LOCUS       NM_007505               2443 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus ATP synthase F1 subunit alpha (Atp5f1a), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_007505
VERSION     NM_007505.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2443)
  AUTHORS   He,Y., Wang,H., Hong,T., Hu,L., Gao,C., Gao,L., Cui,Y., Tan,R.,
            Pu,D. and Wu,J.
  TITLE     HFM1 is essential for the germ cell intercellular bridge transport
            in primordial follicle formation in mice
  JOURNAL   Cell Mol Life Sci 82 (1), 28 (2024)
   PUBMED   39725823
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2443)
  AUTHORS   Ohanele,C., Peoples,J.N., Karlstaedt,A., Geiger,J.T., Gayle,A.D.,
            Ghazal,N., Sohani,F., Brown,M.E., Davis,M.E., Porter,G.A. Jr.,
            Faundez,V. and Kwong,J.Q.
  TITLE     The mitochondrial citrate carrier SLC25A1 regulates metabolic
            reprogramming and morphogenesis in the developing heart
  JOURNAL   Commun Biol 7 (1), 1422 (2024)
   PUBMED   39482367
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2443)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Crotty Alexander,L.E., Borok,Z.,
            Shen,Y., Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   4  (bases 1 to 2443)
  AUTHORS   Liu,X., Meng,Q., Shi,S., Geng,X., Wang,E., Li,Y., Lin,F., Liang,X.,
            Xi,X., Han,W., Fan,H. and Zhou,X.
  TITLE     Cardiac-derived extracellular vesicles improve mitochondrial
            function to protect the heart against ischemia/reperfusion injury
            by delivering ATP5a1
  JOURNAL   J Nanobiotechnology 22 (1), 385 (2024)
   PUBMED   38951822
  REMARK    GeneRIF: Cardiac-derived extracellular vesicles improve
            mitochondrial function to protect the heart against
            ischemia/reperfusion injury by delivering ATP5a1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2443)
  AUTHORS   Xu,M., Zhang,H., Chang,Y., Hua,X., Chen,X., Sheng,Y., Shan,D.,
            Bao,M., Hu,S. and Song,J.
  TITLE     Overexpression of ATP5F1A in Cardiomyocytes Promotes Cardiac
            Reverse Remodeling
  JOURNAL   Circ Heart Fail 17 (7), e011504 (2024)
   PUBMED   38910562
  REMARK    GeneRIF: Overexpression of ATP5F1A in Cardiomyocytes Promotes
            Cardiac Reverse Remodeling.
REFERENCE   6  (bases 1 to 2443)
  AUTHORS   Baumgart,E., Vanhorebeek,I., Grabenbauer,M., Borgers,M.,
            Declercq,P.E., Fahimi,H.D. and Baes,M.
  TITLE     Mitochondrial alterations caused by defective peroxisomal
            biogenesis in a mouse model for Zellweger syndrome (PEX5 knockout
            mouse)
  JOURNAL   Am J Pathol 159 (4), 1477-1494 (2001)
   PUBMED   11583975
REFERENCE   7  (bases 1 to 2443)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 2443)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   9  (bases 1 to 2443)
  AUTHORS   Ishiguro,T., Nakajima,M., Naito,M., Muto,T. and Tsuruo,T.
  TITLE     Identification of genes differentially expressed in B16 murine
            melanoma sublines with different metastatic potentials
  JOURNAL   Cancer Res 56 (4), 875-879 (1996)
   PUBMED   8631027
REFERENCE   10 (bases 1 to 2443)
  AUTHORS   Yotov,W.V. and St-Arnaud,R.
  TITLE     Cloning and functional expression analysis of the alpha subunit of
            mouse ATP synthase
  JOURNAL   Biochem Biophys Res Commun 191 (1), 142-148 (1993)
   PUBMED   7916601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ155200.1, AK159540.1 and BY465601.1.
            
            On Mar 2, 2007 this sequence version replaced NM_007505.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.55532.1, AK152054.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               CJ155200.1         2-235
            235-2429            AK159540.1         3-2197
            2430-2443           BY465601.1         430-443
FEATURES             Location/Qualifiers
     source          1..2443
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 52.38 cM"
     gene            1..2443
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1; Atpm; D18Ertd206e; Mom2"
                     /note="ATP synthase F1 subunit alpha"
                     /db_xref="GeneID:11946"
                     /db_xref="MGI:MGI:88115"
     exon            1..343
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1; Atpm; D18Ertd206e; Mom2"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..1945
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1; Atpm; D18Ertd206e; Mom2"
                     /note="ATP synthase subunit alpha, mitochondrial; modifier
                     of Min 2; ATP synthase, H+ transporting, mitochondrial F1
                     complex, alpha subunit 1"
                     /codon_start=1
                     /product="ATP synthase subunit alpha, mitochondrial
                     precursor"
                     /protein_id="NP_031531.1"
                     /db_xref="CCDS:CCDS29358.1"
                     /db_xref="GeneID:11946"
                     /db_xref="MGI:MGI:88115"
                     /translation="MLSVRVAAAVARALPRRAGLVSKNALGSSFVGARNLHASNTRLQ
                     KTGTAEMSSILEERILGADTSVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGL
                     KGMSLNLEPDNVGVVVFGNDKLIKEGDVVKRTGAIVDVPVGEELLGRVVDALGNAIDG
                     KGPIGSKTRRRVGLKAPGIIPRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGK
                     TSIAIDTIINQKRFNDGTDEKKKLYCIYVAIGQKRSTVAQLVKRLTDADAMKYTIVVS
                     ATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGR
                     EAYPGDVFYLHSRLLERAAKMNDSFGGGSLTALPVIETQAGDVSAYIPTNVISITDGQ
                     IFLETELFYKGIRPAINVGLSVSRVGSAAQTRAMKQVAGTMKLELAQYREVAAFAQFG
                     SDLDAATQQLLSRGVRLTELLKQGQYSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFE
                     NAFLSHVISQHQSLLGNIRSDGKISEQSDAKLKEIVTNFLAGFEP"
     exon            344..422
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1; Atpm; D18Ertd206e; Mom2"
                     /inference="alignment:Splign:2.1.0"
     exon            423..592
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1; Atpm; D18Ertd206e; Mom2"
                     /inference="alignment:Splign:2.1.0"
     exon            593..766
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1; Atpm; D18Ertd206e; Mom2"
                     /inference="alignment:Splign:2.1.0"
     exon            767..933
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1; Atpm; D18Ertd206e; Mom2"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1082
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1; Atpm; D18Ertd206e; Mom2"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1234
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1; Atpm; D18Ertd206e; Mom2"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1459
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1; Atpm; D18Ertd206e; Mom2"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1567
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1; Atpm; D18Ertd206e; Mom2"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1712
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1; Atpm; D18Ertd206e; Mom2"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1863
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1; Atpm; D18Ertd206e; Mom2"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2432
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1; Atpm; D18Ertd206e; Mom2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2406..2411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1; Atpm; D18Ertd206e; Mom2"
                     /note="hexamer: ATTAAA"
     polyA_site      2432
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1; Atpm; D18Ertd206e; Mom2"
                     /note="major polyA site"
ORIGIN      
        1 gggcaaccac aaggtcgatt caaaaagacc aaaaattaaa atgttgagta ccagggagga
       61 ggctggaaac aatgtattcg ttcattttta gttctaaact taaaaaagaa aaagaaaaag
      121 ttatagaaaa aaaaaaaaaa gatttgcgtc cggaggagca ggagaggggc ggtacttccg
      181 ggtcaggcgg gctggctgcc ttgaccttcc tttgcgctcg gccattttgt gccagtcgtc
      241 cggaggctgc ggctgcagac ggtctctccg agaagctgca aggatgctgt ctgtgcgcgt
      301 cgccgcggcc gtggcccgtg ccctccctcg acgggcggga ctggtctcca aaaatgcttt
      361 ggggtcatcc tttgttggtg caagaaatct ccatgcctct aacactcgac ttcagaagac
      421 tggcacagct gagatgtcct ccattctcga ggagaggatt ctgggagctg acacgtctgt
      481 tgacctggag gagactgggc gtgtgttaag cattggtgat ggtattgcgc gagtgcacgg
      541 gctgaggaat gttcaagcag aggagatggt ggaattctct tcaggcttaa agggtatgtc
      601 cctgaacttg gaacccgaca atgttggagt tgtcgtgttt gggaatgaca agctaattaa
      661 agaaggagac gttgtgaaga ggacaggcgc catcgtggat gtccccgttg gcgaggagct
      721 gttgggccgt gtggttgacg ccctcggtaa tgctattgat ggaaagggtc caattggttc
      781 caagacccgc agacgagtgg gcctgaaagc ccctggaatt atcccccgaa tctctgtgcg
      841 ggagccgatg cagaccggca tcaaggctgt ggatagcctg gtgcccattg gccggggtca
      901 gcgtgagctg attattggtg acagacagac tgggaaaaca tcgattgcca ttgacacaat
      961 catcaaccag aaacgtttca acgatgggac cgacgagaag aagaagctgt actgcatcta
     1021 cgtcgcgatt ggtcagaagc ggtccactgt ggctcagctg gtgaagagac tgacggatgc
     1081 ggatgccatg aagtacacca tcgtggtgtc agccactgcc tctgacgctg ccccgcttca
     1141 gtacttggct ccctactccg gctgctccat gggagagtac tttagagaca acggcaagca
     1201 cgctttgatc atctatgacg atctatccaa gcaggctgtc gcttaccgcc agatgtctct
     1261 gttgctccgc cgaccccctg gtcgtgaggc ctatcctggt gatgtgttct acctacactc
     1321 ccgcctgctg gagagagcag ccaagatgaa cgattccttt ggtggtggct ctttgactgc
     1381 cttaccagtc attgaaacac aggctggtga tgtgtccgct tacattccaa caaatgttat
     1441 ttccatcact gacggacaga tcttcttgga aacagaattg ttctataaag gcatccgccc
     1501 tgccattaat gtgggtttgt ctgtgtcccg tgtcggatct gctgcccaaa ccagagccat
     1561 gaagcaggtg gcaggtacca tgaagctgga gttggctcag taccgggagg tggctgcgtt
     1621 tgcccagttt ggttctgatt tggacgctgc cactcaacag ctcttgagtc gtggtgtgcg
     1681 tctgaccgag ttgctaaagc aaggacagta ctctcccatg gctattgaag aacaggtggc
     1741 tgttatctat gcgggtgtac ggggttatct tgacaaactg gagcccagca agatcacaaa
     1801 gtttgagaat gctttcttgt ctcacgttat cagccagcac cagtccctct tgggcaatat
     1861 caggtctgat gggaaaatct cagaacagtc agacgcaaag ctcaaagaga ttgtaacaaa
     1921 cttcttggct gggtttgaac cataaagccc tgtcactgtc accagatact gctttggttt
     1981 tgtcatttat tctggtaaaa tcagcaccat ttgtaaaggg ttactcttgt attcctgatg
     2041 tacagaaatc acatgaataa aagttccata ctgtgtgcta gtttgtgtgg gggtgggctc
     2101 aggtgtgtac caggatttgt gtggtggtca gaggacagcc agcctgtatg acagtaccct
     2161 ccttccaccg ggaatttaat gcaggttttt atttaaagca cgacttcatg ttgagttcca
     2221 taagttagtt ttgtaagaca gagcttactg tgtgacctca gcaatggcta gcctaggcta
     2281 ttcttgtagc agtctgtctg ccatagctgg caaattgctc tcttaccctg ttcttgctgg
     2341 tgcagtcagc atggatagat aattcaaagc tgtccactat gaaattcgga agtactttgt
     2401 gattgattaa aaagagaact ctgctccgga aaaaaaaaaa aaa
//
