LOCUS       NM_001347365            9047 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus ATPase, Ca++ transporting, plasma membrane 2 (Atp2b2),
            transcript variant 3, mRNA.
ACCESSION   NM_001347365 XM_011241164
VERSION     NM_001347365.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9047)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   2  (bases 1 to 9047)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 9047)
  AUTHORS   Poggio,E., Barazzuol,L., Salmaso,A., Milani,C.,
            Deligiannopoulou,A., Cazorla,A.G., Jang,S.S., Julia-Palacios,N.,
            Keren,B., Kopajtich,R., Lynch,S.A., Mignot,C., Moorwood,C.,
            Neuhofer,C., Nigro,V., Oostra,A., Prokisch,H., Saillour,V.,
            Schuermans,N., Torella,A., Verloo,P., Yazbeck,E., Zollino,M.,
            Jech,R., Winkelmann,J., Necpal,J., Cali,T., Brini,M. and Zech,M.
  TITLE     ATP2B2 de novo variants as a cause of variable neurodevelopmental
            disorders that feature dystonia, ataxia, intellectual disability,
            behavioral symptoms, and seizures
  JOURNAL   Genet Med 25 (12), 100971 (2023)
   PUBMED   37675773
  REMARK    GeneRIF: ATP2B2 de novo variants as a cause of variable
            neurodevelopmental disorders that feature dystonia, ataxia,
            intellectual disability, behavioral symptoms, and seizures.
REFERENCE   4  (bases 1 to 9047)
  AUTHORS   Edwards,W., Bussey,O.K. and Conlon,F.L.
  TITLE     The Tbx20-TLE interaction is essential for the maintenance of the
            second heart field
  JOURNAL   Development 150 (21) (2023)
   PUBMED   37756602
REFERENCE   5  (bases 1 to 9047)
  AUTHORS   Tao,Y., Lamas,V., Du,W., Zhu,W., Li,Y., Whittaker,M.N., Zuris,J.A.,
            Thompson,D.B., Rameshbabu,A.P., Shu,Y., Gao,X., Hu,J.H., Pei,C.,
            Kong,W.J., Liu,X., Wu,H., Kleinstiver,B.P., Liu,D.R. and Chen,Z.Y.
  TITLE     Treatment of monogenic and digenic dominant genetic hearing loss by
            CRISPR-Cas9 ribonucleoprotein delivery in vivo
  JOURNAL   Nat Commun 14 (1), 4928 (2023)
   PUBMED   37582836
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9047)
  AUTHORS   Modolell,M., Corraliza,I.M., Link,F., Soler,G. and Eichmann,K.
  TITLE     Reciprocal regulation of the nitric oxide synthase/arginase balance
            in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines
  JOURNAL   Eur J Immunol 25 (4), 1101-1104 (1995)
   PUBMED   7537672
REFERENCE   7  (bases 1 to 9047)
  AUTHORS   Ikeda,M., Matsui,K., Ishihara,Y., Morita,I., Murota,S., Yuasa,T.
            and Miyatake,T.
  TITLE     Cerebellar nitric oxide synthase, cGMP and motor function in two
            lines of cerebellar mutant mice, Staggerer and Wriggle Mouse Sagami
  JOURNAL   Neurosci Lett 168 (1-2), 65-68 (1994)
   PUBMED   7518067
REFERENCE   8  (bases 1 to 9047)
  AUTHORS   Nhamburo,P.T., Kimura,S., McBride,O.W., Kozak,C.A., Gelboin,H.V.
            and Gonzalez,F.J.
  TITLE     The human CYP2F gene subfamily: identification of a cDNA encoding a
            new cytochrome P450, cDNA-directed expression, and chromosome
            mapping
  JOURNAL   Biochemistry 29 (23), 5491-5499 (1990)
   PUBMED   1974816
REFERENCE   9  (bases 1 to 9047)
  AUTHORS   Ikeda,M., Mikuni,M., Nishikawa,T. and Takahashi,K.
  TITLE     A neurochemical study of a new mutant mouse presenting
            myoclonus-like involuntary movement: a possible model of
            spontaneous serotonergic hyperactivity
  JOURNAL   Brain Res 495 (2), 337-348 (1989)
   PUBMED   2765934
REFERENCE   10 (bases 1 to 9047)
  AUTHORS   Matsui,K., Mukoyama,M., Adachi,K. and Ando,K.
  TITLE     [Fundamental study on ataxic mice (wriggle mouse Sagami)]
  JOURNAL   Jikken Dobutsu 36 (2), 185-189 (1987)
   PUBMED   3038581
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153590.8 and AC117596.6.
            
            On Jul 19, 2022 this sequence version replaced NM_001347365.1.
            
            Transcript Variant: This variant (3) encodes isoform 2. Variants 3
            and 4 both encode the same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054112.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AC153590.8         64302-64511         c
            211-305             AC117596.6         9051-9145
            306-819             AC117596.6         87009-87522
            820-1017            AC117596.6         112309-112506
            1018-1275           AC117596.6         115610-115867
            1276-1401           AC117596.6         116744-116869
            1402-1527           AC117596.6         124068-124193
            1528-1560           AC117596.6         125875-125907
            1561-1620           AC117596.6         127109-127168
            1621-1662           AC117596.6         132503-132544
            1663-1821           AC117596.6         133257-133415
            1822-2036           AC117596.6         135774-135988
            2037-2279           AC117596.6         139659-139901
            2280-2521           AC117596.6         155208-155449
            2522-2756           AC117596.6         156159-156393
            2757-2936           AC117596.6         163487-163666
            2937-3024           AC117596.6         163846-163933
            3025-3131           AC117596.6         166010-166116
            3132-3323           AC117596.6         166698-166889
            3324-3537           AC117596.6         168799-169012
            3538-3749           AC117596.6         170320-170531
            3750-3857           AC117596.6         170628-170735
            3858-4040           AC117596.6         172640-172822
            4041-9047           AC117596.6         180806-185812
FEATURES             Location/Qualifiers
     source          1..9047
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.85 cM"
     gene            1..9047
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /note="ATPase, Ca++ transporting, plasma membrane 2"
                     /db_xref="GeneID:11941"
                     /db_xref="MGI:MGI:105368"
     exon            1..210
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            211..305
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            306..819
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     CDS             621..4352
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /EC_number="7.2.2.10"
                     /note="isoform 2 is encoded by transcript variant 3;
                     plasma membrane calcium-transporting ATPase 2; plasma
                     membrane calcium pump; plasma membrane calcium ATPase;
                     deaf waddler; wriggle"
                     /codon_start=1
                     /product="plasma membrane calcium-transporting ATPase 2
                     isoform 2"
                     /protein_id="NP_001334294.1"
                     /db_xref="CCDS:CCDS85130.1"
                     /db_xref="GeneID:11941"
                     /db_xref="MGI:MGI:105368"
                     /translation="MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVV
                     KIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEA
                     LQDVTLIILEIAAIISLGLSFYHPPGESNEGCATAQGGAEDEGEAEAGWIEGAAILLS
                     VICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQIKY
                     GDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMVVTAV
                     GVNSQTGIIFTLLGAGGEEEEKKDKKGVKKGDGLQIPAADGAAPANAAGSANASLVNG
                     KMQDGSADSSQSKAKQQDGAAAMEMQPLKSAEGGDADDKKKANMHKKEKSVLQGKLTK
                     LAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLTECTPVYVQYFVKFFIIGVTV
                     LVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNR
                     MTVVQAYVGDVHYKEIPDPSSINAKTLELLVNAIAINSAYTTKILPPEKEGALPRQVG
                     NKTECGLLGFVLDLRQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKMPDESFRMYS
                     KGASEIVLKKCCKILSGAGEARVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSS
                     PEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARA
                     IAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHT
                     LVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDD
                     NFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVN
                     LIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLTLIFTLLFV
                     GEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNP
                     IFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSR
                     LKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVKA
                     FRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNSSPPS
                     SLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL"
     exon            820..1017
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1275
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1401
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1527
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1560
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1620
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1662
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1821
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..2036
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2279
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2521
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2756
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2936
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3024
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3131
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3323
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            3324..3537
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3749
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            3750..3857
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            3858..4040
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     exon            4041..9047
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7186..7191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /note="hexamer: AATAAA"
     polyA_site      7216
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
     regulatory      9024..9029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /note="hexamer: AATAAA"
     polyA_site      9047
                     /gene="Atp2b2"
                     /gene_synonym="D6Abb2e; dfw; Gena300; jog; PMCA2; Tmy;
                     wms; wri"
                     /note="major polyA site"
ORIGIN      
        1 catttgcccg gggcctcaga tatctggcct ggccaaacct cctgttctgc tcccagccgc
       61 tccggcagag gctagagccg gctttgaaca agtgagggaa ataaggcatg tttggggtgg
      121 catggcccag agaccccagg agcagctctg caccccagct ttccactggc cagcccaggc
      181 actgctggga attgaaaaga aacaaaacag agctgaactt ggtcacacag tccctagagc
      241 cggcaagaca tgggctccac tgtgcagctc ctggcgcctc tgatgtaacc agaagatgtg
      301 taggggagct gtcccgacca tgtagatgcc agccccaggg atcagcatgg gccccactga
      361 atggagactc ctgggtcagc attcctgagc ctcttcggcc cctggacctc accccactcc
      421 tggggacact cctcagagct ctccagtgct gtcgccagcc cacctcagcc atcacctcct
      481 cctgggactc gaagttgacc gcctcgtgct actaccctct ggtgagggtg tactgagggc
      541 agccacacac agccatcacc cagaggcccc ttttccagtg ctgaccctca ggcccagcct
      601 gagtagacac ttcagcaaac atgggtgaca tgaccaacag cgacttttac tccaaaaacc
      661 aaagaaatga gtcgagccat gggggcgagt tcgggtgcac catggaggag ctgcgctccc
      721 tcatggagct gcggggcacc gaggctgtgg tcaagatcaa ggagacgtat ggggacactg
      781 aagccatctg ccggcgcctc aaaacctcgc ctgttgaagg tttaccaggc actgctccag
      841 acttggaaaa gaggaaacag atttttgggc aaaacttcat acctccaaag aaaccaaaaa
      901 ccttcctgca gctggtgtgg gaagcgctac aggacgtgac acttatcatc ctggagatcg
      961 cggccatcat ctccctggga ctgtccttct accacccacc gggagagagc aatgaaggat
     1021 gtgccacggc ccagggtggg gcagaggatg aaggtgaagc agaagcaggc tggattgagg
     1081 gggctgccat cctgctgtca gtcatctgtg tggtcctggt cacagccttc aatgactgga
     1141 gtaaggagaa acagttccgg ggcctgcaga gccgaattga gcaggagcag aagttcactg
     1201 tggtccgggc cggccaggtg gttcagatcc ctgtggccga gatcgtggtc ggggacattg
     1261 cccagatcaa atatggtgac cttcttcccg ctgatggcct cttcatccag ggaaatgacc
     1321 tcaaaattga tgaaagctca ctcacagggg aatctgacca ggtgcgcaag tctgtggata
     1381 aggaccccat gttgctgtca ggaacccatg tgatggaggg ctcaggacgg atggtggtta
     1441 ctgctgtggg tgtgaactct cagactggca tcatatttac cctgcttggg gctggtggtg
     1501 aagaggaaga gaagaaagac aaaaaaggtg tgaagaaggg ggatggcctt cagataccag
     1561 cggccgacgg cgcagcgcct gcaaacgctg caggtagcgc aaatgccagc ctagtcaatg
     1621 gtaaaatgca ggatggcagt gccgacagca gccagagcaa agccaagcag caggatgggg
     1681 cagctgccat ggagatgcag cctctgaaga gtgcagaggg cggcgatgca gatgacaaga
     1741 agaaagccaa catgcacaag aaagagaagt cggtgcttca gggcaagctc accaaactgg
     1801 ctgtgcagat aggcaaggcg ggcctggtga tgtcggccat cacagtgatc atcctggtac
     1861 tctacttcac cgtggacacc ttcgtggtca acaagaagcc atggctgacg gaatgcacac
     1921 ccgtctacgt acagtacttt gtcaagttct tcatcattgg tgtgacggtg ctggtggtcg
     1981 ctgtgcccga gggcctccct ctggctgtca ccatctcact ggcctattct gtgaagaaaa
     2041 tgatgaagga caacaacctg gtacgccacc tggatgcctg tgagaccatg ggcaatgcca
     2101 cagccatctg ctcagacaag acaggaacgc tgaccaccaa ccgcatgacc gtggtccagg
     2161 cctatgtcgg tgacgtccac tacaaggaga tccccgatcc cagctccatc aatgccaaga
     2221 cgctggagct gctggtcaac gccattgcca tcaacagcgc ctacaccacc aagatccttc
     2281 ccccagaaaa agagggagcc ctgccccggc aggtgggcaa caagacagag tgcggcctgc
     2341 tgggctttgt gctggacttg aggcaggact acgagccggt gcgcagccag atgccagagg
     2401 agaagctgta taaggtgtac accttcaact ccgtgcgcaa gtccatgagc accgtcatca
     2461 agatgcccga cgagagcttc cgcatgtaca gcaagggcgc ctcggagatt gtgctcaaaa
     2521 agtgctgcaa gatcctcagt ggggcagggg aagcccgtgt cttccggccc cgagacaggg
     2581 atgagatggt taagaaggtg attgagccca tggcctgtga cgggctccgt accatctgcg
     2641 tggcctatcg tgacttcccc agcagccctg agcctgactg ggacaatgag aatgacattc
     2701 tcaatgaact cacgtgcatc tgcgtggtgg gcatcgaaga cccagtacga cctgaggtcc
     2761 cagaagccat ccgcaagtgc cagcgggcag gtatcacagt ccgcatggtc accggtgaca
     2821 atatcaacac agcccgggcc atcgccatca agtgtggcat tatccaccct ggagaggact
     2881 tcctgtgcct ggaaggcaaa gaattcaatc ggaggattcg caacgagaag ggggagattg
     2941 agcaggagcg gattgacaag atctggccaa agctgagggt gctggctcgc tcctcgccca
     3001 cggataagca cacgctggtc aaaggcatca tcgacagtac acacactgag cagcggcagg
     3061 tggtggctgt gacaggggat gggaccaacg acgggcctgc tctcaagaag gcagatgtgg
     3121 gcttcgcaat gggcatcgca ggcacagatg tggccaagga ggcctcagac atcatcctga
     3181 cagatgacaa cttcagcagc atcgtcaagg cagtgatgtg gggccgtaac gtctatgaca
     3241 gcatatccaa attcctgcag ttccagctga ctgtcaacgt ggtggcggtg atcgtggcct
     3301 tcacgggcgc ctgcattaca caggactccc ctctcaaggc tgtgcagatg ctctgggtga
     3361 acctcatcat ggacacgttt gcctccctgg ccctggccac agagccacct acggagactc
     3421 tgcttctgag gaaaccgtac ggtcgcaaca agccgctcat ctcgaggacc atgatgaaga
     3481 acatcctggg ccacgccgtc taccagctca ccctcatctt caccctgctc ttcgtgggtg
     3541 agaagatgtt ccagatcgac agcggaagga acgccccgct gcactcacca ccctcagagc
     3601 actacaccat catcttcaac accttcgtca tgatgcagct tttcaacgag atcaacgccc
     3661 gcaagatcca cggcgagcgc aacgtctttg acgggatctt ccggaacccc atcttctgca
     3721 ccatcgttct tggcactttc gccatccaga tagtgatcgt gcagtttggc gggaagccct
     3781 tcagctgctc cccactccag ctggaccagt ggatgtggtg catcttcata ggcctgggag
     3841 agctcgtctg gggccaggtc atcgccacca tccctaccag caggctcaag ttcctgaaag
     3901 aggcagggcg tctaacacag aaggaggaga tccccgagga ggagttaaat gaggatgtgg
     3961 aagagataga ccacgcagag cgggagcttc gccgtggcca gatcctgtgg ttccggggcc
     4021 tgaatcggat ccagacacag atccgcgtcg tgaaggcgtt ccgtagctct ctctatgaag
     4081 ggttagaaaa acccgagtct cgaacctcca tccataactt catggctcat cctgaattcc
     4141 ggatcgaaga ttcccagccc cacatccccc tcatcgatga caccgacctg gaagaagatg
     4201 ccgcgctcaa gcagaactcg agcccgccgt cctcgctcaa caagaacaat agcgccatcg
     4261 acagcgggat caacctgacg accgacacga gcaaatcagc tacctcttca agtccaggga
     4321 gccccatcca cagcctggag acgtcgcttt agctgaggcc cctgtcgcct ggccacgctc
     4381 atggacccgc cgccacccgc ctccaggcgc acacccttcc aggcaccaac tccccgacac
     4441 agcaaggagc actgggcgga acccacacag cagagaggga accagacctt tctctggcag
     4501 ccatgctgtt tgaactcttt ttcactcctt aggccttggg cggggttgcc ctggggtcat
     4561 ctggagcaga gagtggcgtg gatttttttt tctccaaaac ataaaaaata ataataacga
     4621 attaattaaa aaaaaaaaga gcctttccag gctccagccc agacacggac cagccatgca
     4681 cccgccggcc accgtggccc cagcatgaat gtacctggac actattaatc ccctccctca
     4741 tttggttctt ggagggctag ggaggggagt tttttgtttg tttccttagg cgggaactgc
     4801 aaacaggaac tggaacagag actactgttc gttcagtcca ctggtctatg aggtttcaaa
     4861 tgcttgccca gcatggtctc aaatgtctag attaatttaa taactttttg aaatcacaga
     4921 gtaggtttgc accaatgaaa cccaagaact ccacagacac tcacgaggtt atatccgttt
     4981 ctttgtatct atatcaacgt atacttcttg aagactgtat acgtgcgtat agataagtag
     5041 atattatata tatatatata tacatatata tacatggata tataaagttc ctttgccggc
     5101 atgttgcctt gtttctgctt aaattgctct attttaactt atgtcctaaa agaagaatgt
     5161 aatttgttta caaacctgta gataatgtct ttggctattt gtgtggttta aggacactgg
     5221 tggccaagat gcttacaaac agctcgggcc caacagacac atcccctgga ttgcatcctt
     5281 gaagttttac gatagccatg ctctgatttt tgcctgctat ttccgttcaa taatgtcact
     5341 actgtgggaa gctcaggcag aaagccaacg gctcccaagg atccaccctg aggagctaag
     5401 caacgcgctc gctcactcca ccgtagacaa gggagaagag gagagaaggc ttcctgggtt
     5461 tgcaacacgg ccgtccaggt ctggtgacgt caacgtctgt agtgcacccg gagaaggaag
     5521 acttttctct caatgaaact cgcttgagtt tacagagagc atttcagaac tgagttgtct
     5581 ttggcactgt ctgtgagtca aggtagtgtt cagatattac aaatgctatt gtgttgaatt
     5641 tttttttttt tttagttagt aatttagaag tttcttttct tataaacggc agcatagaca
     5701 ctgctgacat actggatgag ggttggtacg gcttgctgct tttgtttttt ttttttttct
     5761 ttttgaagaa gaatagcctt ttttctctgc actatttaga tccgaatgaa ccttataatg
     5821 tgtacattga gatgtattca gtgtgatttt taaaccaaat tgtcttcctg tagttacaat
     5881 atatactgta gccttttaac agcaagtcct gctttcccag acagaaagcc attctgatat
     5941 cttcccatat cacaggtgag aaaaggtggc tatcccctct cccaacaata acagcactag
     6001 ttatcccact taataagagc ttgtctgtcg gcctcttact gctaagcact ttgtgggtct
     6061 cagctttttt tcataaaaga acttttgtat ttaatacaaa gtttgctttg agacttttca
     6121 gcatacaatc tttttccata aacttgtaca gtgcaaaaga cattttgaat accatgaccg
     6181 atgatgtccc gtgcttcgag gaaatcaaac actttccgcc tcacttgtga actccatcct
     6241 tcactctctc cctcctcaca atcgctcctc ctcgctcttc agcctggccc cccagccctc
     6301 ctccaggccc agagacctct tcactaaaca agatgacagc cacttgggaa aagagccata
     6361 gtcagctggg agggcccacg tctggatggc tgtgaaaaac ttgagttctt ggtttgggct
     6421 tcaaagtctg cccatcccac ctggccataa tctttctata aggaagaata tctctgaagg
     6481 attctgattg tatccaggag agagagagag ctacctctcc agcaggtgga ccagccctag
     6541 atgtactcac tggattccag tacagacacc accagagcca gtccatagta cccctccaag
     6601 ggagggaagg aaacccgggg ctgccttgga acaggatagg tttttggttt ggttttgttg
     6661 ttgttgttgt tgttgttgct gctgctgctg ttgttgtttg attggtttgg gacttttggt
     6721 ggggagtcct ttgtcacatt tttcatcctg ccctccttca ttcaaccatg catctatgac
     6781 ctcattccat gccaccaggg ttcttgctct taacaaaccg gggtcctcgg gctttggaac
     6841 caggcctcca gggcaaagag gaaggggttc tctgagcaga gccaggttct cagacaggag
     6901 cagaggaaac tagcaaggag gcctgacatt agtgctggct tcccggtgtc aggaatgaga
     6961 gatagcctat gccccagccc ctcactctca cactcttcca tacacacaca cacctacaca
     7021 ggagatggtt ggtttgtcag aactcactgt aatacacaag cttgcacttc tgcgtcctat
     7081 atctagcagc atgggatacg tttggcagtt caccccatta gggggtcaat aatttatgac
     7141 cattcatctg tttttatgaa tttttttatc tagacaataa ttgtaaataa agaattcacc
     7201 gtctctgctc atttaatact atgcaatggt tatgttttcc atggctggct cttctggctc
     7261 acataggtgt ttctgatgtg tctatggtat ttaaaaaaaa atcaagcaga aataggaaat
     7321 ctctactctt ttctagcgtg gcccccaccc ccttctttcc tgtcctctgc attctgtaag
     7381 tgcatcaatc ccctagcctg tcagataact gagaaaacac aggtgagcat ccagcagggg
     7441 acctgaactt tggctctggc tacttcagag tcacccatct gtggagggat agggagaggc
     7501 tcaacttgct gctcccagct atccaggatt gaggagcagc ctccatgtct ccacccaccc
     7561 atgctctcct atcctcaacc caaccacagc agagctgact ggagggaggt gccctatttc
     7621 tgagagtgga tgtggcactg gctgctccca agccagagcc catcctatcc tgggtcctct
     7681 ggttaataaa gaaccactgt gtccccatgc ctgttgaaaa gccacctttg ccttctccta
     7741 attttttaca cagacttcag tccaactcta gaatttctct ttcactccct tatctggcac
     7801 caaccacatg ttctaattac tgtccctctc aaacatgtta gtgtacggca ggggagtaag
     7861 tccccctccc tgttcacaag atttccccac cccaccccca tctgttcttc tgaagaaata
     7921 ctaagttttg ccagatcctc caaccttctc ttactccaga ctctgggccc tgttgctgtg
     7981 tgtgccaccc ccacccccat tgtaatcact gtccactgag atcctctatg tgcagaatgt
     8041 cctatgagaa cagacaaagc aacacctgaa ttctgagaag ctatcaactt acttgtcccc
     8101 taagccccgg aattgtcgag agagaccacc aagccccacc taacaagtca tcgcctgtgg
     8161 ttgtcccaga gcaagccccc atatgctcct tgtctggatg ggaaaggaag acctctccca
     8221 ggcccagtac ttggacagaa cattccgact catcagaccc acacaacaga gggacagagg
     8281 gacagtggga cagagggacg ttttctgtct gccttttcta aactggcttt tggtcatttt
     8341 atttgggtta ctgggagtca tctcttattc agagttttaa cacctttggg atacaagaat
     8401 gtcttgcctg gatgtcgttg cacccttgat gtagctatag gaggttgcca actgaaccac
     8461 acactgacaa gctttccacc caacacactg acagttttcc acctgaggcc ccacccttgg
     8521 agaaccctag gagtgaggat tcttctagaa gcaccaaggc cacactcaga ccctaaaagt
     8581 tcccatgtgt tttccaaggt ccaaatgaag ccctctgatt taatatagag atccgaccca
     8641 cccaaggcat gggaccccag gccctgggta gctgccatca tcccctgctc ccaaaaacaa
     8701 aaggtttgag gctgcttggg cccttccagg cccttggtct gttttgtaac gtctgtggtg
     8761 ctctccctcc agggcccctc ctctcggggg gtcaccacac tctgctatct ctcgtgtgca
     8821 catcttttat aacggagtag cgagggaatg gtgccgcctc cagcttccat aagctgcctg
     8881 ggctctgggg ggctctggga caatcggggc tgggaagtga ctgtgctctt attgtacact
     8941 ctttatttct ctgtatctct ggcttgtgct ctttgtaact aacaggattt gtctgccttt
     9001 tcaacactat actaagcaat aacaataaat gcacacatgg aaacgca
//
