LOCUS       NM_027439               2376 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus ATPase, H+ transporting, lysosomal accessory protein 2
            (Atp6ap2), mRNA.
ACCESSION   NM_027439 XM_622793
VERSION     NM_027439.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2376)
  AUTHORS   Chen,L., Xiong,L., Guo,H., Feng,X., Zhu,X. and Xiong,W.C.
  TITLE     Osteoclastic ATP6AP2 maintains beta-catenin levels to prevent
            hyper-osteoclastic activation and trabecular bone-loss
  JOURNAL   J Bone Miner Res 39 (12), 1821-1834 (2024)
   PUBMED   39400061
REFERENCE   2  (bases 1 to 2376)
  AUTHORS   Luo,R., Yang,K.T., Wang,F., Zheng,H. and Yang,T.
  TITLE     Collecting Duct Pro(Renin) Receptor Contributes to Unilateral
            Ureteral Obstruction-Induced Kidney Injury via Activation of the
            Intrarenal RAS
  JOURNAL   Hypertension 81 (10), 2152-2161 (2024)
   PUBMED   39171392
  REMARK    GeneRIF: Collecting Duct Pro(Renin) Receptor Contributes to
            Unilateral Ureteral Obstruction-Induced Kidney Injury via
            Activation of the Intrarenal RAS.
REFERENCE   3  (bases 1 to 2376)
  AUTHORS   Zhang,X., Dong,X., Jie,H., Li,S., Li,H., Su,Y., Li,L., Kang,L.,
            Dong,B. and Zhang,Y.
  TITLE     Downregulation of the (pro)renin receptor alleviates
            ferroptosis-associated cardiac pathological changes via the NCOA
            4-mediated ferritinophagy pathway in diabetic cardiomyopathy
  JOURNAL   Int Immunopharmacol 138, 112605 (2024)
   PUBMED   38963979
  REMARK    GeneRIF: Downregulation of the (pro)renin receptor alleviates
            ferroptosis-associated cardiac pathological changes via the NCOA
            4-mediated ferritinophagy pathway in diabetic cardiomyopathy.
REFERENCE   4  (bases 1 to 2376)
  AUTHORS   Culver,S.A., Hargett,S.R., Balugo,J.L.L.Q., Gildea,J.J.,
            Harris,T.E. and Siragy,H.M.
  TITLE     Nephron specific ATP6AP2 knockout increases urinary excretion of
            fatty acids and decreases renal cortical megalin expression
  JOURNAL   Sci Rep 14 (1), 18724 (2024)
   PUBMED   39134597
  REMARK    GeneRIF: Nephron specific ATP6AP2 knockout increases urinary
            excretion of fatty acids and decreases renal cortical megalin
            expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2376)
  AUTHORS   Song,R. and Yosypiv,I.V.
  TITLE     Deletion of the prorenin receptor in the ureteric bud in mice
            inhibits Dot1/H3K79 pathway
  JOURNAL   Pediatr Res 95 (7), 1754-1757 (2024)
   PUBMED   38287105
REFERENCE   6  (bases 1 to 2376)
  AUTHORS   Satofuka,S., Ichihara,A., Nagai,N., Noda,K., Ozawa,Y., Fukamizu,A.,
            Tsubota,K., Itoh,H., Oike,Y. and Ishida,S.
  TITLE     (Pro)renin receptor promotes choroidal neovascularization by
            activating its signal transduction and tissue renin-angiotensin
            system
  JOURNAL   Am J Pathol 173 (6), 1911-1918 (2008)
   PUBMED   18974301
  REMARK    GeneRIF: Defined the role of (pro)renin receptor in choroidal
            neovascularization (CNV) generation;(Pro)renin receptor blockade
            suppressed ERK activation & the production of MCP-1 & VEGF, but not
            ICAM-1, VEGFR-1 or VEGFR-2, in AT1-R-deficient mice with CNV.
REFERENCE   7  (bases 1 to 2376)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 2376)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   9  (bases 1 to 2376)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2376)
  AUTHORS   Ludwig,J., Kerscher,S., Brandt,U., Pfeiffer,K., Getlawi,F.,
            Apps,D.K. and Schagger,H.
  TITLE     Identification and characterization of a novel 9.2-kDa membrane
            sector-associated protein of vacuolar proton-ATPase from chromaffin
            granules
  JOURNAL   J Biol Chem 273 (18), 10939-10947 (1998)
   PUBMED   9556572
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY784908.1, AK076495.1, AW985491.1 and AW475779.1.
            
            On Oct 28, 2009 this sequence version replaced NM_027439.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.189472.1,
                                           SRR1660821.155110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BY784908.1         2-57
            57-536              AK076495.1         2-481
            537-878             AW985491.1         104-445
            879-2127            AK076495.1         824-2072
            2128-2376           AW475779.1         1-249               c
FEATURES             Location/Qualifiers
     source          1..2376
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 7.42 cM"
     gene            1..2376
                     /gene="Atp6ap2"
                     /gene_synonym="(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2;
                     ATP6M8-9; M8-9; PRR"
                     /note="ATPase, H+ transporting, lysosomal accessory
                     protein 2"
                     /db_xref="GeneID:70495"
                     /db_xref="MGI:MGI:1917745"
     exon            1..177
                     /gene="Atp6ap2"
                     /gene_synonym="(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2;
                     ATP6M8-9; M8-9; PRR"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1190
                     /gene="Atp6ap2"
                     /gene_synonym="(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2;
                     ATP6M8-9; M8-9; PRR"
                     /note="ATPase, H+ transporting, lysosomal interacting
                     protein 1; ATPase, H+ transporting, lysosomal interacting
                     protein 2; renin receptor; renin/prorenin receptor; ATPase
                     H(+)-transporting lysosomal-interacting protein 2"
                     /codon_start=1
                     /product="renin receptor precursor"
                     /protein_id="NP_081715.1"
                     /db_xref="CCDS:CCDS30023.1"
                     /db_xref="GeneID:70495"
                     /db_xref="MGI:MGI:1917745"
                     /translation="MAVLVVLLFFLVAGALGNEFSILRSPGSVVFRNGNWPIPGDRIP
                     DVAALSMGFSVKEDLSWPGLAVGNLFHRPRATIMVMVKGVDKLALPAGSVISYPLENA
                     VPFSLDSVANSIHSLFSEETPVVLQLAPSEERVYMVGKANSVFEDLSVTLRQLRNRLF
                     QENSLLNSLPLNSLSRNNEVDLLFLSELQVLHDISSLLSRHKHLAKDHSPDLYSLELA
                     GLDELGKRYGEDSEQFRDASKILVDALQKFADDMYSLYGGNAVVELVTVKSFDTSLVR
                     KSRTILEAKQENTQSPYNLAYKYNLEYSVVFNLVLWIMIGLALAVIITSYNIWNMDPG
                     YDSIIYRMTNQKIRID"
     exon            178..308
                     /gene="Atp6ap2"
                     /gene_synonym="(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2;
                     ATP6M8-9; M8-9; PRR"
                     /inference="alignment:Splign:2.1.0"
     exon            309..440
                     /gene="Atp6ap2"
                     /gene_synonym="(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2;
                     ATP6M8-9; M8-9; PRR"
                     /inference="alignment:Splign:2.1.0"
     exon            441..536
                     /gene="Atp6ap2"
                     /gene_synonym="(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2;
                     ATP6M8-9; M8-9; PRR"
                     /inference="alignment:Splign:2.1.0"
     exon            537..674
                     /gene="Atp6ap2"
                     /gene_synonym="(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2;
                     ATP6M8-9; M8-9; PRR"
                     /inference="alignment:Splign:2.1.0"
     exon            675..728
                     /gene="Atp6ap2"
                     /gene_synonym="(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2;
                     ATP6M8-9; M8-9; PRR"
                     /inference="alignment:Splign:2.1.0"
     exon            729..878
                     /gene="Atp6ap2"
                     /gene_synonym="(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2;
                     ATP6M8-9; M8-9; PRR"
                     /inference="alignment:Splign:2.1.0"
     exon            879..998
                     /gene="Atp6ap2"
                     /gene_synonym="(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2;
                     ATP6M8-9; M8-9; PRR"
                     /inference="alignment:Splign:2.1.0"
     exon            999..2368
                     /gene="Atp6ap2"
                     /gene_synonym="(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2;
                     ATP6M8-9; M8-9; PRR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2041..2046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6ap2"
                     /gene_synonym="(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2;
                     ATP6M8-9; M8-9; PRR"
                     /note="hexamer: AATAAA"
     polyA_site      2061
                     /gene="Atp6ap2"
                     /gene_synonym="(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2;
                     ATP6M8-9; M8-9; PRR"
                     /note="major polyA site"
     regulatory      2103..2108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6ap2"
                     /gene_synonym="(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2;
                     ATP6M8-9; M8-9; PRR"
                     /note="hexamer: ATTAAA"
     polyA_site      2126
                     /gene="Atp6ap2"
                     /gene_synonym="(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2;
                     ATP6M8-9; M8-9; PRR"
     regulatory      2343..2348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp6ap2"
                     /gene_synonym="(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2;
                     ATP6M8-9; M8-9; PRR"
                     /note="hexamer: AATAAA"
     polyA_site      2368
                     /gene="Atp6ap2"
                     /gene_synonym="(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2;
                     ATP6M8-9; M8-9; PRR"
ORIGIN      
        1 gtcttggagc ggctaaaggg gaggggcttg gggatcggaa ccgtcgggag cgcgtcactc
       61 ggtcgagctg cagtgctcgc ttgagtcccg gcgtcccttt tcgtgtggct catctccgct
      121 tcagcaaccg tggcaccatg gctgtgctgg tcgttctcct gttctttctg gtggcgggtg
      181 ctttagggaa tgaatttagc atattaagat cgccagggtc tgttgttttc cgaaatggaa
      241 attggcctat accaggagat cgaatcccag acgtagctgc actgtccatg ggcttctctg
      301 taaaggaaga cctgtcttgg ccagggcttg ccgtgggtaa cctattccac cggccacggg
      361 ctaccattat ggtgatggtg aagggggtgg ataaactggc acttccggca ggcagcgtca
      421 tctcctaccc tttggagaat gcagttcctt ttagtctaga cagcgttgca aattccattc
      481 actccttatt ttcggaggaa acacctgtag ttttgcagtt ggctcccagc gaggagagag
      541 tgtatatggt ggggaaagca aactcggtgt ttgaagacct ttcagtcaca ttgcggcagc
      601 tccgtaaccg cctgtttcaa gaaaactccc ttctcaactc tcttcccctc aattctctga
      661 gtaggaataa tgaggttgac ctgctctttc tctccgaact gcaagtgcta catgatattt
      721 ccagtttgtt gtctcgtcat aagcatctag ccaaggacca ttcacccgac ttgtattcat
      781 tggagctggc aggtttggat gaacttggga agcgttatgg ggaagactct gaacagttca
      841 gggatgcttc taagatcctt gttgatgctc tccaaaagtt tgcagatgac atgtacagtc
      901 tctatggtgg gaacgcagtg gtagagttag tgactgtcaa atcattcgac acatcccttg
      961 tgaggaagtc aaggaccatc cttgaggcaa aacaagagaa cacccaaagt ccctataacc
     1021 ttgcatataa gtataatttg gagtattcag tggttttcaa cttggtactg tggattatga
     1081 tcggcttggc cttggctgtg ataatcacct cttacaacat ttggaatatg gatcctggat
     1141 atgatagcat catctatagg atgacaaatc agaagattcg aatagattga attttcctta
     1201 tgctagactt agacaacagg tttggtaatt ggctgttttg ttaaagtata tcttttagtg
     1261 ttgtttaaag tagacggtat accttaagtt tattaaaaag aaaacataga tttcattatc
     1321 tattttgtgt gtgcctattg tttctttaga gtgatttata gtgttgacaa gttgaattgt
     1381 gatatagatt caatgtgctc aaatattgtt gacatagcca tttaataatg taatttcatt
     1441 ccatttaata catgtggaaa tacgcactga gagaactgta aaccacttag tcatgttact
     1501 cgcgctggag aacgcactgg gtttcttaga gaaccttaaa atgcttgact tcttgcacag
     1561 gctacgtagt gcagctgtta gtcactatga actatttgta aatgtcttga tctgctgtaa
     1621 atatctctga gacaggagga aatatgttaa ctaagagcag cccaaaaata ctggatatgc
     1681 ttatccaatc gcttagttct ggacgtgtat atgactagca agctagctgt ttttaatctc
     1741 ttctgcaagt ttggtgatcc gtgtggttta gtagagatat taaaattatt aaaaatacta
     1801 tgttgatttc agaagagact agctttgtgg aatatagatg cttgtaatta ggtacataaa
     1861 aacaaatctg tgggggatat cttgaagcat gaatataaaa tatttttatt tctgtacttt
     1921 ccccctgtga agttactctt ggtttgtgtg tggtatggct tcaatctgta gactattata
     1981 tggaagtgga tgattgctac tgttcatgtg caaatggacc aatatctata tagaatgaca
     2041 aataaagata atgattcaaa atctgtgtca ctgcaattct gaatttatat tataaaaacc
     2101 taattaaaca gggtgttatt tcaccaggac tggctggttt attatacaaa gggtgaattc
     2161 acattgtttt ctacatttgc ttattctcat tgcctcctaa gactttgtac caatgtaagg
     2221 aaagtatttt aattgctatt cctgttactg aacttgtgca taataaattt acacttgact
     2281 gtgtaggaaa ggtttaaatt ttcctgtagc cttttaaaag atgaacaaac acttggttag
     2341 aaaataaagg gctttctaag gtgaggaaaa aaaaaa
//
