LOCUS       NM_016774               1879 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus ATP synthase F1 subunit beta (Atp5f1b), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_016774
VERSION     NM_016774.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1879)
  AUTHORS   Hu,Y., Zheng,Y., Liu,C., You,Y., Wu,Y., Wang,P., Wu,Y., Ba,H.,
            Lu,J., Yuan,Y., Liu,P. and Mao,Y.
  TITLE     Mitochondrial MOF regulates energy metabolism in heart failure via
            ATP5B hyperacetylation
  JOURNAL   Cell Rep 43 (10), 114839 (2024)
   PUBMED   39392752
  REMARK    GeneRIF: Mitochondrial MOF regulates energy metabolism in heart
            failure via ATP5B hyperacetylation.
REFERENCE   2  (bases 1 to 1879)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1879)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   4  (bases 1 to 1879)
  AUTHORS   Yang,Y., Zhan,X., Zhang,C., Shi,J., Wu,J., Deng,X., Hong,Y., Li,Q.,
            Ge,S., Xu,G. and He,F.
  TITLE     USP25-PKM2-glycolysis axis contributes to ischemia
            reperfusion-induced acute kidney injury by promoting M1-like
            macrophage polarization and proinflammatory response
  JOURNAL   Clin Immunol 251, 109279 (2023)
   PUBMED   36894047
REFERENCE   5  (bases 1 to 1879)
  AUTHORS   Mohammed,Y., Michaud,S.A., Petrosova,H., Yang,J., Ganguly,M.,
            Schibli,D., Flenniken,A.M., Nutter,L.M.J., Adissu,H.A.,
            Lloyd,K.C.K., McKerlie,C. and Borchers,C.H.
  TITLE     Proteotyping of knockout mouse strains reveals sex- and
            strain-specific signatures in blood plasma
  JOURNAL   NPJ Syst Biol Appl 7 (1), 25 (2021)
   PUBMED   34050187
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1879)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   7  (bases 1 to 1879)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1879)
  AUTHORS   Andersson,U., Antonicka,H., Houstek,J. and Cannon,B.
  TITLE     A novel principle for conferring selectivity to poly(A)-binding
            proteins: interdependence of two ATP synthase beta-subunit
            mRNA-binding proteins
  JOURNAL   Biochem J 346 Pt 1 (Pt 1), 33-39 (2000)
   PUBMED   10657236
REFERENCE   9  (bases 1 to 1879)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   10 (bases 1 to 1879)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131120.4.
            
            On Mar 21, 2007 this sequence version replaced NM_016774.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010314.1, AK159978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AC131120.4         203328-203474
            148-330             AC131120.4         203913-204095
            331-505             AC131120.4         204318-204492
            506-627             AC131120.4         205112-205233
            628-812             AC131120.4         205463-205647
            813-971             AC131120.4         206059-206217
            972-1094            AC131120.4         206319-206441
            1095-1307           AC131120.4         208342-208554
            1308-1509           AC131120.4         208978-209179
            1510-1879           AC131120.4         210040-210409
FEATURES             Location/Qualifiers
     source          1..1879
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.39 cM"
     gene            1..1879
                     /gene="Atp5f1b"
                     /gene_synonym="Atp5b"
                     /note="ATP synthase F1 subunit beta"
                     /db_xref="GeneID:11947"
                     /db_xref="MGI:MGI:107801"
     exon            1..147
                     /gene="Atp5f1b"
                     /gene_synonym="Atp5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1610
                     /gene="Atp5f1b"
                     /gene_synonym="Atp5b"
                     /EC_number="7.1.2.2"
                     /note="ATP synthase subunit beta, mitochondrial;
                     mitochondrial ATP synthase, H+ transporting F1 complex
                     beta subunit; ATP synthase, H+ transporting mitochondrial
                     F1 complex, alpha subunit; ATP synthase, H+ transporting
                     mitochondrial F1 complex, beta subunit"
                     /codon_start=1
                     /product="ATP synthase subunit beta, mitochondrial
                     precursor"
                     /protein_id="NP_058054.2"
                     /db_xref="CCDS:CCDS24259.1"
                     /db_xref="GeneID:11947"
                     /db_xref="MGI:MGI:107801"
                     /translation="MLSLVGRVASASASGALRGLSPSAALPQAQLLLRAAPAGVHPAR
                     DYAAQASAAPKAGTATGRIVAVIGAVVDVQFDEGLPPILNALEVQGRDSRLVLEVAQH
                     LGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKT
                     KQFAPIHAEAPEFIEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIME
                     LINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPP
                     GARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPT
                     LATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAEL
                     GIYPAVDPLDSTSRIMDPNIVGNEHYDVARGVQKILQDYKSLQDIIAILGMDELSEED
                     KLTVSRARKIQRFLSQPFQVAEVFTGHMGKLVPLKETIKGFQQILAGEYDHLPEQAFY
                     MVGPIEEAVAKADKLAEEHGS"
     exon            148..330
                     /gene="Atp5f1b"
                     /gene_synonym="Atp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            331..505
                     /gene="Atp5f1b"
                     /gene_synonym="Atp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            506..627
                     /gene="Atp5f1b"
                     /gene_synonym="Atp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            628..812
                     /gene="Atp5f1b"
                     /gene_synonym="Atp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            813..971
                     /gene="Atp5f1b"
                     /gene_synonym="Atp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1094
                     /gene="Atp5f1b"
                     /gene_synonym="Atp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1307
                     /gene="Atp5f1b"
                     /gene_synonym="Atp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1509
                     /gene="Atp5f1b"
                     /gene_synonym="Atp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1879
                     /gene="Atp5f1b"
                     /gene_synonym="Atp5b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1745..1750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp5f1b"
                     /gene_synonym="Atp5b"
                     /note="hexamer: AATAAA"
     polyA_site      1764
                     /gene="Atp5f1b"
                     /gene_synonym="Atp5b"
                     /note="major polyA site"
ORIGIN      
        1 gtctccaccc ggattccgcc atgttgagtc ttgtggggcg tgtggcctcg gcctcggcct
       61 ccggggcctt gcggggactc agcccttcgg cggctctgcc acaggcgcag cttctactgc
      121 gagctgctcc cgccggggtt catcctgcca gagactatgc ggcgcaggcg tctgcggccc
      181 cgaaggcagg cactgccacc gggcgaatcg tggcagtcat cggcgctgtg gtggacgtcc
      241 agttcgatga gggattacca cccatcctaa atgccctgga agtgcaaggc agggacagca
      301 gactggtttt ggaggtggcc cagcatttgg gggagagcac ggtcagaact attgctatgg
      361 atggcactga aggcttggtt agaggccaga aagtactgga ttcaggggca ccaatcaaaa
      421 ttcctgttgg tcctgagacc ttgggcagaa tcatgaatgt cattggagaa cctattgatg
      481 agagaggtcc tatcaaaacc aaacaatttg ctcctattca tgctgaggct cctgagttca
      541 tagagatgag tgttgagcag gagattctgg tgactgggat aaaggttgtg gatctgctgg
      601 ccccatacgc caagggtggg aaaatcggac tctttggagg tgctggcgtt ggaaagacag
      661 tactgatcat ggagctaatc aacaatgtcg ccaaagccca tggtggttac tctgtatttg
      721 ctggtgttgg tgagaggacc cgtgagggca atgatttata ccatgaaatg attgaatctg
      781 gtgttatcaa tctaaaagat gccacttcca aggtagcgtt ggtatatgga cagatgaacg
      841 aaccacctgg cgctcgagcc cgggtagctc tgactggttt gaccgttgct gaatacttca
      901 gagaccagga gggccaagat gtcctgctgt ttattgacaa catcttccgc tttacccagg
      961 ctggctcaga ggtgtctgcc ttattgggca gaatcccttc tgctgtaggc taccagccca
     1021 ccctagccac cgacatgggc acaatgcagg aaaggatcac caccaccaag aagggatcga
     1081 tcacctcggt gcaggctatc tatgtgcctg ctgatgacct gactgaccct gcccctgcaa
     1141 ccacctttgc ccatttggat gctaccactg tgttgtcccg ggctattgct gagttgggca
     1201 tctatccagc tgtggatcca ctggactcca cctctcgaat tatggatccc aacattgttg
     1261 gcaatgagca ttatgacgtc gcccgaggag tgcagaaaat cctgcaggac tacaaatctc
     1321 tccaggacat cattgccatc ttgggtatgg atgaactttc tgaggaagat aaattgactg
     1381 tgtcccgggc aagaaagata cagcgcttct tgtctcagcc attccaagtt gctgaggtct
     1441 tcacgggtca catggggaag ctggtgccct tgaaggagac cattaaagga ttccagcaga
     1501 ttttagcagg tgaatatgac catctcccag aacaagcctt ctacatggtg ggacccattg
     1561 aagaagccgt ggcaaaggct gataagctgg cagaagagca cgggtcgtga gggactccag
     1621 ccaaaggcag cactgcaact gatctctcca tatcaagcga gagctcaggt ttccttccat
     1681 gcaggccaca caagagcctt gattgaagat gtgatgttct ctctgaagag tatttaaagt
     1741 tttcaataaa gtatataccc ctcatttatg tctgtttatg ttgcttctga aacagcttat
     1801 aattgagctc acagtggtgg gccacattta ggaaattgtt agaaacagga ttattattaa
     1861 aaagatcaat ttattaatg
//
