LOCUS       NM_018731               3470 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus ATPase, H+/K+ exchanging, gastric, alpha polypeptide
            (Atp4a), transcript variant 2, mRNA.
ACCESSION   NM_018731 XM_994434
VERSION     NM_018731.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3470)
  AUTHORS   Douchi,D., Yamamura,A., Matsuo,J., Melissa Lim,Y.H.,
            Nuttonmanit,N., Shimura,M., Suda,K., Chen,S., Pang,S., Kohu,K.,
            Abe,T., Shioi,G., Kim,G., Shabbir,A., Srivastava,S., Unno,M.,
            Bok-Yan So,J., Teh,M., Yeoh,K.G., Chuang,L.S.H. and Ito,Y.
  TITLE     Induction of Gastric Cancer by Successive Oncogenic Activation in
            the Corpus
  JOURNAL   Gastroenterology 161 (6), 1907-1923 (2021)
   PUBMED   34391772
REFERENCE   2  (bases 1 to 3470)
  AUTHORS   Ayasse,N., Berg,P., Andersen,J.F., Svendsen,S.L., Sorensen,M.V.,
            Fedosova,N.U., Lynch,I.J., Wingo,C.S. and Leipziger,J.
  TITLE     Benzamil-mediated urine alkalization is caused by the inhibition of
            H+-K+-ATPases
  JOURNAL   Am J Physiol Renal Physiol 320 (4), F596-F607 (2021)
   PUBMED   33554781
REFERENCE   3  (bases 1 to 3470)
  AUTHORS   DeLaForest,A., Kohlnhofer,B.M., Franklin,O.D., Stavniichuk,R.,
            Thompson,C.A., Pulakanti,K., Rao,S. and Battle,M.A.
  TITLE     GATA4 Controls Epithelial Morphogenesis in the Developing Stomach
            to Promote Establishment of Glandular Columnar Epithelium
  JOURNAL   Cell Mol Gastroenterol Hepatol 12 (4), 1391-1413 (2021)
   PUBMED   34111600
REFERENCE   4  (bases 1 to 3470)
  AUTHORS   Sayols,S., Klassek,J., Werner,C., Mockel,S., Ritz,S.,
            Mendez-Lago,M. and Soshnikova,N.
  TITLE     Signalling codes for the maintenance and lineage commitment of
            embryonic gastric epithelial progenitors
  JOURNAL   Development 147 (18) (2020)
   PUBMED   32878924
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3470)
  AUTHORS   Liu,W., Pan,H.F., Yang,L.J., Zhao,Z.M., Yuan,D.S., Liu,Y.L. and
            Lin,L.Z.
  TITLE     Panax ginseng C.A. Meyer (Rg3) Ameliorates Gastric Precancerous
            Lesions in Atp4a-/- Mice via Inhibition of Glycolysis through
            PI3K/AKT/miRNA-21 Pathway
  JOURNAL   Evid Based Complement Alternat Med 2020, 2672648 (2020)
   PUBMED   32076440
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3470)
  AUTHORS   Mathews,P.M., Claeys,D., Jaisser,F., Geering,K., Horisberger,J.D.,
            Kraehenbuhl,J.P. and Rossier,B.C.
  TITLE     Primary structure and functional expression of the mouse and frog
            alpha-subunit of the gastric H(+)-K(+)-ATPase
  JOURNAL   Am J Physiol 268 (5 Pt 1), C1207-C1214 (1995)
   PUBMED   7762614
  REMARK    Erratum:[Am J Physiol 1995 Oct;269(4 Pt 1):section C followi]
REFERENCE   7  (bases 1 to 3470)
  AUTHORS   Malo,D., Gros,P., Bergmann,A., Trask,B., Mohrenweiser,H.W.,
            Canfield,V.A. and Levenson,R.
  TITLE     Genes encoding the H,K-ATPase alpha and Na,K-ATPase alpha 3
            subunits are linked on mouse chromosome 7 and human chromosome 19
  JOURNAL   Mamm Genome 4 (11), 644-649 (1993)
   PUBMED   7904196
REFERENCE   8  (bases 1 to 3470)
  AUTHORS   Cantley,L.G., Zhou,X.M., Cunha,M.J., Epstein,J. and Cantley,L.C.
  TITLE     Ouabain-resistant transfectants of the murine ouabain resistance
            gene contain mutations in the alpha-subunit of the Na,K-ATPase
  JOURNAL   J Biol Chem 267 (24), 17271-17278 (1992)
   PUBMED   1324928
REFERENCE   9  (bases 1 to 3470)
  AUTHORS   Morley,G.P., Callaghan,J.M., Rose,J.B., Toh,B.H., Gleeson,P.A. and
            van Driel,I.R.
  TITLE     The mouse gastric H,K-ATPase beta subunit. Gene structure and
            co-ordinate expression with the alpha subunit during ontogeny
  JOURNAL   J Biol Chem 267 (2), 1165-1174 (1992)
   PUBMED   1370459
REFERENCE   10 (bases 1 to 3470)
  AUTHORS   Canfield,V.A. and Levenson,R.
  TITLE     Structural organization and transcription of the mouse gastric H+,
            K(+)-ATPase beta subunit gene
  JOURNAL   Proc Natl Acad Sci U S A 88 (18), 8247-8251 (1991)
   PUBMED   1654563
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167978.4.
            
            On Mar 15, 2014 this sequence version replaced NM_018731.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction at the 3' end of an exon compared to variant 1. The
            resulting isoform (2) has the same N- and C-termini but is shorter
            compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015262.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849376,
                                           SAMN00849385 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC167978.4         42737-42790         c
            55-195              AC167978.4         42505-42645         c
            196-255             AC167978.4         42331-42390         c
            256-459             AC167978.4         41712-41915         c
            460-573             AC167978.4         39915-40028         c
            574-826             AC167978.4         39428-39680         c
            827-1095            AC167978.4         38990-39258         c
            1096-1294           AC167978.4         38266-38464         c
            1295-1404           AC167978.4         37838-37947         c
            1405-1539           AC167978.4         37629-37763         c
            1540-1732           AC167978.4         37116-37308         c
            1733-1908           AC167978.4         35845-36020         c
            1909-2045           AC167978.4         34870-35006         c
            2046-2169           AC167978.4         34659-34782         c
            2170-2338           AC167978.4         34364-34532         c
            2339-2493           AC167978.4         34119-34273         c
            2494-2617           AC167978.4         32384-32507         c
            2618-2763           AC167978.4         31934-32079         c
            2764-2897           AC167978.4         30673-30806         c
            2898-2999           AC167978.4         30240-30341         c
            3000-3091           AC167978.4         30053-30144         c
            3092-3470           AC167978.4         29465-29843         c
FEATURES             Location/Qualifiers
     source          1..3470
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.2 cM"
     gene            1..3470
                     /gene="Atp4a"
                     /note="ATPase, H+/K+ exchanging, gastric, alpha
                     polypeptide"
                     /db_xref="GeneID:11944"
                     /db_xref="MGI:MGI:88113"
     exon            1..54
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..3120
                     /gene="Atp4a"
                     /EC_number="7.2.2.19"
                     /note="isoform 2 is encoded by transcript variant 2;
                     potassium-transporting ATPase alpha chain 1; proton pump;
                     gastric H(+)/K(+) ATPase subunit alpha; ATPase, H+/K+
                     transporting, alpha polypeptide; ATPase, H+/K+ exchanging,
                     alpha polypeptide; H+/K+-ATPase alpha; H+K+-transporting
                     alpha 1"
                     /codon_start=1
                     /product="potassium-transporting ATPase alpha chain 1
                     isoform 2"
                     /protein_id="NP_061201.2"
                     /db_xref="CCDS:CCDS52182.1"
                     /db_xref="GeneID:11944"
                     /db_xref="MGI:MGI:88113"
                     /translation="MGKAENYELYSVELGSGPGGDMTAKMSKKKAGGGGGKKKEKLEN
                     MKKEMEINDHQLSVSELEQKYQTSATKGLKASLAAELLLRDGPNALRPPRGTPEYVKF
                     ARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAVALIAVVVVTGCFGYYQ
                     EFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILSA
                     QGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTAQGLVVSTGDRTI
                     IGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFVVAMCIGYTFLRAMVFF
                     MAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLT
                     QNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAV
                     PVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSINKFQLSIHTLEDP
                     RDSRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFC
                     QLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVI
                     MVTGDHPITAKAIAASVGIISEGSETVEDIAARLRMPVDQVNRKDARACVINGMQLKD
                     MDPSELVEALRTHPEMVFARTSPQQKLGAIVAVTGDGVNDSPALKKADIGVAMGIAGS
                     DAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVS
                     VPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYF
                     QIGAIQSFAGFADYFTAMAQEGWFPLLCVGLRPQWEDHHLQDLQDSYGQEWTFGQRLY
                     QQYTCYTVFFISIEMCQIADVLIRKTRRLSVFQQGFFRNKILVIAIVFQVCIGCFLCY
                     CPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGVRCCPGSWWDQELYY"
     exon            55..195
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            196..255
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            256..459
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            460..573
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            574..826
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1095
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1294
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1404
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1539
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1732
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1908
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2045
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2169
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2338
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2493
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2617
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2763
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2897
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..2999
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3091
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3470
                     /gene="Atp4a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagtaggctc tgtaggccaa ggagggcaga gcaccaggca ccatggggaa ggcagagaat
       61 tatgaactgt actcagtgga actggggtct ggccctggtg gggacatgac tgccaagatg
      121 agcaagaaga aggcaggagg tgggggaggc aagaagaagg agaagctgga gaacatgaag
      181 aaggagatgg agattaacga ccaccagcta tcagtgtctg agctggagca gaagtatcag
      241 accagcgcca ccaagggcct gaaggcgagc ctggcagctg agctgctgct gagggatgga
      301 cccaatgcgc tccggccacc tcggggcact cccgagtatg tgaagtttgc ccgtcagctg
      361 gcaggtggtc tgcagtgcct catgtgggtg gctgctgcta tctgcctcat tgcctttgcc
      421 atccaggcca gcgagggtga cctgaccact gatgataatc tgtacctggc ggtggcactc
      481 attgctgtgg ttgtggtcac tggctgtttt ggctactacc aggagttcaa gagcacaaat
      541 atcatcgcca gcttcaagaa tcttgtaccc cagcaagcca ctgtgatccg agacggggac
      601 aagttccaga tcaacgcgga tcagcttgtg gtgggcgacc tggtggagat gaaaggcggg
      661 gaccgcgtgc cagcagacat ccgcattctg tcagcccagg gctgcaaggt ggacaactcc
      721 tcgctcactg gagagtctga accgcagacc cgctcgcccg agtgtacaca tgagagtccc
      781 cttgagaccc gcaacatcgc cttcttctcc accatgtgtc tggagggaac agctcagggt
      841 ttggtggtga gcaccggcga tcgcaccatc attgggcgca tcgcctcgct ggcctcgggt
      901 gtggaaaacg agaagactcc gattgcaatc gagattgaac attttgtgga catcattgcc
      961 ggcctggcca tcctcttcgg tgccacattc tttgtggtgg ccatgtgtat tggctatacc
     1021 ttccttcggg ccatggtctt cttcatggcc attgtggtag cctatgtgcc tgaggggctg
     1081 ctggcaactg tcacagtctg cctgtcactg acagcaaaga ggttggccag taaaaactgc
     1141 gtggttaaaa acttagaagc agttgagacc ctaggttcta catcagtcat ctgctcagac
     1201 aagacaggaa ctctcactca gaaccgcatg acggtgtctc atctatggtt tgacaaccat
     1261 atccacacgg cggacaccac agaagaccag tcagggcaaa cgttcgatca gtcgtcggag
     1321 acatggcgag cgctgtgccg cgtgctcacc ctgtgcaacc gcgctgcctt caagtccggc
     1381 caggacgcgg tgccggtgcc caagcgcatc gtgatcggag acgcgtcaga gactgcgctg
     1441 ctcaagtttt cggagctgac gttgggcaac gccatgggtt acagggaccg cttccccaaa
     1501 gtttgcgaga tccccttcaa ctccatcaac aagttccagc tgtccattca taccctggag
     1561 gatccacgcg actcccggca cctgctggtg atgaagggcg cccctgagcg cgtgctggag
     1621 cgttgcagct ccatcctcat caagggccag gagctgcctc tggacgagca atggcgtgag
     1681 gccttccaga cagcctacct cagcctggga ggcctaggcg aacgtgttct tggtttctgc
     1741 cagctctacc tgaatgagaa ggactaccca cctggctatg cctttgatgt ggaggccatg
     1801 aactttccga gtagtggcct ctgctttgcg ggacttgtat ccatgattga ccctccccgg
     1861 gccaccgttc ctgatgctgt gctcaaatgc cgcacggcag gcatccgggt gatcatggtg
     1921 accggtgacc atcccatcac ggccaaggcc atcgcagcca gcgtgggtat catctcagag
     1981 ggcagcgaga cagtggaaga catcgccgcc cgcctccgga tgccggtgga ccaggttaat
     2041 aggaaggatg cccgggcctg cgtgatcaat ggtatgcagc tgaaggacat ggacccgtct
     2101 gagctggtgg aggcgctacg cacccaccct gagatggtgt ttgctcgaac cagtcctcag
     2161 cagaagctgg gtgccattgt ggctgtaaca ggggatggtg tgaatgactc cccagccctg
     2221 aagaaagctg acattggtgt agccatgggc attgctggct cggatgctgc taaaaatgct
     2281 gctgacatga tcttgctgga tgacaacttt gcttccattg tgacaggcgt ggagcagggc
     2341 cgactgatct ttgacaacct gaagaaatcc attgcatata cactgaccaa gaacattcca
     2401 gaactgacac cctaccttat ctatatcact gtcagtgtgc ccctacccct tgggtgtatc
     2461 accattctct tcatagaact ctgcacagat atctttccat ctgtgtccct ggcgtacgag
     2521 aaggctgaga gcgacatcat gcacctgcgc ccacggaacc ctaagcgtga ccggttggtc
     2581 aacgaacccc tggctgctta ttcctatttc cagattggtg ccattcagtc atttgccggc
     2641 tttgctgact acttcacggc catggcgcag gagggctggt tccctctgtt gtgtgtagga
     2701 ctgcggccac aatgggagga ccaccatcta caagatcttc aagacagcta cggccaggaa
     2761 tggacatttg gtcagcgcct gtaccagcag tacacctgtt acaccgtgtt cttcatcagc
     2821 atcgagatgt gccagatcgc agatgtcctc atccgcaaga cacggcgcct ctctgttttc
     2881 cagcagggat tcttcaggaa caagatcctg gtgatcgcca tcgtgttcca ggtctgcatt
     2941 ggctgcttcc tgtgctactg cccagggatg cctaacatct tcaacttcat gcccatccgg
     3001 ttccagtggt ggctggtccc catgcccttc ggccttctca tctttgtcta tgatgagatc
     3061 cggaaacttg gagttcgctg ttgcccaggg agctggtggg accaggaact ctactattag
     3121 agggataatc atctctccat ccactatcag ctgggactca tgggtgtcca tcaaaacatc
     3181 gatgtactcg attcccagcc ctctggaact gtacccactt ctgcagcctg ttgactccat
     3241 tggagggaat ctatccttca cccctcaccc catagttcca caccctcttg gagcagttgc
     3301 accccaggaa ctgctcccag gatgggaggg gctaaattaa gcggttggca gttcctgtgg
     3361 aggtgtgtcc atctcaagga ctccatctgg acaagaaggt tgtctgttac aaacccctca
     3421 tgttctactg ggcagtaata aagccaggcc atgttgcctg cacagtctga
//
