LOCUS       NM_020615               1180 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus ATP synthase F1 subunit gamma (Atp5f1c), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_020615 XM_910580
VERSION     NM_020615.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1180)
  AUTHORS   Li,Y., Ivica,N.A., Dong,T., Papageorgiou,D.P., He,Y., Brown,D.R.,
            Kleyman,M., Hu,G., Chen,W.W., Sullivan,L.B., Del Rosario,A.,
            Hammond,P.T., Vander Heiden,M.G. and Chen,J.
  TITLE     MFSD7C switches mitochondrial ATP synthesis to thermogenesis in
            response to heme
  JOURNAL   Nat Commun 11 (1), 4837 (2020)
   PUBMED   32973183
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1180)
  AUTHORS   Brody,M.J., Hacker,T.A., Patel,J.R., Feng,L., Sadoshima,J.,
            Tevosian,S.G., Balijepalli,R.C., Moss,R.L. and Lee,Y.
  TITLE     Ablation of the cardiac-specific gene leucine-rich repeat
            containing 10 (Lrrc10) results in dilated cardiomyopathy
  JOURNAL   PLoS One 7 (12), e51621 (2012)
   PUBMED   23236519
REFERENCE   3  (bases 1 to 1180)
  AUTHORS   Wang,Q., Chow,J., Hong,J., Smith,A.F., Moreno,C., Seaby,P.,
            Vrana,P., Miri,K., Tak,J., Chung,E.D., Mastromonaco,G., Caniggia,I.
            and Varmuza,S.
  TITLE     Recent acquisition of imprinting at the rodent Sfmbt2 locus
            correlates with insertion of a large block of miRNAs
  JOURNAL   BMC Genomics 12, 204 (2011)
   PUBMED   21510876
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1180)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   5  (bases 1 to 1180)
  AUTHORS   Sano,M., Izumi,Y., Helenius,K., Asakura,M., Rossi,D.J., Xie,M.,
            Taffet,G., Hu,L., Pautler,R.G., Wilson,C.R., Boudina,S., Abel,E.D.,
            Taegtmeyer,H., Scaglia,F., Graham,B.H., Kralli,A., Shimizu,N.,
            Tanaka,H., Makela,T.P. and Schneider,M.D.
  TITLE     Menage-a-trois 1 is critical for the transcriptional function of
            PPARgamma coactivator 1
  JOURNAL   Cell Metab 5 (2), 129-142 (2007)
   PUBMED   17276355
REFERENCE   6  (bases 1 to 1180)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1180)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   8  (bases 1 to 1180)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   9  (bases 1 to 1180)
  AUTHORS   Ichida,M., Endo,H., Ikeda,U., Matsuda,C., Ueno,E., Shimada,K. and
            Kagawa,Y.
  TITLE     MyoD is indispensable for muscle-specific alternative splicing in
            mouse mitochondrial ATP synthase gamma-subunit pre-mRNA
  JOURNAL   J Biol Chem 273 (14), 8492-8501 (1998)
   PUBMED   9525963
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158675.1 and BC055785.1.
            
            On Dec 21, 2007 this sequence version replaced NM_020615.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer protein (isoform a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010700.1, AK158675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1160              AK158675.1         2-1161
            1161-1180           BC055785.1         1655-1674
FEATURES             Location/Qualifiers
     source          1..1180
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 6.86 cM"
     gene            1..1180
                     /gene="Atp5f1c"
                     /gene_synonym="1700094F02Rik; Atp5c1"
                     /note="ATP synthase F1 subunit gamma"
                     /db_xref="GeneID:11949"
                     /db_xref="MGI:MGI:1261437"
     exon            1..163
                     /gene="Atp5f1c"
                     /gene_synonym="1700094F02Rik; Atp5c1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1004
                     /gene="Atp5f1c"
                     /gene_synonym="1700094F02Rik; Atp5c1"
                     /EC_number="3.6.1.14"
                     /note="isoform a is encoded by transcript variant 1; ATP
                     synthase gamma-subunit gene encoding a mitochondrial
                     protein; ATP synthase subunit gamma, mitochondrial;
                     F-ATPase gamma subunit; F1 gamma; ATP synthase, H+
                     transporting, mitochondrial F1 complex, gamma polypeptide
                     1"
                     /codon_start=1
                     /product="ATP synthase subunit gamma, mitochondrial
                     isoform a"
                     /protein_id="NP_065640.2"
                     /db_xref="CCDS:CCDS38045.1"
                     /db_xref="GeneID:11949"
                     /db_xref="MGI:MGI:1261437"
                     /translation="MFSRASVVGLSACAVQPQWIQVRNMATLKDITRRLKSIKNIQKI
                     TKSMKMVAAAKYARAERELKPARVYGTGSLALYEKADIKAPEDKKKHLIIGVSSDRGL
                     CGAIHSSVAKQMKNEVAALTAAGKEVMIVGVGEKIKGILYRTHSDQFLVSFKDVGRKP
                     PTFGDASVIALELLNSGYEFDEGSIIFNQFKSVISYKTEEKPIFSLNTIATAETMSIY
                     DDIDADVLQNYQEYNLANLIYYSLKESTTSEQSARMTAMDNASKNASDMIDKLTLTFN
                     RTRQAVITKELIEIISGAAALD"
     exon            164..198
                     /gene="Atp5f1c"
                     /gene_synonym="1700094F02Rik; Atp5c1"
                     /inference="alignment:Splign:2.1.0"
     exon            199..330
                     /gene="Atp5f1c"
                     /gene_synonym="1700094F02Rik; Atp5c1"
                     /inference="alignment:Splign:2.1.0"
     exon            331..535
                     /gene="Atp5f1c"
                     /gene_synonym="1700094F02Rik; Atp5c1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..679
                     /gene="Atp5f1c"
                     /gene_synonym="1700094F02Rik; Atp5c1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..744
                     /gene="Atp5f1c"
                     /gene_synonym="1700094F02Rik; Atp5c1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..900
                     /gene="Atp5f1c"
                     /gene_synonym="1700094F02Rik; Atp5c1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..997
                     /gene="Atp5f1c"
                     /gene_synonym="1700094F02Rik; Atp5c1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1034
                     /gene="Atp5f1c"
                     /gene_synonym="1700094F02Rik; Atp5c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1166
                     /gene="Atp5f1c"
                     /gene_synonym="1700094F02Rik; Atp5c1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1143..1148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp5f1c"
                     /gene_synonym="1700094F02Rik; Atp5c1"
                     /note="hexamer: AATAAA"
     polyA_site      1166
                     /gene="Atp5f1c"
                     /gene_synonym="1700094F02Rik; Atp5c1"
                     /note="major polyA site"
ORIGIN      
        1 gctcacgaga tttagcgaga ccgaggacgc aggcggagcg ggccggggcg cctgagctcc
       61 cgcgcacgcg cactgagtcc cgtctgcccg accttcaagg ctccaccatg ttctcgcggg
      121 cgagcgttgt cgggctgtcg gcctgcgccg tgcagccgca atggatccaa gttcgaaaca
      181 tggcaactct gaaagatatt accaggagac tgaagtccat caaaaacatc cagaaaatta
      241 ccaagtctat gaagatggtg gcagctgcaa agtatgcccg ggctgagcgg gagctgaagc
      301 ctgcccgagt gtatgggaca ggttctttgg ctctgtatga gaaggctgat attaaggcac
      361 ctgaggacaa gaagaagcac ctcattattg gtgtgtcctc agatagaggg ctttgtggtg
      421 ctattcactc ctcagtggct aaacagatga agaatgaagt ggctgccctc acagcagctg
      481 ggaaagaagt tatgattgtt ggagttggtg aaaaaatcaa gggcatactt tataggactc
      541 attctgatca gtttttggtg tcattcaaag atgtgggacg gaagcctcct acttttggag
      601 atgcatcagt cattgccctt gagttgttaa attctggata tgaatttgat gaaggctcta
      661 tcatttttaa tcagttcaag tctgttatct cctacaagac agaagagaag cccatcttct
      721 ctctgaatac cattgcgact gctgagacca tgagcatcta tgatgacatt gatgctgatg
      781 tgctgcagaa ttaccaggag tacaatctgg ccaacctcat ctactactcc ctgaaggagt
      841 ccaccaccag tgagcagagt gccaggatga ccgccatgga caacgccagc aagaacgctt
      901 ctgatatgat tgacaaattg accttgactt tcaaccgcac ccgccaggct gtcatcacaa
      961 aggagttgat tgaaatcatc tctggggctg ctgctctgga ttaatgaaaa tcaagttgca
     1021 tcctcagaca agaggtaaag aagaagaatg cgcaggctga ttttaactga ttgctgtctt
     1081 tgtcagaaga aacttggtcc actgagttac aaagacagca ggatgtttgt aaattatctt
     1141 acaataaaca acttacaatg agaaaaaaaa aaaaaaaaaa
//
