LOCUS       NM_001290389            4266 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus ATPase Na+/K+ transporting, beta 4 polypeptide
            (Atp1b4), transcript variant 2, mRNA.
ACCESSION   NM_001290389 XM_006541532
VERSION     NM_001290389.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4266)
  AUTHORS   Pestov,N.B., Ahmad,N., Korneenko,T.V., Zhao,H., Radkov,R.,
            Schaer,D., Roy,S., Bibert,S., Geering,K. and Modyanov,N.N.
  TITLE     Evolution of Na,K-ATPase beta m-subunit into a coregulator of
            transcription in placental mammals
  JOURNAL   Proc Natl Acad Sci U S A 104 (27), 11215-11220 (2007)
   PUBMED   17592128
  REMARK    GeneRIF: During evolution, ATP1B4 lost its ancestral function,
            accumulated in nuclear membrane of perinatal myocytes, and
            associates with transcriptional coregulator Ski-interacting protein
            (SKIP).
REFERENCE   2  (bases 1 to 4266)
  AUTHORS   Zhao,H., Pestov,N.B., Korneenko,T.V., Shakhparonov,M.I. and
            Modyanov,N.N.
  TITLE     Accumulation of beta (m), a structural member of X,K-ATPase
            beta-subunit family, in nuclear envelopes of perinatal myocytes
  JOURNAL   Am J Physiol Cell Physiol 286 (4), C757-C767 (2004)
   PUBMED   14656723
  REMARK    GeneRIF: primary structure was determined and developmental
            regulation of the gene (ATP1B4) was analyzed
REFERENCE   3  (bases 1 to 4266)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY771893.1, AK053500.1, AK003843.1 and AV247095.1.
            
            On Mar 12, 2014 this sequence version replaced XM_006541532.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site, compared to variant 1. The encoded isoform (2) is
            shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF348325.1, BC137923.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                BY771893.1         1-62
            63-458              AK053500.1         2-397
            459-3410            AK053500.1         410-3361
            3411-4264           AK003843.1         965-1818
            4265-4266           AV247095.1         221-222
FEATURES             Location/Qualifiers
     source          1..4266
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 22.58 cM"
     gene            1..4266
                     /gene="Atp1b4"
                     /gene_synonym="1110020B02Rik"
                     /note="ATPase Na+/K+ transporting, beta 4 polypeptide"
                     /db_xref="GeneID:67821"
                     /db_xref="MGI:MGI:1915071"
     exon            1..208
                     /gene="Atp1b4"
                     /gene_synonym="1110020B02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1204
                     /gene="Atp1b4"
                     /gene_synonym="1110020B02Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     x/potassium-transporting ATPase subunit beta-m; protein
                     ATP1B4; x,K-ATPase subunit beta-m; ATPase, (Na+)/K+
                     transporting, beta 4 polypeptide"
                     /codon_start=1
                     /product="protein ATP1B4 isoform 2"
                     /protein_id="NP_001277318.1"
                     /db_xref="CCDS:CCDS72368.1"
                     /db_xref="GeneID:67821"
                     /db_xref="MGI:MGI:1915071"
                     /translation="MRRQLRSRRAPAFPYGYRYRLDDQDEANHNYLADEEEEAEEEAQ
                     VMMVPGLEEEEEEEEGKEEEEEREEEEGQGQSTGSAWWRKLQIVNEYLWDPEKRMSLA
                     RTGLILVIYFFFYASLAAVITLFIYMLFLAISPYMPTFTEQVKPPGVMIRPFAHSLNF
                     NFNVSEPETWQRYVISLNGFLQGYNDSLQEEMNIDCPPGRYFIQDGDEDEDKKACQFK
                     RSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPEFGDPVKVSCKVQKGDENDIRS
                     INYYPESASFDLRYYPYYGKLTHVNYTSPLVAMHFTDVVKNQAVPVQCQLKGKGIVND
                     VINDRFVGRIIFTLNIET"
     exon            209..458
                     /gene="Atp1b4"
                     /gene_synonym="1110020B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            459..587
                     /gene="Atp1b4"
                     /gene_synonym="1110020B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            588..692
                     /gene="Atp1b4"
                     /gene_synonym="1110020B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            693..889
                     /gene="Atp1b4"
                     /gene_synonym="1110020B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            890..946
                     /gene="Atp1b4"
                     /gene_synonym="1110020B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1042
                     /gene="Atp1b4"
                     /gene_synonym="1110020B02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..4266
                     /gene="Atp1b4"
                     /gene_synonym="1110020B02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3953..3958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp1b4"
                     /gene_synonym="1110020B02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3979
                     /gene="Atp1b4"
                     /gene_synonym="1110020B02Rik"
     regulatory      4233..4238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp1b4"
                     /gene_synonym="1110020B02Rik"
                     /note="hexamer: AATAAA"
     regulatory      4242..4247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atp1b4"
                     /gene_synonym="1110020B02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4253
                     /gene="Atp1b4"
                     /gene_synonym="1110020B02Rik"
     polyA_site      4266
                     /gene="Atp1b4"
                     /gene_synonym="1110020B02Rik"
                     /note="major polyA site"
ORIGIN      
        1 attttgggga agggctcgtg ccagcaaggt tcacttttag taggcgccaa gtgtccccag
       61 caaccagtgt ctcctgtacc agcagaagct ccagaagcct gccctactcg cctgcctctg
      121 catcgtcttg gccaactgag cagccatgag acggcaactc cgctccagaa gggctcccgc
      181 ctttccttac ggttatcgct acagacttga tgatcaggat gaagcgaatc acaactactt
      241 agcagatgaa gaggaggaag ctgaagagga ggctcaggtg atgatggtgc ctggtctaga
      301 ggaagaggaa gaagaggagg aaggaaaaga ggaggaggaa gaaagggagg aagaagaagg
      361 tcagggtcag tcaacaggca gtgcctggtg gcggaaattg cagatcgtga atgaatacct
      421 gtgggacccg gagaaaagga tgtctctggc ccgaacaggt cttattttag tcatttactt
      481 cttcttctat gcctccctgg ctgccgtgat caccctgttc atatacatgc tgttcctagc
      541 catcagtcct tacatgccga ccttcaccga gcaggtgaaa cctcctggag ttatgatcag
      601 acccttcgct catagcctta acttcaactt caacgtttct gaacctgaaa cttggcagcg
      661 ttacgtgatt agcctaaatg gctttctcca gggctataat gacagtcttc aagaggaaat
      721 gaatatagat tgtcctccgg gtcggtactt catccaagat ggagatgaag atgaggacaa
      781 gaaggcctgc caatttaagc gctccttcct gaagaattgc tctgggttgg aggatcccac
      841 ttttggatac tctactggac agccttgcat cctcctcaag atgaaccgga ttgtaggctt
      901 ccgtcctgag tttggagatc ctgtgaaggt gtcctgcaaa gttcagaaag gtgatgaaaa
      961 tgacattcga tccatcaatt actacccgga gtccgcttct tttgacctcc gctactaccc
     1021 ttactatggc aaactgactc atgttaacta cacctccccg ctggtggcaa tgcattttac
     1081 agatgtggtg aagaaccaag cagtgcctgt acagtgccag ctgaagggca aaggcatcgt
     1141 aaatgatgtc atcaatgatc gttttgttgg gaggataatc tttaccctga acatagaaac
     1201 ctaggaactc cagggagcca ctcccaccag ccactccacc ataatctaat tctgattatg
     1261 ttctattttg tgtcacccct ggtagcccct caattccttt tttcagttaa gacacagcca
     1321 gatggacccc taagatcatc tttccttgcc tttgacgtgt gtatgaagtg atattgtggg
     1381 acctgcttgg ttttttttta aggtcatcat ctctcctgat gacaaatatg actatattaa
     1441 tttctgctcc ttcacttcaa attcagacct attcttgctg ctagaagtct cactatatac
     1501 aaaaacagta tctgatagca ttcaccatgg tcaggagagt gttctatcac gttttctaaa
     1561 aatatgttgg ttttagaggt gatactattc ccagaatcta accaacccat agacatcttt
     1621 aaaactgcct gtcaaggtct tttctcagaa accaacatca gaccaaccaa gactactact
     1681 ctctctacag aactttatat ctgggggggg ggggttgaaa atttggctgt ctcccatagg
     1741 tgactcaata ctgatttaaa gactccatta ttttcagcca ggacagcagg acagcaggat
     1801 agcaagcaaa gctgacacat tattgatctg ggctagagat gaagaccttc tgtgagacgt
     1861 tttgtgggga gagttagatc ctagtataag tgagaagaac tgttagcata gggtgtgctt
     1921 ggttgttgag tgctctgtag tttaatcatc caaaggcaaa cgggtttttc tccactccag
     1981 gcaaaagaga aaacatgaaa aaaaatattc tttggtcaaa tctttttggc ccatatgctt
     2041 gatagttgtg tggttttctt tgagataagc agcgatgggt gccttgaacc ccacccccca
     2101 cccacagcta taaccttggg gattgaaatt agcattctcc agctaaaaca tggcaagaca
     2161 gaaagcttct gtcaggcctc cctgaagcca atgctcatta gccagttttg catctacttt
     2221 aaaaaaaaat cacatgaggc agatgtttat tcaggttgtg gatcagccaa gtgactttgt
     2281 ttttatcttt ggccatgtga ccattccaat cgcttcttaa cacctccacc agggggaggg
     2341 ctgggacaaa aagaggaggc aagcattaca gaccagcatc ctgtctcagg gtccaaagca
     2401 aacttaaatt ccacttacaa ggctgcagaa tctgatctac tctacaatgt ttagtttctc
     2461 ccaaattagg gaactggaag actaatgggg aaagacaagt gaaacctggc tataatgtag
     2521 ggtgacaaga gacctaaaaa tagtatacgg aaatgctatg ggaaacatga ggcacaatga
     2581 ctctctccag ctgtgacagt aacagaggaa atgacacatt cgaagccata agcatgaaga
     2641 catcttgtgc tttggtgatt ctgaacagtt cacatgagag ctcacgggaa ggatgaggag
     2701 actgaatcgc acaagtactt agagatgttg agagaaaggg agtctttaaa gtggtttaat
     2761 caggaaatcc ctgtaagcac atttgcattt gatcaagagc actggggcag tcataacatc
     2821 aggagtgaat ccatgacaga aaggacaaaa ccaagacagg aattggggga gaggaggaag
     2881 agtggacaaa tgagcccagg attttgagct tggcaaaaat caatgagata gtgatattga
     2941 taatcgagga ataaaagaga aagagattgg aaaggaagct gttgaggtca ctttgggaca
     3001 gttttatctt gtgagttcct ctggtcagac actgatgtag agatatgaac acatgtagag
     3061 tagaagagaa ggaaagcaga agacaaaagc aacatttgat gatgtgaact catttaggaa
     3121 atatttaatc ttgggaactt gagccagtta tgtaaacaca ctgatctagc tcctaatgtg
     3181 gtgcttttct ctgggtcttg ttgcagaatg ggctgctatt actcttggga gtctcccttg
     3241 cagagccctt ctaaatattc tccatactag tgaggggcag acagcattta acaagcaaca
     3301 gaagatgagc gggacggcag ggctacataa gacaccaaca caaaaatccc gactcctccg
     3361 gagttacttt ctcacaaagt tcaagtttcc tagcctttga acagaaaact aataaaaaat
     3421 gaaaacgaga acagcttgag accatttaaa aatggcctta atcaaaacct taagatttaa
     3481 tagcaaaaga gtatacagca tctgatctgg aaaggatctt taagggaaac aacctgcatt
     3541 gcatctgact ccaggtccag tgctctctca actcagagct gctgcttacc aggaagtacc
     3601 atctttttaa aagtcaacag accatatccc aaacattctg aaacatgtca aacttgagtt
     3661 aaaatagtta acatttcaca ggaattcaac tactggtgct atattttata cataatacat
     3721 ggtcctgttg aatatgttta actattagat aagaaattag gaatgatttt gtcatatgtg
     3781 tttctcattc ggtggcagat ataatgtcca cagtttcaaa gaagtattca aaagtactaa
     3841 gacagtttgt gctgtcagct ggaacatgaa aaatggcttt cttattcaaa actggatatt
     3901 atacagaact ggattaatga gtatgtttgt tcatgtgcaa ttctaactgt tcaataaatt
     3961 tctagttgat taatttaaat gggctcccat actgtgctgt accaggattt gatttctata
     4021 ccatctgttg caatgcactt ggctttactt gtcaatgaga aatactactt ccacatggct
     4081 tcatggtttt gttcttgcta tagtttatgt atgcgttttc acttttgact cctttgaaat
     4141 cattatttta aagaaatcat ccttaggcat ccatttactt ggagtcttcg atgtagaaaa
     4201 tatttatact gtcttgggga gttggtgcca acaataaacg aaataaaaag caatgtatga
     4261 tccctc
//
