LOCUS       NM_026922               3223 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ATPase, Ca++ transporting, type 2C, member 2 (Atp2c2),
            mRNA.
ACCESSION   NM_026922 XM_486167 XM_917337
VERSION     NM_026922.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3223)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3223)
  AUTHORS   Fenech,M.A., Sullivan,C.M., Ferreira,L.T., Mehmood,R.,
            MacDonald,W.A., Stathopulos,P.B. and Pin,C.L.
  TITLE     Atp2c2 Is Transcribed From a Unique Transcriptional Start Site in
            Mouse Pancreatic Acinar Cells
  JOURNAL   J Cell Physiol 231 (12), 2768-2778 (2016)
   PUBMED   27017909
  REMARK    GeneRIF: The goal of this study was to delineate the gene structure
            and regulation of a novel pancreas-specific isoform for Secretory
            Pathway Ca(2+) ATPase 2 (termed SPCA2C), which is encoded from the
            Atp2c2 gene.
REFERENCE   3  (bases 1 to 3223)
  AUTHORS   Cross,B.M., Hack,A., Reinhardt,T.A. and Rao,R.
  TITLE     SPCA2 regulates Orai1 trafficking and store independent Ca2+ entry
            in a model of lactation
  JOURNAL   PLoS One 8 (6), e67348 (2013)
   PUBMED   23840669
  REMARK    GeneRIF: SPCA2 and Orai1 function together to regulate
            store-independent calcium entry.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3223)
  AUTHORS   Garside,V.C., Kowalik,A.S., Johnson,C.L., DiRenzo,D.,
            Konieczny,S.F. and Pin,C.L.
  TITLE     MIST1 regulates the pancreatic acinar cell expression of Atp2c2,
            the gene encoding secretory pathway calcium ATPase 2
  JOURNAL   Exp Cell Res 316 (17), 2859-2870 (2010)
   PUBMED   20599950
  REMARK    GeneRIF: Atp2c2 transcription is regulated by MIST1
REFERENCE   5  (bases 1 to 3223)
  AUTHORS   Feng,M., Grice,D.M., Faddy,H.M., Nguyen,N., Leitch,S., Wang,Y.,
            Muend,S., Kenny,P.A., Sukumar,S., Roberts-Thomson,S.J.,
            Monteith,G.R. and Rao,R.
  TITLE     Store-independent activation of Orai1 by SPCA2 in mammary tumors
  JOURNAL   Cell 143 (1), 84-98 (2010)
   PUBMED   20887894
REFERENCE   6  (bases 1 to 3223)
  AUTHORS   Xiang,M., Mohamalawari,D. and Rao,R.
  TITLE     A novel isoform of the secretory pathway Ca2+,Mn(2+)-ATPase,
            hSPCA2, has unusual properties and is expressed in the brain
  JOURNAL   J Biol Chem 280 (12), 11608-11614 (2005)
   PUBMED   15677451
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104882.30 and AC161435.7.
            
            On or before Jun 5, 2008 this sequence version replaced
            XM_917337.3, XM_486167.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF688288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               AC104882.30        193195-193443
            250-360             AC161435.7         213707-213817       c
            361-477             AC161435.7         211719-211835       c
            478-567             AC161435.7         207901-207990       c
            568-603             AC161435.7         206787-206822       c
            604-665             AC161435.7         206622-206683       c
            666-774             AC161435.7         202731-202839       c
            775-924             AC161435.7         198572-198721       c
            925-993             AC161435.7         198431-198499       c
            994-1069            AC161435.7         197707-197782       c
            1070-1136           AC161435.7         194549-194615       c
            1137-1261           AC161435.7         190555-190679       c
            1262-1359           AC161435.7         190319-190416       c
            1360-1461           AC161435.7         188590-188691       c
            1462-1551           AC161435.7         187406-187495       c
            1552-1653           AC161435.7         185294-185395       c
            1654-1810           AC161435.7         184698-184854       c
            1811-1981           AC161435.7         183815-183985       c
            1982-2079           AC161435.7         183139-183236       c
            2080-2130           AC161435.7         182998-183048       c
            2131-2297           AC161435.7         181683-181849       c
            2298-2366           AC161435.7         180153-180221       c
            2367-2483           AC161435.7         179949-180065       c
            2484-2631           AC161435.7         178660-178807       c
            2632-2730           AC161435.7         177373-177471       c
            2731-2872           AC161435.7         176893-177034       c
            2873-3223           AC161435.7         175291-175641       c
FEATURES             Location/Qualifiers
     source          1..3223
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 68.21 cM"
     gene            1..3223
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /note="ATPase, Ca++ transporting, type 2C, member 2"
                     /db_xref="GeneID:69047"
                     /db_xref="MGI:MGI:1916297"
     exon            1..249
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..2991
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /EC_number="7.2.2.10"
                     /note="secretory pathway Ca2+-ATPase; ATPase 2C2;
                     Secretory pathway Ca(2+)-ATPase 2; Ca(2+)/Mn(2+)-ATPase
                     2C2; secretory pathway Ca(2+)-transporting ATPase type 2"
                     /codon_start=1
                     /product="calcium-transporting ATPase type 2C member 2"
                     /protein_id="NP_081198.1"
                     /db_xref="CCDS:CCDS52684.1"
                     /db_xref="GeneID:69047"
                     /db_xref="MGI:MGI:1916297"
                     /translation="MGRRLKFLQKLAFLGQNHRYKALERDEVETLIDEQCELKAIERE
                     KTVAALPPGEACKCSREELARAFHVDLDSGLSEFAVAQRRLVHGWNEFVTDNAEPVWK
                     KYLDQFRNPLILLLLGSSVVSVLTKEYEDAVSIALAVLIVVTVGFIQEYRSEKSLEEL
                     TKLVPPECNCLRDGKLRHMLARDLVPGDIVSLSMGDRIPADIRLTEVTDLLVDESSFT
                     GEVEPCGKTDSPLADGGDLSTLSNVVFMGTLVQCGKGQGVVIGTGEQSQFGEVFKMMR
                     AEETPKTPLQKSMDKLGKQLTIFSFGIIGLLMLVGWVQGKPFLSMFTVGVSLAVAAIP
                     EGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCNVICSDKTGTLTANEMTATQL
                     VTSDGFHAEVSGVGYSGEGTVCLLPSKEVIKGFDNVSVGKLVEAGCVANNAVIRKNAV
                     MGQPTEGALVVLAMKMNLGSIKDSYVRKKEIPFSSEQKWMAVRCGPKSEDGEDIYFMK
                     GAFEEVIHHCSMYNNGGIPLPLTPQQKSYCQQEEKKMGSLGLRVLALASGPELGRLTF
                     LGLVGIIDPPRAGVKEAVQVLSESGVSVKMVTGDALETALAIGRTIGLCNEKLKAMSG
                     EEVEGTEQGALAARVRQVSVFFRTSPKHKVKIIKALQESGAIVAMTGDGVNDSVALKS
                     ADIGIAMGQTGTDVSKEAANMILVDDDFSAIMSAVEEGKGIFYNIKNFVRFQLSTSIA
                     ALSLITLSTVCNLPSPLNAMQILWVNIIMDGPPAQSLGVEPVDRDALRRPPRSVGDTI
                     LNRALILRVLMSAAVIIGGTLFIFWREIPANGTSTPRTTTMAFTCFVFFDLFNALSCR
                     SQTKLIFEIGFFRNRMFLYSVLGSLLGQLAVIYAPPLQKVFQTENLSALDLLLLTGLA
                     SSVFILSELLKLWEKFLSRARPTQMLPEAV"
     exon            250..360
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            361..477
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            478..567
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            568..603
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            604..665
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            666..774
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            775..924
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..993
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1069
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1136
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1261
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1359
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1461
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1551
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1653
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1810
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1981
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2079
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2130
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2297
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2366
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2483
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2631
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2730
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2872
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..3223
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3196..3201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /note="hexamer: ATTAAA"
     polyA_site      3223
                     /gene="Atp2c2"
                     /gene_synonym="1810010G06Rik; mKIAA0703; Spca2"
                     /note="major polyA site"
ORIGIN      
        1 tcacctgggg accaggtaga cagctccccg gcaacctggc cgcccgggaa gcctgggcgc
       61 gcagcagccg cggcctcgct agggccccag ggacgcgggc agggactgcg accagcccca
      121 cggccggctg tggagcagcc tggacaccag ttcaccatgg ggagacgcct caagtttctg
      181 cagaaactgg ccttcttggg ccagaaccac cggtacaagg cgctggagag ggacgaggtg
      241 gagaccctga ttgatgaaca gtgcgagctg aaagctatcg agagagaaaa gaccgtcgct
      301 gctctgccgc ccggggaagc ttgcaaatgc agcagagagg agctggccag agccttccat
      361 gtggacctgg acagcggcct gtcagaattt gcagtggccc agcgcaggct ggtccatggg
      421 tggaacgagt ttgtcacaga taacgctgag cccgtgtgga agaaatacct ggatcagttc
      481 aggaaccccc taattctgct gctgctgggc tcatccgtgg tgagcgtcct caccaaagaa
      541 tatgaggatg ctgtcagcat cgccctggca gttctcatcg tggtgaccgt tggcttcatc
      601 caggaataca ggtcggagaa gtctctggaa gagctcacca agctggtacc cccagagtgc
      661 aactgcctga gagacggcaa actccggcac atgctcgcac gagacctggt tccaggagac
      721 attgtgtcct tgtccatggg agatcggatc cctgctgaca tccgactcac cgaggtcaca
      781 gatctcctgg tggatgaatc cagcttcaca ggcgaagtgg agccatgcgg caaaacagac
      841 agcccactgg ctgacggtgg ggatctcagc accctgagca acgtggtctt catggggacg
      901 ctggtgcagt gcgggaaggg tcagggagtt gtgatcggaa ccggggaaca gtctcagttt
      961 ggagaagttt tcaagatgat gcgggcagaa gagacaccta aaacgccgct gcagaagagc
     1021 atggacaagc tgggcaagca gctaacaatc ttttcctttg gcatcatcgg tctcctgatg
     1081 ctggttggct gggtgcaagg gaagcccttt ctcagcatgt tcactgtcgg ggtcagcctg
     1141 gcggtggcag ccattccaga ggggctgccc atcgttgtca tggtgacact ggtcctgggg
     1201 gtgctgcgga tggcgaagaa gcgggtcatc gtgaagaagc tgcccattgt agagactctt
     1261 ggttgctgta atgtcatctg ctctgacaag acaggcactc tgacagccaa cgaaatgaca
     1321 gccactcagc ttgtcacatc tgatgggttc catgccgagg tcagtggtgt cggatacagc
     1381 ggagaaggga ctgtgtgcct tctgccatct aaggaagtaa tcaaaggatt tgacaacgtg
     1441 tcagtgggga agctggtgga ggcaggctgc gtggccaaca acgctgtcat caggaagaac
     1501 gccgtaatgg ggcagcccac agaaggggcc ttggtggtgc tggccatgaa gatgaactta
     1561 ggcagcatca aagattccta tgtacggaaa aaggaaattc ccttcagctc agagcagaag
     1621 tggatggcag tcaggtgcgg cccgaagagc gaggatgggg aagacattta cttcatgaag
     1681 ggggcctttg aggaagtgat ccatcactgc agcatgtata acaatggggg catccccctg
     1741 cctctgacac cccagcagaa gtcctactgc cagcaggaag agaagaagat gggctcgctt
     1801 ggcctgcggg tgctggccct ggcgtctgga cctgagctgg ggagactgac attcctgggt
     1861 ctcgtgggca tcatcgaccc accaagggct ggtgtgaagg aagcggtcca ggtcctctct
     1921 gagtctggtg tgtcggttaa gatggtgaca ggggatgctc tggagaccgc cttggccata
     1981 ggaagaacca tcggcctgtg caacgagaaa ctgaaagcta tgtccgggga ggaggtggaa
     2041 ggcacggagc agggtgcact agcagcccga gtgaggcagg tgtctgtgtt cttcaggacc
     2101 agcccaaagc acaaggttaa aatcataaag gcgttgcagg agtcgggggc aattgtagcc
     2161 atgacggggg atggtgtgaa tgactccgtt gccctgaagt ctgcggacat cgggatcgcc
     2221 atgggacaga cagggacaga tgtcagcaaa gaggcagcca acatgatcct ggtggatgac
     2281 gacttctcgg ccatcatgag cgcagtggag gaaggcaagg gcatcttcta caacatcaag
     2341 aactttgtcc gtttccagct gagcacgagc atcgcagccc tgagcctcat caccctgtcc
     2401 accgtgtgta acctgcccag ccccctcaac gccatgcaga tcctgtgggt caacatcatc
     2461 atggacgggc cgccagcgca gagccttggg gtggagcctg tggacagaga cgccctgcgg
     2521 aggcctccac ggagtgtcgg ggacacgatc ctgaacagag ccctgatcct gagggtcctc
     2581 atgtcggccg ctgtcatcat aggggggacc ctctttatct tctggagaga gatcccagcg
     2641 aacggcacca gcaccccacg tacaaccacc atggccttca cctgcttcgt gtttttcgac
     2701 ctcttcaatg ccctgagctg tcgctctcag accaagctga tatttgagat tggctttttc
     2761 cggaaccgca tgttcctgta ctcagtcctt gggtccctcc tggggcagct ggccgtgatc
     2821 tatgccccgc ccctacaaaa ggtcttccag actgaaaacc tgagcgcgct cgacctgctg
     2881 ctgctgacgg gcctggcctc gtctgtcttc attctgtcgg agctgctcaa gctctgggaa
     2941 aagttcttgt ccagagccag gcccactcag atgctcccgg aagctgtgta acggaaccag
     3001 tgtgtcaagg ccctgactga cctgtgtgct tgggtgcctc tggcctgtcc ccatccatct
     3061 gtactaacca ctccaagggg caattctcag gaccgtgcag catcggacgc tggctccacc
     3121 tgtcctcctg gcctgctggg ccatgtcccg cacaggacag ggtggagctt attatactga
     3181 aacgtggcgc tatttattaa accaccgtgg tttttttatt taa
//
