LOCUS       NM_033617                983 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus ATPase, H+ transporting, lysosomal V0 subunit B
            (Atp6v0b), transcript variant 1, mRNA.
ACCESSION   NM_033617
VERSION     NM_033617.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 983)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 983)
  AUTHORS   Wee,Y.S., Roundy,K.M., Weis,J.J. and Weis,J.H.
  TITLE     Interferon-inducible transmembrane proteins of the innate immune
            response act as membrane organizers by influencing clathrin and
            v-ATPase localization and function
  JOURNAL   Innate Immun 18 (6), 834-845 (2012)
   PUBMED   22467717
REFERENCE   3  (bases 1 to 983)
  AUTHORS   Nishi,T., Kawasaki-Nishi,S. and Forgac,M.
  TITLE     Expression and function of the mouse V-ATPase d subunit isoforms
  JOURNAL   J Biol Chem 278 (47), 46396-46402 (2003)
   PUBMED   12963731
REFERENCE   4  (bases 1 to 983)
  AUTHORS   Mburu,P., Mustapha,M., Varela,A., Weil,D., El-Amraoui,A.,
            Holme,R.H., Rump,A., Hardisty,R.E., Blanchard,S., Coimbra,R.S.,
            Perfettini,I., Parkinson,N., Mallon,A.M., Glenister,P.,
            Rogers,M.J., Paige,A.J., Moir,L., Clay,J., Rosenthal,A., Liu,X.Z.,
            Blanco,G., Steel,K.P., Petit,C. and Brown,S.D.
  TITLE     Defects in whirlin, a PDZ domain molecule involved in stereocilia
            elongation, cause deafness in the whirler mouse and families with
            DFNB31
  JOURNAL   Nat Genet 34 (4), 421-428 (2003)
   PUBMED   12833159
REFERENCE   5  (bases 1 to 983)
  AUTHORS   Nishi,T., Kawasaki-Nishi,S. and Forgac,M.
  TITLE     Expression and localization of the mouse homologue of the yeast
            V-ATPase 21-kDa Subunit c' (Vma16p)
  JOURNAL   J Biol Chem 276 (36), 34122-34130 (2001)
   PUBMED   11441017
REFERENCE   6  (bases 1 to 983)
  AUTHORS   Sun-Wada,G.H., Murakami,H., Nakai,H., Wada,Y. and Futai,M.
  TITLE     Mouse Atp6f, the gene encoding the 23-kDa proteolipid of vacuolar
            proton translocating ATPase
  JOURNAL   Gene 274 (1-2), 93-99 (2001)
   PUBMED   11675001
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627128.16.
            
            On Mar 30, 2023 this sequence version replaced NM_033617.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151847.1, AK152823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AL627128.16        126002-126148       c
            148-196             AL627128.16        125422-125470       c
            197-280             AL627128.16        125108-125191       c
            281-358             AL627128.16        124900-124977       c
            359-428             AL627128.16        124636-124705       c
            429-480             AL627128.16        124461-124512       c
            481-671             AL627128.16        123936-124126       c
            672-983             AL627128.16        123162-123473       c
FEATURES             Location/Qualifiers
     source          1..983
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.73 cM"
     gene            1..983
                     /gene="Atp6v0b"
                     /gene_synonym="2310024H13Rik; Atp6f; VMA16"
                     /note="ATPase, H+ transporting, lysosomal V0 subunit B"
                     /db_xref="GeneID:114143"
                     /db_xref="MGI:MGI:1890510"
     exon            1..147
                     /gene="Atp6v0b"
                     /gene_synonym="2310024H13Rik; Atp6f; VMA16"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..698
                     /gene="Atp6v0b"
                     /gene_synonym="2310024H13Rik; Atp6f; VMA16"
                     /EC_number="7.1.2.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATPase, H+ transporting, lysosomal 21kDa, V0 subunit B;
                     ATPase, H+ transporting, V0 subunit B; V-type proton
                     ATPase 21 kDa proteolipid subunit; 23 kDa subunit of
                     V-ATPase; V-ATPase 21 kDa proteolipid subunit; vacuolar
                     proton pump 21 kDa proteolipid subunit; ATPase, H+
                     transporting, lysosomal (vacuolar proton pump); V-ATPase
                     21 kDa proteolipid subunit c''; vacuolar proton pump 21
                     kDa proteolipid subunit c''; V-type proton ATPase 21 kDa
                     proteolipid subunit c''"
                     /codon_start=1
                     /product="V-type proton ATPase 21 kDa proteolipid subunit
                     c'' isoform 1"
                     /protein_id="NP_291095.1"
                     /db_xref="CCDS:CCDS18540.1"
                     /db_xref="GeneID:114143"
                     /db_xref="MGI:MGI:1890510"
                     /translation="MTGLELLYLGIFVAFWACMVVVGICYTIFDLGFRFDVAWFLTET
                     SPFMWSNLGIGLAISLSVVGAAWGIYITGSSIIGGGVKAPRIKTKNLVSIIFCEAVAI
                     YGIIMAIVISNMAEPFSATEPKAIGHRNYHAGYSMFGAGLTVGLSNLFCGVCVGIVGS
                     GAALADAQNPSLFVKILIVEIFGSAIGLFGVIVAILQTSRVKMGD"
     exon            148..196
                     /gene="Atp6v0b"
                     /gene_synonym="2310024H13Rik; Atp6f; VMA16"
                     /inference="alignment:Splign:2.1.0"
     exon            197..280
                     /gene="Atp6v0b"
                     /gene_synonym="2310024H13Rik; Atp6f; VMA16"
                     /inference="alignment:Splign:2.1.0"
     exon            281..358
                     /gene="Atp6v0b"
                     /gene_synonym="2310024H13Rik; Atp6f; VMA16"
                     /inference="alignment:Splign:2.1.0"
     exon            359..428
                     /gene="Atp6v0b"
                     /gene_synonym="2310024H13Rik; Atp6f; VMA16"
                     /inference="alignment:Splign:2.1.0"
     exon            429..480
                     /gene="Atp6v0b"
                     /gene_synonym="2310024H13Rik; Atp6f; VMA16"
                     /inference="alignment:Splign:2.1.0"
     exon            481..671
                     /gene="Atp6v0b"
                     /gene_synonym="2310024H13Rik; Atp6f; VMA16"
                     /inference="alignment:Splign:2.1.0"
     exon            672..983
                     /gene="Atp6v0b"
                     /gene_synonym="2310024H13Rik; Atp6f; VMA16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      962..967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v0b"
                     /gene_synonym="2310024H13Rik; Atp6f; VMA16"
                     /note="hexamer: AATAAA"
     polyA_site      983
                     /gene="Atp6v0b"
                     /gene_synonym="2310024H13Rik; Atp6f; VMA16"
                     /note="major polyA site"
ORIGIN      
        1 gggccgacag actgcggggc ggacggtgga cgcggtttag ctcaggtccc accgatccga
       61 cccctgccgt cgccgctgcc atgacggggc tggagttgct ctacctcggg atctttgtgg
      121 ccttctgggc ctgcatggtc gttgtgggaa tctgctacac catctttgac ctgggctttc
      181 gctttgatgt ggcatggttc ctgacggaaa cttccccctt catgtggtcg aatctgggca
      241 ttggcctagc aatttctctg tctgtggttg gagcagcctg gggaatctat ataaccggct
      301 catccattat tgggggtggg gtgaaagccc ccagaatcaa aaccaagaac ttggttagta
      361 ttatcttctg tgaagcggtg gccatctatg gcatcatcat ggcaattgtc atcagcaaca
      421 tggctgagcc tttcagtgct acggagccca aggccattgg ccatcgaaac taccatgcag
      481 gttactccat gtttggggct ggcctcacag tcggtctgtc caacctgttc tgtggagtct
      541 gcgtgggcat cgtgggcagt ggggccgccc tggcggatgc acagaacccc agcctctttg
      601 taaaaattct catcgtggag atctttggca gtgccattgg cctctttggg gtcattgttg
      661 caatccttca gacctccaga gtgaagatgg gtgactagat gacctgtatg ggtggggccg
      721 tgccctactg ttatttattg ctggttttcc tgggacagct ggagctgtgt ccctcagcct
      781 ttctggggct tggtgttcag ggtctcccct gcactcacct cttgctgcct gttgactctg
      841 gaggcattgc agtccagact gaaccccagt gtggggagtg ggctgctgat ggtgactgtg
      901 tacagctgtg cacctgtgcc cccctcaacc cccatccagc ccatcttcct agtgtttgtg
      961 aaataaactt ggtatttgtc cca
//
