LOCUS       NM_138597                772 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus ATP synthase peripheral stalk subunit OSCP (Atp5po),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_138597
VERSION     NM_138597.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 772)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 772)
  AUTHORS   Gauba,E., Sui,S., Tian,J., Driskill,C., Jia,K., Yu,C., Rughwani,T.,
            Wang,Q., Kroener,S., Guo,L. and Du,H.
  TITLE     Modulation of OSCP mitigates mitochondrial and synaptic deficits in
            a mouse model of Alzheimer's pathology
  JOURNAL   Neurobiol Aging 98, 63-77 (2021)
   PUBMED   33254080
  REMARK    GeneRIF: Modulation of OSCP mitigates mitochondrial and synaptic
            deficits in a mouse model of Alzheimer's pathology.
REFERENCE   3  (bases 1 to 772)
  AUTHORS   Burstein,S.R., Kim,H.J., Fels,J.A., Qian,L., Zhang,S., Zhou,P.,
            Starkov,A.A., Iadecola,C. and Manfredi,G.
  TITLE     Estrogen receptor beta modulates permeability transition in brain
            mitochondria
  JOURNAL   Biochim Biophys Acta Bioenerg 1859 (6), 423-433 (2018)
   PUBMED   29550215
  REMARK    GeneRIF: Estrogen receptor beta modulates mitochondrial
            permeability transition by regulating CypD interaction with OSCP.
REFERENCE   4  (bases 1 to 772)
  AUTHORS   Yang,W., Nagasawa,K., Munch,C., Xu,Y., Satterstrom,K., Jeong,S.,
            Hayes,S.D., Jedrychowski,M.P., Vyas,F.S., Zaganjor,E., Guarani,V.,
            Ringel,A.E., Gygi,S.P., Harper,J.W. and Haigis,M.C.
  TITLE     Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent
            Deacetylation in Response to Membrane Depolarization
  JOURNAL   Cell 167 (4), 985-1000 (2016)
   PUBMED   27881304
REFERENCE   5  (bases 1 to 772)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 772)
  AUTHORS   Ceni,C., Pochon,N., Brun,V., Muller-Steffner,H., Andrieux,A.,
            Grunwald,D., Schuber,F., De Waard,M., Lund,F., Villaz,M. and
            Moutin,M.J.
  TITLE     CD38-dependent ADP-ribosyl cyclase activity in developing and adult
            mouse brain
  JOURNAL   Biochem J 370 (Pt 1), 175-183 (2003)
   PUBMED   12403647
REFERENCE   7  (bases 1 to 772)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   8  (bases 1 to 772)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   9  (bases 1 to 772)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   10 (bases 1 to 772)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC126053.3.
            
            On Nov 17, 2006 this sequence version replaced NM_138597.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005309.1, CX566766.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC126053.3         115577-115687
            112-162             AC126053.3         116803-116853
            163-273             AC126053.3         118198-118308
            274-403             AC126053.3         120225-120354
            404-516             AC126053.3         120636-120748
            517-603             AC126053.3         121580-121666
            604-772             AC126053.3         121816-121984
FEATURES             Location/Qualifiers
     source          1..772
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 53.26 cM"
     gene            1..772
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; ATPO; D12Wsu28e; OSCP"
                     /note="ATP synthase peripheral stalk subunit OSCP"
                     /db_xref="GeneID:28080"
                     /db_xref="MGI:MGI:106341"
     exon            1..111
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; ATPO; D12Wsu28e; OSCP"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..717
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; ATPO; D12Wsu28e; OSCP"
                     /EC_number="7.1.2.2"
                     /note="ATP synthase subunit O, mitochondrial; ATP
                     synthase, H+ transporting, mitochondrial F1 complex, O
                     subunit; oligomycin sensitivity conferral protein; ATP
                     synthase, H+ transporting, mitochondrial F1 complex, O
                     subunit; DNA segment, Chr 12, Wayne State University 28,
                     expressed"
                     /codon_start=1
                     /product="ATP synthase subunit O, mitochondrial precursor"
                     /protein_id="NP_613063.1"
                     /db_xref="CCDS:CCDS28331.1"
                     /db_xref="GeneID:28080"
                     /db_xref="MGI:MGI:106341"
                     /translation="MAAPAASGLSRQVRSFSTSVVRPFAKLVRPPVQVYGIEGRYATA
                     LYSAASKEKKLDQVEKELLRVGQLLKDPKVSLAVLNPYIKRTVKVKSLNDITKREKFS
                     PLTANLMNLLAENGRLGNTQGIISAFSTIMSVHRGEVPCTVTTASPLDDAVLSELKTV
                     LKSFLSPNQILKLEIKTDPSIMGGMIVRIGEKYVDMSAKSKIQKLSKAMREML"
     exon            112..162
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; ATPO; D12Wsu28e; OSCP"
                     /inference="alignment:Splign:2.1.0"
     exon            163..273
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; ATPO; D12Wsu28e; OSCP"
                     /inference="alignment:Splign:2.1.0"
     exon            274..403
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; ATPO; D12Wsu28e; OSCP"
                     /inference="alignment:Splign:2.1.0"
     exon            404..516
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; ATPO; D12Wsu28e; OSCP"
                     /inference="alignment:Splign:2.1.0"
     exon            517..603
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; ATPO; D12Wsu28e; OSCP"
                     /inference="alignment:Splign:2.1.0"
     exon            604..772
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; ATPO; D12Wsu28e; OSCP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggcgcgcg cgcgtgcgct ctggcgccag tagtctcttt tcatttgggt ttgacctaca
       61 gccgcccggg aaaagatggc cgcgcctgca gcgtccggac tgtctcgaca ggttcggagc
      121 ttcagtacat ctgtggtcag gccctttgcc aagcttgtaa ggccccctgt tcaggtctac
      181 ggcatcgaag gccgctatgc aaccgccctg tactctgctg catctaagga gaagaagctg
      241 gaccaggtgg agaaggagct gctgcgcgta gggcaactcc tgaaggaccc caaagtgtct
      301 ctggctgttc tgaatcccta catcaagcgc accgtcaaag tgaaaagcct aaatgacatc
      361 acgaaaaggg aaaagttctc cccgctgacg gccaacctca tgaatttact tgctgaaaat
      421 ggtcgcctag gcaacaccca gggtatcatc tctgcctttt ccaccatcat gagtgtccac
      481 cgcggagaag tgccatgcac agtgaccaca gcatctcctc tagatgacgc tgttctctct
      541 gagttaaaga cggtgctgaa gagcttcctg agtccaaacc aaatactgaa actggagatc
      601 aagactgacc cgtcaatcat gggcgggatg attgtccgaa ttggggaaaa gtacgttgat
      661 atgtctgcaa agagcaagat tcagaagctc agcaaggcca tgcgggagat gctctgagag
      721 actgtcacct gtgtgagctc ttgtccttgg agcaacaata aaatgcttcc tg
//
