LOCUS       NM_080467               3300 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus ATPase, H+ transporting, lysosomal V0 subunit A4
            (Atp6v0a4), mRNA.
ACCESSION   NM_080467
VERSION     NM_080467.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3300)
  AUTHORS   Yano-Sakamoto,K., Kitai,Y., Toriu,N., Yamamoto,S., Mizuta,K.,
            Saitou,M., Tsukiyama,T., Taniuchi,I., Osato,M. and Yanagita,M.
  TITLE     Expression pattern of Runt-related transcription factor (RUNX)
            family members and the role of RUNX1 during kidney development
  JOURNAL   Biochem Biophys Res Commun 722, 150155 (2024)
   PUBMED   38795454
REFERENCE   2  (bases 1 to 3300)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3300)
  AUTHORS   Su,K., Collins,M.P., McGuire,C.M., Alshagawi,M.A., Alamoudi,M.K.,
            Li,Z. and Forgac,M.
  TITLE     Isoform a4 of the vacuolar ATPase a subunit promotes 4T1-12B breast
            cancer cell-dependent tumor growth and metastasis in vivo
  JOURNAL   J Biol Chem 298 (10), 102395 (2022)
   PUBMED   35988642
  REMARK    GeneRIF: Isoform a4 of the vacuolar ATPase a subunit promotes
            4T1-12B breast cancer cell-dependent tumor growth and metastasis in
            vivo.
REFERENCE   4  (bases 1 to 3300)
  AUTHORS   Sun-Wada,G.H. and Wada,Y.
  TITLE     The a subunit isoforms of vacuolar-type proton ATPase exhibit
            differential distribution in mouse perigastrulation embryos
  JOURNAL   Sci Rep 12 (1), 13590 (2022)
   PUBMED   35948619
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3300)
  AUTHORS   Honda,K., Kim,S.H., Kelly,M.C., Burns,J.C., Constance,L., Li,X.,
            Zhou,F., Hoa,M., Kelley,M.W., Wangemann,P., Morell,R.J. and
            Griffith,A.J.
  TITLE     Molecular architecture underlying fluid absorption by the
            developing inner ear
  JOURNAL   Elife 6, e26851 (2017)
   PUBMED   28994389
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3300)
  AUTHORS   Jouret,F., Auzanneau,C., Debaix,H., Wada,G.H., Pretto,C.,
            Marbaix,E., Karet,F.E., Courtoy,P.J. and Devuyst,O.
  TITLE     Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are
            differentially expressed during nephrogenesis
  JOURNAL   J Am Soc Nephrol 16 (11), 3235-3246 (2005)
   PUBMED   16177003
REFERENCE   7  (bases 1 to 3300)
  AUTHORS   Dou,H., Xu,J., Wang,Z., Smith,A.N., Soleimani,M., Karet,F.E.,
            Greinwald,J.H. Jr. and Choo,D.
  TITLE     Co-expression of pendrin, vacuolar H+-ATPase alpha4-subunit and
            carbonic anhydrase II in epithelial cells of the murine
            endolymphatic sac
  JOURNAL   J Histochem Cytochem 52 (10), 1377-1384 (2004)
   PUBMED   15385584
REFERENCE   8  (bases 1 to 3300)
  AUTHORS   Jouret,F., Igarashi,T., Gofflot,F., Wilson,P.D., Karet,F.E.,
            Thakker,R.V. and Devuyst,O.
  TITLE     Comparative ontogeny, processing, and segmental distribution of the
            renal chloride channel, ClC-5
  JOURNAL   Kidney Int 65 (1), 198-208 (2004)
   PUBMED   14675051
REFERENCE   9  (bases 1 to 3300)
  AUTHORS   Smith,A.N., Finberg,K.E., Wagner,C.A., Lifton,R.P., Devonald,M.A.,
            Su,Y. and Karet,F.E.
  TITLE     Molecular cloning and characterization of Atp6n1b: a novel fourth
            murine vacuolar H+-ATPase a-subunit gene
  JOURNAL   J Biol Chem 276 (45), 42382-42388 (2001)
   PUBMED   11495928
REFERENCE   10 (bases 1 to 3300)
  AUTHORS   Oka,T., Murata,Y., Namba,M., Yoshimizu,T., Toyomura,T.,
            Yamamoto,A., Sun-Wada,G.H., Hamasaki,N., Wada,Y. and Futai,M.
  TITLE     a4, a unique kidney-specific isoform of mouse vacuolar H+-ATPase
            subunit a
  JOURNAL   J Biol Chem 276 (43), 40050-40054 (2001)
   PUBMED   11498539
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143790.1 and BC046979.1.
            
            On Apr 1, 2008 this sequence version replaced NM_080467.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF435090.1, AF326316.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-788               AK143790.1         2-789
            789-3029            BC046979.1         811-3051
            3030-3300           BC046979.1         3053-3323
FEATURES             Location/Qualifiers
     source          1..3300
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 17.5 cM"
     gene            1..3300
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /note="ATPase, H+ transporting, lysosomal V0 subunit A4"
                     /db_xref="GeneID:140494"
                     /db_xref="MGI:MGI:2153480"
     exon            1..259
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            260..393
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..2778
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /EC_number="7.1.2.2"
                     /note="V-type proton ATPase 116 kDa subunit a; vacuolar
                     proton translocating ATPase 100 kDa a4 subunit; V-ATPase
                     116 kDa; ATPase, H+ transporting, lysosomal (vacuolar
                     proton pump) noncatalytic accessory protein 1B; V-ATPase
                     alpha 4; V-ATPase 116 kDa isoform a 4"
                     /codon_start=1
                     /product="V-type proton ATPase 116 kDa subunit a 4"
                     /protein_id="NP_536715.3"
                     /db_xref="CCDS:CCDS20010.1"
                     /db_xref="GeneID:140494"
                     /db_xref="MGI:MGI:2153480"
                     /translation="MASVFRSEEMCLSQVFLQVEAAYCCVAELGELGLVQFKDLNANV
                     NSFQRKFVNEVRRCESLERILRFLEDEMQNEILIQVPEKDAETPLPREMITLETTLEK
                     LEGELQEANQSHQALKKSFLELTELKYLLKKTQDFFETETNLGEDFFVEDTSGLLELR
                     TIPAFMTGKLGFTAGVINRERMASFERLLWRVCRGNVYLKFSEMDTLLEDPVTKEEIK
                     KNIFIIFYQGEQLRLKIKKICDGFRATIYPCPEHAAERREMLTSVNVRLEDLITVITQ
                     TESHRQRLLQEAAANWHSWVIKVQKMKAVYHVLNMCNIDVTQQCIIAEIWFPVADTRH
                     IKKALEQGMELSGSSMIPIMTEVETKTDPPTFNRTNKFTAGFQNIVDAYGVGSYREIN
                     PAPYTIITFPFLFAVMFGDCGHGMVMLMAALWMVLNERHLLAQKSTNEMWNIFFNGRY
                     LILLMGIFSIYTGLIYNDCFSKSFNIFGSSWSVQPMFRNGTWNTHIVENSPYLQLDPA
                     IPGVYSGNPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIAHMIFGVILSLFNHIYF
                     RRTLNIILQFIPEMIFMLSLFGYLVFMIIFKWCRYDAHTSRKAPSILIHFIGMFLFDY
                     DDSSNAPLYGHQQEVQTFFVIIALVSVPWMLLIKPFVLRAKHQKSQLQSFTIHEDAVE
                     GDHSGHSSKKTAGAHGMKDGHEEEFNFGDIFVHQAIHTIEYCLGCISNTASYLRLWAL
                     SLAHAELSEVLWTMVMSIGLRLQGWAGLVGVFIIFAVFAVLTVAILLVMEGLSAFLHA
                     LRLHWVEFQNKFYEGAGSKFSPFSFKHVLEGTAEE"
     exon            394..472
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            473..567
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            568..693
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            694..788
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            789..915
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            916..998
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1092
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1305
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1456
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1596
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1754
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1848
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1967
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2184
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2286
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2394
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2512
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2684
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..3285
                     /gene="Atp6v0a4"
                     /gene_synonym="a4; Atp6n1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttagaaag atgttgggtc aaggttctag gagcaggaca gagtgttcct gtcatagtac
       61 acactaagtt tcccactagc agagtcctcg ccatgtcatt tctacctcca aagtcatcag
      121 agcctgcttg tccacatctg gtccaggtgg gagtacaagg aaggctgctt ctacacccat
      181 gagcacaaat acgtctgtgt gggacagtcc actgaacgtc gtcatttagt ccagcccatt
      241 gcaggcattc ctggaacaga ctaaggctgg accaacatgg catctgtgtt tcgaagtgag
      301 gagatgtgtt tatcccaagt gtttctccag gtggaggctg cgtattgctg tgtagctgag
      361 ctgggagagc ttggcttggt tcagttcaaa gatctaaatg caaatgtgaa cagcttccag
      421 aggaagtttg tgaatgaagt ccgaaggtgt gagtcactgg agagaatcct gcgttttctg
      481 gaagatgaga tgcaaaacga gattttaatc caagtgcctg agaaggatgc tgagacccct
      541 ctccctcggg aaatgatcac cctggagacg actctagaga agttggaagg agagctgcag
      601 gaagccaacc agagccacca ggctttgaag aagagctttc tggaactgac agagctcaaa
      661 tacctcctaa agaaaaccca ggactttttt gagacagaaa ccaacttagg tgaagatttc
      721 tttgttgaag acacttcggg tctcttggag ctaagaacca tacctgcctt catgactgga
      781 aagttggggt tcacggctgg tgtgataaac agggagagga tggcttcctt cgagaggctg
      841 ctgtggagag tttgccgggg aaacgtgtac ttgaagttca gtgaaatgga cacacttctg
      901 gaggaccctg tgacgaaaga agaaattaaa aagaatatat tcatcatatt ttaccaagga
      961 gaacagctca ggctgaaaat caagaagatc tgtgacgggt ttcgtgctac catctacccc
     1021 tgcccagagc atgcagcaga gcgcagagag atgctgacca gtgtcaacgt gaggctggaa
     1081 gacttaatca ccgtcattac ccaaacagag tctcaccgac agcgcctgct gcaggaagca
     1141 gctgccaact ggcactcctg ggtcatcaaa gtacagaaga tgaaggccgt ctaccatgtg
     1201 ctgaacatgt gcaacattga cgtcacccag cagtgcatca ttgccgagat ctggttccca
     1261 gtagcagaca ctagacacat taagaaggcc ctggagcaag gcatggaact cagtggctcc
     1321 tccatgattc ccatcatgac agaagtggaa actaaaacag accctcccac cttcaacagg
     1381 acgaataaat ttacagctgg cttccagaac attgttgatg cgtatggtgt aggtagctac
     1441 cgagagataa acccagctcc ctacactatc atcaccttcc ccttcctgtt cgctgtgatg
     1501 tttggagact gtggtcatgg aatggtgatg ctgatggcag ccttgtggat ggtcctaaat
     1561 gagaggcact tgctggctca gaagagcacc aacgagatgt ggaacatctt cttcaatggg
     1621 cgctatttga tcctgctcat gggtatcttc tccatctaca ccggcttgat ctacaacgac
     1681 tgtttctcca aatcttttaa catctttggc tcctcttgga gtgtccagcc tatgttcaga
     1741 aacggcacgt ggaatactca catcgtggaa aacagtccat atttgcagct ggacccagcc
     1801 atcccaggag tgtattctgg gaatccctac ccatttggaa ttgatccgat ttggaacctg
     1861 gcttcaaaca agcttacatt tttaaactcc tataagatga agatgtcagt catcctggga
     1921 atcgctcata tgatttttgg tgttattctc agcctcttca atcacattta cttcagaaga
     1981 accctcaaca tcattctgca attcattccc gagatgattt ttatgctgag tctgtttgga
     2041 tacctggttt tcatgatcat tttcaagtgg tgccgatatg atgcccacac atcccggaag
     2101 gctcctagca tcctcatcca ctttatcggc atgtttctgt tcgactacga tgactcttcc
     2161 aacgcacccc tgtatggaca tcagcaagaa gtccagactt tctttgtcat catagcgctg
     2221 gtgtctgtgc catggatgct tttgattaag ccatttgttc ttagagccaa gcaccagaaa
     2281 tctcagctgc agtctttcac gatccacgag gatgctgtgg agggtgacca ctcgggccac
     2341 tcttctaaga agactgcagg tgcccatggg atgaaggacg gccatgagga ggagttcaac
     2401 tttggagaca tctttgtcca ccaagccatt cacaccattg agtactgcct aggctgcatc
     2461 tctaatacag cctcgtacct tcggctctgg gccctcagct tggctcacgc tgagctgtcc
     2521 gaggtgctct ggaccatggt catgagcatc ggccttcgcc ttcaaggctg ggcagggctc
     2581 gttggtgtct tcatcatttt tgcggtcttc gccgtcctca ccgtggccat cctccttgtc
     2641 atggagggtc tctcagcctt tctgcacgcc ctccggctgc attgggtgga attccagaac
     2701 aagttctatg agggggctgg ctccaagttc tcccccttct cctttaagca cgtcctggaa
     2761 ggcacagctg aggagtaggt ctgtctgtat cctggtgcag gcgacagctg aagaagctct
     2821 cactcttgtc tctgacatca gcccaggcca ggtgtcccat gctgcagtcc ttctgaatgg
     2881 ctgtctgcag tgtgaagctg tgtatggtgc agtatttaac aggacttagc cacctaactg
     2941 aggggctact ttggtgaatc attcggactt catgtgtagt cttcatgatc aaatactaaa
     3001 ataactggga aacggggggg gggggggggc ggacatgaca cttgaccacc atcttcctgt
     3061 gatagtttat ttttatttta cttcctttct gtttgagaca aggtctctct agctttaact
     3121 gttctggaaa taaccacacg gccaaggatg tccttgactt tgaactcagg ttcctcctgc
     3181 ctctacttcc caaatgctga gatgacaggc aggaaccccc tcacctgaag ttcctgcagt
     3241 atttcaagtg ttataatcat gaaaataaat gtctgcttta ttcacaaaaa aaaaaaaaaa
//
