LOCUS       NM_177236               6748 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ATPase, Ca++ transporting, plasma membrane 3 (Atp2b3),
            transcript variant 1, mRNA.
ACCESSION   NM_177236
VERSION     NM_177236.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6748)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6748)
  AUTHORS   Savy,V., Stein,P., Shi,M. and Williams,C.J.
  TITLE     PMCA1 depletion in mouse eggs amplifies calcium signaling and
            impacts offspring growthdagger
  JOURNAL   Biol Reprod 107 (6), 1439-1451 (2022)
   PUBMED   36130203
REFERENCE   3  (bases 1 to 6748)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6748)
  AUTHORS   Fecher-Trost,C., Lux,F., Busch,K.M., Raza,A., Winter,M.,
            Hielscher,F., Belkacemi,T., van der Eerden,B., Boehm,U.,
            Freichel,M. and Weissgerber,P.
  TITLE     Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is
            Involved In Offspring Bone Development
  JOURNAL   J Bone Miner Res 34 (4), 699-710 (2019)
   PUBMED   30786075
REFERENCE   5  (bases 1 to 6748)
  AUTHORS   Wang,C.X., Cui,G.S., Liu,X., Xu,K., Wang,M., Zhang,X.X.,
            Jiang,L.Y., Li,A., Yang,Y., Lai,W.Y., Sun,B.F., Jiang,G.B.,
            Wang,H.L., Tong,W.M., Li,W., Wang,X.J., Yang,Y.G. and Zhou,Q.
  TITLE     METTL3-mediated m6A modification is required for cerebellar
            development
  JOURNAL   PLoS Biol 16 (6), e2004880 (2018)
   PUBMED   29879109
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6748)
  AUTHORS   Reuter,H., Henderson,S.A., Han,T., Mottino,G.A., Frank,J.S.,
            Ross,R.S., Goldhaber,J.I. and Philipson,K.D.
  TITLE     Cardiac excitation-contraction coupling in the absence of Na(+) -
            Ca2+ exchange
  JOURNAL   Cell Calcium 34 (1), 19-26 (2003)
   PUBMED   12767889
REFERENCE   7  (bases 1 to 6748)
  AUTHORS   Krizaj,D., Demarco,S.J., Johnson,J., Strehler,E.E. and
            Copenhagen,D.R.
  TITLE     Cell-specific expression of plasma membrane calcium ATPase isoforms
            in retinal neurons
  JOURNAL   J Comp Neurol 451 (1), 1-21 (2002)
   PUBMED   12209837
REFERENCE   8  (bases 1 to 6748)
  AUTHORS   Shull,G.E.
  TITLE     Gene knockout studies of Ca2+-transporting ATPases
  JOURNAL   Eur J Biochem 267 (17), 5284-5290 (2000)
   PUBMED   10951186
  REMARK    Review article
REFERENCE   9  (bases 1 to 6748)
  AUTHORS   Garcia,M.L. and Strehler,E.E.
  TITLE     Plasma membrane calcium ATPases as critical regulators of calcium
            homeostasis during neuronal cell function
  JOURNAL   Front Biosci 4, D869-D882 (1999)
   PUBMED   10577388
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 6748)
  AUTHORS   Zacharias,D.A. and Kappen,C.
  TITLE     Developmental expression of the four plasma membrane calcium ATPase
            (Pmca) genes in the mouse
  JOURNAL   Biochim Biophys Acta 1428 (2-3), 397-405 (1999)
   PUBMED   10434059
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045516.1, AK032322.1 and AL805924.5.
            
            On Mar 12, 2014 this sequence version replaced NM_177236.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045516.1, SRR17784644.315331.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-423               AK045516.1         2-424
            424-3711            AK032322.1         349-3636
            3712-4483           AK045516.1         3711-4482
            4484-6748           AL805924.5         57898-60162
FEATURES             Location/Qualifiers
     source          1..6748
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.33 cM"
     gene            1..6748
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /note="ATPase, Ca++ transporting, plasma membrane 3"
                     /db_xref="GeneID:320707"
                     /db_xref="MGI:MGI:1347353"
     exon            1..249
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            250..577
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     CDS             370..4032
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /EC_number="7.2.2.10"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="plasma membrane calcium-transporting ATPase 3
                     isoform 1"
                     /protein_id="NP_796210.2"
                     /db_xref="CCDS:CCDS30205.1"
                     /db_xref="GeneID:320707"
                     /db_xref="MGI:MGI:1347353"
                     /translation="MGDMANSSIEFHPKPQQQREVPHVGGFGCTLAELRSLMELRGAE
                     ALQKIQEAYGDVSGLCRRLKTSPTEGLADNTNDLEKRRQIYGQNFIPPKQPKTFLQLV
                     WEALQDVTLIILEVAAIVSLGLSFYAPPGEESEACGNVSGGAEDEGEAEAGWIEGAAI
                     LLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQ
                     VKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKSADKDPMLLSGTHVMEGSGRMVV
                     TAVGVNSQTGIIFTLLGAGGEEEEKKDKKGKQQDGAMDSSQTRAKKQDGAVAMEMQPL
                     KSAEGGEMEEREKKKANVPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVI
                     ETFVVDGRVWLAECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMK
                     DNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIPAPSALTPKI
                     LDLLVHAISINSAYTTKILPPEKEGALPRQVGNKTECALLGFVLDLKRDFQPVREQIP
                     EDQLYKVYTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILNSNGELRGFRP
                     RDRDDMVKKIIEPMACDGLRTICIAYRDFSAIQEPDWDNENEVVGDLTCIAVVGIEDP
                     VRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEDFLCLEGKEFNRRI
                     RNEKGEIEQERLDKVWPKLRVLARSSPTDKHTLVKGIIDSTTGEQRQVVAVTGDGTND
                     GPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQ
                     LTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPY
                     GRDKPLISRTMMKNILGHAVYQLTIIFTLLFVGELFFDIDSGRNAPLHSPPSEHYTII
                     FNTFVMMQLFNEINARKIHGERNVFDGIFSNPIFCTIVLGTFGIQIVIVQFGGKPFSC
                     SPLSTEQWLWCLFVGVGELVWGQVIATIPTSQLKCLKEAGHGPGKDEMTDEELAEGEE
                     EIDHAERELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESKSCIHNFMATPE
                     FLINDYTHNIPLIDDTDVDENEERLRAPPPPPPNQNNNAIDSGIYLTTHATKSATSSA
                     FSSRPGSPLHSMETSL"
     exon            578..775
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            776..1033
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1159
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1285
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1327
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1492
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1707
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1950
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2192
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2427
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2607
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2695
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2802
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..2994
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3208
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3420
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            3421..3528
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            3529..3711
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     exon            3712..6748
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6544..6549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /note="hexamer: TATAAA"
     polyA_site      6567
                     /gene="Atp2b3"
                     /gene_synonym="6430519O13Rik; Pmca3"
                     /note="major polyA site"
ORIGIN      
        1 agagctgcgg ctggagtcga gcgcgcagcg tcgcccgccg ccgccgctgc cgccgccggt
       61 gcggagcgtg gggagcactc ggccacagcc ctcgcctgcc gcggagggtc ctgctccgca
      121 ctgctggcca ggcggcccag tgccccggcc tttccgtcct tggagctgat cgttgcttgc
      181 cgggagccct cccgcagcaa cagcgaaagc cacagcagag gccgcggtgg cggctgtgcc
      241 catgccgggg tgttcacact tagcctcttt tccaccacca ccttgcctca gcactgggat
      301 cttaggtgga cacctgtccc tagctgcaat tgagttgaag cagcacctgt gagaaggcta
      361 acagacagga tgggcgacat ggcaaacagt tccattgagt tccaccccaa gccccagcag
      421 cagcgggaag tgccccatgt gggtggcttt ggatgcacac tggcagaact acgaagcctc
      481 atggagctcc gaggtgctga ggcactgcag aagattcaag aagcctatgg ggatgtcagc
      541 gggctgtgca ggaggctgaa gacctcacct actgagggcc tggcagacaa caccaatgac
      601 ttggagaaac gcaggcagat ctatgggcag aacttcatcc ccccaaagca gcctaagacc
      661 ttcctgcaac tggtgtggga agccctgcag gacgtgactc tcatcatcct ggaggtggct
      721 gctatcgtct ccctgggcct ctccttctat gcacctcctg gagaggaaag tgaagcctgt
      781 gggaatgtgt ctggtggggc agaggatgaa ggagaggctg aagctggctg gattgagggg
      841 gctgccatcc tactctctgt catctgtgtg gtgctggtca cagccttcaa tgactggagc
      901 aaggaaaagc agttccgagg tcttcaaagc cgtattgagc aggagcagaa gtttactgtc
      961 atacgaaatg ggcagctcct ccaggtccct gtggcggccc tggtggtagg ggacattgcc
     1021 caggtcaaat atggagatct tctgcctgcc gatggtgtgc tcatccaagg caatgacctc
     1081 aagatcgatg agagctccct gaccggcgag tcggaccatg ttcgaaaatc agcagacaaa
     1141 gatcctatgc tgctctcagg aactcatgtc atggaaggtt ctgggagaat ggtggtaaca
     1201 gctgttggtg tgaactccca gacaggcatc atctttacat tgcttggggc aggtggagag
     1261 gaggaggaga agaaagacaa gaaaggcaag cagcaggatg gggcgatgga cagtagccaa
     1321 accagagcta agaagcagga tggggctgtt gccatggaaa tgcaacccct gaagagcgcc
     1381 gagggtgggg aaatggagga gcgggaaaag aagaaagcca acgtacccaa gaaggagaag
     1441 tcagtcctgc aaggaaagct cacaaaactg gctgtgcaga ttgggaaagc aggattggtg
     1501 atgtctgcta tcactgtcat cattctggtc ctctactttg tgattgagac ctttgtcgtg
     1561 gatggccggg tatggctggc agagtgcaca ccagtgtatg tgcagtactt cgtgaagttc
     1621 ttcattattg gagtcactgt tttggttgtg gctgtccctg agggcctgcc tcttgctgtt
     1681 actatctcct tggcttattc tgtcaagaaa atgatgaagg ataataacct ggtacgccac
     1741 ctggatgcct gtgagaccat gggcaatgcc acagccatct gttctgacaa gacgggcaca
     1801 ctcaccacca accgcatgac agtggtccag tcctacctag gagacaccca ctacaaagag
     1861 attccagctc ccagcgccct gacccccaag attcttgacc ttctggttca cgccatctcc
     1921 atcaacagtg cctacaccac caaaattcta cctccagaga aagaaggcgc tctcccacgc
     1981 caagtgggca acaaaacaga gtgtgctctg ctgggcttcg tcttggacct gaaacgtgac
     2041 ttccagccag tacgggagca gataccagaa gatcagcttt acaaagtgta caccttcaac
     2101 tcagttcgca agtctatgag cacagttatc cgcatgcctg atggtggctt ccgcctcttt
     2161 agcaagggag cctcagagat tctgctcaaa aagtgtacaa acatcttaaa cagcaatggt
     2221 gaactccgag gatttcgtcc tcgggaccgg gatgatatgg tgaagaagat cattgagcct
     2281 atggcttgtg atggcctccg caccatctgc attgcctaca gggacttctc tgctatccag
     2341 gagcctgatt gggacaatga gaatgaggtg gttggtgacc ttacctgcat agctgttgtg
     2401 ggcatcgagg accctgtgcg acctgaggtc cctgaagcca ttcgaaaatg ccagcgtgct
     2461 ggcatcacag tccgtatggt gactggagac aacatcaaca ctgcccgggc tattgcagct
     2521 aagtgtggca tcatccagcc aggagaggac ttcctgtgcc tggaggggaa ggaattcaac
     2581 agaagaattc gaaatgagaa aggcgagatt gaacaggagc ggctggacaa agtgtggccc
     2641 aagctgcggg tgcttgcccg gtcatctccc actgataaac atactctggt taaaggcatt
     2701 attgacagca caactggtga gcagcggcag gtggtggctg tgactggaga tggcaccaat
     2761 gatgggccag ccctcaaaaa ggcagatgtg ggcttcgcca tgggcattgc aggcactgat
     2821 gtggccaagg aggcctctga catcattctg actgatgaca acttcaccag cattgtcaag
     2881 gcggtcatgt ggggccgcaa tgtctatgac agcatctcca agttcctgca gtttcagttg
     2941 acagtcaacg tggtagctgt gatcgtggcc ttcacgggtg cctgcattac tcaggactct
     3001 cctctcaaag ctgtgcagat gttgtgggtg aacttaatca tggacacatt tgcctcactt
     3061 gccctggcaa cggaaccccc aactgagtca ctgctgctgc ggaagccata cggccgggac
     3121 aagcctctca tctcgagaac catgatgaag aacatccttg gacatgctgt ctaccagctc
     3181 accatcatct ttaccctgct atttgttggg gagcttttct ttgacattga cagtggaaga
     3241 aatgcacctc tgcactcacc accgtcagag cactatacca tcatcttcaa cacgttcgtc
     3301 atgatgcagc ttttcaatga gatcaatgct cgcaagatcc atggtgagag gaatgtcttt
     3361 gatggcatct tcagcaaccc catcttctgc accattgtct tgggcacctt tggaattcag
     3421 attgtcattg tccaatttgg agggaagccc ttcagctgtt ccccactgtc cacagaacag
     3481 tggctttggt gcctgtttgt tggtgttggg gagctggtct ggggacaggt cattgccacc
     3541 atccccacca gccagctcaa gtgcctgaag gaagcagggc atgggcctgg gaaggatgag
     3601 atgactgatg aagagctggc cgaaggggaa gaagaaattg accatgctga acgagagctc
     3661 cgcaggggcc agatcctctg gtttcggggc ctcaaccgga tccagacaca gatccgggtg
     3721 gtgaaagcat tccgtagctc gctttatgaa ggcctggaga aaccagaatc caagagttgc
     3781 atccataact tcatggcaac acccgagttt ttgatcaatg actacaccca caatatcccg
     3841 ctcatcgatg acacagatgt ggatgagaac gaagagcgcc tgagggcccc acctccccca
     3901 ccccctaacc agaacaacaa cgccatagac agcggcatct acctgaccac gcatgccacc
     3961 aagtcagcta cctcttcagc attctcttcc aggcccggga gcccactcca cagcatggag
     4021 acatccctct aaccgaaact tttctcagca catgtacaca cacacacaca cacacacaca
     4081 cacacacaca cacacacaat cacacacgca gtcacacatg cacccagagg ggaacctgta
     4141 cacctgccaa agagggaaat gactaacatg gctaaagact ttacttatgt ggtattttca
     4201 ggaagccaat tgaattcaat aaggacacag tctactaggc ttcttactaa gttcccatga
     4261 ggtgggggaa ggagaaagaa ggaaagggga gggagggagg gagggaggtt cttcgcccaa
     4321 tgtgaaggaa aaagggagca tgagacaaga tgcgcttccc accatttttc tactgatgct
     4381 tctgttttta atgaacacta gttctaccat gtgttcacca tttgggctgt gcaatgcggt
     4441 aggggctacc agagcctatt tggagctttg ctatacccat atcaaaagaa aaagaaaaaa
     4501 agtataccaa aaccaagaag gagttcattg cgcagatcgg ccaccagagg gagccacctg
     4561 taaaggtacc ttctactgca aagcacacaa gacccatctg cagaccgcat gtgtgcgtgt
     4621 gtctatatgt atgtgtctat atgcatatac atatatgtga caaaatccat atttaaagaa
     4681 taaggaacta tttattggca tgatatttct attcttctca ccaggcattt cccttttgag
     4741 gtttcatttt tgaatgtagc aaggctcttt tcagggaaca agactgcaag aacatcctct
     4801 tggtactgta cttccctcct cagcccctga cccgaggatc tccatacctg accctgccga
     4861 gattccagaa gaggcagtct ggggagtgtt gtgtaaagcc ttgcacttag aacctttgcg
     4921 ctttgagacc tctacccgta gaggagaagg acttttcaac ggcattttta tttaaaagga
     4981 aaataccaaa gtattgatga cagtggtccc ctccagtgtg cagcaaggca agttttgatt
     5041 ttggcttcct tccacttcat ttccaacacc ttcatttttg gctggcagct ttctgttttc
     5101 atactccaag tttaaaaaca tgatgaaccc taggaagagc tgtgatggag cagagacaga
     5161 tgctaggaaa ggacggtcca ggtttattcc tctgcacttg tactgtgtgc tttggcaaag
     5221 ggcagcaagt cctcactgga tgtcctcatt gtctgcgaag gcgtgggtgt gtctgcgagg
     5281 gcgtgtctgc aaggtcgtgg gtgtgtcacc caccaaagca tgcttccagc ccaggtcttc
     5341 ttgcccgcag gacaaatcca acccagaagg cataactata gaaacagaac attgccattg
     5401 ttcttttctg gcctcttctg ggcctgtgag gactgagcac ggggtcagtc agccggcctt
     5461 gggtccacct agacaggtaa gactagaaaa gccaggtctg ggaatcctga gatattgtct
     5521 tccaggagcc tgtcccagca gtgtgggcac ccattgtgcc aagcctgctt tcctagaaag
     5581 agtgatagcc tgagagaagg cagaggaaag aggtctaatg tctgctgccc ctccagggaa
     5641 gcccaggctg atgactcctt cctagtggaa agctgactct cctctatgct cctaggtcct
     5701 gaatctggac acccactgta acggaggtga aataggtagc atcctgccct tgaggtttct
     5761 tcaccttctg aacttatgga tgtcacactt ttcaggaaga tgtctagaat atcacactac
     5821 tcttaaatat gcctgtcact tgagctcaag gtttgtctgc caggagacag gtgtgaattg
     5881 agagagagac aggagctgtg tttgtcccac tccccccccc cccactcaca cacaccacta
     5941 aaagtttgtc tcagctttct ggcatccaca gaaagtcaaa tggaaacttg ctatgttccc
     6001 actggtcaca ccaatgccat gtcaccccta agcaggagta gtcacatctc gggaaaaaga
     6061 attttggtta ccagaaaact ccactttaaa atgccagcta cagatcacat aaagccatcc
     6121 cttttttcta aagggcatat tgagaatgtt tcccatttgt aaattgttcc ctgatgtcct
     6181 tgtttaaacc accacagcaa aagggcaact tggtttgctg agggtctttg tgttcttcaa
     6241 taagtaatca aaatgtggag tattgtgact gaagcaggtc agctgtgtcc agctatgctc
     6301 atgggcttct tgtcatcctc tgttgtagac atacacatag agcaaatggc cactatgtat
     6361 taaaaagcca acccctgatg atgctgtgta aagttgcctg atgtcagtgt caattgtgtg
     6421 atatccaggc tgcctttatg ctgagctatg gggttcagaa aaggccctgg gaacccgcat
     6481 catctgttct gattcttgta cagtcttcag gccgagagac ctgtctcatc ggaagcttct
     6541 ctttataaag cattatacta tatggaatgg cttggtcaac tgtgttcagt tcataaatat
     6601 gttttacatt tttatctgcc tgttaaaaat gaacaaaata tcttaatgag gaagaccaca
     6661 gatgcataat aaattaaaat ctgtagttga atttcctaat ttaaagaata gatcaaaaat
     6721 tttgtgtata aaaaaatgaa tgggtctg
//
