LOCUS       NM_011596               5357 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus ATPase, H+ transporting, lysosomal V0 subunit A2
            (Atp6v0a2), mRNA.
ACCESSION   NM_011596
VERSION     NM_011596.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5357)
  AUTHORS   Sun-Wada,G.H. and Wada,Y.
  TITLE     The a subunit isoforms of vacuolar-type proton ATPase exhibit
            differential distribution in mouse perigastrulation embryos
  JOURNAL   Sci Rep 12 (1), 13590 (2022)
   PUBMED   35948619
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5357)
  AUTHORS   Peterson,T.V., Jaiswal,M.K., Beaman,K.D. and Reynolds,J.M.
  TITLE     Conditional Deletion of the V-ATPase a2-Subunit Disrupts
            Intrathymic T Cell Development
  JOURNAL   Front Immunol 10, 1911 (2019)
   PUBMED   31456807
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5357)
  AUTHORS   Sahoo,M., Katara,G.K., Bilal,M.Y., Ibrahim,S.A., Kulshrestha,A.,
            Fleetwood,S., Suzue,K. and Beaman,K.D.
  TITLE     Hematopoietic stem cell specific V-ATPase controls breast cancer
            progression and metastasis via cytotoxic T cells
  JOURNAL   Oncotarget 9 (69), 33215-33231 (2018)
   PUBMED   30237863
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5357)
  AUTHORS   Tulin,E.E., Onoda,N., Maeda,M., Hasegawa,M., Nosaka,T., Nomura,H.,
            Asano,S. and Kitamura,T.
  TITLE     A novel secreted form of immune suppressor factor with high
            homology to vacuolar ATPases identified by a forward genetic
            approach of functional screening based on cell proliferation
  JOURNAL   J Biol Chem 276 (29), 27519-27526 (2001)
   PUBMED   11375395
REFERENCE   5  (bases 1 to 5357)
  AUTHORS   Toyomura,T., Oka,T., Yamaguchi,C., Wada,Y. and Futai,M.
  TITLE     Three subunit a isoforms of mouse vacuolar H(+)-ATPase.
            Preferential expression of the a3 isoform during osteoclast
            differentiation
  JOURNAL   J Biol Chem 275 (12), 8760-8765 (2000)
   PUBMED   10722719
REFERENCE   6  (bases 1 to 5357)
  AUTHORS   Nishi,T. and Forgac,M.
  TITLE     Molecular cloning and expression of three isoforms of the 100-kDa a
            subunit of the mouse vacuolar proton-translocating ATPase
  JOURNAL   J Biol Chem 275 (10), 6824-6830 (2000)
   PUBMED   10702241
REFERENCE   7  (bases 1 to 5357)
  AUTHORS   Kang,J.A., McBey,B.A., Angkachatchai,V., Croy,B.A. and Beaman,K.D.
  TITLE     Expression of TJ6 during pregnancy
  JOURNAL   Am J Reprod Immunol 38 (3), 183-188 (1997)
   PUBMED   9325490
REFERENCE   8  (bases 1 to 5357)
  AUTHORS   Merali,F.S., Arck,P.C., Beaman,K. and Clark,D.A.
  TITLE     Transforming growth factor-beta 2-related-decidual suppressor
            factor is not related to TJ6 protein
  JOURNAL   Am J Reprod Immunol 35 (4), 342-347 (1996)
   PUBMED   8739451
REFERENCE   9  (bases 1 to 5357)
  AUTHORS   Mandal,M. and Beaman,K.D.
  TITLE     Purification and characterization of a pregnancy-associated
            protein: TJ6s
  JOURNAL   Am J Reprod Immunol 33 (1), 60-67 (1995)
   PUBMED   7619235
REFERENCE   10 (bases 1 to 5357)
  AUTHORS   Lee,C., Ghoshal,K. and Beaman,K.D.
  TITLE     Cloning of a cDNA for a T cell produced molecule with a putative
            immune regulatory role
  JOURNAL   Mol Immunol 27 (11), 1137-1144 (1990)
   PUBMED   2247090
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ076040.1, AF218252.1,
            AK017467.1, AK032909.1, AK160318.1 and BP764071.1.
            
            On May 2, 2013 this sequence version replaced NM_011596.4.
            
            Summary: This gene encodes a subunit of vacuolar ATPase, a
            multimeric enzyme that localizes to intracellular vesicles and to
            the plasma membrane of specialized cells. The encoded protein is a
            component of the V(0) domain, which functions in proton
            translocation across membranes. Function of this gene is important
            in fetal-specific immune suppression during pregnancy. [provided by
            RefSeq, May 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC112905.1, SRR1660815.214226.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CJ076040.1         1-15
            16-3043             AF218252.1         1-3028
            3044-3537           AK017467.1         1068-1561
            3538-4481           AK032909.1         2292-3235
            4482-5344           AK160318.1         82-944
            5345-5357           BP764071.1         35-47               c
FEATURES             Location/Qualifiers
     source          1..5357
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.7 cM"
     gene            1..5357
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /note="ATPase, H+ transporting, lysosomal V0 subunit A2"
                     /db_xref="GeneID:21871"
                     /db_xref="MGI:MGI:104855"
     exon            1..239
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..2693
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /EC_number="7.1.2.1"
                     /note="ATPase, H+ transporting, lysosomal V0 subunit a;
                     T-cell expressing clone j6; ATPase, H+ transporting,
                     lysosomal (vacuolar proton pump) non-catalytic accessory
                     protein 2 (38kD); immune suppressor factor J6B7; vacuolar
                     proton translocating ATPase 116 kDa subunit a; V-type
                     proton ATPase 116 kDa subunit a; V-ATPase 116 kDa subunit
                     a2; V-type proton ATPase 116 kDa subunit a2; V-ATPase 116
                     kDa subunit a 2; lysosomal H(+)-transporting ATPase V0
                     subunit a 2"
                     /codon_start=1
                     /product="V-type proton ATPase 116 kDa subunit a 2"
                     /protein_id="NP_035726.2"
                     /db_xref="CCDS:CCDS84963.1"
                     /db_xref="GeneID:21871"
                     /db_xref="MGI:MGI:104855"
                     /translation="MGSLFRSESMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNV
                     SSFQRKFVGEVKRCEELERILVYLVQEITRADIPLPEGEASPPAPPLKHVLEMQEQLQ
                     KLEVELREVTKNKEKLRKNLLELVEYTHMLRVTKTFLKRNVEFEPTYEEFPALENDSL
                     LDYSCMQRLGAKLGFVSGLIQQGRVEAFERMLWRACKGYTIVTYAELDECLEDPETGE
                     VIKWYVFLISFWGEQIGHKVKKICDCYHCHIYPYPNTAEERREIQEGLNTRIQDLYTV
                     LHKTEDYLRQVLCKAAESVCSRVVQVRKMKAIYHMLNMCSFDVTNKCLIAEVWCPEVD
                     LPGLRRALEEGSRESGATIPSFMNTIPTKETPPTLIRTNKFTEGFQNIVDAYGVGSYR
                     EVNPALFTIITFPFLFAVMFGDFGHGFVMFLFALLLVLNENHPRLSQSQEILRMFFDG
                     RYILLLMGLFSVYTGLIYNDCFSKSVNLFGSGWNVSAMYSSSHSPEEQRKMVLWNDST
                     IRHSRTLQLDPNIPGVFRGPYPFGIDPIWNLATNRLTFLNSFKMKMSVILGIFHMTFG
                     VVLGIFNHLHFRKKFNVYLVSVPEILFMLCIFGYLIFMIIYKWLAYSAETSREAPSIL
                     IEFINMFLFPTSKTHGLYPGQAHVQRVLVALTVLAVPVLFLGKPLFLLWLHNGRNCFG
                     MSRSGYTLVRKDSEEEVSLLGNQDIEEGNSRMEEGCREVTCEEFNFGEILMTQAIHSI
                     EYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVMAFFA
                     VLTIFILLVMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPFSFSLLSSKFSNDDSIA
                     "
     exon            240..318
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     exon            319..416
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     exon            417..554
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..643
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     exon            644..770
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     exon            771..853
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     exon            854..947
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1160
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1311
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1448
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1636
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1727
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1846
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2057
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2177
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2297
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2415
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2587
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..5345
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2916..2921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /note="hexamer: AATATA"
     polyA_site      2938
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
     regulatory      3507..3512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /note="hexamer: AATAAA"
     polyA_site      3539
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /note="major polyA site"
     regulatory      5320..5325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
                     /note="hexamer: AATAAA"
     polyA_site      5340
                     /gene="Atp6v0a2"
                     /gene_synonym="8430408C20Rik; ATP6a2; Atp6n1d; Atp6n2;
                     ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa;
                     V-ATPase a2"
ORIGIN      
        1 ggcggtgggc ggggcgtggc gggtggttgt ggcggcggct gagcggtggc cgcggtggca
       61 tcggagggga gccccatggt gcgggtgcgc gggccgtgga ggctgagcga ggcagcgccg
      121 ccatgggctc tctcttccgc agcgagagca tgtgcctggc gcagctcttc ctgcagtcgg
      181 gcacggccta cgagtgtctg agcgcgctgg gcgagaaggg cctggtgcag ttccgagacc
      241 tcaatcaaaa tgtaagttct tttcaaagaa aattcgtcgg tgaggtaaag aggtgtgaag
      301 agctcgaacg aatactggtg tacctggtgc aggaaatcac cagagctgat attcccctgc
      361 ctgaaggaga ggccagtcct cccgcaccac ctcttaaaca tgtcctagaa atgcaggaac
      421 agctgcagaa gctggaggtg gagctcagag aagtcaccaa gaacaaggag aagctgagga
      481 agaacctgtt ggagctggtg gagtacaccc acatgctgag ggtcacgaag accttcctca
      541 agcggaatgt ggagtttgag cccacgtatg aagagtttcc cgccttagag aacgactctc
      601 tgttggacta cagctgcatg cagcggctgg gcgccaagct gggattcgtt tctggcctga
      661 ttcagcaagg cagagttgaa gcatttgaaa ggatgctgtg gcgggcctgc aaagggtaca
      721 ccattgtgac ctatgcagag ctggacgagt gcctggagga ccctgaaacg ggtgaagtca
      781 taaagtggta cgtgttcctg atttcctttt ggggagagca gattggccac aaggttaaga
      841 agatatgtga ctgttaccac tgccacatct acccgtatcc aaacacggct gaggagcgca
      901 gggagattca ggaggggctc aatactcgga tccaagacct ttacacggtg ctgcacaaaa
      961 cggaggacta tctgcggcaa gtgctctgca aagctgccga gtccgtgtgc agccgtgtgg
     1021 tccaggtgag gaagatgaag gccatctacc acatgctcaa catgtgcagc tttgacgtca
     1081 ccaacaagtg cctcatagct gaggtctggt gccccgaggt ggacctgcca ggcttgcgca
     1141 gagcactgga ggaaggctcg agagagagcg gagctacaat cccctcgttc atgaacacaa
     1201 tccctacgaa agaaacaccc cccactctga tccgcaccaa caaattcact gaaggtttcc
     1261 agaacatcgt ggatgcctat ggagtcggga gctacagaga agtgaaccca gctctcttta
     1321 ccatcatcac cttcccgttc ctgtttgctg tgatgtttgg cgactttggg cacggctttg
     1381 tcatgttcct gtttgccctc ttactggtgt taaatgagaa tcaccccaga ctaagccagt
     1441 cacaggagat ccttaggatg ttctttgacg gccggtatat cctgctgctg atggggctgt
     1501 tctctgtgta caccggcctc atctacaacg actgcttctc caagtctgtg aacctctttg
     1561 gttctgggtg gaacgtatct gccatgtaca gctccagcca ctctccagag gagcagagga
     1621 agatggtact ttggaatgac agcaccatca ggcacagcag gactttgcag ctggacccga
     1681 atatccctgg agttttccga ggcccctacc cttttggcat tgatcctatt tggaacctgg
     1741 ccacaaaccg cctcacgttc ctcaactcct tcaagatgaa aatgtctgtg attttaggaa
     1801 tttttcacat gacttttggt gttgttctgg gaatatttaa ccacttgcac tttaggaaga
     1861 agttcaacgt ctacctggtc tcggtgcctg agatcctgtt catgctctgc atctttgggt
     1921 acctgatttt catgatcatt tacaagtggc tggcatactc ggcagagacc tcgagagagg
     1981 ccccgagcat cctgatcgag ttcattaaca tgttcctgtt cccaaccagc aagacacacg
     2041 ggctctaccc agggcaggca cacgtccaga gagtgttggt ggctctcacg gtgctggctg
     2101 tccccgtgct cttcttagga aagccgcttt ttctgctgtg gctgcacaac gggcgcaatt
     2161 gctttggcat gagccggagc ggttacacac tcgtgaggaa ggacagcgag gaagaggtgt
     2221 ctcttctggg caaccaggac atagaagagg gcaacagccg catggaagaa ggctgccgag
     2281 aagtgacgtg tgaggagttt aacttcgggg agatcctgat gacgcaggcc atccactcca
     2341 ttgagtactg cctcggctgc atctccaaca ccgcctccta cctgaggctc tgggcactca
     2401 gcctggccca tgcacagctc tctgatgtgc tgtgggccat gctgatgcgc gtggggctgc
     2461 gtgtggacac cacctatggg gtcttgctgc tgctgcctgt catggctttc tttgcagttt
     2521 tgaccatttt tatccttctg gtcatggagg gtctttctgc attcctccac gccataaggc
     2581 ttcactgggt agaatttcag aacaaattct acgttggtgc aggcaccaag tttgttccct
     2641 tctccttcag tctgctctcc tccaagttca gtaatgatga cagcatagca tgattgcacg
     2701 ctgcagcaag cccgctctga tcaacggagg actatcatgt tacagaattc actcactcac
     2761 tccggtcaga acttaccagg ggaaagttcc accctcgttg attgccttac gattcagcca
     2821 aatggttctg taagatacac ctcttcctca tggtgaagat tttgtaaaac tcaccactcc
     2881 ggacacagaa atttcgttgg tttttattat gagcaaatat aagttaatgc caacgctact
     2941 ttaaagttat tttttaaagt gtaagattgg aggagagaag ccagctgaac agctagctaa
     3001 aaatggtctt agatacttga ttccttttca acttaaaaaa aaagaaacat gaagttattc
     3061 catcgcaaga agatgtcaga taatattttc caacagctca agttaggcat agtgttttca
     3121 gacattactg ctgggtcatc agcaggtccc cgctcccact gcctgctcca gaatgtatgt
     3181 gagttctccc aaaatgctcg caggattgcc gggaggggca gcgtgacagc ctgatcttct
     3241 tttaataatc ggagacaatg tgacaaagtg gcacagcgat ggctctcctg cttgcatatt
     3301 ttttaaagac gcttgtcctt catccttgtg ttagaccagt cacggcagtt gtgcgttctg
     3361 aaggatgact gtcctgagcc ttaaaaccca ggggagacag gaaaagccgt gtgtattttt
     3421 atagcaaaga acagatgaag atattttacc acagagactg cttctactgg acaatagtat
     3481 agttttttac tttggcacta attctgaata aaggtctgat ggccagtttg atttcccaag
     3541 ctgttcaggt tagctgaaaa ctgattctta ctaacctgtt aatttattac attcatgtaa
     3601 gatcacctgt cctcagcttt gagtgaagtt ggctcaatcc cattgaacac ttagatccat
     3661 gtcacagtct tagaaattat cctcactttc acattttacg ttaagcgagt ttagctaagt
     3721 atttcagaaa gcaatctgag gctggggtgt ggcctgattg tttccatccc ccgaaccact
     3781 tcacccaggt gtggtggcat ctgactggta ttccaaggac ttagaaggtg gaggcaggag
     3841 gatcaggaag ttcagggttt cctttggcta tgtggtaagt ttgaggccag cctgggctat
     3901 gtaataaccc taaagagaga aaggaatcta acatgtctct ggcctcttaa aattctgagt
     3961 tccacgctat tgcagagacc ttttggtgcc tcagccctcc agaaccatgt ggtagagtgt
     4021 gggtcccttt ccttaaaagc caagcctctg gcagccagaa tttcacagct tcttgggtcc
     4081 tgtaagagct gcatgctgag aggcatggac tgcttgtgcc tcagctggag agtaacatca
     4141 gatcgctcca gcccctgtgg ggtccacact gacggcagcg aggctccagc taggatgccg
     4201 agcctgccgg cagctgggta agctggtgcc gcccagtgta gacctgctct tacctgtatc
     4261 atgtgtcacc cccatgtcac tcttgttact gtgcccccag ggtctttggt caccacagag
     4321 atagctgctt ccagggacag gaaccaaaca gtttctgcca tatgtactgt ccctgttggc
     4381 agttgtgatg gggcctcttt tataactggc atctcttacc tgggtacaga acacagagca
     4441 agagtaactt ctcagttgaa gcctgtcaca gttaaataga aatgtccttg cataaatgga
     4501 agtcactgtt tcatgagccc tctggaaata taattggtag cgtcctctca ggggatgcag
     4561 ctctttggtg gtgtcacatg ttcctcttcc tagaacaaca tcaatggagc cacgtcacat
     4621 agacttatgc tggtgggaag gcccgatgtg atgtggccag tagaggcatg caaagggctt
     4681 tgagctcctg cacgctccct cctccatagg acctgggaca gactcctttt cccccagatc
     4741 ctcccctggc ctcagttctg gaatgggtct ctatgcttca agatatttaa tgccaccgac
     4801 gcaggccttg gccttgccat cctcttgcct tagtctctca gctggcacta caggtatgca
     4861 atgctggcca tgggtgtaat gacattcagg cccactgctc cgtctgcagg agtgtagtaa
     4921 ggcacagacc gtccactggt aacttacagg gctggcacat caagctgtga tttagagttt
     4981 gaacaagttt tggaaaataa aaacaaaacc agctccaagg tcacattttt ctacggaggg
     5041 aggaagtctg ggtatgcata catgccacac tatccagatg ggccttagga actcttgtgg
     5101 tgttgtgaag aggcagtttg cccaccagca gaccactgct ctaatacatc aagaaatcct
     5161 cagaccgtgc aactccacag gatgattcgt caaggctgtg ttctggagct gggacctggg
     5221 gcggaaacta cgggagccag ccagagccgc actgtactga tagacgcatg gaaggactag
     5281 tctgcctgac agtattgaac tcccttttgc tagtgacaaa ataaatgtat atttttgaga
     5341 tgccaaaaaa aaaaaaa
//
