LOCUS       NM_175015                729 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus ATP synthase membrane subunit c locus 3 (Atp5mc3),
            transcript variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_175015
VERSION     NM_175015.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 729)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 729)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   3  (bases 1 to 729)
  AUTHORS   Yao,Y., Liu,Q., Adrianto,I., Wu,X., Glassbrook,J., Khalasawi,N.,
            Yin,C., Yi,Q., Dong,Z., Geissmann,F., Zhou,L. and Mi,Q.S.
  TITLE     Histone deacetylase 3 controls lung alveolar macrophage development
            and homeostasis
  JOURNAL   Nat Commun 11 (1), 3822 (2020)
   PUBMED   32732898
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 729)
  AUTHORS   Sakamoto,T., Matsuura,T.R., Wan,S., Ryba,D.M., Kim,J.U., Won,K.J.,
            Lai,L., Petucci,C., Petrenko,N., Musunuru,K., Vega,R.B. and
            Kelly,D.P.
  TITLE     A Critical Role for Estrogen-Related Receptor Signaling in Cardiac
            Maturation
  JOURNAL   Circ Res 126 (12), 1685-1702 (2020)
   PUBMED   32212902
REFERENCE   5  (bases 1 to 729)
  AUTHORS   Vrbacky,M., Kovalcikova,J., Chawengsaksophak,K., Beck,I.M.,
            Mracek,T., Nuskova,H., Sedmera,D., Papousek,F., Kolar,F., Sobol,M.,
            Hozak,P., Sedlacek,R. and Houstek,J.
  TITLE     Knockout of Tmem70 alters biogenesis of ATP synthase and leads to
            embryonal lethality in mice
  JOURNAL   Hum Mol Genet 25 (21), 4674-4685 (2016)
   PUBMED   28173120
REFERENCE   6  (bases 1 to 729)
  AUTHORS   Poche,R.A., Zhang,M., Rueda,E.M., Tong,X., McElwee,M.L., Wong,L.,
            Hsu,C.W., Dejosez,M., Burns,A.R., Fox,D.A., Martin,J.F., Zwaka,T.P.
            and Dickinson,M.E.
  TITLE     RONIN Is an Essential Transcriptional Regulator of Genes Required
            for Mitochondrial Function in the Developing Retina
  JOURNAL   Cell Rep 14 (7), 1684-1697 (2016)
   PUBMED   26876175
REFERENCE   7  (bases 1 to 729)
  AUTHORS   Hupe,M., Li,M.X., Gertow Gillner,K., Adams,R.H. and Stenman,J.M.
  TITLE     Evaluation of TRAP-sequencing technology with a versatile
            conditional mouse model
  JOURNAL   Nucleic Acids Res 42 (2), e14 (2014)
   PUBMED   24165879
REFERENCE   8  (bases 1 to 729)
  AUTHORS   Huang,Y., Wang,L., Bennett,B., Williams,R.W., Wang,Y.J., Gu,W.K.
            and Jiao,Y.
  TITLE     Potential role of Atp5g3 in epigenetic regulation of alcohol
            preference or obesity from a mouse genomic perspective
  JOURNAL   Genet Mol Res 12 (3), 3662-3674 (2013)
   PUBMED   24085430
  REMARK    GeneRIF: We obtained correlations between Atp5g3 and alcoholism-
            and obesity-relevant phenotypes.
            Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL844581.7, CF104340.1 and
            AI851824.1.
            
            On Sep 11, 2014 this sequence version replaced NM_175015.2.
            
            Summary: The protein encoded by this gene is a subunit of
            mitochondrial membrane ATP synthase, the enzyme that catalyzes ATP
            synthesis during oxidative phosphorylation. This gene encodes
            subunit 9, which is present in multiple copies in the transmembrane
            part of the ATP synthase complex. Phenotype and gene expression
            profiles suggest correlations between this gene and alcoholism- and
            obesity-related phenotypes. Alternative splicing results in
            multiple transcript variants and protein isoforms. [provided by
            RefSeq, Sep 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB202871.1, CB202057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AL844581.7         89787-89790         c
            5-587               CF104340.1         1-583
            588-729             AI851824.1         1-142               c
FEATURES             Location/Qualifiers
     source          1..729
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 43.9 cM"
     gene            1..729
                     /gene="Atp5mc3"
                     /gene_synonym="6030447M23; Atp5g3"
                     /note="ATP synthase membrane subunit c locus 3"
                     /db_xref="GeneID:228033"
                     /db_xref="MGI:MGI:2442035"
     exon            1..75
                     /gene="Atp5mc3"
                     /gene_synonym="6030447M23; Atp5g3"
                     /inference="alignment:Splign:2.1.0"
     exon            76..181
                     /gene="Atp5mc3"
                     /gene_synonym="6030447M23; Atp5g3"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..568
                     /gene="Atp5mc3"
                     /gene_synonym="6030447M23; Atp5g3"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; ATP synthase lipid-binding protein,
                     mitochondrial; ATPase protein 9; ATPase subunit c; ATP
                     synthase proteolipid P3; ATP synthase F(0) complex subunit
                     C3, mitochondrial; ATP synthase, H+ transporting,
                     mitochondrial F0 complex, subunit C3 (subunit 9)"
                     /codon_start=1
                     /product="ATP synthase F(0) complex subunit C3,
                     mitochondrial isoform a precursor"
                     /protein_id="NP_778180.1"
                     /db_xref="CCDS:CCDS16136.1"
                     /db_xref="GeneID:228033"
                     /db_xref="MGI:MGI:2442035"
                     /translation="MFACAKLARTPALIRAGSRVAYRPISASVLSRPETRTGEGSTVF
                     NGAQNGVCQLIRREFQTSVISRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGY
                     ARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAM"
     exon            182..259
                     /gene="Atp5mc3"
                     /gene_synonym="6030447M23; Atp5g3"
                     /inference="alignment:Splign:2.1.0"
     exon            260..453
                     /gene="Atp5mc3"
                     /gene_synonym="6030447M23; Atp5g3"
                     /inference="alignment:Splign:2.1.0"
     exon            454..714
                     /gene="Atp5mc3"
                     /gene_synonym="6030447M23; Atp5g3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      695..700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp5mc3"
                     /gene_synonym="6030447M23; Atp5g3"
                     /note="hexamer: ATTAAA"
     polyA_site      714
                     /gene="Atp5mc3"
                     /gene_synonym="6030447M23; Atp5g3"
                     /note="major polyA site"
ORIGIN      
        1 aagagccgca ccgcgcttgc gcgcccagcc ccactgcttc gacctctgcc gccgccactg
       61 ccgccgcctc gggagagagg aagcgggaga ggagcccacg tcgcctgtca cctagatcca
      121 cgccgcgccg ccaggaagaa agatgttcgc ctgcgccaag ctcgcccgca cccccgctct
      181 gatccgagct ggatccagag ttgcatatag accaatttct gcatcagtgt tatctcggcc
      241 agagactagg actggagagg gctctacagt ttttaatggg gcccagaatg gtgtgtgtca
      301 gctgatccga agggagtttc agaccagtgt aatcagcaga gacattgata ctgctgccaa
      361 attcattggt gcaggtgctg caacagtagg agttgctggt tctggtgctg gtattggaac
      421 agtctttggc agtcttatca ttggttatgc cagaaaccct tcactgaagc agcagctgtt
      481 ctcatatgct atcctgggat ttgccttgtc tgaagctatg ggtctctttt gtttgatggt
      541 tgcgttcttg atcttgtttg ccatgtaaca gaaattactg cctgaaatgt tggcattcat
      601 agtaattacg gatgtaattc tgtgtatctt gctgtgactc cgaagactgt agtactggtg
      661 tcatggaaat atatgttatt tccacagtca tttcattaaa gatgaaaact ttaaaaaaaa
      721 aaaaaaaaa
//
