LOCUS       NP_001240760             952 aa            linear   ROD 04-JUN-2024
DEFINITION  calcium-transporting ATPase type 2C member 1 isoform 1 [Mus
            musculus].
ACCESSION   NP_001240760
VERSION     NP_001240760.1
DBSOURCE    REFSEQ: accession NM_001253831.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 952)
  AUTHORS   Brown,J.M. and Garcia-Garcia,M.J.
  TITLE     Secretory pathway calcium ATPase 1 (SPCA1) controls mouse neural
            tube closure by regulating cytoskeletal dynamics
  JOURNAL   Development 145 (19) (2018)
   PUBMED   30228103
  REMARK    GeneRIF: SPCA1 promotes neurulation by regulating the cytoskeletal
            dynamics
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 952)
  AUTHORS   Reinhardt,T.A., Lippolis,J.D. and Sacco,R.E.
  TITLE     The Ca(2+)/H(+) antiporter TMEM165 expression, localization in the
            developing, lactating and involuting mammary gland parallels the
            secretory pathway Ca(2+) ATPase (SPCA1)
  JOURNAL   Biochem Biophys Res Commun 445 (2), 417-421 (2014)
   PUBMED   24530912
  REMARK    GeneRIF: The timing, magnitude of TMEM165 expression and its Golgi
            location supports a role for this Golgi Ca2+/H+ antiporter as a
            contributor to mammary Golgi calcium transport needs, in addition
            to the better-characterized roles of SPCA 1 and 2.
REFERENCE   3  (residues 1 to 952)
  AUTHORS   Cross,B.M., Hack,A., Reinhardt,T.A. and Rao,R.
  TITLE     SPCA2 regulates Orai1 trafficking and store independent Ca2+ entry
            in a model of lactation
  JOURNAL   PLoS One 8 (6), e67348 (2013)
   PUBMED   23840669
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 952)
  AUTHORS   Shull,G.E., Miller,M.L. and Prasad,V.
  TITLE     Secretory pathway stress responses as possible mechanisms of
            disease involving Golgi Ca2+ pump dysfunction
  JOURNAL   Biofactors 37 (3), 150-158 (2011)
   PUBMED   21674634
  REMARK    Review article
REFERENCE   5  (residues 1 to 952)
  AUTHORS   Feng,M., Grice,D.M., Faddy,H.M., Nguyen,N., Leitch,S., Wang,Y.,
            Muend,S., Kenny,P.A., Sukumar,S., Roberts-Thomson,S.J.,
            Monteith,G.R. and Rao,R.
  TITLE     Store-independent activation of Orai1 by SPCA2 in mammary tumors
  JOURNAL   Cell 143 (1), 84-98 (2010)
   PUBMED   20887894
REFERENCE   6  (residues 1 to 952)
  AUTHORS   Sepulveda,M.R., Vanoevelen,J., Raeymaekers,L., Mata,A.M. and
            Wuytack,F.
  TITLE     Silencing the SPCA1 (secretory pathway Ca2+-ATPase isoform 1)
            impairs Ca2+ homeostasis in the Golgi and disturbs neural polarity
  JOURNAL   J Neurosci 29 (39), 12174-12182 (2009)
   PUBMED   19793975
  REMARK    GeneRIF: Impaired cellular divalent calcium ion Ca2+ homeostasis
            and/or the altered targeting of organellar proteins under
            conditions of SPCA1 knockdown highlight the importance of SPCA1
            function for normal neural differentiation.
REFERENCE   7  (residues 1 to 952)
  AUTHORS   Sepulveda,M.R., Marcos,D., Berrocal,M., Raeymaekers,L., Mata,A.M.
            and Wuytack,F.
  TITLE     Activity and localization of the secretory pathway Ca2+-ATPase
            isoform 1 (SPCA1) in different areas of the mouse brain during
            postnatal development
  JOURNAL   Mol Cell Neurosci 38 (4), 461-473 (2008)
   PUBMED   18599310
  REMARK    GeneRIF: Has a potential role in intracellular signaling and in
            Golgi secretory processes involved in dendritic growth and in
            functional maturation of the mouse nervous system.
REFERENCE   8  (residues 1 to 952)
  AUTHORS   Okunade,G.W., Miller,M.L., Azhar,M., Andringa,A., Sanford,L.P.,
            Doetschman,T., Prasad,V. and Shull,G.E.
  TITLE     Loss of the Atp2c1 secretory pathway Ca(2+)-ATPase (SPCA1) in mice
            causes Golgi stress, apoptosis, and midgestational death in
            homozygous embryos and squamous cell tumors in adult heterozygotes
  JOURNAL   J Biol Chem 282 (36), 26517-26527 (2007)
   PUBMED   17597066
  REMARK    GeneRIF: loss of the Golgi Ca(2+) pump causes Golgi stress,
            expansion of the Golgi, increased apoptosis, and embryonic
            lethality and demonstrates that SPCA1 haploinsufficiency causes a
            genetic predisposition to cancer.
REFERENCE   9  (residues 1 to 952)
  AUTHORS   Mitchell,K.J., Tsuboi,T. and Rutter,G.A.
  TITLE     Role for plasma membrane-related Ca2+-ATPase-1 (ATP2C1) in
            pancreatic beta-cell Ca2+ homeostasis revealed by RNA silencing
  JOURNAL   Diabetes 53 (2), 393-400 (2004)
   PUBMED   14747290
REFERENCE   10 (residues 1 to 952)
  AUTHORS   Shull,G.E.
  TITLE     Gene knockout studies of Ca2+-transporting ATPases
  JOURNAL   Eur J Biochem 267 (17), 5284-5290 (2000)
   PUBMED   10951186
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133703.1, AK163049.1, AK173154.1 and BC043091.1.
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133703.1, SRR10223970.11809.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..952
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 56.61 cM"
     Protein         1..952
                     /product="calcium-transporting ATPase type 2C member 1
                     isoform 1"
                     /EC_number="7.2.2.10"
                     /note="calcium-transporting ATPase type 2C member 1;
                     ATPase, Ca++ transporting, type 2C, member 1; ATPase 2C1;
                     ATP-dependent Ca(2+) pump PMR1; Ca(2+)/Mn(2+)-ATPase 2C1;
                     secretory pathway Ca(2+)-transporting ATPase type 1"
                     /calculated_mol_wt=104173
     Region          88..929
                     /region_name="P-type_ATPase_SPCA"
                     /note="golgi-associated secretory pathway Ca(2+) transport
                     ATPases, similar to human ATPase secretory pathway Ca(2+)
                     transporting 1/hSPCA1 and Saccharomyces cerevisiae
                     Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; cd02085"
                     /db_xref="CDD:319779"
     Site            order(383..385,487,513..515,558,603..605,652,655,658,677,
                     680)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319779"
     Site            order(738,742..743,745..746,771,774..775)
                     /site_type="other"
                     /note="putative cation binding site [ion binding]"
                     /db_xref="CDD:319779"
     CDS             1..952
                     /gene="Atp2c1"
                     /gene_synonym="1700121J11Rik; ATP2C1A; BCPM;
                     D930003G21Rik; HHD; pmr1; SPCA; SPCA1"
                     /coded_by="NM_001253831.1:111..2969"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS57698.1"
                     /db_xref="GeneID:235574"
                     /db_xref="MGI:MGI:1889008"
ORIGIN      
        1 menllppsgf sylkkyplhs irkylstlrs qraeeqvarf qkipnvenet mipvltskra
       61 selavsevag llqadlqngl nksevshrra fhgwnefdis edeplwkkyi sqfknpliml
      121 llasavisil mrqfddavsi tvaivivvtv afvqeyrsek sleelsklvp pechcvregk
      181 lehtlardlv pgdtvclsvg drvpadlrlf eavdlsvdes sltgetapcs kvtapqpaan
      241 gdlasrsnia fmgtlvrcgk akgivigtge nsefgevfkm mqaeeapktp lqksmdllgk
      301 qlsfysfgii giimlvgwll gkdilemfti svslavaaip eglpivvtvt lalgvmrmvk
      361 kraivkklpi vetlgccnvi csdktgtltk nemtvthilt sdglhaevtg vgynqfgevi
      421 vdgdvvhgfy npavsrivea gcvcndavir nntlmgkpte galialamkm gldglqqdyi
      481 rkaeypfsse qkwmavkcvh rtqqdrpeic fmkgayeqvi kycttynskg qtlaltqqqr
      541 dlyqqekarm gsaglrvlal asgpelgqlt flglvgiidp prtgvkeavt tliasgvsik
      601 mitgdsqeta iaiasrlgly sktsqsvsge evdtmevqhl sqivpkvavf yrasprhkmk
      661 iikslqknga vvamtgdgvn davalkaadi gvamgqtgtd vckeaadmil vdddfqtims
      721 aieegkgiyn niknfvrfql stsiaaltli slatlmnfpn plnamqilwi niimdgppaq
      781 slgvepvdkd virkpprnwk dsiltknlil kilvssiiiv cgtlfvfwre lrdnvitprd
      841 ttmtftcfvf fdmfnalssr sqtksvfeig lcsnkmfcya vlgsimgqll viyfpplqkv
      901 fqteslsild llfllgltss vcivseiikk versrekvqk nagsasssfl ev
//
