LOCUS       NM_001110140            4565 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus ATPase, Ca++ transporting, cardiac muscle, slow twitch
            2 (Atp2a2), transcript variant 1, mRNA.
ACCESSION   NM_001110140
VERSION     NM_001110140.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4565)
  AUTHORS   Hashimoto,K., Ohira,M., Kodama,A., Kimoto,M., Inoue,M., Tone,S.,
            Usui,Y., Hanashima,A., Goto,T., Ogura,Y., Ujihara,Y. and Mohri,S.
  TITLE     Loss of connectin novex-3 leads to heart dysfunction associated
            with impaired cardiomyocyte proliferation and abnormal nuclear
            mechanics
  JOURNAL   Sci Rep 14 (1), 13727 (2024)
   PUBMED   38877142
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4565)
  AUTHORS   Barry,C., Rouhana,S., Braun,J.L., Geromella,M.S., Fajardo,V.A. and
            Pyle,W.G.
  TITLE     Perimenopause Decreases SERCA2a Activity in the Hearts of a Mouse
            Model of Ovarian Failure
  JOURNAL   Biomolecules 14 (6), 675 (2024)
   PUBMED   38927078
  REMARK    GeneRIF: Perimenopause Decreases SERCA2a Activity in the Hearts of
            a Mouse Model of Ovarian Failure.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4565)
  AUTHORS   Li,C., Warren,D.T., Zhou,C., De Silva,S., Wilson,D.G.S.,
            Garcia-Maya,M., Wheeler,M.A., Meinke,P., Sawyer,G., Ehler,E.,
            Wehnert,M., Rao,L., Zhang,Q. and Shanahan,C.M.
  TITLE     Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in
            the cardiomyocyte sarcomere
  JOURNAL   J Biol Chem 300 (5), 107254 (2024)
   PUBMED   38569934
REFERENCE   4  (bases 1 to 4565)
  AUTHORS   Wang,Y., Duan,F., Li,J., Li,X., Xia,L., Zhao,W., Wang,Z., Song,X.,
            Chen,J., Wang,J., Wang,Y., Zhang,J., Zhang,X. and Jiao,D.
  TITLE     Involvement of nucleus accumbens SERCA2b in methamphetamine-induced
            conditioned place preference
  JOURNAL   Addict Biol 29 (3), e13382 (2024)
   PUBMED   38488467
  REMARK    GeneRIF: Involvement of nucleus accumbens SERCA2b in
            methamphetamine-induced conditioned place preference.
REFERENCE   5  (bases 1 to 4565)
  AUTHORS   Han,J., Fang,Z., Han,B., Ye,B., Lin,W., Jiang,Y., Han,X., Wang,X.,
            Wu,G., Wang,Y. and Liang,G.
  TITLE     Deubiquitinase JOSD2 improves calcium handling and attenuates
            cardiac hypertrophy and dysfunction by stabilizing SERCA2a in
            cardiomyocytes
  JOURNAL   Nat Cardiovasc Res 2 (8), 764-777 (2023)
   PUBMED   39195964
  REMARK    GeneRIF: Deubiquitinase JOSD2 improves calcium handling and
            attenuates cardiac hypertrophy and dysfunction by stabilizing
            SERCA2a in cardiomyocytes.
REFERENCE   6  (bases 1 to 4565)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (bases 1 to 4565)
  AUTHORS   Ya,J., Erdtsieck-Ernste,E.B., de Boer,P.A., van Kempen,M.J.,
            Jongsma,H., Gros,D., Moorman,A.F. and Lamers,W.H.
  TITLE     Heart defects in connexin43-deficient mice
  JOURNAL   Circ Res 82 (3), 360-366 (1998)
   PUBMED   9486664
  REMARK    Review article
REFERENCE   8  (bases 1 to 4565)
  AUTHORS   Harrer,J.M., Haghighi,K., Kim,H.W., Ferguson,D.G. and Kranias,E.G.
  TITLE     Coordinate regulation of SR Ca(2+)-ATPase and phospholamban
            expression in developing murine heart
  JOURNAL   Am J Physiol 272 (1 Pt 2), H57-H66 (1997)
   PUBMED   9038922
REFERENCE   9  (bases 1 to 4565)
  AUTHORS   Hawkins,C., Xu,A. and Narayanan,N.
  TITLE     Sarcoplasmic reticulum calcium pump in cardiac and slow twitch
            skeletal muscle but not fast twitch skeletal muscle undergoes
            phosphorylation by endogenous and exogenous
            Ca2+/calmodulin-dependent protein kinase. Characterization of
            optimal conditions for calcium pump phosphorylation
  JOURNAL   J Biol Chem 269 (49), 31198-31206 (1994)
   PUBMED   7983062
REFERENCE   10 (bases 1 to 4565)
  AUTHORS   Hsu,D.K., Donohue,P.J., Alberts,G.F. and Winkles,J.A.
  TITLE     Fibroblast growth factor-1 induces phosphofructokinase, fatty acid
            synthase and Ca(2+)-ATPase mRNA expression in NIH 3T3 cells
  JOURNAL   Biochem Biophys Res Commun 197 (3), 1483-1491 (1993)
   PUBMED   7506544
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ162528.1, AK220538.1, AJ131821.1 and CF742600.1.
            
            On Jun 20, 2009 this sequence version replaced NM_001110140.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (b), also known as SERCA2B.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ131821.1, AK220538.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                CJ162528.1         2-52
            52-534              AK220538.1         1-483
            535-4486            AJ131821.1         205-4156
            4487-4565           CF742600.1         416-494
FEATURES             Location/Qualifiers
     source          1..4565
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.38 cM"
     gene            1..4565
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /note="ATPase, Ca++ transporting, cardiac muscle, slow
                     twitch 2"
                     /db_xref="GeneID:11938"
                     /db_xref="MGI:MGI:88110"
     exon            1..658
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             541..3675
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /note="isoform b is encoded by transcript variant 1;
                     sarcoplasmic/endoplasmic reticulum calcium ATPase 2;
                     calcium pump 2; SR Ca(2+)-ATPase 2; endoplasmic reticulum
                     class 1/2 Ca(2+) ATPase; sarco/endoplasmic reticulum
                     Ca2+-ATPase 2"
                     /codon_start=1
                     /product="sarcoplasmic/endoplasmic reticulum calcium
                     ATPase 2 isoform b"
                     /protein_id="NP_001103610.1"
                     /db_xref="CCDS:CCDS57378.1"
                     /db_xref="GeneID:11938"
                     /db_xref="MGI:MGI:88110"
                     /translation="MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAE
                     EGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANA
                     IVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVP
                     ADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGK
                     AMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINI
                     GHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVR
                     SLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFSITGSTYAPI
                     GEVQKDDKPVKCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE
                     KMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSM
                     SKMFVKGAPEGVIDRCTHIRVGSTKVPMTPGVKQKIMSVIREWGSGSDTLRCLALATH
                     DNPLKREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMIT
                     GDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELSPSAQRDACLNARCFARVEPSH
                     KSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMGSGTAVAKTASEMVLADDNFS
                     TIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVT
                     DGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFI
                     AADGGPRVSFYQLSHFLQCKEDNPDFDGVDCAIFESPYPMTMALSVLVTIEMCNALNS
                     LSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNLTQWLMVLKI
                     SLPVILMDETLKFVARNYLEQPGKECVQPATKSSCSLSACTDGISWPFVLLIMPLVVW
                     VYSTDTNFSDMFWS"
     exon            659..676
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     exon            677..759
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     exon            760..864
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1003
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1084
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1170
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1635
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1724
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1827
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1959
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2082
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2301
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2637
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2858
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..3061
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3147
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3281
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3399
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..4502
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4469..4474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /note="hexamer: AATAAA"
     polyA_site      4498
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /note="major polyA site"
ORIGIN      
        1 agagcagcct ccgcggagcc gtccccgacg ccgccacctc ccgtctcctc cgccgcagtt
       61 ccctccgccg ccgctgtcgg gggtgcagag ctgaggggct cgggccggcg cgccgcgcag
      121 ctcctctccc gtcgcctgcc tcgcggttcc cggcgccgag ggctcggccc ggcgccgctc
      181 ctcatctgcg ccccgtctcc tcggcgcagc gcccggggcc tgcgctgccc gcggccggct
      241 ggcagctgct gaagcgaccc acactcgcgg cggggcggga ggctcgcagt ccctcgggcg
      301 ggctcggcga ggccgggccg cgtgcggcgg tttctggggg agggggctcg ggtgattcag
      361 cgccccggtc aggcggaagc ggccgccgcc gccgcggagg aggaggagga gaagaaaaag
      421 gaggggacag ctgtccgcgc ccgggcgccc gcggtggcac gagcccgcgg ccggagtgcg
      481 aggcggtagg cgaggaggcc gcggggacgc gaggcgaggc cggccggggc ccccgcagcc
      541 atggagaacg ctcacacaaa gaccgtggag gaggtgctgg gccacttcgg ggtcaacgag
      601 agcacggggc tgagcttgga gcaggtcaag aagctcaagg agagatgggg ctccaacgaa
      661 ttgccggctg aagaaggaaa aaccttgctg gaacttgtga ttgagcagtt tgaagactta
      721 ctagttagaa ttttactgct ggcagcatgt atatctttcg ttttggcttg gttcgaggaa
      781 ggggaagaaa cgattacagc ctttgtagag ccgtttgtaa ttctgcttat cttggtagcc
      841 aatgcaatcg tgggtgtgtg gcaggaaaga aatgctgaaa atgcaataga agctcttaag
      901 gaatatgagc ctgaaatggg caaagtgtat cgacaggaca gaaagagtgt gcaacgaatt
      961 aaagctaaag acatagttcc tggtgatata gtggaaattg ctgttggtga caaagttcct
     1021 gctgatatta gattgacatc catcaagtct acaactctaa gagtcgacca gtcaattctt
     1081 acaggtgaat ctgtctccgt catcaagcat actgaccctg tccctgaccc ccgagctgtt
     1141 aatcaagaca aaaagaacat gctcttttct ggtacaaaca ttgctgctgg gaaagctatg
     1201 ggagtggtgg tggcaactgg agttaatact gagatcggca agatccggga tgaaatggtg
     1261 gcaacagaac aggagagaac acccctacag cagaagctag acgagtttgg ggagcagctt
     1321 tccaaagtta tctccctcat ttgcattgca gtctggatca tcaacattgg gcatttcaat
     1381 gacccagttc atggtggctc ctggatcagg ggtgccatct actactttaa gattgccgtg
     1441 gccctggctg ttgccgcaat ccctgagggt ctgcctgctg tcatcaccac ctgcttagct
     1501 cttggaactc gtaggatggc aaagaaaaat gctatcgttc gaagtctgcc ttctgtggag
     1561 acccttggtt gtacttctgt tatctgctca gataagacag gcacacttac cacaaaccag
     1621 atgtccgtgt gcaggatgtt cattctggac aaagtagaag gtgacacttg ttcccttaat
     1681 gagttcagca taactggatc cacatatgca ccaattggag aagtgcaaaa ggatgataag
     1741 ccagtgaagt gccatcagta tgacgggctt gtagagttag ccaccatctg tgctctgtgt
     1801 aatgactctg ctttggatta taatgaggca aagggtgtgt atgagaaagt tggagaagct
     1861 accgagactg ctctcacgtg cctggtggag aagatgaatg tatttgatac tgagctgaag
     1921 gggctttcta aaatagagcg tgcaaacgcc tgcaactcgg tcataaagca gctgatgaag
     1981 aaggagttca ctctggagtt ttcacgggat agaaaatcaa tgtccgtcta ttgtacccca
     2041 aacaagccaa gccggacatc catgagcaag atgtttgtga agggggctcc agaaggtgtc
     2101 atcgataggt gcacccacat ccgagttgga agtaccaagg tccccatgac tcctggtgtc
     2161 aaacagaaga ttatgtctgt cattcgggag tggggcagtg gcagcgacac gctacggtgc
     2221 ctggctctgg ccactcatga caacccactg aagagagagg agatgcacct ggaagactct
     2281 gctaacttca tcaaatacga gaccaacctg actttcgtcg gctgtgtggg catgctggat
     2341 cctcccagga ttgaagtagc ctcttctgtg aagctgtgcc ggcaagcagg catccgggtc
     2401 atcatgatca ctggagacaa caaaggcacc gctgtggcca tctgtcgccg cattggcatc
     2461 tttgggcagg atgaggatgt gacatcaaag gcttttacag ggcgagagtt tgatgaatta
     2521 agcccttcag cccagagaga tgcctgctta aatgcccgct gttttgctcg agttgaacct
     2581 tcccacaagt ctaagattgt tgagttcctt cagtcctttg atgagatcac agctatgact
     2641 ggtgatggtg tgaatgatgc tcctgctctg aagaaatctg aaatcgggat tgccatgggc
     2701 tcagggactg cagtggctaa gactgcttct gagatggtcc tggcagatga caacttctcc
     2761 accattgtgg ctgctgttga ggaggggcga gccatctaca acaacatgaa gcagttcatc
     2821 cgctacctca tctcatccaa cgtgggggaa gtggtctgta tcttcctgac ggcagccctt
     2881 gggtttcctg aggctttaat tcctgtccag ttactctggg tcaatctggt gacagatggt
     2941 ctgcctgcca ctgcgctggg gttcaatcct ccagacctgg acatcatgaa caaacccccc
     3001 cggaacccaa aagaaccact gatcagcggg tggctctttt tccgttacct ggctattggc
     3061 tgttatgttg gcgctgccac cgtgggtgct gctgcatggt ggttcatcgc tgctgacggc
     3121 ggtccaagag tctccttcta ccagctgagt catttcctac agtgtaagga ggacaaccca
     3181 gacttcgatg gagtggattg tgcaatcttt gagtccccat atccaatgac aatggcactt
     3241 tctgttctag taaccataga gatgtgtaat gccctcaaca gcttgtctga aaaccagtct
     3301 ttgctgagga tgcccccctg ggagaatatc tggctcgtgg gctccatctg cttgtccatg
     3361 tcacttcact tcttgatcct ctacgtggaa cctttgccgc tcattttcca gatcacaccg
     3421 ctgaatctga cccagtggct gatggtgctg aaaatctcct tgcctgtgat cctcatggat
     3481 gagacgctca agtttgtggc ccgaaactac ctggaacaac ccggtaaaga gtgtgtgcag
     3541 cctgccacca aatcttcctg ctccctgtcg gcatgcaccg atggcatttc ctggccgttt
     3601 gtgctgctca ttatgcccct ggtggtctgg gtctacagca cagacactaa ctttagcgat
     3661 atgttctggt cttgactgac agcgctacat acagaagatg tttaacttaa tcaattaatt
     3721 ttttattgtt taaagcaact gtctatttct gctgaatttt cacatgaaca tattggctgg
     3781 tgaaggaggt ttcatatcta gattttgttt tgctttttct gactccagtg ggacaagatt
     3841 ttcctttttt tatacacata attaaagtgt ccattgacgt gtacagagaa ctaacactat
     3901 tttatgcaga tatttttttg tagatgaaaa agcatgtaca gtgttctgtt taatactcat
     3961 acttgtacaa agatagttga gccagcagac attgtcagca aattaattgg cagcagactt
     4021 aggaaatgaa tgtgtgtggt ttttaaaaga aaaaaaacta aatagcatgt attgtgtctt
     4081 ttgcatgatt ctctggattt aatttggtat cacagtctaa tttttattca taagccaatt
     4141 tttctgcact gagcagagtc ctgctacctc agtcagtatt tttggtttgc cacttcctgc
     4201 accctcagcc tctgtcaccc ccagcccacc ccagcctgct cggcttcttc tgtaggtctg
     4261 atggttctgt ttacatccgt cttcacgaga ggtttgcctg tctcgcttgt gcagaaaaca
     4321 ttgctccaga tccaatcgac tgggtttctg tcccttcgcc tagtttttaa ggttatttat
     4381 ttaaatgtct aatgtatttt attgtaacag acattgtttt gccaacattg cctattcaat
     4441 ggcacttcac aatctagttt aaaagaaaaa taaaacattt taaatggaca gagaaaaata
     4501 acaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     4561 aaaaa
//
