebellum
  JOURNAL   Biochem Biophys Res Commun 176 (3), 1062-1067 (1991)
   PUBMED   1828149
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY245103.1, AK002570.1 and BC050939.1.
            
            On Mar 28, 2018 this sequence version replaced NM_009729.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (b) is
            shorter at the N-terminus compared to isoform a. Variants 2 and 3
            both encode the same isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099475.1, AK014361.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BY245103.1         2-45
            45-1170             AK002570.1         33-1158
            1171-1197           BC050939.1         892-918
FEATURES             Location/Qualifiers
     source          1..1197
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.29 cM"
     gene            1..1197
                     /gene="Atp6v0c"
                     /gene_synonym="Atp6c; Atp6c2; Atp6l; Atpl; Atpl-rs1; PL16;
                     VATL; Vma3"
                     /note="ATPase, H+ transporting, lysosomal V0 subunit C"
                     /db_xref="GeneID:11984"
                     /db_xref="MGI:MGI:88116"
     exon            1..245
                     /gene="Atp6v0c"
                     /gene_synonym="Atp6c; Atp6c2; Atp6l; Atpl; Atpl-rs1; PL16;
                     VATL; Vma3"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..634
                     /gene="Atp6v0c"
                     /gene_synonym="Atp6c; Atp6c2; Atp6l; Atpl; Atpl-rs1; PL16;
                     VATL; Vma3"
                     /EC_number="7.1.2.2"
                     /note="isoform b is encoded by transcript variant 3;
                     ATPase, H+ transporting, lysosomal 16kD, V0 subunit C;
                     ATPase, H+ transporting, lysosomal (vacuolar proton pump)
                     16 kDa; V-type proton ATPase 16 kDa proteolipid subunit;
                     V-ATPase 16 kDa proteolipid subunit; vacuolar proton pump
                     16 kDa proteolipid subunit; ATPase, H+ transporting,
                     lysosomal 2; H(+)-ATPase (mvp); V-ATPase 16 kDa
                     proteolipid subunit c; vacuolar proton pump 16 kDa
                     proteolipid subunit c; V-type proton ATPase 16 kDa
                     proteolipid subunit c"
                     /codon_start=1
                     /product="V-type proton ATPase 16 kDa proteolipid subunit
                     c isoform b"
                     /protein_id="NP_033859.1"
                     /db_xref="CCDS:CCDS28476.1"
                     /db_xref="GeneID:11984"
                     /db_xref="MGI:MGI:88116"
                     /translation="MADIKNNPEYSSFFGVMGASSAMVFSAMGAAYGTAKSGTGIAAM
                     SVMRPELIMKSIIPVVMAGIIAIYGLVVAVLIANSLTDGITLYRSFLQLGAGLSVGLS
                     GLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK"
     exon            246..429
                     /gene="Atp6v0c"
                     /gene_synonym="Atp6c; Atp6c2; Atp6l; Atpl; Atpl-rs1; PL16;
                     VATL; Vma3"
                     /inference="alignment:Splign:2.1.0"
     exon            430..1173
                     /gene="Atp6v0c"
                     /gene_synonym="Atp6c; Atp6c2; Atp6l; Atpl; Atpl-rs1; PL16;
                     VATL; Vma3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1153..1158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v0c"
                     /gene_synonym="Atp6c; Atp6c2; Atp6l; Atpl; Atpl-rs1; PL16;
                     VATL; Vma3"
                     /note="hexamer: AATAAA"
     polyA_site      1173
                     /gene="Atp6v0c"
                     /gene_synonym="Atp6c; Atp6c2; Atp6l; Atpl; Atpl-rs1; PL16;
                     VATL; Vma3"
                     /note="major polyA site"
ORIGIN      
        1 ggccgccatc ttgctttgcg gtgctggtat ttagagcgca gcgcctgact ggcggggtcg
       61 ccttcccatc cgctgcctcg acgatcttcg cttgcctcct cgctcgctgt cccgttgtcc
      121 tagctcgccg ccgcccgctg agcttgtctt ttccctgctt gcagacatgg ctgacatcaa
      181 gaacaacccc gaatattctt cgtttttcgg tgtcatgggc gcctcgtccg ccatggtctt
      241 cagcgccatg ggagccgcct atggcacagc caagagtggc actggcatcg cagccatgtc
      301 agtcatgagg ccagagctga tcatgaagtc catcatccca gtggttatgg ctgggatcat
      361 cgccatctac ggcctggtgg tggcagtact tatcgctaac tccctgactg atggcatcac
      421 cctctacagg agttttcttc aactgggtgc tggcctgagt gtggggctga gtggcctggc
      481 tgctggcttt gccattggca tcgtcggaga tgctggtgtt cggggcactg cccagcagcc
      541 tcgactgttc gtgggcatga tcctgatcct catctttgcg gaggtgcttg gcctctacgg
      601 tctcatcgtg gccctaatcc tctccacaaa gtagtccttt tccaccatca gtcacaggat
      661 aggatgtaaa gatcacccct cctcattcca gaacgaacag cctgacacat gcacgggcag
      721 ctgcccctca gtagttggtc ttgtaaatgt gcagtgtcct agtgcccatt gtctgtcgcc
      781 cccgccttgc ccctactgca ccgtgctgtg gacatacggg cccactcatc tcccacccag
      841 gcccctgacc agtgacgaag tcagcctctg gttaccccac ccatcgccct agagtgctcc
      901 tgtgtataag aatgaactag agttgtcatt tttctcttca ctggatgttt atttataaaa
      961 gatttgacct attcatgcgt ctgtggagca gctcctgtct cccaactata tagtaatcat
     1021 tagtagactg ttgccttgtg gggttcctgt tgctgagact ccttggatgg agccaccctt
     1081 ccccctgccc tgaacagcca gggtggagga tagagtgcta ctgctcctca gagctggctc
     1141 ccagctgtgt ccaataaaag ttctcggatg tgaaaaaaaa aaaaaaaaaa aaaaaaa
//
