LOCUS       NM_018794               2189 bp    mRNA    linear   ROD 12-NOV-2023
DEFINITION  Mus musculus ATPase, H+ transporting, lysosomal accessory protein 1
            (Atp6ap1), transcript variant 1, mRNA.
ACCESSION   NM_018794 XM_207722
VERSION     NM_018794.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2189)
  AUTHORS   Yang W, Zhu Z, Li L, McVicar A, Gao N, Wang L, Li YP and Chen W.
  TITLE     Silencing of Ac45 Simultaneously Inhibits Osteoclast-Mediated Bone
            Resorption and Attenuates Dendritic Cell-Mediated Inflammation
            through Impairing Acidification and Cathepsin K Secretion
  JOURNAL   Infect Immun 89 (1), e00436-20 (2020)
   PUBMED   33077625
  REMARK    GeneRIF: Silencing of Ac45 Simultaneously Inhibits
            Osteoclast-Mediated Bone Resorption and Attenuates Dendritic
            Cell-Mediated Inflammation through Impairing Acidification and
            Cathepsin K Secretion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2189)
  AUTHORS   Matsumoto N, Matsukawa R, Takahashi S, Kudo K, Sun-Wada GH, Wada Y
            and Nakanishi-Matsui M.
  TITLE     V-ATPase a3 isoform mutations identified in osteopetrosis patients
            abolish its expression and disrupt osteoclast function
  JOURNAL   Exp Cell Res 389 (2), 111901 (2020)
   PUBMED   32045577
  REMARK    GeneRIF: V-ATPase a3 isoform mutations identified in osteopetrosis
            patients abolish its expression and disrupt osteoclast function.
REFERENCE   3  (bases 1 to 2189)
  AUTHORS   Rao VK, Zavala G, Deb Roy A, Mains RE and Eipper BA.
  TITLE     A pH-sensitive luminal His-cluster promotes interaction of PAM with
            V-ATPase along the secretory and endocytic pathways of peptidergic
            cells
  JOURNAL   J Cell Physiol 234 (6), 8683-8697 (2019)
   PUBMED   30317586
  REMARK    GeneRIF: Peptidylglycine alpha-amidating mono-oxygenase serves as a
            luminal pH-sensor, regulating V-ATPase action by altering its
            assembly status in peptidergic cells.
REFERENCE   4  (bases 1 to 2189)
  AUTHORS   Bodzeta A, Kahms M and Klingauf J.
  TITLE     The Presynaptic v-ATPase Reversibly Disassembles and Thereby
            Modulates Exocytosis but Is Not Part of the Fusion Machinery
  JOURNAL   Cell Rep 20 (6), 1348-1359 (2017)
   PUBMED   28793259
REFERENCE   5  (bases 1 to 2189)
  AUTHORS   Jansen EJ, Timal S, Ryan M, Ashikov A, van Scherpenzeel M, Graham
            LA, Mandel H, Hoischen A, Iancu TC, Raymond K, Steenbergen G,
            Gilissen C, Huijben K, van Bakel NH, Maeda Y, Rodenburg RJ,
            Adamowicz M, Crushell E, Koenen H, Adams D, Vodopiutz J,
            Greber-Platzer S, Muller T, Dueckers G, Morava E, Sykut-Cegielska
            J, Martens GJ, Wevers RA, Niehues T, Huynen MA, Veltman JA, Stevens
            TH and Lefeber DJ.
  TITLE     ATP6AP1 deficiency causes an immunodeficiency with hepatopathy,
            cognitive impairment and abnormal protein glycosylation
  JOURNAL   Nat Commun 7, 11600 (2016)
   PUBMED   27231034
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2189)
  AUTHORS   Feng H, Cheng T, Pavlos NJ, Yip KH, Carrello A, Seeber R, Eidne K,
            Zheng MH and Xu J.
  TITLE     Cytoplasmic terminus of vacuolar type proton pump accessory subunit
            Ac45 is required for proper interaction with V(0) domain subunits
            and efficient osteoclastic bone resorption
  JOURNAL   J Biol Chem 283 (19), 13194-13204 (2008)
   PUBMED   18227071
  REMARK    GeneRIF: cytoplasmic terminus of Ac45 contains elements necessary
            for its proper interaction with V(0) domain and efficient
            osteoclastic bone resorption
REFERENCE   7  (bases 1 to 2189)
  AUTHORS   Sakai H, Kawawaki J, Moriura Y, Mori H, Morihata H and Kuno M.
  TITLE     pH dependence and inhibition by extracellular calcium of proton
            currents via plasmalemmal vacuolar-type H+-ATPase in murine
            osteoclasts
  JOURNAL   J Physiol 576 (Pt 2), 417-425 (2006)
   PUBMED   16901940
  REMARK    GeneRIF: In osteoclasts, the activity-dependent accumulation of
            acids and Ca(2+) in the closed extracellular compartment might
            serve as negative feedback signals for regulating the V-ATPase.
REFERENCE   8  (bases 1 to 2189)
  AUTHORS   Kaput J, Klein KG, Reyes EJ, Kibbe WA, Cooney CA, Jovanovic B,
            Visek WJ and Wolff GL.
  TITLE     Identification of genes contributing to the obese yellow Avy
            phenotype: caloric restriction, genotype, diet x genotype
            interactions
  JOURNAL   Physiol Genomics 18 (3), 316-324 (2004)
   PUBMED   15306695
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2189)
  AUTHORS   Schoonderwoert VT and Martens GJ.
  TITLE     Targeted disruption of the mouse gene encoding the V-ATPase
            accessory subunit Ac45
  JOURNAL   Mol Membr Biol 19 (1), 67-71 (2002)
   PUBMED   11989824
  REMARK    GeneRIF: Targeted disruption of the gene for the chromaffin
            granular V-ATPase-associated protein Ac45 in embryonic stem cells
            affects the normal blastocyst development, suggesting an essential
            role for the V-ATPase in early embryonic development. [AC45]
REFERENCE   10 (bases 1 to 2189)
  AUTHORS   Rivella S, Tamanini F, Bione S, Mancini M, Herman G, Chatterjee A,
            Maestrini E and Toniolo D.
  TITLE     A comparative transcriptional map of a region of 250 kb on the
            human and mouse X chromosome between the G6PD and the FLN1 genes
  JOURNAL   Genomics 28 (3), 377-382 (1995)
   PUBMED   7490070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807376.4, AK158956.1 and AK136210.1.
            
            [WARNING] On Dec 7, 2023 this sequence was replaced by NM_018794.5.
            
            On Oct 27, 2009 this sequence version replaced NM_018794.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220247.1, AK093961.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AL807376.4         79483-79495
            14-2158             AK158956.1         2-2146
            2159-2189           AK136210.1         1824-1854
FEATURES             Location/Qualifiers
     source          1..2189
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.96 cM"
     gene            1..2189
                     /gene="Atp6ap1"
                     /gene_synonym="16A; AC45; Atp6ip1; Atp6s1; C7-1; CF2;
                     mFLJ00383; VATPS1; XAP-3"
                     /note="ATPase, H+ transporting, lysosomal accessory
                     protein 1"
                     /db_xref="GeneID:54411"
                     /db_xref="MGI:MGI:109629"
     exon            1..225
                     /gene="Atp6ap1"
                     /gene_synonym="16A; AC45; Atp6ip1; Atp6s1; C7-1; CF2;
                     mFLJ00383; VATPS1; XAP-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1474
                     /gene="Atp6ap1"
                     /gene_synonym="16A; AC45; Atp6ip1; Atp6s1; C7-1; CF2;
                     mFLJ00383; VATPS1; XAP-3"
                     /EC_number="7.1.2.2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ATPase, H+ transporting, lysosomal interacting
                     protein 1; V-type proton ATPase subunit S1; V-ATPase
                     subunit Ac45; vacuolar H+ ATPase accessory subunit 1;
                     protein C7-1; V-ATPase subunit S1; V-ATPase Ac45 subunit;
                     V-ATPase S1 accessory protein; vacuolar proton pump
                     subunit S1; ATPase, H+ transporting, lysosomal (vacuolar
                     proton pump), subunit 1"
                     /codon_start=1
                     /product="V-type proton ATPase subunit S1 isoform 1
                     precursor"
                     /protein_id="NP_061264.1"
                     /db_xref="CCDS:CCDS30226.1"
                     /db_xref="GeneID:54411"
                     /db_xref="MGI:MGI:109629"
                     /translation="MMAATVVSRIRTGTGRAPVMWLSLSLVAVAAAVATEQQVPLVLW
                     SSDRNLWAPVADTHEGHITSDMQLSTYLDPALELGPRNVLLFLQDKLSIEDFTAYGGV
                     FGNKQDSAFSNLENALDLAPSSLVLPAVDWYAISTLTTYLQEKLGASPLHVDLATLKE
                     LKLNASLPALLLIRLPYTASSGLMAPREVLTGNDEVIGQVLSTLKSEDVPYTAALTAV
                     RPSRVARDITMVAGGLGRQLLQTQVASPAIHPPVSYNDTAPRILFWAQNFSVAYKDEW
                     KDLTSLTFGVENLNLTGSFWNDSFAMLSLTYEPLFGATVTFKFILASRFYPVSARYWF
                     AMERLEIHSNGSVAHFNVSQVTGPSIYSFHCEYVSSVSKKGNLLVTNVPSVWQMTLHN
                     FQIQAFNVTGEQFSYASDCAGFFSPGIWMGLLTTLFMLFIFTYGLHMILSLKTMDRFD
                     DHKGPTITLTQIV"
     exon            226..352
                     /gene="Atp6ap1"
                     /gene_synonym="16A; AC45; Atp6ip1; Atp6s1; C7-1; CF2;
                     mFLJ00383; VATPS1; XAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            353..427
                     /gene="Atp6ap1"
                     /gene_synonym="16A; AC45; Atp6ip1; Atp6s1; C7-1; CF2;
                     mFLJ00383; VATPS1; XAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            428..621
                     /gene="Atp6ap1"
                     /gene_synonym="16A; AC45; Atp6ip1; Atp6s1; C7-1; CF2;
                     mFLJ00383; VATPS1; XAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            622..662
                     /gene="Atp6ap1"
                     /gene_synonym="16A; AC45; Atp6ip1; Atp6s1; C7-1; CF2;
                     mFLJ00383; VATPS1; XAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            663..748
                     /gene="Atp6ap1"
                     /gene_synonym="16A; AC45; Atp6ip1; Atp6s1; C7-1; CF2;
                     mFLJ00383; VATPS1; XAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            749..987
                     /gene="Atp6ap1"
                     /gene_synonym="16A; AC45; Atp6ip1; Atp6s1; C7-1; CF2;
                     mFLJ00383; VATPS1; XAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1035
                     /gene="Atp6ap1"
                     /gene_synonym="16A; AC45; Atp6ip1; Atp6s1; C7-1; CF2;
                     mFLJ00383; VATPS1; XAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1264
                     /gene="Atp6ap1"
                     /gene_synonym="16A; AC45; Atp6ip1; Atp6s1; C7-1; CF2;
                     mFLJ00383; VATPS1; XAP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..2189
                     /gene="Atp6ap1"
                     /gene_synonym="16A; AC45; Atp6ip1; Atp6s1; C7-1; CF2;
                     mFLJ00383; VATPS1; XAP-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagggcgggg cttgggcgga ggtgccggtc atctgatctg cagtggcttc agaggcccag
       61 gcactcactg aaagctgagg ctatgatggc ggcaacagtg gtatctcgga tacggacggg
      121 gacagggcgg gctccagtca tgtggctgtc tctgtcgttg gtggcagtgg cagcagcagt
      181 ggccacggag cagcaggtgc cactggtact gtggtcgagt gaccggaatc tgtgggctcc
      241 tgtggccgac acacatgagg gtcatatcac cagcgatatg cagctttcta cctacttaga
      301 ccctgccctg gagctgggtc cccgtaatgt actgctgttc ctacaggaca agctaagcat
      361 tgaggatttc acagcatacg gtggtgtgtt tggaaataag caggacagtg ccttttctaa
      421 cctggagaat gccctggact tggccccctc ctcactggtg cttcctgctg tggactggta
      481 tgcaatcagc actctgacca cctacctaca ggagaagctt ggggctagcc ccttgcatgt
      541 ggatctagct accttaaagg agctgaagct caatgccagc cttcctgccc tgctgctcat
      601 ccgtctgccc tacacagcca gctccggtct gatggcgccc agggaggtcc tcacaggtaa
      661 cgatgaggtc atcggacagg tactgagcac actcaagtct gaagatgtcc cttacaccgc
      721 agctcttact gcagtccgcc cttctagagt ggcccgtgat ataaccatgg tggctggggg
      781 tctaggtcgc cagctgcttc agactcaggt ggcatctcct gcgatccatc ctcctgtgag
      841 ttacaatgac actgccccaa ggatcctgtt ttgggcacaa aacttctctg tggcatacaa
      901 agacgagtgg aaagacttga cctccctcac ctttggtgtg gagaatctta acttgaccgg
      961 ctccttctgg aatgactcct ttgccatgct ttcactgacc tatgagccac tctttggtgc
     1021 aacagtgaca ttcaagttca ttctggctag tcgcttctat ccagtgtctg cccgatattg
     1081 gtttgccatg gaacgacttg aaatccacag caatggctct gttgcccatt tcaatgtttc
     1141 ccaagtcaca ggacctagca tctattcttt ccactgtgag tacgtcagca gtgtgagcaa
     1201 gaaaggcaat ctccttgtga ccaacgtgcc ctcagtctgg cagatgactc ttcataactt
     1261 ccagatccag gccttcaatg tgactggtga acagttctcc tatgctagcg actgtgctgg
     1321 tttcttctct ccgggcatct ggatgggtct gctcaccacc ctcttcatgc ttttcatatt
     1381 cacctatggt ctgcacatga tactcagcct aaagaccatg gatcgctttg atgaccacaa
     1441 gggccccacc atcactttga cccagattgt gtgacataca cctgagagga attgagggag
     1501 tattggtgtc taggttgtca tgtttctgtt ttgtgacaca gtggatggaa aggtttgtcc
     1561 tcttcctact atagcatgaa ccctacatac gccaccctca gtctctcttg cttcctcttt
     1621 aacccggaga gggactcccc tgtggctatc ccccatctct accaacaaag tgtattcttc
     1681 atagatatta gataaatctt ccaggcttca tcatcaagag gggaagggac cttaattcta
     1741 gggtctcccc tttaccctct ctccttattt attcttgccc ctctgctatt attccttgct
     1801 gtttatagtg cttttgtgta gtaaatgctc actccccaag ctttatggag cttccagcaa
     1861 cagccatgaa cttgaggttc cttgaatttg cgaggtgtgg aaagactact tgactgtctg
     1921 tccagcttag ctgttatgtt ttttgggggg gaggggtgat gtgttaagag tgagtggtac
     1981 actggggttt atttctgtgg cctgggaagg aagaaaccat cacgaggatt ggtgaacaaa
     2041 gtgtgctcac tgggtttctg gattattccc ataaagactg cctgtcaaga ggccggaggt
     2101 gtgtgtgggg ggttgctctg ttgtttcctt cctaataaaa taaagacgtg ttgccttgtg
     2161 ttgggcttcg tgtcactcat ttctgcact
//
