LOCUS       NM_025983                419 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ATP synthase F1 subunit epsilon (Atp5f1e), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_025983
VERSION     NM_025983.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 419)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 419)
  AUTHORS   Beutner,G., Burris,J.R., Collins,M.P., Kulkarni,C.A.,
            Nadtochiy,S.M., de Mesy Bentley,K.L., Cohen,E.D., Brookes,P.S. and
            Porter,G.A. Jr.
  TITLE     Coordinated metabolic responses to cyclophilin D deletion in the
            developing heart
  JOURNAL   iScience 27 (3), 109157 (2024)
   PUBMED   38414851
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 419)
  AUTHORS   Sharma,S., Kajjo,S., Harra,Z., Hasaj,B., Delisle,V., Ray,D.,
            Gutierrez,R.L., Carrier,I., Kleinman,C., Morris,Q., Hughes,T.R.,
            McInnes,R. and Fabian,M.R.
  TITLE     Uncovering a mammalian neural-specific poly(A) binding protein with
            unique properties
  JOURNAL   Genes Dev 37 (15-16), 760-777 (2023)
   PUBMED   37704377
REFERENCE   4  (bases 1 to 419)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 419)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 419)
  AUTHORS   Hupe,M., Li,M.X., Gertow Gillner,K., Adams,R.H. and Stenman,J.M.
  TITLE     Evaluation of TRAP-sequencing technology with a versatile
            conditional mouse model
  JOURNAL   Nucleic Acids Res 42 (2), e14 (2014)
   PUBMED   24165879
REFERENCE   7  (bases 1 to 419)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 419)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (bases 1 to 419)
  AUTHORS   Tu,Q., Yu,L., Zhang,P., Zhang,M., Zhang,H., Jiang,J., Chen,C. and
            Zhao,S.
  TITLE     Cloning, characterization and mapping of the human ATP5E gene,
            identification of pseudogene ATP5EP1, and definition of the ATP5E
            motif
  JOURNAL   Biochem J 347 Pt 1 (Pt 1), 17-21 (2000)
   PUBMED   10727396
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ322223.1 and W78532.1.
            
            On Sep 8, 2006 this sequence version replaced NM_025983.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU843356.1, BU963076.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               CJ322223.1         1-412
            413-419             W78532.1           388-394
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 97.95 cM"
     gene            1..419
                     /gene="Atp5f1e"
                     /gene_synonym="2410043G19Rik; Atp5e; ATPE"
                     /note="ATP synthase F1 subunit epsilon"
                     /db_xref="GeneID:67126"
                     /db_xref="MGI:MGI:1855697"
     exon            1..137
                     /gene="Atp5f1e"
                     /gene_synonym="2410043G19Rik; Atp5e; ATPE"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..264
                     /gene="Atp5f1e"
                     /gene_synonym="2410043G19Rik; Atp5e; ATPE"
                     /EC_number="7.1.2.2"
                     /note="ATP synthase epsilon chain, mitochondrial; ATPase
                     subunit epsilon; mitochondrial ATP synthase epsilon
                     subunit; ATP synthase, H+ transporting, mitochondrial F1
                     complex, epsilon subunit"
                     /codon_start=1
                     /product="ATP synthase subunit epsilon, mitochondrial"
                     /protein_id="NP_080259.1"
                     /db_xref="CCDS:CCDS38360.1"
                     /db_xref="GeneID:67126"
                     /db_xref="MGI:MGI:1855697"
                     /translation="MVAYWRQAGLSYIRFSQICAKAVRDALKTEFKANAEKTSGSSIK
                     IVKVSKKE"
     exon            138..267
                     /gene="Atp5f1e"
                     /gene_synonym="2410043G19Rik; Atp5e; ATPE"
                     /inference="alignment:Splign:2.1.0"
     exon            268..414
                     /gene="Atp5f1e"
                     /gene_synonym="2410043G19Rik; Atp5e; ATPE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      391..396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp5f1e"
                     /gene_synonym="2410043G19Rik; Atp5e; ATPE"
                     /note="hexamer: AATAAA"
     polyA_site      414
                     /gene="Atp5f1e"
                     /gene_synonym="2410043G19Rik; Atp5e; ATPE"
                     /note="major polyA site"
ORIGIN      
        1 cccacccctt ccgctactca ggcctgacct tcctgctgcc gggccggttt gaggctactc
       61 tgaagcgacc cagcggttct gcccgacgcg cccgctcgag acaccatggt ggcgtactgg
      121 cgacaggctg gactcagcta catccggttt tcccagatct gtgcaaaagc agtgagggat
      181 gccctgaaga ccgagttcaa agcgaacgct gagaagactt cgggcagcag cataaaaatt
      241 gtgaaagtct cgaagaagga gtagctgaat ctgaagcctg aagtgctgag tcttgaaggt
      301 gaagcatgtg ggcccctgtt ctggcagatg gaaatcaacc tcacctcctg ggggacaggc
      361 tgcccatctc gttgataaat tgactatgcc aataaattaa catggttcac tttcaaaaa
//
