LOCUS       NM_007504               3486 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus ATPase, Ca++ transporting, cardiac muscle, fast twitch
            1 (Atp2a1), mRNA.
ACCESSION   NM_007504
VERSION     NM_007504.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3486)
  AUTHORS   Piasecka,A., Szczesniak,M.W., Sekrecki,M., Kajdasz,A.,
            Sznajder,L.J., Baud,A. and Sobczak,K.
  TITLE     MBNL splicing factors regulate the microtranscriptome of skeletal
            muscles
  JOURNAL   Nucleic Acids Res 52 (19), 12055-12073 (2024)
   PUBMED   39258536
REFERENCE   2  (bases 1 to 3486)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3486)
  AUTHORS   Dos Santos,M., Shah,A.M., Zhang,Y., Bezprozvannaya,S., Chen,K.,
            Xu,L., Lin,W., McAnally,J.R., Bassel-Duby,R., Liu,N. and Olson,E.N.
  TITLE     Opposing gene regulatory programs governing myofiber development
            and maturation revealed at single nucleus resolution
  JOURNAL   Nat Commun 14 (1), 4333 (2023)
   PUBMED   37468485
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3486)
  AUTHORS   Fang,H., Xie,A., Du,M., Li,X., Yang,K., Fu,Y., Yuan,X., Fan,R.,
            Yu,W., Zhou,Z., Sang,T., Nie,K., Li,J., Zhao,Q., Chen,Z., Yang,Y.,
            Hong,C. and Lyu,J.
  TITLE     SERAC1 is a component of the mitochondrial serine transporter
            complex required for the maintenance of mitochondrial DNA
  JOURNAL   Sci Transl Med 14 (634), eabl6992 (2022)
   PUBMED   35235340
  REMARK    GeneRIF: SERAC1 is a component of the mitochondrial serine
            transporter complex required for the maintenance of mitochondrial
            DNA.
REFERENCE   5  (bases 1 to 3486)
  AUTHORS   Son,J.S., Chae,S.A., Zhao,L., Wang,H., de Avila,J.M., Zhu,M.J.,
            Jiang,Z. and Du,M.
  TITLE     Maternal exercise intergenerationally drives muscle-based
            thermogenesis via activation of apelin-AMPK signaling
  JOURNAL   EBioMedicine 76, 103842 (2022)
   PUBMED   35081489
REFERENCE   6  (bases 1 to 3486)
  AUTHORS   Odermatt,A., Taschner,P.E., Scherer,S.W., Beatty,B., Khanna,V.K.,
            Cornblath,D.R., Chaudhry,V., Yee,W.C., Schrank,B., Karpati,G.,
            Breuning,M.H., Knoers,N. and MacLennan,D.H.
  TITLE     Characterization of the gene encoding human sarcolipin (SLN), a
            proteolipid associated with SERCA1: absence of structural mutations
            in five patients with Brody disease
  JOURNAL   Genomics 45 (3), 541-553 (1997)
   PUBMED   9367679
REFERENCE   7  (bases 1 to 3486)
  AUTHORS   Harrer,J.M., Haghighi,K., Kim,H.W., Ferguson,D.G. and Kranias,E.G.
  TITLE     Coordinate regulation of SR Ca(2+)-ATPase and phospholamban
            expression in developing murine heart
  JOURNAL   Am J Physiol 272 (1 Pt 2), H57-H66 (1997)
   PUBMED   9038922
REFERENCE   8  (bases 1 to 3486)
  AUTHORS   Schleef,M., Simon-Chazottes,D., Lengeling,A., Klocke,R.,
            Jockusch,H., Yarden,Y. and Guenet,J.
  TITLE     The gene encoding sarcoplasmic reticulum calcium ATPase-1 (Atp2a1)
            maps to distal mouse chromosome 7
  JOURNAL   Mamm Genome 7 (10), 788 (1996)
   PUBMED   8854873
REFERENCE   9  (bases 1 to 3486)
  AUTHORS   Antony,C., Huchet,M., Changeux,J.P. and Cartaud,J.
  TITLE     Developmental regulation of membrane traffic organization during
            synaptogenesis in mouse diaphragm muscle
  JOURNAL   J Cell Biol 130 (4), 959-968 (1995)
   PUBMED   7642711
REFERENCE   10 (bases 1 to 3486)
  AUTHORS   Schleef,M., Zuhlke,C., Schoffl,F. and Jockusch,H.
  TITLE     Subtractive cDNA cloning as a tool to analyse secondary effects of
            a muscle disease. Characterization of affected genes in the
            myotonic ADR mouse
  JOURNAL   Neuromuscul Disord 4 (3), 205-217 (1994)
   PUBMED   7522680
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC036292.1.
            
            On Sep 26, 2003 this sequence version replaced NM_007504.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036292.1, AY081946.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3486
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.04 cM"
     gene            1..3486
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /note="ATPase, Ca++ transporting, cardiac muscle, fast
                     twitch 1"
                     /db_xref="GeneID:11937"
                     /db_xref="MGI:MGI:105058"
     exon            1..269
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..3136
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /EC_number="7.2.2.10"
                     /note="calcium pump 1; SR Ca(2+)-ATPase 1; endoplasmic
                     reticulum class 1/2 Ca(2+) ATPase"
                     /codon_start=1
                     /product="sarcoplasmic/endoplasmic reticulum calcium
                     ATPase 1"
                     /protein_id="NP_031530.2"
                     /db_xref="CCDS:CCDS40125.1"
                     /db_xref="GeneID:11937"
                     /db_xref="MGI:MGI:105058"
                     /translation="MEAAHSKSTEECLSYFGVSETTGLTPDQVKRHLEKYGPNELPAE
                     EGKSLWELVVEQFEDLLVRILLLAACISFVLAWFEEGEETVTAFVEPFVILLILIANA
                     IVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVP
                     ADIRILSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGK
                     AVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINI
                     GHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVR
                     SLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDVCSLNEFSITGSTYAPE
                     GEVLKNDKPVRAGQYDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVE
                     KMNVFNTEVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAV
                     GNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMSVIKEWGTGRDTLRCLALAT
                     RDTPPKREEMVLDDSAKFMEYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMI
                     TGDNKGTAIAICRRIGIFSENEEVTDRAYTGREFDDLPLAEQREACRRACCFARVEPS
                     HKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNF
                     STIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLV
                     TDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWF
                     LYAEDGPHVSYHQLTHFMQCTEHNPEFDGLDCEVFEAPEPMTMALSVLVTIEMCNALN
                     SLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDFTQWLMVLK
                     ISLPVIGLDELLKFIARNYLEG"
     exon            270..287
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            288..370
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..475
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..614
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..695
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..781
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            782..1079
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1246
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1335
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1438
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1570
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1696
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1915
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2251
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2472
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2675
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2761
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2895
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3013
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3131
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3173
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..3440
                     /gene="Atp2a1"
                     /gene_synonym="SERCA1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtggaaagg agaagaatct ggggggggca agcaagaaaa aggaaggagc ccagatcaac
       61 aggcaggtgg ataagctgaa gaagtccccc cacaagtgag aggcccctaa gaagaaacac
      121 atcaccccct ggcccccagg aagggagcac aatggaggcc gcgcactcca agtccacaga
      181 ggaatgtttg tcctatttcg gggtgagcga gaccacaggc cttaccccag accaagttaa
      241 gcgacatctg gaaaaatacg gccccaatga gctccctgct gaggaaggca agtctctgtg
      301 ggagttggtg gtagagcagt tcgaagacct gcttgtgcgg attcttctcc tggctgcctg
      361 catttccttt gtgctggcct ggtttgagga aggcgaagaa accgtcactg cctttgtgga
      421 accttttgtc attctcttga tcctcattgc caacgccatt gtgggggttt ggcaggaacg
      481 gaatgcagag aacgctatcg aagcgctgaa agaatatgaa cccgagatgg gaaaggtcta
      541 tcgggctgac cgaaagtcag tgcaaaggat caaggctcgg gacatcgttc ctggggacat
      601 cgtggaggtg gccgttgggg acaaagtccc tgcagacatc cgcatcctct ccatcaaatc
      661 caccaccctc cgggtcgacc agtccatcct gacaggagag tctgtgtctg tcatcaagca
      721 cacagaccct gtccctgacc cccgagctgt caaccaggac aagaagaaca tgctcttctc
      781 aggtaccaac atcgcagccg gcaaggctgt aggcatcgtg gccaccactg gtgtgagtac
      841 tgagattggc aagatccgag accagatggc tgccaccgag caggacaaga ctccactgca
      901 gcagaagctt gacgagtttg gggagcagct gtccaaggtc atctctctca tctgtgtggc
      961 tgtctggctt atcaacattg gccacttcaa cgatcctgtc catgggggct cctggttccg
     1021 gggtgccatt tactacttca agattgctgt ggccttggct gtggcggcca tcccagaagg
     1081 gcttcctgct gtcatcacca cctgcttggc tttgggtacc cgccggatgg caaagaagaa
     1141 cgccatcgtg aggagtctgc cctctgtgga gaccctgggc tgtacctctg tcatctgttc
     1201 tgacaaaaca gggaccctca ccaccaacca gatgtcagtt tgcaagatgt tcatcattga
     1261 caaggtggat ggggatgtct gctcactgaa cgagttctcc atcactggct ctacttatgc
     1321 tcctgaggga gaggtcttga agaatgataa gccagtccga gcagggcagt atgatgggct
     1381 ggtggagctc gctaccatct gtgccctctg caatgattcc tccttggact ttaatgagac
     1441 caaaggtgtc tatgagaagg tgggcgaggc cacggagact gctctcacca ccttggtgga
     1501 gaagatgaac gtattcaaca cggaagtgag aagcctctct aaagtggagc gggccaacgc
     1561 ctgcaattcg gtgatccgcc aactcatgaa gaaggaattc accctggaat tttcccgaga
     1621 caggaagtct atgtctgtct actgttcacc agctaagtcc tcacgggctg ccgtgggcaa
     1681 caagatgttt gtcaagggtg cccccgaggg ggtcatcgac cgctgtaact atgtgcgtgt
     1741 tggcacgacc cgtgtgccat tgacaggccc cgtgaaggag aagatcatgt ctgtgatcaa
     1801 ggagtggggc actggtcggg acacactgcg gtgcctggcg ctggccaccc gcgacacgcc
     1861 ccccaaacgc gaggagatgg ttctggatga ttcagccaag ttcatggagt atgagatgga
     1921 cctgacgttt gttggtgttg tgggcatgtt ggatccaccc cgcaaggagg tcacaggctc
     1981 tatccagctg tgtcgtgatg ctgggatccg agtgatcatg atcactgggg acaacaaggg
     2041 tacagccatt gccatctgcc gacgaattgg catcttttcg gagaatgagg aagtgacaga
     2101 ccgtgcctac actggccgtg agtttgacga tctgcccctg gccgagcagc gggaggcctg
     2161 cagacgcgcc tgctgctttg ctcgtgtgga gccctcacac aagtccaaga ttgtggagta
     2221 cctgcagtcc tacgatgaga tcacagccat gacaggggat ggtgtcaatg atgcccctgc
     2281 tctgaagaag gccgagattg gcattgccat gggatctggt actgctgtgg ctaagacggc
     2341 ctctgaaatg gtactggccg atgataactt ctccaccatc gtggctgccg tggaggaagg
     2401 ccgcgccatc tacaacaaca tgaagcagtt catccgctac ctcatctcct ccaatgtggg
     2461 cgaggtggtc tgtatcttct tgacagcagc cttggggctg cctgaggctc tgatccctgt
     2521 gcagctgctc tgggtgaact tggtgactga tgggctcccg gctactgccc tgggattcaa
     2581 cccacctgac ctggacatca tggaccgccc ccccaggagt cccaaggagc ctcttatcag
     2641 tggctggctc tttttccgct acatggcaat tgggggctat gtgggtgcag ccactgtagg
     2701 agcagctgcc tggtggtttt tgtatgcaga ggacgggcct catgtcagct accatcagct
     2761 gactcatttc atgcagtgca ctgagcacaa ccctgaattc gatggcctgg actgtgaggt
     2821 ctttgaggcc cccgagccca tgaccatggc cttgtctgtg ttggtgacca tcgagatgtg
     2881 caatgctctc aacagcctgt ctgagaacca gtccctactg cggatgccac cctgggtgaa
     2941 catctggctg ctgggttcca tctgcctgtc catgtccctc cacttcctca tcctctatgt
     3001 cgaccccctg ccgatgatct tcaagctccg ggccctggac tttacccagt ggctcatggt
     3061 cctcaagatc tcactgccag tcatcgggct ggatgagctt ctcaagttca ttgctcggaa
     3121 ctatctggag ggataaccac ccccctcctc catgtctttg aaccgtgtca cagatccaga
     3181 agacgaaaga aggaagtaac cagcccttgt gccctgtgtt ccccacccca atagccatgc
     3241 atcttcagcc aaagctgagg cactgaccct tcttccccct caattctgtt tataaataaa
     3301 gtcctccacc ctcgtcccct tcagcaaccc gctctccctc cgaaccttgt aaatcccctt
     3361 cccgaactca cggggcttgc aggcacaagg caactgacta gctgattgct tatttattga
     3421 aaataaatga cagaaaagtc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3481 aaaaaa
//
