LOCUS       NM_007512               1514 bp    mRNA    linear   ROD 19-FEB-2023
DEFINITION  Mus musculus ATPase inhibitory factor 1 (Atpif1), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_007512
VERSION     NM_007512.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1514)
  AUTHORS   Zhou B, Caudal A, Tang X, Chavez JD, McMillen TS, Keller A, Villet
            O, Zhao M, Liu Y, Ritterhoff J, Wang P, Kolwicz SC Jr, Wang W,
            Bruce JE and Tian R.
  TITLE     Upregulation of mitochondrial ATPase inhibitory factor 1 (ATPIF1)
            mediates increased glycolysis in mouse hearts
  JOURNAL   J Clin Invest 132 (10) (2022)
   PUBMED   35575090
  REMARK    GeneRIF: Upregulation of mitochondrial ATPase inhibitory factor 1
            (ATPIF1) mediates increased glycolysis in mouse hearts.
REFERENCE   2  (bases 1 to 1514)
  AUTHORS   Zhang K, Bao R, Huang F, Yang K, Ding Y, Lauterboeck L, Yoshida M,
            Long Q and Yang Q.
  TITLE     ATP synthase inhibitory factor subunit 1 regulates islet beta-cell
            function via repression of mitochondrial homeostasis
  JOURNAL   Lab Invest 102 (1), 69-79 (2022)
   PUBMED   36775575
  REMARK    GeneRIF: ATP synthase inhibitory factor subunit 1 regulates islet
            beta-cell function via repression of mitochondrial homeostasis.
REFERENCE   3  (bases 1 to 1514)
  AUTHORS   Zhang K, Bao R, Huang F, Yang K, Ding Y, Lauterboeck L, Yoshida M,
            Long Q and Yang Q.
  TITLE     ATP synthase inhibitory factor subunit 1 regulates islet beta-cell
            function via repression of mitochondrial homeostasis
  JOURNAL   Lab Invest 102 (1), 69-79 (2022)
   PUBMED   34608240
  REMARK    GeneRIF: ATP synthase inhibitory factor subunit 1 regulates islet
            beta-cell function via repression of mitochondrial homeostasis.
REFERENCE   4  (bases 1 to 1514)
  AUTHORS   Zhong G, Zhang J, Guo Y, Wang Y, Wu M, Ren J, Li Y, Zhang X, Zhou
            B, Zhao W, Lou Y, Wang H and Ye J.
  TITLE     IF1 inactivation attenuates experimental colitis through
            downregulation of neutrophil infiltration in colon mucosa
  JOURNAL   Int Immunopharmacol 99, 107980 (2021)
   PUBMED   34298397
REFERENCE   5  (bases 1 to 1514)
  AUTHORS   Wang Y, Zhang J, Cao X, Guan Y, Shen S, Zhong G, Xiong X, Xu Y,
            Zhang X, Wang H and Ye J.
  TITLE     Mitochondrial protein IF1 is a potential regulator of glucagon-like
            peptide (GLP-1) secretion function of the mouse intestine
  JOURNAL   Acta Pharm Sin B 11 (6), 1568-1577 (2021)
   PUBMED   34221868
REFERENCE   6  (bases 1 to 1514)
  AUTHORS   Shah DI, Takahashi-Makise N, Cooney JD, Li L, Schultz IJ, Pierce
            EL, Narla A, Seguin A, Hattangadi SM, Medlock AE, Langer NB, Dailey
            TA, Hurst SN, Faccenda D, Wiwczar JM, Heggers SK, Vogin G, Chen W,
            Chen C, Campagna DR, Brugnara C, Zhou Y, Ebert BL, Danial NN,
            Fleming MD, Ward DM, Campanella M, Dailey HA, Kaplan J and Paw BH.
  TITLE     Mitochondrial Atpif1 regulates haem synthesis in developing
            erythroblasts
  JOURNAL   Nature 491 (7425), 608-612 (2012)
   PUBMED   23135403
  REMARK    GeneRIF: the identification of mitochondrial Atpif1 as a regulator
            of haem synthesis advances our understanding of the mechanisms
            regulating mitochondrial haem homeostasis and red blood cell
            development
            Erratum:[Nature. 2013 Apr 18;496(7445):386]
REFERENCE   7  (bases 1 to 1514)
  AUTHORS   Sanchez-Cenizo L, Formentini L, Aldea M, Ortega AD, Garcia-Huerta
            P, Sanchez-Arago M and Cuezva JM.
  TITLE     Up-regulation of the ATPase inhibitory factor 1 (IF1) of the
            mitochondrial H+-ATP synthase in human tumors mediates the
            metabolic shift of cancer cells to a Warburg phenotype
  JOURNAL   J Biol Chem 285 (33), 25308-25313 (2010)
   PUBMED   20538613
  REMARK    GeneRIF: Findings support that the mitochondrial content of IF1
            controls the activity of oxidative phosphorylation mediating the
            shift of cancer cells to an enhanced aerobic glycolysis.
REFERENCE   8  (bases 1 to 1514)
  AUTHORS   Shen L, Zhi L, Hu W and Wu MX.
  TITLE     IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation
  JOURNAL   Cell Death Differ 16 (4), 603-612 (2009)
   PUBMED   19096392
  REMARK    GeneRIF: The study reveals that IEX-1 targets the mitochondrial
            F1Fo-ATPase Inhibitor (IF1) for degradation, resulting in
            acceleration of ATP hydrolysis, concomitant with reduction in ROS
            production.
REFERENCE   9  (bases 1 to 1514)
  AUTHORS   Campanella M, Casswell E, Chong S, Farah Z, Wieckowski MR, Abramov
            AY, Tinker A and Duchen MR.
  TITLE     Regulation of mitochondrial structure and function by the
            F1Fo-ATPase inhibitor protein, IF1
  JOURNAL   Cell Metab 8 (1), 13-25 (2008)
   PUBMED   18590689
REFERENCE   10 (bases 1 to 1514)
  AUTHORS   Yamada E, Ishiguro N, Miyaishi O, Takeuchi A, Nakashima I, Iwata H
            and Isobe K.
  TITLE     Differential display analysis of murine collagen-induced arthritis:
            cloning of the cDNA-encoding murine ATPase inhibitor
  JOURNAL   Immunology 92 (4), 571-576 (1997)
   PUBMED   9497501
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK152389.1 and BU055998.1.
            
            [WARNING] On May 5, 2023 this sequence was replaced by NM_007512.5.
            
            On Apr 3, 2015 this sequence version replaced NM_007512.3.
            
            Summary: This gene encodes a member of the ATPase inhibitor family
            of proteins. This protein has been shown to negatively regulate the
            ATP hydrolysis activity of the F1Fo-ATPase. Knockdown of this gene
            is associated with reduced heme synthesis in differentiating
            erythroid cells. Misregulation of this gene has been found to lead
            to increased aerobic glycolysis in mouse cancer cells, while high
            expression levels of this gene have been correlated with gastric
            and liver cancer severity in human patients. A pseudogene of this
            gene has been identified. [provided by RefSeq, Apr 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-425               AK152389.1         2-426
            426-1484            AK152389.1         428-1486
            1485-1514           BU055998.1         459-488
FEATURES             Location/Qualifiers
     source          1..1514
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4"
     gene            1..1514
                     /gene="Atpif1"
                     /gene_synonym="ATP5IF1; Atpi; IF(1); If1"
                     /note="ATPase inhibitory factor 1"
                     /db_xref="GeneID:11983"
                     /db_xref="MGI:MGI:1196457"
     exon            1..676
                     /gene="Atpif1"
                     /gene_synonym="ATP5IF1; Atpi; IF(1); If1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..1130
                     /gene="Atpif1"
                     /gene_synonym="ATP5IF1; Atpi; IF(1); If1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1044..1364
                     /gene="Atpif1"
                     /gene_synonym="ATP5IF1; Atpi; IF(1); If1"
                     /note="ATPase inhibitor, mitochondrial; inhibitor of
                     F(1)F(o)-ATPase; ATP synthase F1 subunit epsilon"
                     /codon_start=1
                     /product="ATPase inhibitor, mitochondrial precursor"
                     /protein_id="NP_031538.2"
                     /db_xref="CCDS:CCDS18727.1"
                     /db_xref="GeneID:11983"
                     /db_xref="MGI:MGI:1196457"
                     /translation="MAGSALAVRARFGVWGMKVLQTRGFVSDSSDSMDTGAGSIREAG
                     GAFGKREKAEEDRYFREKTKEQLAALRKHHEDEIDHHSKEIERLQKQIERHKKKIQQL
                     KNNH"
     exon            1131..1222
                     /gene="Atpif1"
                     /gene_synonym="ATP5IF1; Atpi; IF(1); If1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1491
                     /gene="Atpif1"
                     /gene_synonym="ATP5IF1; Atpi; IF(1); If1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1468..1473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atpif1"
                     /gene_synonym="ATP5IF1; Atpi; IF(1); If1"
     polyA_site      1487
                     /gene="Atpif1"
                     /gene_synonym="ATP5IF1; Atpi; IF(1); If1"
                     /note="This is a major 5' polyA site."
     polyA_site      1491
                     /gene="Atpif1"
                     /gene_synonym="ATP5IF1; Atpi; IF(1); If1"
ORIGIN      
        1 agtgttgccc tggttgtctc cagtctctga cagaaagaaa tctgttgtct ctggatatac
       61 ctattattat tctggacatt tcccatggat ggaatctact tatacaattc ttatttaggt
      121 ttttttcatg tgacagtttt ttggtttttt tgacccagga tttctctgtg tagccttggt
      181 tgtcctggaa ttctctctgt agaccaggct gacctcaaac tcacagagat ctacatgact
      241 ccctggagtg ctggaactgg cctgggtaac caccatgtac cagtttttta agagtttatc
      301 ccagtggagc ctatcctggt actccagagg cagaggtagg cagatcttct gagtttgggg
      361 ccagcctagt ctctatagta agtttcagga cagccaggcc tgtgaaaaaa aaactgtcaa
      421 aaaaattttt ttttttttta ctgcatttta tggtggcatc caattcctca aaggtatgtc
      481 tatgctatga tttgttgacc tcttcagtag ttcaacattt ggggtcttct cacctttgga
      541 ccactgtgaa atagtattat gaagctggac atatgcctgt aaccccaact ctggggaggt
      601 ggagacggaa agatgagaaa ttggcttctt cactgcgagt ttgaggccat cccgagttac
      661 aacagatctc attgagggct tgccatcgtg tacattttta ataaaatcga cctttggacg
      721 gaaattgtgc agtgggagtg aacgaaatgc ctcattctaa agagaccaaa agccaagatt
      781 catcttttga cttcgctctg tagactcctg ggtcatgatg cgttagagcc ttgtttatta
      841 actgttaact aagggataaa tccgcctccc tctcaacaaa cgctgcagat atcataagcc
      901 ccgccccctc cctcctgatt cgcggtttcc gtgctcgtcc cacctccccg gcgtctagat
      961 tggcagttca gccgccctcg cagttagcgc gctaggagag aagcagccac gcccgcaacg
     1021 cgagctgagc aacgccgaag acaatggcag gctcggcgtt ggcagttcgg gctcggttcg
     1081 gtgtctgggg tatgaaggtc ctgcaaaccc gaggcttcgt ctcggactcg tcggatagca
     1141 tggatacggg cgctggctcc atccgagaag ctggtggagc cttcggaaaa cgagaaaagg
     1201 ctgaagagga tcggtacttc cgagagaaga ctaaagaaca gctggctgcc ctgaggaaac
     1261 accatgaaga tgagattgac caccattcga aggagataga gcgtctgcag aagcaaattg
     1321 aacgccataa gaagaagatc caacaactaa agaataatca ttgaatgcgc gcagtcggtc
     1381 cctcacagag tggcccgtat cactccccac gtctgtagac acatggcttt gaatgattac
     1441 tatttggtct gtgtgctact aacagataat aaacgatcac caggaaactt gaaaaaaaaa
     1501 aaaaaaaaaa aaaa
//
