LOCUS       NM_001302213             851 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus ATP synthase peripheral stalk subunit F6 (Atp5pf),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001302213 XM_006522875
VERSION     NM_001302213.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 851)
  AUTHORS   Liu,B., Hua,D., Shen,L., Li,T., Tao,Z., Fu,C., Tang,Z., Yang,J.,
            Zhang,L., Nie,A., Jiang,Y., Wang,J., Li,Y., Gu,Y. and Ning,G.
  TITLE     NPC1 is required for postnatal islet beta cell differentiation by
            maintaining mitochondria turnover
  JOURNAL   Theranostics 14 (5), 2058-2074 (2024)
   PUBMED   38505613
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 851)
  AUTHORS   Izumiyama,K., Osanai,T., Sagara,S., Yamamoto,Y., Itoh,T.,
            Sukekawa,T., Nishizaki,F., Magota,K. and Okumura,K.
  TITLE     Estrogen attenuates coupling factor 6-induced salt-sensitive
            hypertension and cardiac systolic dysfunction in mice
  JOURNAL   Hypertens Res 35 (5), 539-546 (2012)
   PUBMED   22258022
  REMARK    GeneRIF: Coupling factor 6 overexpression induced salt-sensitive
            hypertension, complicated by systolic cardiac dysfunction, but its
            onset was delayed in females. Estrogen has an important role in the
            regulation of coupling factor 6-mediated pathophysiology.
REFERENCE   3  (bases 1 to 851)
  AUTHORS   Sagara,S., Osanai,T., Itoh,T., Izumiyama,K., Shibutani,S.,
            Hanada,K., Yokoyama,H., Yamamoto,Y., Yokota,T., Tomita,H.,
            Magota,K. and Okumura,K.
  TITLE     Overexpression of coupling factor 6 attenuates exercise-induced
            physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling
            in mice
  JOURNAL   J Hypertens 30 (4), 778-786 (2012)
   PUBMED   22306848
  REMARK    GeneRIF: Overexpression of coupling factor 6 attenuates
            exercise-induced physiological cardiac hypertrophy by
            downregulating Akt signaling, thereby cancelling its benefit for
            cardiac function in mice.
REFERENCE   4  (bases 1 to 851)
  AUTHORS   Osanai,T., Tanaka,M., Magota,K., Tomita,H. and Okumura,K.
  TITLE     Coupling factor 6-induced activation of ecto-F1F(o) complex induces
            insulin resistance, mild glucose intolerance and elevated blood
            pressure in mice
  JOURNAL   Diabetologia 55 (2), 520-529 (2012)
   PUBMED   22038518
  REMARK    GeneRIF: CF6 plays a crucial role in the development of insulin
            resistance and hypertension
REFERENCE   5  (bases 1 to 851)
  AUTHORS   Ashitate,T., Osanai,T., Tanaka,M., Magota,K., Echizen,T.,
            Izumiyama,K., Yokoyama,H., Shibutani,S., Hanada,K., Tomita,H. and
            Okumura,K.
  TITLE     Overexpression of coupling factor 6 causes cardiac dysfunction
            under high-salt diet in mice
  JOURNAL   J Hypertens 28 (11), 2243-2251 (2010)
   PUBMED   20811295
  REMARK    GeneRIF: coupling factor 6 induces the development of systolic
            dysfunction and upregulation of nicotinamide adenine dinucleotide
            phosphate oxidase in the heart under the high-salt diet
REFERENCE   6  (bases 1 to 851)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   7  (bases 1 to 851)
  AUTHORS   Patton,J., Block,S., Coombs,C. and Martin,M.E.
  TITLE     Identification of functional elements in the murine Gabp alpha/ATP
            synthase coupling factor 6 bi-directional promoter
  JOURNAL   Gene 369, 35-44 (2006)
   PUBMED   16309857
  REMARK    GeneRIF: identification of functional elements in bi-directional
            promoter
REFERENCE   8  (bases 1 to 851)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 851)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (bases 1 to 851)
  AUTHORS   Chinenov,Y., Coombs,C. and Martin,M.E.
  TITLE     Isolation of a bi-directional promoter directing expression of the
            mouse GABPalpha and ATP synthase coupling factor 6 genes
  JOURNAL   Gene 261 (2), 311-320 (2000)
   PUBMED   11167019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164162.2.
            
            On Feb 15, 2023 this sequence version replaced NM_001302213.1.
            
            Summary: The protein encoded by this gene is a component of
            mitochondrial adenosine triphosphate synthase, which catalyzes the
            conversion of ATP from ADP. Mitochondrial adenosine triphosphate
            synthase consists of extrinsic and intrinsic membrane domains that
            are joined by a stalk. The protein encoded by this gene is a
            subunit of the stalk domain. A bi-directional promoter that drives
            expression of this gene has been has been identified. Pseudogenes
            of this gene are found on chromosomes 14 and 17. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CJ235642.1, SRR7652917.138408.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               AC164162.2         38284-38470
            188-362             AC164162.2         38908-39082
            363-417             AC164162.2         40017-40071
            418-596             AC164162.2         42384-42562
            597-721             AC164162.2         45342-45466
            722-851             AC164162.2         45896-46025
FEATURES             Location/Qualifiers
     source          1..851
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 46.92 cM"
     gene            1..851
                     /gene="Atp5pf"
                     /gene_synonym="Atp5j; CF6"
                     /note="ATP synthase peripheral stalk subunit F6"
                     /db_xref="GeneID:11957"
                     /db_xref="MGI:MGI:107777"
     exon            1..187
                     /gene="Atp5pf"
                     /gene_synonym="Atp5j; CF6"
                     /inference="alignment:Splign:2.1.0"
     exon            188..362
                     /gene="Atp5pf"
                     /gene_synonym="Atp5j; CF6"
                     /inference="alignment:Splign:2.1.0"
     exon            363..417
                     /gene="Atp5pf"
                     /gene_synonym="Atp5j; CF6"
                     /inference="alignment:Splign:2.1.0"
     exon            418..596
                     /gene="Atp5pf"
                     /gene_synonym="Atp5j; CF6"
                     /inference="alignment:Splign:2.1.0"
     exon            597..721
                     /gene="Atp5pf"
                     /gene_synonym="Atp5j; CF6"
                     /inference="alignment:Splign:2.1.0"
     exon            722..851
                     /gene="Atp5pf"
                     /gene_synonym="Atp5j; CF6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      824..829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp5pf"
                     /gene_synonym="Atp5j; CF6"
                     /note="hexamer: AATAAA"
     polyA_site      851
                     /gene="Atp5pf"
                     /gene_synonym="Atp5j; CF6"
                     /note="major polyA site"
ORIGIN      
        1 aagccccgga accaggccgc ccgcgcgggc ccgcgctccc cgccagcccg cgtccgcaac
       61 tcaccagctc cggaattcgt cccgtggccc tagcccgcgc ttccacagcc ggctgggaac
      121 ggcggcggcg cgggctccag gtacagcgcc tctccgggcg agccgcgccg ctcccgcgag
      181 tagcaggagg cgtccggtcg cagactccct tcgaggcgct tcctgtccgg tgagcgtcga
      241 acgactgaag ccgcggccca tagtgccttg cgatggcggg taggcgtgtg taggcggagc
      301 cagggccgga agtagaacgg tggcggcggc ggtgactctg gcagctcggg actcagtgca
      361 agaagaaatg accgtcttgg cagttagatt gggagcaggt tgactgtgga atgttagtac
      421 agagactcag ccatggttct gcagaggatc ttcaggctct cctctgtcct tcggtcagca
      481 gtctctgtgc atttgaagag gaacattggt gttacagctg tggcctttaa taaggaactt
      541 gatcctgtac agaaactctt cgtggacaag ataagagagt acaaatcaaa gcgacaggca
      601 tctggaggac ctgttgatat tggcccagag tatcagcaag atctggacag agagctttat
      661 aagcttaaac aaatgtatgg taaaggagag atggatacat ttcctacctt caaatttgat
      721 gatcccaaat ttgaagtcat cgacaaaccc cagtcctgag gaacatacaa aatccatgtg
      781 gtaatttgtc atgaattagt tgtacaacta atcaaaaaat tcaaataaac attcatttca
      841 cagttatcaa a
//
