LOCUS       NM_001417934             757 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus ATP synthase peripheral stalk subunit d (Atp5pd),
            transcript variant 4, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001417934
VERSION     NM_001417934.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 757)
  AUTHORS   Li,Y., Ivica,N.A., Dong,T., Papageorgiou,D.P., He,Y., Brown,D.R.,
            Kleyman,M., Hu,G., Chen,W.W., Sullivan,L.B., Del Rosario,A.,
            Hammond,P.T., Vander Heiden,M.G. and Chen,J.
  TITLE     MFSD7C switches mitochondrial ATP synthesis to thermogenesis in
            response to heme
  JOURNAL   Nat Commun 11 (1), 4837 (2020)
   PUBMED   32973183
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 757)
  AUTHORS   Song,K.H., Kim,J.H., Lee,Y.H., Bae,H.C., Lee,H.J., Woo,S.R.,
            Oh,S.J., Lee,K.M., Yee,C., Kim,B.W., Cho,H., Chung,E.J.,
            Chung,J.Y., Hewitt,S.M., Chung,T.W., Ha,K.T., Bae,Y.K., Mao,C.P.,
            Yang,A., Wu,T.C. and Kim,T.W.
  TITLE     Mitochondrial reprogramming via ATP5H loss promotes multimodal
            cancer therapy resistance
  JOURNAL   J Clin Invest 128 (9), 4098-4114 (2018)
   PUBMED   30124467
  REMARK    GeneRIF: multimodality resistance arises through a core metabolic
            reprogramming pathway instigated by epigenetic loss of the ATP
            synthase subunit ATP5H, which leads to ROS accumulation and
            HIF-1alpha stabilization under normoxia
REFERENCE   3  (bases 1 to 757)
  AUTHORS   Brody,M.J., Hacker,T.A., Patel,J.R., Feng,L., Sadoshima,J.,
            Tevosian,S.G., Balijepalli,R.C., Moss,R.L. and Lee,Y.
  TITLE     Ablation of the cardiac-specific gene leucine-rich repeat
            containing 10 (Lrrc10) results in dilated cardiomyopathy
  JOURNAL   PLoS One 7 (12), e51621 (2012)
   PUBMED   23236519
REFERENCE   4  (bases 1 to 757)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   5  (bases 1 to 757)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   6  (bases 1 to 757)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 757)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627096.9.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.1703812.1,
                                           SRR17784650.231436.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AL627096.9         11826-11883         c
            59-160              AL627096.9         11126-11227         c
            161-205             AL627096.9         10633-10677         c
            206-336             AL627096.9         10320-10450         c
            337-433             AL627096.9         9773-9869           c
            434-505             AL627096.9         8787-8858           c
            506-568             AL627096.9         7949-8011           c
            569-757             AL627096.9         7625-7813           c
FEATURES             Location/Qualifiers
     source          1..757
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.84 cM"
     gene            1..757
                     /gene="Atp5pd"
                     /gene_synonym="0610009D10Rik; Atp5h"
                     /note="ATP synthase peripheral stalk subunit d"
                     /db_xref="GeneID:71679"
                     /db_xref="MGI:MGI:1918929"
     exon            1..58
                     /gene="Atp5pd"
                     /gene_synonym="0610009D10Rik; Atp5h"
                     /inference="alignment:Splign:2.1.0"
     exon            59..160
                     /gene="Atp5pd"
                     /gene_synonym="0610009D10Rik; Atp5h"
                     /inference="alignment:Splign:2.1.0"
     exon            161..205
                     /gene="Atp5pd"
                     /gene_synonym="0610009D10Rik; Atp5h"
                     /inference="alignment:Splign:2.1.0"
     exon            206..336
                     /gene="Atp5pd"
                     /gene_synonym="0610009D10Rik; Atp5h"
                     /inference="alignment:Splign:2.1.0"
     exon            337..433
                     /gene="Atp5pd"
                     /gene_synonym="0610009D10Rik; Atp5h"
                     /inference="alignment:Splign:2.1.0"
     exon            434..505
                     /gene="Atp5pd"
                     /gene_synonym="0610009D10Rik; Atp5h"
                     /inference="alignment:Splign:2.1.0"
     exon            506..568
                     /gene="Atp5pd"
                     /gene_synonym="0610009D10Rik; Atp5h"
                     /inference="alignment:Splign:2.1.0"
     exon            569..757
                     /gene="Atp5pd"
                     /gene_synonym="0610009D10Rik; Atp5h"
                     /inference="alignment:Splign:2.1.0"
     regulatory      733..738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp5pd"
                     /gene_synonym="0610009D10Rik; Atp5h"
                     /note="hexamer: AATAAA"
     polyA_site      757
                     /gene="Atp5pd"
                     /gene_synonym="0610009D10Rik; Atp5h"
                     /note="major polyA site"
ORIGIN      
        1 aactctcttc cgttccttgc ttgctggaga gagagcactc cgccgggggt cggtgaagag
       61 acgtaagctg tactgaggaa ggaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa
      121 ggagagagac cggcatttga caactttgat cgataggaag tgtttctggt gctggagagg
      181 gaacccagga ctctgtccat gccagtatcc caagatggct gggcgtaaac ttgctctaaa
      241 aaccattgat tgggtatctt ttgtggaggt catgccccaa aaccagaagg caattggaaa
      301 tgccctgaag tcctggaatg agaccttcca cgccaggttg gctagtctgt ctgagaaacc
      361 acctgcgatt gactgggctt actacagggc caatgtggcc aagcctggct tggtggatga
      421 ttttgaaaag aagtataatg ccctgaagat tcctgtgcct gaggataaat acacagccct
      481 ggtggaccag gaggagaagg aggatgtgaa gagctgtgct gagtttgtgt ctggatccca
      541 gctcaggatc caggagtatg agaagcagct ggagaaaatg aggaacataa ttccctttga
      601 ccagatgacc attgatgact tgaatgagat cttcccagaa accaagctgg acaaaaagaa
      661 gtacccgtac tggccccacc agcccatcga gaacctgtga agcagcctgg gacggagccc
      721 cggccgacat gaaataaaac atttaaatag tgctggc
//
