LOCUS       NM_026482               7130 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus ATPase, Ca++ transporting, plasma membrane 1 (Atp2b1),
            transcript variant 2, mRNA.
ACCESSION   NM_026482 XM_483944
VERSION     NM_026482.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7130)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7130)
  AUTHORS   Javkhlant,A., Toyama,K., Abe,Y., Spin,J.M. and Mogi,M.
  TITLE     Lack of ATP2B1 in CD4+ T Cells Causes Colitis
  JOURNAL   Inflamm Bowel Dis 30 (10), 1852-1864 (2024)
   PUBMED   38507609
  REMARK    GeneRIF: Lack of ATP2B1 in CD4+ T Cells Causes Colitis.
REFERENCE   3  (bases 1 to 7130)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 7130)
  AUTHORS   Beckmann,D., Langnaese,K., Gottfried,A., Hradsky,J., Tedford,K.,
            Tiwari,N., Thomas,U., Fischer,K.D. and Korthals,M.
  TITLE     Ca2+ Homeostasis by Plasma Membrane Ca2+ ATPase (PMCA) 1 Is
            Essential for the Development of DP Thymocytes
  JOURNAL   Int J Mol Sci 24 (2), 1442 (2023)
   PUBMED   36674959
  REMARK    GeneRIF: Ca[2+] Homeostasis by Plasma Membrane Ca[2+] ATPase (PMCA)
            1 Is Essential for the Development of DP Thymocytes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7130)
  AUTHORS   Savy,V., Stein,P., Shi,M. and Williams,C.J.
  TITLE     PMCA1 depletion in mouse eggs amplifies calcium signaling and
            impacts offspring growthdagger
  JOURNAL   Biol Reprod 107 (6), 1439-1451 (2022)
   PUBMED   36130203
REFERENCE   6  (bases 1 to 7130)
  AUTHORS   Garcia,M.L. and Strehler,E.E.
  TITLE     Plasma membrane calcium ATPases as critical regulators of calcium
            homeostasis during neuronal cell function
  JOURNAL   Front Biosci 4, D869-D882 (1999)
   PUBMED   10577388
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7130)
  AUTHORS   Zacharias,D.A. and Kappen,C.
  TITLE     Developmental expression of the four plasma membrane calcium ATPase
            (Pmca) genes in the mouse
  JOURNAL   Biochim Biophys Acta 1428 (2-3), 397-405 (1999)
   PUBMED   10434059
REFERENCE   8  (bases 1 to 7130)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 7130)
  AUTHORS   Jaisser,F. and Beggah,A.T.
  TITLE     The nongastric H+-K+-ATPases: molecular and functional properties
  JOURNAL   Am J Physiol 276 (6), F812-F824 (1999)
   PUBMED   10362770
  REMARK    Review article
REFERENCE   10 (bases 1 to 7130)
  AUTHORS   Du,Y., Carlock,L. and Kuo,T.H.
  TITLE     The mouse plasma membrane Ca2+ pump isoform 1 promoter: cloning and
            characterization
  JOURNAL   Arch Biochem Biophys 316 (1), 302-310 (1995)
   PUBMED   7840630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133920.1, AC153906.4, AI892140.1, CJ321142.1, BC030901.1 and
            AC160410.3.
            
            On Jun 20, 2009 this sequence version replaced NM_026482.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.10057.1,
                                           SRR10223971.10520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-639               AK133920.1         3-641
            640-640             AC153906.4         16621-16621         c
            641-740             AK133920.1         643-742
            741-1120            AI892140.1         1-380               c
            1121-1507           CJ321142.1         66-452
            1508-4779           BC030901.1         149-3420
            4780-7130           AC160410.3         155353-157703
FEATURES             Location/Qualifiers
     source          1..7130
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 50.97 cM"
     gene            1..7130
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /note="ATPase, Ca++ transporting, plasma membrane 1"
                     /db_xref="GeneID:67972"
                     /db_xref="MGI:MGI:104653"
     exon            1..220
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            221..651
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     CDS             444..4106
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /EC_number="7.2.2.10"
                     /note="isoform 2 is encoded by transcript variant 2;
                     plasma membrane calcium pump; plasma membrane calcium
                     ATPase; plasma membrane calcium-transporting ATPase 1"
                     /codon_start=1
                     /product="plasma membrane calcium-transporting ATPase 1
                     isoform 2"
                     /protein_id="NP_080758.1"
                     /db_xref="CCDS:CCDS24145.1"
                     /db_xref="GeneID:67972"
                     /db_xref="MGI:MGI:104653"
                     /translation="MGDMANNSVAYSGVKNSLKEANHDGDFGITLTELRALMELRSTD
                     ALRKIQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFIPPKKPKTFLQLV
                     WEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIEGAAIL
                     LSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQV
                     KYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVMEGSGRMVVT
                     AVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQ
                     PLKSEEGGDGDEKDKKKANLPKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYF
                     VIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKM
                     MKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKVPEPEAIPP
                     NILSYLVTGISVNCAYTSKILPPEKEGGLPRHVGNKTECALLGFLLDLKRDYQDVRNE
                     IPEEALYKVYTFNSVRKSMSTVLKNSDGSFRIFSKGASEIILKKCFKILSANGEAKVF
                     RPRDRDDIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDVVTGLTCIAVVGI
                     EDPVRPEVPEAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFN
                     RRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSEQRQVVAVTGDG
                     TNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFL
                     QFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLR
                     KPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHY
                     TIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQIIIVQFGGKP
                     FSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFLKEAGHGTQKEEIPEEELAE
                     DVEEIDHAERELRRGQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRSSIHNFMT
                     HPEFRIEDSEPHIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVDSGIHLTIEMNKSA
                     TSSSPGSPLHSLETSL"
     exon            652..849
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1104
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1230
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1371
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1410
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1572
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1787
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..2030
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2272
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2510
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2690
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2778
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2885
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..3077
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3291
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            3292..3503
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            3504..3611
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            3612..3794
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     exon            3795..7130
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7106..7111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /note="hexamer: AATATA"
     polyA_site      7130
                     /gene="Atp2b1"
                     /gene_synonym="2810442I22Rik; E130111D10Rik; Pmca1"
                     /note="major polyA site"
ORIGIN      
        1 gcagcgtgag tagggagccc cggctggtgg acgccgagtc tctgggctcc gccgccgccg
       61 cctccttccc gaggtgcagc cgcacctccg cgtggcgccc cgaacccagc gagccggctg
      121 cgggcacgtc ccgcgacccc tcgccgccat cccccggacc cacccgccta gctttccttg
      181 attcttcccc tcggaaaaaa tggttcccgc tgcgggcgag atgtatacat ctcaagattg
      241 agaggaagaa acaagtcatg ggccagtggt caagatactt ctctgggaat tgttgctgct
      301 gatactgctc ttcagagtcc tacaatgagt gtgtggttta aggaagattt tcatatttaa
      361 aagattttca gcttggaaat ctacatcaag tgaaaatttc attcttctgg gaaacatttt
      421 cctcctaata aattatcctt gtgatgggcg acatggccaa caactcagtt gcgtatagcg
      481 gtgtgaagaa ctctttgaaa gaagctaacc atgatggaga ctttggaatt acgcttacag
      541 agctgcgagc tctcatggag ctcagatcca cggatgcatt acggaaaata caggagagct
      601 atggagatgt ctatggcatt tgcaccaagt tgaaaacatc tcccaatgaa ggtttaagtg
      661 gaaatcctgc agatttagaa agaagagaag cagtgtttgg aaagaacttt atacctccta
      721 agaagccaaa aacctttctt cagttagtct gggaagcatt acaagatgtc actttaatta
      781 tactagaaat tgcagccata gtatcattgg gcctttcttt ttatcaacct ccggaagggg
      841 ataatgcact ttgtggagaa gtttctgttg gggaagaaga aggtgaagga gaaacggggt
      901 ggattgaagg agctgcgatc ctcttgtcgg tggtgtgtgt ggtgttggtg acggctttca
      961 acgactggag caaggagaag cagttccgag gcctgcagag tcgaattgag caggaacaga
     1021 agttcaccgt catcaggggt gggcaggtca tccagatacc tgtagctgac attactgttg
     1081 gagacattgc ccaagtgaag tacggtgacc ttcttccagc tgatggcata ctgattcaag
     1141 gcaatgacct gaagattgat gagagctcat tgactggtga atctgatcat gttaagaagt
     1201 ctctagataa ggatccctta cttctttcag gtactcatgt gatggaaggt tctggaagaa
     1261 tggtggtcac tgctgtaggt gtgaattctc aaacaggaat catcttcacc ttacttggag
     1321 ctgggggtga agaagaggaa aagaaagatg agaagaagaa ggaaaagaaa aataagaaac
     1381 aagatggagc tattgagaat cgcaacaaag caaaagccca ggacggcgcg gccatggaga
     1441 tgcaacctct gaagagtgaa gaaggagggg acggtgatga gaaagacaag aagaaagcaa
     1501 atctgccaaa aaaggaaaaa tccgtgttac aggggaaact cacaaagctg gctgttcaga
     1561 ttggcaaagc aggtctgctg atgtctgcca tcacagttat catcctagtg ttgtattttg
     1621 tgatcgatac cttctgggtt cagaaaagac catggcttgc agagtgcaca ccgatctaca
     1681 tccagtactt cgtgaagttc ttcattattg gagtcacagt tctagtggtc gccgtgccgg
     1741 aaggtcttcc gctggcagtc accatctcac tggcttactc agtcaagaaa atgatgaagg
     1801 ataataactt agtgagacat ctggatgctt gtgagaccat ggggaatgct acagctatct
     1861 gttcagataa aacaggaacc ctgacgatga acaggatgac ggttgttcaa gcttacataa
     1921 atgaaaagca ttataaaaag gttccggaac cagaagccat cccaccaaat atcctgtcct
     1981 acctggtaac ggggatttct gtgaattgtg cttatacgtc aaaaatattg ccaccggaga
     2041 aagagggtgg attaccccgc catgtgggta acaaaacaga gtgtgccttg ttggggtttc
     2101 tcttggattt aaaacgggat tatcaagatg ttagaaatga aataccagag gaagcactgt
     2161 acaaagtcta taccttcaat tctgttagga agtccatgag cacagtcctg aaaaactcag
     2221 atggaagttt ccgcatcttt agcaagggtg cctccgagat cattctgaaa aagtgtttca
     2281 aaatcctgag tgctaatggc gaggcaaaag tattccgacc cagagaccgc gatgacattg
     2341 tgaaaactgt gatcgagccc atggcatcag aaggcctgag gaccatatgc ctagcgttca
     2401 gagacttccc agcgggggag ccagaaccag agtgggataa tgagaatgat gtcgtcaccg
     2461 gccttacgtg tatcgcggtt gtggggattg aagatcctgt gaggcctgag gtaccagagg
     2521 caataaagaa atgtcagagg gctggaatta ctgtgcgcat ggtcactggt gataatatta
     2581 acactgctcg ggccattgct accaaatgtg gtattttaca cccaggggaa gatttcctat
     2641 gcttagaagg taaagatttt aaccgaagaa tacgaaatga aaaaggagag attgaacaag
     2701 aaaggataga caagatttgg ccaaagcttc gagtacttgc aagatcatct cccactgaca
     2761 aacatacact ggtgaaaggt ataattgaca gcacagtctc agagcaacga caggttgtag
     2821 ctgtaacggg tgatggtaca aatgacgggc ctgcactgaa gaaagcagac gttggctttg
     2881 caatgggcat tgctggaact gatgtggcta aagaagcgtc tgatattatt ctcacagatg
     2941 acaactttac aagcattgtc aaagcagtta tgtggggacg aaatgtctat gacagcatct
     3001 caaaattcct tcagttccag cttactgtta atgtagtagc agtgattgtt gctttcacgg
     3061 gcgcttgtat tactcaagac tcgccactta aggcggtgca gatgctctgg gtaaacctca
     3121 tcatggacac gctggcttcc ctggctctgg ctacggaacc acccaccgag tcactcctgc
     3181 ttcggaagcc ttatggtaga aataagcctc tcatctcacg cacgatgatg aagaacatct
     3241 tgggccatgc attctatcag ctcgtagtgg tctttacact cttatttgct ggagaaaagt
     3301 tttttgatat cgacagcggg aggaatgcgc ctctgcacgc tcccccgtca gaacattaca
     3361 ccatcgtgtt caataccttt gtgctgatgc agctcttcaa tgaaataaac gcccggaaaa
     3421 ttcacgggga aagaaatgtg tttgaaggaa tcttcaataa cgccatcttc tgcaccattg
     3481 tcctgggcac ctttgtggtg cagataataa ttgtgcagtt tggcgggaag cctttcagct
     3541 gctcagaact ttcaatagag caatggctgt ggtcgatatt cctgggaatg gggaccttac
     3601 tctggggcca gcttatttca accattccaa ccagccgctt aaagtttcta aaagaagctg
     3661 gtcatggaac ccagaaggag gagatacctg aggaggaatt agcagaggat gttgaagaga
     3721 ttgaccatgc cgaaagggag ttgcggcgtg gccagatctt gtggtttaga ggcctgaaca
     3781 gaatccaaac acagatccga gtggtgaatg catttcgtag ttctttatac gaagggttag
     3841 agaagccaga atcaagaagt tcaatccaca actttatgac acaccctgag tttaggatag
     3901 aagattcaga gccgcacatc ccccttattg atgacactga tgctgaagac gacgccccaa
     3961 caaaacgcaa ctccagccct ccgccctctc ctaacaaaaa taacaatgct gttgacagcg
     4021 gaattcacct tacaatagaa atgaacaagt ctgctacctc ttcatcccca ggaagcccac
     4081 tacatagttt ggaaacatca ctctgattgt aagatgaatg gtaacacact agctgcattg
     4141 taaagaaaca aatcgaaact gagtcttttc acatattgtg acggacaaga tagtattctt
     4201 gtctctggac ttcaacagaa gacacacttg tacgaatgta gatttatttt tttaaaaaaa
     4261 acaaaagcaa agctttctgc cagactgagg gtgctttttt ggggtgtggg agaaacgaac
     4321 tgacagatga acagcggtga ctcggcagga gtggcctgtg ggtcgtcagt ggtacctaac
     4381 gttgtcctga ctagcagagc tgtggtttat ctcagttctt gatgggaggg agggaggagt
     4441 gacgctgggt gagacagaga gccctggatc attgagtgaa tactttaatt tctgctgttg
     4501 gctgttaata atttggatta tttatgttta taaatgatac agatctgttt acaaggtttg
     4561 tagatacttt ttttgttctt catagacggg aagcttcctt atagtaatgc agagaaaaat
     4621 tagtccttca aatactgctg tattttcagg aaaaaaaagg ggggggtgtt tctattgaaa
     4681 ctgtactaaa tttttgccta caatttatct tgttacatat gtagataaat tgctaatact
     4741 aatagccaaa tagataacac taatgctttg tttaaaaaac aaaaaagaaa aaagaaaaca
     4801 agacaaaaaa aaaaacaaca aaaaccatga gcagtggtgt tctaatgaag ttatggcatc
     4861 tgtcctaatt agtttcttaa atacatttac tacttaatgg ttttgaaaga actgtttaat
     4921 ttttaaattt tttgaaaact tgctaataac cttttgttca gaatttagta gattgtttat
     4981 tgcgggacat caaatacaca atgaaagatg cttgaaatgc ctttgttatt tcaggccaat
     5041 caaattaaac tatcaaagta caagagaaac ctttagtctt tttttttttt tgtttttgtc
     5101 taaatatgtt agttcagtga tgtcttagtg aactgtgagt gactgcattg atttttctaa
     5161 taactgcgta gagaccttca cacagcatag agggggctgt tggcattttg agaaaggtta
     5221 atagagagag gcatacatcg tttccttttg tttttgaaac ttgtttgtaa acataaataa
     5281 atatgccctt ttattaaata aatacacagc aatggttctt cagacagctc agctccttgg
     5341 ttctctacgt gtgccgcatt ggcctgtctc ctctaaccac aactagaata aatttcaagc
     5401 tggtggcagc ctcaggaagg gctgtttgaa tcctttcttg gtcaccccat ggagtcgagc
     5461 tgagacagca gttttgccac ctagcacacc cttcatagaa tctactttta tctaaagtaa
     5521 agtagtctcg ccattttata cgaagtaatg accacagttg tctgatgtat ttgtttttta
     5581 ttaagtgtcc cagtcacaga ttagattaaa gggatggcgc atgaagattt gaggaagcgg
     5641 ctaaacacga tctctgtaat aaccaactct atgccgaact ctatgctcat ctctgagaca
     5701 attgaatttc caggctctct gcttcttttc tgtctacctt cttcctttgt ctgcctctcg
     5761 tcttgacctt ttagaaagtg gtattgtttc agggcgcaga tctcgccagt taaacaatcc
     5821 tcaggctgac ctaaagttta cgaggactac tacatccaag aatgctgacc tagcaaagaa
     5881 acatctagtt gatggtgctt gatatatata tatatttttt ttttgggcgg gtgggaggaa
     5941 tctttttctc cccatcagtt gcctgcagta actctctgca agtcttagaa acacatcggc
     6001 tctgtcccat cgatcactgt acatttttac tcatcaggtg tttgtagtta ttcatactgt
     6061 aaaaagaggt agcatgatat gctgggacgc atatttagac caggagccca aggtggactc
     6121 ctcgtcttga atttgccatt aacgtgctgc atgatcttgg ggcagtgact caccctgacg
     6181 gagggtgggg gactcctctt gaagaaccct ttcaactcta agaattgacc ctatccactg
     6241 aagaagcctg tgaggcatag ggaatagaga aagggaaatg ttctcagctt tcttttttat
     6301 tttggttatg cttaaatatg aatgtaatta ccaagagaat gagacctgca tgtgctctgg
     6361 agggtttgtg tctagctttt ccggtttttt tttttttttt ccaaaactca aggcaatggc
     6421 tttttacccc acctctaaat ccataagtgg gtcttaggac atccgtgaag tcataatagc
     6481 aaaacacgct cggtgtgcgt ttctctcttt gagacactgt aatttctacc agaaatgtcc
     6541 acagcattat gtaagtagga aaaaaaaaaa aaaatacaag caagctgtta aagatcttgg
     6601 atcccattct atagtgtgta tacctaaatc aacatctgta attcacattt ttctctttta
     6661 ttctctaacc aaaatcagaa agaaaaaaaa aacttgttta attttgcatc ccaaatgttt
     6721 ttaatctttg tatatttttt agactccctt ttctccccat cattgccttt ccgtggttgt
     6781 aaatagttgt cacactctga ggatgagtta cgtcttgtca tcttacaaat atgtgatatg
     6841 gtaattttca taacagatta tcagttttga accaagaaaa tggtgatttg tttataagag
     6901 aaaaaaaaac aaaacaacaa aaaaaaccac ctggcttcat ttctgtgaaa ttgctctttg
     6961 aaactttcat ttccacgtgt aagccaactg ggatactacc gtgatggtgt tgatttcttt
     7021 taatgatgct taccatctct tttagccact gagcctttta ttatttgtct atttgtaaag
     7081 tttatttgtc ttaactcatt taataaatat actgtttatc tgtttctgaa
//
