LOCUS       NM_016745               4593 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus ATPase, Ca++ transporting, ubiquitous (Atp2a3),
            transcript variant 2, mRNA.
ACCESSION   NM_016745
VERSION     NM_016745.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4593)
  AUTHORS   Feng,M., Elaib,Z., Borgel,D., Denis,C.V., Adam,F., Bryckaert,M.,
            Rosa,J.P. and Bobe,R.
  TITLE     NAADP/SERCA3-Dependent Ca2+ Stores Pathway Specifically Controls
            Early Autocrine ADP Secretion Potentiating Platelet Activation
  JOURNAL   Circ Res 127 (7), e166-e183 (2020)
   PUBMED   32588751
  REMARK    GeneRIF: NAADP/SERCA3-Dependent Ca(2+) Stores Pathway Specifically
            Controls Early Autocrine ADP Secretion Potentiating Platelet
            Activation.
REFERENCE   2  (bases 1 to 4593)
  AUTHORS   Fecher-Trost,C., Lux,F., Busch,K.M., Raza,A., Winter,M.,
            Hielscher,F., Belkacemi,T., van der Eerden,B., Boehm,U.,
            Freichel,M. and Weissgerber,P.
  TITLE     Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is
            Involved In Offspring Bone Development
  JOURNAL   J Bone Miner Res 34 (4), 699-710 (2019)
   PUBMED   30786075
REFERENCE   3  (bases 1 to 4593)
  AUTHORS   Anderson,D.M., Makarewich,C.A., Anderson,K.M., Shelton,J.M.,
            Bezprozvannaya,S., Bassel-Duby,R. and Olson,E.N.
  TITLE     Widespread control of calcium signaling by a family of
            SERCA-inhibiting micropeptides
  JOURNAL   Sci Signal 9 (457), ra119 (2016)
   PUBMED   27923914
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4593)
  AUTHORS   Elaib,Z., Adam,F., Berrou,E., Bordet,J.C., Prevost,N., Bobe,R.,
            Bryckaert,M. and Rosa,J.P.
  TITLE     Full activation of mouse platelets requires ADP secretion regulated
            by SERCA3 ATPase-dependent calcium stores
  JOURNAL   Blood 128 (8), 1129-1138 (2016)
   PUBMED   27301859
  REMARK    GeneRIF: SERCA3-dependent Ca(2+) stores control a specific ADP
            secretion pathway.
REFERENCE   5  (bases 1 to 4593)
  AUTHORS   Anderson,D.M., Anderson,K.M., Chang,C.L., Makarewich,C.A.,
            Nelson,B.R., McAnally,J.R., Kasaragod,P., Shelton,J.M., Liou,J.,
            Bassel-Duby,R. and Olson,E.N.
  TITLE     A micropeptide encoded by a putative long noncoding RNA regulates
            muscle performance
  JOURNAL   Cell 160 (4), 595-606 (2015)
   PUBMED   25640239
REFERENCE   6  (bases 1 to 4593)
  AUTHORS   Paul,R.J.
  TITLE     The role of phospholamban and SERCA3 in regulation of smooth
            muscle-endothelial cell signalling mechanisms: evidence from
            gene-ablated mice
  JOURNAL   Acta Physiol Scand 164 (4), 589-597 (1998)
   PUBMED   9887981
  REMARK    Review article
REFERENCE   7  (bases 1 to 4593)
  AUTHORS   Dode,L., De Greef,C., Mountian,I., Attard,M., Town,M.M.,
            Casteels,R. and Wuytack,F.
  TITLE     Structure of the human sarco/endoplasmic reticulum Ca2+-ATPase 3
            gene. Promoter analysis and alternative splicing of the SERCA3
            pre-mRNA
  JOURNAL   J Biol Chem 273 (22), 13982-13994 (1998)
   PUBMED   9593748
REFERENCE   8  (bases 1 to 4593)
  AUTHORS   Ozog,A., Pouzet,B., Bobe,R. and Lompre,A.M.
  TITLE     Characterization of the 3' end of the mouse SERCA 3 gene and tissue
            distribution of mRNA spliced variants
  JOURNAL   FEBS Lett 427 (3), 349-352 (1998)
   PUBMED   9637255
REFERENCE   9  (bases 1 to 4593)
  AUTHORS   Liu,L.H., Paul,R.J., Sutliff,R.L., Miller,M.L., Lorenz,J.N.,
            Pun,R.Y., Duffy,J.J., Doetschman,T., Kimura,Y., MacLennan,D.H.,
            Hoying,J.B. and Shull,G.E.
  TITLE     Defective endothelium-dependent relaxation of vascular smooth
            muscle and endothelial cell Ca2+ signaling in mice lacking
            sarco(endo)plasmic reticulum Ca2+-ATPase isoform 3
  JOURNAL   J Biol Chem 272 (48), 30538-30545 (1997)
   PUBMED   9374548
REFERENCE   10 (bases 1 to 4593)
  AUTHORS   Slack,J.P., Grupp,I.L., Ferguson,D.G., Rosenthal,N. and
            Kranias,E.G.
  TITLE     Ectopic expression of phospholamban in fast-twitch skeletal muscle
            alters sarcoplasmic reticulum Ca2+ transport and muscle relaxation
  JOURNAL   J Biol Chem 272 (30), 18862-18868 (1997)
   PUBMED   9228063
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK155904.1, AK089487.1, U49393.1, AK152999.1 and BY549777.1.
            
            On Jul 17, 2009 this sequence version replaced NM_016745.2.
            
            Transcript Variant: This variant (2) includes an additional exon in
            the 3' coding region resulting in a frameshift, compared to variant
            1. Variant 2 encodes isoform b, which is longer and has a distinct
            C-terminus compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017639.1, U49393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1805              AK155904.1         2-1806
            1806-1806           AK089487.1         1806-1806
            1807-3164           AK155904.1         1808-3165
            3165-3355           U49393.1           3026-3216
            3356-4576           AK152999.1         1155-2375
            4577-4593           BY549777.1         413-429
FEATURES             Location/Qualifiers
     source          1..4593
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.0 cM"
     gene            1..4593
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /note="ATPase, Ca++ transporting, ubiquitous"
                     /db_xref="GeneID:53313"
                     /db_xref="MGI:MGI:1194503"
     exon            1..303
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..3302
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /EC_number="7.2.2.10"
                     /note="isoform b is encoded by transcript variant 2;
                     sarcoendoplasmic reticulum Ca2+ ATPase type 3;
                     sarcoplasmic/endoplasmic reticulum calcium ATPase 3;
                     calcium pump 3; SR Ca(2+)-ATPase 3; sarco /endoplasmic
                     reticulum Ca2+ -ATPase"
                     /codon_start=1
                     /product="sarcoplasmic/endoplasmic reticulum calcium
                     ATPase 3 isoform b"
                     /protein_id="NP_058025.2"
                     /db_xref="CCDS:CCDS24991.1"
                     /db_xref="GeneID:53313"
                     /db_xref="MGI:MGI:1194503"
                     /translation="MEEAHLLSAADVLRRFSVTAEGGLSLEQVTDARERYGPNELPTE
                     EGKSLWELVVEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANA
                     IVGVWQERNAESAIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVP
                     ADLRLIEIKSTTLRVDQSILTGESVSVTKHTDAIPDPRAVNQDKKNMLFSGTNIASGK
                     ALGVAVATGLQTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINI
                     GHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVR
                     SLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEAEAGTCRLHEFTISGTTYTPE
                     GEVRQGEQPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE
                     KMNVFDTDLKGLSRVERAGACNSVIKQLMRKEFTLEFSRDRKSMSVYCTPTRADPKVQ
                     GSKMFVKGAPESVIERCSSVRVGSRTAPLSTTSREHILAKIRDWGSGSDTLRCLALAT
                     RDTPPRKEDMHLDDCSRFVQYETDLTFVGCVGMLDPPRPEVAACITRCSRAGIRVVMI
                     TGDNKGTAVAICRRLGIFGDTEDVLGKAYTGREFDDLSPEQQRQACRTARCFARVEPA
                     HKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNF
                     ASIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLV
                     TDGLPATALGFNPPDLDIMEKPPRNPREALISGWLFFRYLAIGVYVGLATVAAATWWF
                     LYDTEGPQVTFYQLRNFLKCSEDNPLFAGIDCKVFESRFPTTMALSVLVTIEMCNALN
                     SVSENQSLLRMPPWLNPWLLGAVVMSMALHFLILLVPPLPLIFQVTPLSGRQWGVVLQ
                     MSLPVILLDEALKYLSRNHMDGVLGTFMQARSRQLPTTSRTPYHTGKKGPEVNPGSRG
                     ESPVWPSD"
     exon            304..321
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            322..404
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            405..509
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            510..648
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            649..729
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            730..815
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1280
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1369
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1472
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1604
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1730
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1949
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2285
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2506
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2709
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2795
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2929
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3047
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            3048..3165
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3238
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..4593
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4567..4572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /note="hexamer: AATAAA"
     polyA_site      4589
                     /gene="Atp2a3"
                     /gene_synonym="Serca3; SERCA3b"
                     /note="major polyA site"
ORIGIN      
        1 agaggacgga gccccgggca cagcatcctg gcgcgggccc gggctgccat agccactgcc
       61 gtcggggaag gtcccagcgt ggtcatggcc tcccgagggg cccgccccgc cccaagctcg
      121 cagcactcca cacagtagcc ttgaggagaa gcgacctgga cgtcgcggac ggccgggcag
      181 gcagcatgga ggaggcgcac ctgctctccg ctgccgacgt gctgcgtcgc ttctcggtga
      241 cagccgaggg cggcttgagc ctggagcagg tgaccgacgc gcgggagcgt tacggcccca
      301 acgagctccc gaccgaggaa gggaaatccc tgtgggagct ggtggtggag cagtttgagg
      361 acctcttggt gcgcatcctg ctgctggcag ctctggtttc ctttgtcctg gcctggttcg
      421 aggagggtga ggagaccaca acggccttcg tggagcccct ggtcatcatg ctaattctcg
      481 tggccaatgc gatcgtggga gtgtggcagg aacgcaacgc agagagtgca attgaggcct
      541 tgaaggagta tgagcctgag atgggtaagg tgatccggtc tgaccgcaag ggtgtacaga
      601 ggatccgagc cagggacatc gtccctgggg acattgtgga agtggcagtg ggagacaagg
      661 tacccgctga cctccgtctc atcgagatca agtccaccac acttcgagtg gaccagtcca
      721 tcctgacagg ggaatccgtg tctgtgacga agcacacaga tgccattcca gacccccgag
      781 ccgtgaacca ggacaagaag aacatgctat tttctggcac caatattgca tcaggcaaag
      841 ccctgggtgt ggctgtggct acaggcctgc agacagagct gggcaagatt cggagccaga
      901 tggcggctgt ggagcctgag cggacgccat tgcagcgcaa gctggatgaa tttgggaggc
      961 agctgtccca tgccatctct gtgatctgtg tggctgtgtg ggtcatcaac atcggccact
     1021 ttgctgaccc ggcccacggt ggatcctggc tccgtggtgc agtctactac ttcaagatcg
     1081 ctgtggccct ggctgtggct gctatccccg agggtctccc agcagtcatc actacatgcc
     1141 tggccctggg cacaagacgt atggcacgta agaatgccat tgtgcggagc ctgccttctg
     1201 tggagacgct gggctgcacc tcggtcatct gctctgacaa gacggggacg ctcaccacca
     1261 atcagatgtc tgtctgcagg atgttcgtgg tggctgaagc agaggcaggc acctgtcgtt
     1321 tgcatgaatt caccatttcg ggtaccacgt acaccccaga gggcgaagtg aggcaagggg
     1381 agcagcctgt gcgctgtggg cagtttgatg ggctagtgga gctcgccacc atctgtgccc
     1441 tctgcaatga ttctgcgctg gactacaatg aggccaaggg tgtgtatgag aaggtaggag
     1501 aggccacaga gaccgccctg acttgcctgg tagagaagat gaatgtgttt gacacagacc
     1561 tgaaaggact gtcgcgggtg gagcgtgctg gcgcctgcaa ctcagtcatc aagcaactca
     1621 tgcggaaaga gttcaccctg gagttctccc gggaccggaa gtctatgtcc gtgtactgca
     1681 cacctactcg tgctgacccc aaggtccagg gcagcaagat gtttgtgaag ggagctcctg
     1741 agagtgtaat tgagcgctgt agctcagtcc gagtgggcag ccgaacagca cccctgagca
     1801 ccacttccag agagcatatc ctggccaaga tccgggactg gggctcaggc tctgacacac
     1861 tgcgctgctt agccttggcc accagggaca cacccccaag gaaggaggac atgcatctag
     1921 atgactgcag ccggtttgta cagtacgaga cagacctgac cttcgtgggc tgcgtgggca
     1981 tgttagaccc accgagacca gaggtggctg cttgtatcac acgctgttcc cgggctggca
     2041 ttcgagtggt catgatcaca ggggacaaca aagggacagc tgtggccatc tgccgccgac
     2101 ttggcatctt tggggacacg gaggatgtgt tgggcaaggc ctacacgggc cgtgagtttg
     2161 atgacctcag cccagagcag cagcgccagg cttgtcgcac tgcccggtgc tttgcccgag
     2221 tggaacccgc acataagtct cgaatcgtgg agaacctaca gtcctttaat gagatcactg
     2281 ccatgactgg cgatggggtg aatgatgcac cagccctgaa gaaggcagag atcggcatcg
     2341 ccatgggctc aggcactgct gtggccaagt cagcagcaga gatggtgctg tccgatgaca
     2401 actttgcctc cattgtggct gcagtagaag agggcagggc catctacaac aacatgaagc
     2461 agttcatccg ctacctcatc tcctccaatg ttggcgaggt tgtctgcatc ttcctcacag
     2521 caattctggg cctgcccgaa gctctgatcc ctgtgcagct gctctgggtg aacctggtaa
     2581 cagatggctt accggccaca gcccttggct tcaacccacc agatctggat atcatggaga
     2641 agccgcctcg gaatccccgt gaggccctca tcagtggctg gctttttttc cgctatttgg
     2701 ctattggagt gtatgtaggc ctggctacag tggctgccgc cacctggtgg ttcctgtatg
     2761 acaccgaggg acctcaagtc accttctatc agctgaggaa cttcctgaag tgctctgaag
     2821 acaatccact gtttgctggc attgactgca aggtttttga gtcacgcttc cccacaacca
     2881 tggccttatc tgtgcttgtg accattgaaa tgtgcaacgc cctcaacagc gtctctgaga
     2941 accagtcact gctgcgcatg ccaccctggc tgaacccttg gctgctgggg gctgtggtca
     3001 tgtccatggc tctgcatttt cttatcctcc tggtgccacc tctgcctctc atttttcagg
     3061 tgaccccact gagtggtcgg cagtgggggg tggtgcttca gatgtctctg cctgtcatcc
     3121 tgctcgatga ggccctcaag tatctgtcca ggaatcacat ggatggtgtt ctcgggacat
     3181 ttatgcaggc tcggagtagg cagctgccga ctacttccag gaccccatac cacaccggaa
     3241 aaaaaggacc tgaagtaaat cctgggagca gaggggagtc tccagtgtgg ccctcagact
     3301 gagagcatcc aggcatttgt cctgttccca cccctgcctc cacactcagc cacccgtctc
     3361 ctggaccctg ctgaacataa caggccttaa acaggaatgg ccacctctcc gtctggtccc
     3421 aggttcccgt ctcccatttc tgtccctccc tactgctctg gcccagaagc tgagtccagg
     3481 aggggaagct aagaagccag agctgattgc agagccaccg cgcattcccc accccagctc
     3541 tgcaaccttt cccccgcttg gagatgggcg aactagtgcc tctgccctga tggaggactc
     3601 atgggggcct tcttactgac tctgacctat tgcttagttt gggtctggag cctggtccgc
     3661 tatgggtagg aggagtctga gggaaccatc tgggtccagc tgtgaacaca aggagaggca
     3721 gctccttcca cttggctcag cttccaccaa gtccactcct gtgtctgttt atatatgtgc
     3781 cggccggccc cagggggttg aaggatcaca ggcagatagg aacataagaa gcagggggcg
     3841 ggcctggaca atgactccct ttcccaggag tgagcctgcg ctggctggct gacctcagcc
     3901 ctattcccac ctttgaggct cacttcctca gctcaggttg gctcagggtg tcctaatttt
     3961 accgtctatg cccctggtgt ctgagactcc aggcatccct gggtccatgt cagcttctcc
     4021 tgccacccag cctggtgtga tactttgtca cttgctgcct ggtcccctgg cattactctt
     4081 tgctctgctc ctcctagcat acattttttg agtcagagag atgtcactag ggaagtgact
     4141 ccataaggga cttcctcccc tacctcccca ctgaaagaaa gcatctcgtg gggaatctat
     4201 cagatgaacg tacattgctc ttcttttttt ttttttctct taactctgct gttgcccctt
     4261 tgacaaaagc tagctaactg tcacaggaaa cggagtaagt gtgacttagc tcttcttggg
     4321 tgtgtacaat atgattattt tatatgtaaa tcaagattca catcactgtc ctgaccccca
     4381 gtaacaaaag ccccctcagc ctaccttgca gacagatgaa ctccgtgttt ggctgcccac
     4441 tctcctgcat ctcctccccc cgccccccgc aggctctgga ggggcctcag agagaaatag
     4501 agtttggagg gatggcttgg caggagcaga gcgctgtgcc cacttgctga ttgtttctga
     4561 tggagaaata aaggtgtgtg tctgagggat tgg
//
